nuoG

Functionⁱ

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityⁱ

NADH + a quinone = NAD⁺ + a quinol.

Cofactorⁱ

Protein has several cofactor binding sites:

[2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit.By similarity
[4Fe-4S] clusterBy similarityNote: Binds 3 [4Fe-4S] clusters per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	34	Iron-sulfur 1 (2Fe-2S)By similarity	1
Metal bindingⁱ	45	Iron-sulfur 1 (2Fe-2S)By similarity	1
Metal bindingⁱ	48	Iron-sulfur 1 (2Fe-2S)By similarity	1
Metal bindingⁱ	67	Iron-sulfur 1 (2Fe-2S)By similarity	1
Metal bindingⁱ	99	Iron-sulfur 2 (4Fe-4S); via tele nitrogenPROSITE-ProRule annotation	1
Metal bindingⁱ	103	Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation	1
Metal bindingⁱ	106	Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation	1
Metal bindingⁱ	112	Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation	1
Metal bindingⁱ	151	Iron-sulfur 3 (4Fe-4S)By similarity	1
Metal bindingⁱ	154	Iron-sulfur 3 (4Fe-4S)By similarity	1
Metal bindingⁱ	157	Iron-sulfur 3 (4Fe-4S)By similarity	1
Metal bindingⁱ	201	Iron-sulfur 3 (4Fe-4S)By similarity	1
Metal bindingⁱ	228	Iron-sulfur 4 (4Fe-4S)Sequence analysis	1
Metal bindingⁱ	231	Iron-sulfur 4 (4Fe-4S)Sequence analysis	1
Metal bindingⁱ	235	Iron-sulfur 4 (4Fe-4S)Sequence analysis	1
Metal bindingⁱ	263	Iron-sulfur 4 (4Fe-4S)Sequence analysis	1

GO - Molecular functionⁱ

2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
electron transfer activity Source: InterPro
metal ion binding Source: UniProtKB-KW
NADH dehydrogenase (ubiquinone) activity Source: InterPro
quinone binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ATP synthesis coupled electron transport Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

BioCycⁱ	PPUT160488:G1G01-4391-MONOMER

BioCycⁱ

PPUT160488:G1G01-4391-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NADH-quinone oxidoreductase subunit G (EC:1.6.5.11) Alternative name(s): NADH dehydrogenase I subunit G NDH-1 subunit G
Gene namesⁱ	Name:nuoG Ordered Locus Names:PP_4124
Organismⁱ	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifierⁱ	160488 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas putida group › Pseudomonas putida
Proteomesⁱ	UP000000556 Componentⁱ: Chromosome

Subcellular locationⁱ

GO - Cellular componentⁱ

membrane Source: InterPro

View the complete GO annotation on QuickGO ...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000118551	1 – 904	NADH-quinone oxidoreductase subunit GAdd BLAST		904

Keywords - PTMⁱ

Quinone

Proteomic databases

PRIDEⁱ	Q88FH2

PRIDEⁱ

Q88FH2

Interactionⁱ

Subunit structureⁱ

Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.

Protein-protein interaction databases

STRINGⁱ	160488.PP_4124

STRINGⁱ

160488.PP_4124

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q88FH2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 83	2Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST	83
Domainⁱ	83 – 122	4Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	221 – 277	4Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST	57

Sequence similaritiesⁱ

Belongs to the complex I 75 kDa subunit family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4107R0R Bacteria COG1034 LUCA
HOGENOMⁱ	HOG000276177
KEGG Orthology (KO) More...KOⁱ	K00336
OMAⁱ	GYGYVNR

