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Protein

Beta sliding clamp

Gene

dnaN

Organism
Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation, DNA-directed DNA polymeraseUniRule annotationSAAS annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPSYR223283:G1G0D-2-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Beta sliding clampUniRule annotation
Gene namesi
Name:dnaNImported
Ordered Locus Names:PSPTO_0002Imported
OrganismiPseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)Imported
Taxonomic identifieri223283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002515 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a ring-shaped head-to-tail homodimer around DNA.UniRule annotation

Protein-protein interaction databases

STRINGi223283.PSPTO_0002

Structurei

3D structure databases

ProteinModelPortaliQ88BK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 119DNA_pol3_betaInterPro annotationAdd BLAST119
Domaini130 – 244DNA_pol3_beta_2InterPro annotationAdd BLAST115
Domaini247 – 366DNA_pol3_beta_3InterPro annotationAdd BLAST120

Sequence similaritiesi

Belongs to the beta sliding clamp family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CZ8 Bacteria
COG0592 LUCA
HOGENOMiHOG000071791
KOiK02338
OMAiNYEAVIP
OrthoDBiPOG091H02B3
PhylomeDBiQ88BK2

Family and domain databases

CDDicd00140 beta_clamp, 1 hit
InterProiView protein in InterPro
IPR001001 DNA_polIII_beta
IPR022635 DNA_polIII_beta_C
IPR022637 DNA_polIII_beta_cen
IPR022634 DNA_polIII_beta_N
PANTHERiPTHR30478 PTHR30478, 1 hit
PfamiView protein in Pfam
PF00712 DNA_pol3_beta, 1 hit
PF02767 DNA_pol3_beta_2, 1 hit
PF02768 DNA_pol3_beta_3, 1 hit
PIRSFiPIRSF000804 DNA_pol_III_b, 1 hit
SMARTiView protein in SMART
SM00480 POL3Bc, 1 hit
TIGRFAMsiTIGR00663 dnan, 1 hit

Sequencei

Sequence statusi: Complete.

Q88BK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFTIQREAL LKPLQLVAGV VERRQTLPVL SNVLLVVQGQ QLSLTGTDLE
60 70 80 90 100
VELVGRVQLE EPAEPGEITV PARKLMDICK SLPNDALIDI KLDDSKLIVK
110 120 130 140 150
AGRSRFTLST LPANDFPTVE EGPGSLTFNL VQSKLRRLIE RTSFAMAQQD
160 170 180 190 200
VRYYLNGMLL EVSAGILRAV ATDGHRLAMC SMSADIEHAD RHQVIVPRKG
210 220 230 240 250
ILEMARLLTE QDGMVSIVLG QHHIRATTGE FTFTSKLVDG KFPDYERVLP
260 270 280 290 300
KGGDKLVLGD RQSLREAFSR TAILSNEKYR GIRLQLANGQ LKIQANNPEQ
310 320 330 340 350
EEAEEEIGVE YNGEALEIGF NVSYLLDVLS VMTTEQVRLI LSDSNSSALV
360
QESDNDDSAY VVMPMRL
Length:367
Mass (Da):40,724
Last modified:June 1, 2003 - v1
Checksum:i748498F4D38855C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA Translation: AAO53559.1
RefSeqiNP_789864.1, NC_004578.1
WP_005768226.1, NC_004578.1

Genome annotation databases

EnsemblBacteriaiAAO53559; AAO53559; PSPTO_0002
GeneIDi1181610
KEGGipst:PSPTO_0002
PATRICifig|223283.9.peg.2

Similar proteinsi

Entry informationi

Entry nameiQ88BK2_PSESM
AccessioniPrimary (citable) accession number: Q88BK2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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