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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciLPLA220668:G1GW0-701-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:lp_0806
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000432 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761081 – 230Uracil-DNA glycosylaseAdd BLAST230

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_0806

Structurei

3D structure databases

ProteinModelPortaliQ88YG1
SMRiQ88YG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q88YG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAFIHTDWW DVLKPEFEKP YYHQLHEFLK NEYRTKNIHP DMYNIFQAFE
60 70 80 90 100
WTPFADTKVV ILGQDPYHGP GQAHGLSFSV LPGVAVPPSL VNIYKELQDD
110 120 130 140 150
VGCTPVNHGY LESWAKQGVL LLNSVLTVQN GVAFSHAGKG WERLTDVAIQ
160 170 180 190 200
RLSERSTPVV FILWGKAARS KIKLIDTQTN VVLQAPHPSP LSAYRGFFGS
210 220 230
KPFSKTNIAL TSFGEQPINW QLPEHVNLEH
Length:230
Mass (Da):26,076
Last modified:June 20, 2003 - v1
Checksum:i11470E86B26C7096
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA Translation: CCC78265.1
RefSeqiWP_003643980.1, NC_004567.2
YP_004888779.1, NC_004567.2

Genome annotation databases

EnsemblBacteriaiCCC78265; CCC78265; lp_0806
GeneIDi1063885
KEGGilpl:lp_0806
PATRICifig|220668.9.peg.682

Similar proteinsi

Entry informationi

Entry nameiUNG_LACPL
AccessioniPrimary (citable) accession number: Q88YG1
Secondary accession number(s): F9UM26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: February 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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