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Protein

Formimidoylglutamase

Gene

hutG

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.UniRule annotation

Catalytic activityi

N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (hydrolase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formimidoylglutamase (hutG)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (hydrolase route), the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi137Manganese 1UniRule annotation1
Metal bindingi166Manganese 1UniRule annotation1
Metal bindingi166Manganese 2UniRule annotation1
Metal bindingi168Manganese 2UniRule annotation1
Metal bindingi170Manganese 1UniRule annotation1
Metal bindingi259Manganese 1UniRule annotation1
Metal bindingi259Manganese 2UniRule annotation1
Metal bindingi261Manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHistidine metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciCTET212717:G1G04-1886-MONOMER
UniPathwayiUPA00379; UER00552

Names & Taxonomyi

Protein namesi
Recommended name:
FormimidoylglutamaseUniRule annotation (EC:3.5.3.8UniRule annotation)
Alternative name(s):
FormiminoglutamaseUniRule annotation
Formiminoglutamate hydrolaseUniRule annotation
Gene namesi
Name:hutGUniRule annotation
Ordered Locus Names:CTC_01812
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001412 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737521 – 338FormimidoylglutamaseAdd BLAST338

Interactioni

Protein-protein interaction databases

STRINGi212717.CTC01812

Structurei

3D structure databases

ProteinModelPortaliQ893K6
SMRiQ893K6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41088SP Bacteria
COG0010 LUCA
KOiK01479
OMAiNFDAHLD
OrthoDBiPOG091H04CY

Family and domain databases

HAMAPiMF_00737 Formimidoylglutam, 1 hit
InterProiView protein in InterPro
IPR005923 HutG
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01227 hutG, 1 hit
PROSITEiView protein in PROSITE
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q893K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGINYKPCN EDFWQGRTDS EENFLAFRWH QWIKPINLNK DDLSPFTGKL
60 70 80 90 100
GFAFIGFCCD EGIRRNKGRT GAAKGPETIR EEMANLPCCF TDEVKLFDAG
110 120 130 140 150
NILVENISLE EGQDLLSKAI NKILSLNLFP IVLGGGHEVA FGNYLGVLSH
160 170 180 190 200
LKTINSKPNI GIINFDAHLD IRPYTEGMGS SGTMFRQISD ICKKEDLNYS
210 220 230 240 250
YLCMGVQKHS NTLELFKTAD KLGANYVFAK NITYGDNWIV FESLDDFMKA
260 270 280 290 300
QDYIYVTVCS DVFSSAFAPG VSASQSLGLD PEIVVRFIKY ILRSNKVISF
310 320 330
DIAEVSPRFD QGHVTANLAA VVIFSVIDTI AKIYGLGL
Length:338
Mass (Da):37,641
Last modified:June 1, 2003 - v1
Checksum:iBCBA6FBF744A3903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015927 Genomic DNA Translation: AAO36336.1
RefSeqiWP_011099996.1, NC_004557.1

Genome annotation databases

EnsemblBacteriaiAAO36336; AAO36336; CTC_01812
GeneIDi24254363
KEGGictc:CTC_01812

Similar proteinsi

Entry informationi

Entry nameiHUTG_CLOTE
AccessioniPrimary (citable) accession number: Q893K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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