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00207 fer2, 1 hit
InterProⁱ	View protein in InterPro IPR036010 2Fe-2S_ferredoxin-like_sf IPR001041 2Fe-2S_ferredoxin-type IPR006656 Mopterin_OxRdtase IPR006963 Mopterin_OxRdtase_4Fe-4S_dom IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS IPR010228 NADH_UbQ_OxRdtase_Gsu IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04879 Molybdop_Fe4S4, 1 hit PF00384 Molybdopterin, 1 hit PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTⁱ	View protein in SMART SM00926 Molybdop_Fe4S4, 1 hit SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMⁱ	SSF54292 SSF54292, 1 hit
TIGRFAMsⁱ	TIGR01973 NuoG, 1 hit
PROSITEⁱ	View protein in PROSITE PS51085 2FE2S_FER_2, 1 hit PS51839 4FE4S_HC3, 1 hit PS51669 4FE4S_MOW_BIS_MGD, 1 hit PS00641 COMPLEX1_75K_1, 1 hit PS00642 COMPLEX1_75K_2, 1 hit PS00643 COMPLEX1_75K_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q88FH2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATIHVDGKA LEVNGADNLL QACLSLGLDI PYFCWHPALG SVGACRQCAV 
        60         70         80         90        100
KQYTDENDTR GRIVMSCMTP ASDGTWISID DEESKAFRAS VVEWLMTNHP 
       110        120        130        140        150
HDCPVCEEGG HCHLQDMTVM TGHNERRYRF TKRTHQNQDL GPFIAHEMNR 
       160        170        180        190        200
CIACYRCVRY YKDYAGGTDL GVYGAHDNVY FGRVEDGVLE SEFSGNLTEV 
       210        220        230        240        250
CPTGVFTDKT HSERYNRKWD MQFAPSICHG CSSGCNISPG ERYGELRRIE 
       260        270        280        290        300
NRFNGSVNQY FLCDRGRFGY GYVNRKDRPR QPQLADGTKL GLDAALDKAA 
       310        320        330        340        350
DLLRGRTIVG IGSPRASLES NYGLRELVGA EYFYSGMEAG ELARVRLALN 
       360        370        380        390        400
VLNNSPLPVP TLRDIEDHDA VFVLGEDLTQ TAARVALAVR QATKGKAEAM 
       410        420        430        440        450
AEAMKVQPWL DAAVKNIGQH ALYPLFIASL AETKLDDVAE ECVHAAPADL 
       460        470        480        490        500
ARIGFAVAHA IDPSAPAVAG LDDEAQALAQ RIADALVAAK RPLVVAGTSL 
       510        520        530        540        550
ADPALIEAAA NIAKALKLRE KNGSLSLVVP EANSLGLAML GGESVDAALD 
       560        570        580        590        600
AVISGKADAI VVLENDLYAR VPAAKVDAAL AAAKVVIVAD HSKTATVDRA 
       610        620        630        640        650
HLVLPAASFA EGDGTLVSQE GRAQRFFQVF DPQYLDSSIQ IHEGWRWMHA 
       660        670        680        690        700
LRATLLNKPV DWTQLDHVTS ACAEAAPQLA GIVNAAPSAA FRIKGMKLAR 
       710        720        730        740        750
EPLRYSGRTA MRANISVHEP RTPQDKDTAF AFSMEGYSGS AEPRQQVPFA 
       760        770        780        790        800
WSPGWNSPQA WNKFQDEVGG HLRAGDPGVR LIESQGDRLN WFNAIPGAFN 
       810        820        830        840        850
PARGIWTAVP FFHLFGSEES SSRAAPVQER IPAAYVALAK SEADRLGVND 
       860        870        880        890        900
GALLSLNVAG VALRLPLRIN EELGAGLVAL PKGLAGIPPA IFGASVEGLQ 

EAAQ

Length:904

Mass (Da):97,582

Last modified:June 1, 2003 - v1

Checksum:ⁱ6A33D03B3292B3F7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE015451 Genomic DNA Translation: AAN69707.1
NCBI Reference Sequences More...RefSeqⁱ	NP_746243.1, NC_002947.4 WP_010954902.1, NC_002947.4

