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Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transforms N2-succinylglutamate into succinate and glutamate.UniRule annotation

Catalytic activityi

N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-arginine degradation via AST pathway

This protein is involved in step 5 of the subpathway that synthesizes L-glutamate and succinate from L-arginine.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Arginine N-succinyltransferase (aruG), Arginine N-succinyltransferase (aruF)
  2. N-succinylarginine dihydrolase (astB)
  3. no protein annotated in this organism
  4. N-succinylglutamate 5-semialdehyde dehydrogenase (astD)
  5. Succinylglutamate desuccinylase (astE)
This subpathway is part of the pathway L-arginine degradation via AST pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate and succinate from L-arginine, the pathway L-arginine degradation via AST pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59ZincUniRule annotation1
Metal bindingi62ZincUniRule annotation1
Metal bindingi151ZincUniRule annotation1
Active sitei215UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processArginine metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciPSYR223283:G1G0D-1873-MONOMER
UniPathwayi
UPA00185;UER00283

Names & Taxonomyi

Protein namesi
Recommended name:
Succinylglutamate desuccinylaseUniRule annotation (EC:3.5.1.96UniRule annotation)
Gene namesi
Name:astEUniRule annotation
Ordered Locus Names:PSPTO_1838
OrganismiPseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Taxonomic identifieri223283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002515 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001746451 – 335Succinylglutamate desuccinylaseAdd BLAST335

Interactioni

Protein-protein interaction databases

STRINGi223283.PSPTO_1838

Structurei

3D structure databases

ProteinModelPortaliQ885J4
SMRiQ885J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107UI5 Bacteria
COG2988 LUCA
HOGENOMiHOG000280300
KOiK05526
OMAiAHAFTVE
OrthoDBiPOG091H04VJ
PhylomeDBiQ885J4

Family and domain databases

CDDicd03855 M14_ASTE, 1 hit
HAMAPiMF_00767 Arg_catab_AstE, 1 hit
InterProiView protein in InterPro
IPR007036 Aste_AspA
IPR016681 SuccinylGlu_desuccinylase
PfamiView protein in Pfam
PF04952 AstE_AspA, 1 hit
PIRSFiPIRSF017020 AstE, 1 hit
TIGRFAMsiTIGR03242 arg_catab_astE, 1 hit

Sequencei

Sequence statusi: Complete.

Q885J4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLALGKLLEL TLAGREPAEK TQLTVEGVRM RWLAEGALEV RPPQARDNGT
60 70 80 90 100
DLLLSAGIHG NETAPIELLD ELIRSIARGD LKPRARILFL FGNPAAMRLG
110 120 130 140 150
ARYVEQDVNR LFNGRHEQSG GAEALRACEL ERLAASFFSL PDRYRLHYDL
160 170 180 190 200
HTAIRGSKIE QFALYPWKEG RQHSRFELAR LRAAGISAVL LQNKPSIVFS
210 220 230 240 250
AYTYEQLGAE AFTLELGKAR PFGQNRHVNL APLRLRLEQI IEGSEPQPDE
260 270 280 290 300
RLEGLQLFSV AREVIKRSDA FTFNLADDVE NFSELEKGYV LAEDVSDSRW
310 320 330
VVKEEGARII FPNPKVKNGL RAGIVIVPAD ADGLG
Length:335
Mass (Da):37,375
Last modified:June 1, 2003 - v1
Checksum:iE43CFD5829B97F3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA Translation: AAO55357.1
RefSeqiNP_791662.1, NC_004578.1
WP_005767756.1, NC_004578.1

Genome annotation databases

EnsemblBacteriaiAAO55357; AAO55357; PSPTO_1838
GeneIDi1183479
KEGGipst:PSPTO_1838
PATRICifig|223283.9.peg.1868

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA Translation: AAO55357.1
RefSeqiNP_791662.1, NC_004578.1
WP_005767756.1, NC_004578.1

3D structure databases

ProteinModelPortaliQ885J4
SMRiQ885J4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi223283.PSPTO_1838

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO55357; AAO55357; PSPTO_1838
GeneIDi1183479
KEGGipst:PSPTO_1838
PATRICifig|223283.9.peg.1868

Phylogenomic databases

eggNOGiENOG4107UI5 Bacteria
COG2988 LUCA
HOGENOMiHOG000280300
KOiK05526
OMAiAHAFTVE
OrthoDBiPOG091H04VJ
PhylomeDBiQ885J4

Enzyme and pathway databases

UniPathwayi
UPA00185;UER00283

BioCyciPSYR223283:G1G0D-1873-MONOMER

Family and domain databases

CDDicd03855 M14_ASTE, 1 hit
HAMAPiMF_00767 Arg_catab_AstE, 1 hit
InterProiView protein in InterPro
IPR007036 Aste_AspA
IPR016681 SuccinylGlu_desuccinylase
PfamiView protein in Pfam
PF04952 AstE_AspA, 1 hit
PIRSFiPIRSF017020 AstE, 1 hit
TIGRFAMsiTIGR03242 arg_catab_astE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASTE_PSESM
AccessioniPrimary (citable) accession number: Q885J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: October 10, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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