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UniProtKB - Q88RB9 (DAVT_PSEPK)
Protein
5-aminovalerate aminotransferase DavT
Gene
davT
Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Status
Functioni
Catalyzes the conversion of 5-aminovalerate to 5-oxopentanoate.
1 PublicationCatalytic activityi
- EC:2.6.1.481 Publication
Cofactori
pyridoxal 5'-phosphateBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 139 | Pyridoxal phosphateBy similarity | 1 | |
Binding sitei | 298 | Pyridoxal phosphateBy similarity | 1 |
GO - Molecular functioni
- 4-aminobutyrate transaminase activity Source: InterPro
- 5-aminovalerate transaminase activity Source: UniProtKB
- pyridoxal phosphate binding Source: InterPro
GO - Biological processi
- gamma-aminobutyric acid metabolic process Source: InterPro
- L-lysine catabolic process Source: UniProtKB
Keywordsi
Molecular function | Aminotransferase, Transferase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BRENDAi | 2.6.1.48, 5092 |
Names & Taxonomyi
Protein namesi | Recommended name: 5-aminovalerate aminotransferase DavT (EC:2.6.1.48)Alternative name(s): 5-aminovalerate transaminase Delta-aminovalerate aminotransferase |
Gene namesi | Name:davT Ordered Locus Names:PP_0214 |
Organismi | Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) |
Taxonomic identifieri | 160488 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Mutants are impaired in lysine utilization and show a slight reduction in the root colonization capacity.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000418395 | 1 – 425 | 5-aminovalerate aminotransferase DavTAdd BLAST | 425 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 269 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Expressioni
Inductioni
Induced in response to corn root exudates, by lysine and by 5-aminovalerate.1 Publication
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 112 – 113 | Pyridoxal phosphate bindingBy similarity | 2 | |
Regioni | 240 – 243 | Pyridoxal phosphate bindingBy similarity | 4 |
Sequence similaritiesi
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.Curated
Phylogenomic databases
eggNOGi | COG0160, Bacteria |
HOGENOMi | CLU_016922_10_0_6 |
OMAi | TSGQMSC |
PhylomeDBi | Q88RB9 |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004632, 4NH2But_aminotransferase_bac IPR005814, Aminotrans_3 IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
PIRSFi | PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR00700, GABAtrnsam, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q88RB9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKTNESLMQ RRVAAVPRGV GQIHPIFVDT AKNSTVIDVE GRELIDFAGG
60 70 80 90 100
IAVLNTGHLH PKVVAAVQEQ LTKVSHTCFQ VLAYEPYVEL CEKINKLVPG
110 120 130 140 150
DFDKKTLLVT TGSEAVENAV KIARAATGRA GVIAFTGGYH GRTMMTLGLT
160 170 180 190 200
GKVVPYSAGM GLMPGGIFRA LFPSELHGIS VDDAIASVER IFKNDAEPRD
210 220 230 240 250
IAAIILEPVQ GEGGFLPAPK ELMKRLRALC DQHGILLIAD EVQTGAGRTG
260 270 280 290 300
TFFAMEQMGV APDLTTFAKS IAGGFPLAGV CGKAEYMDAI APGGLGGTYA
310 320 330 340 350
GSPIACAAAL AVIEVFEEEK LLDRSKAVGE RLTAGLREIQ KKYPIIGDVR
360 370 380 390 400
GLGSMIAVEV FEKGTHTPNA AAVGQVVAKA REKGLILLSC GTYGNVLRIL
410 420
VPLTAEDALL DKGLAIIEEC FAEIA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF299291 Genomic DNA Translation: AAK97868.1 AE015451 Genomic DNA Translation: AAN65846.1 |
RefSeqi | NP_742382.1, NC_002947.4 WP_003255866.1, NC_002947.4 |
Genome annotation databases
EnsemblBacteriai | AAN65846; AAN65846; PP_0214 |
KEGGi | ppu:PP_0214 |
PATRICi | fig|160488.4.peg.228 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF299291 Genomic DNA Translation: AAK97868.1 AE015451 Genomic DNA Translation: AAN65846.1 |
RefSeqi | NP_742382.1, NC_002947.4 WP_003255866.1, NC_002947.4 |
3D structure databases
AlphaFoldDBi | Q88RB9 |
SMRi | Q88RB9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 160488.PP_0214 |
Genome annotation databases
EnsemblBacteriai | AAN65846; AAN65846; PP_0214 |
KEGGi | ppu:PP_0214 |
PATRICi | fig|160488.4.peg.228 |
Phylogenomic databases
eggNOGi | COG0160, Bacteria |
HOGENOMi | CLU_016922_10_0_6 |
OMAi | TSGQMSC |
PhylomeDBi | Q88RB9 |
Enzyme and pathway databases
BRENDAi | 2.6.1.48, 5092 |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004632, 4NH2But_aminotransferase_bac IPR005814, Aminotrans_3 IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
PIRSFi | PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR00700, GABAtrnsam, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DAVT_PSEPK | |
Accessioni | Q88RB9Primary (citable) accession number: Q88RB9 Secondary accession number(s): Q7BII9, Q93G46 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 16, 2013 |
Last sequence update: | June 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families