Genome annotation databases

EnsemblBacteriaⁱ	AAN69707; AAN69707; PP_4124
GeneIDⁱ	1042269
KEGGⁱ	ppu:PP_4124
PATRICⁱ	fig\|160488.4.peg.4383

Protein	Similar proteins		Species	Score	Length	Source
Q88FH2	NADH-quinone oxidoreductase		Pseudomonas sp. SMT-1		904	UniRef100_Q88FH2
UPI000761AEC2		Pseudomonas sp. GTC 16482		780

Protein	Similar proteins		Species	Score	Length	Source
Q88FH2	NADH-quinone oxidoreductase		Pseudomonas sp. SMT-1		904	UniRef90_Q88FH2
NADH-quinone oxidoreductase		Pseudomonas monteilii		904
NADH-quinone oxidoreductase		PSEPU		904
NADH-quinone oxidoreductase		Pseudomonas sp. FW305-E2		904
NADH-quinone oxidoreductase		Pseudomonas putida ND6		904
+167

Protein	Similar proteins		Species	Score	Length	Source
Q88FH2	NADH-quinone oxidoreductase subunit G		ECOLI		908	UniRef50_P33602
NADH-quinone oxidoreductase subunit G		SHIFL		908
NADH-quinone oxidoreductase subunit G		ECO57		908
NADH-quinone oxidoreductase subunit G		ECOL6		908
NADH-quinone oxidoreductase subunit G		SALTI		908
+4630

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE015451 Genomic DNA Translation: AAN69707.1
RefSeqⁱ	NP_746243.1, NC_002947.4 WP_010954902.1, NC_002947.4

3D structure databases

ProteinModelPortalⁱ	Q88FH2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	160488.PP_4124

STRINGⁱ

160488.PP_4124

Proteomic databases

PRIDEⁱ	Q88FH2

PRIDEⁱ

Q88FH2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAN69707; AAN69707; PP_4124
GeneIDⁱ	1042269
KEGGⁱ	ppu:PP_4124
PATRICⁱ	fig\|160488.4.peg.4383

Phylogenomic databases

eggNOGⁱ	ENOG4107R0R Bacteria COG1034 LUCA
HOGENOMⁱ	HOG000276177
KOⁱ	K00336
OMAⁱ	GYGYVNR

Enzyme and pathway databases

BioCycⁱ	PPUT160488:G1G01-4391-MONOMER

BioCycⁱ

PPUT160488:G1G01-4391-MONOMER

Family and domain databases

CDDⁱ	cd00207 fer2, 1 hit
InterProⁱ	View protein in InterPro IPR036010 2Fe-2S_ferredoxin-like_sf IPR001041 2Fe-2S_ferredoxin-type IPR006656 Mopterin_OxRdtase IPR006963 Mopterin_OxRdtase_4Fe-4S_dom IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS IPR010228 NADH_UbQ_OxRdtase_Gsu IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
Pfamⁱ	View protein in Pfam PF04879 Molybdop_Fe4S4, 1 hit PF00384 Molybdopterin, 1 hit PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTⁱ	View protein in SMART SM00926 Molybdop_Fe4S4, 1 hit SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMⁱ	SSF54292 SSF54292, 1 hit
TIGRFAMsⁱ	TIGR01973 NuoG, 1 hit
PROSITEⁱ	View protein in PROSITE PS51085 2FE2S_FER_2, 1 hit PS51839 4FE4S_HC3, 1 hit PS51669 4FE4S_MOW_BIS_MGD, 1 hit PS00641 COMPLEX1_75K_1, 1 hit PS00642 COMPLEX1_75K_2, 1 hit PS00643 COMPLEX1_75K_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NUOG_PSEPK
Accessionⁱ	Q88FH2Primary (citable) accession number: Q88FH2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
	Last sequence update:	June 1, 2003
	Last modified:	May 23, 2018
	This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

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UniProtKB - Q88FH2 (NUOG_PSEPK)

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NADH-quinone oxidoreductase subunit G

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