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Protein

NADH-quinone oxidoreductase subunit G

Gene

nuoG

Organism
Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit.By similarity
  • [4Fe-4S] clusterBy similarityNote: Binds 3 [4Fe-4S] clusters per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi34Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi45Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi48Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi67Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi99Iron-sulfur 2 (4Fe-4S); via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi103Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi106Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi112Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi151Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi154Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi157Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi201Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi228Iron-sulfur 4 (4Fe-4S)Sequence analysis1
Metal bindingi231Iron-sulfur 4 (4Fe-4S)Sequence analysis1
Metal bindingi235Iron-sulfur 4 (4Fe-4S)Sequence analysis1
Metal bindingi263Iron-sulfur 4 (4Fe-4S)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

BioCyciPSYR223283:G1G0D-3425-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit G (EC:1.6.5.11)
Alternative name(s):
NADH dehydrogenase I subunit G
NDH-1 subunit G
Gene namesi
Name:nuoG
Ordered Locus Names:PSPTO_3370
OrganismiPseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Taxonomic identifieri223283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002515 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001185521 – 905NADH-quinone oxidoreductase subunit GAdd BLAST905

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.

Protein-protein interaction databases

STRINGi223283.PSPTO_3370

Structurei

3D structure databases

ProteinModelPortaliQ87ZQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 832Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST83
Domaini83 – 1224Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST40
Domaini221 – 2774Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Belongs to the complex I 75 kDa subunit family.Curated

Phylogenomic databases

eggNOGiENOG4108IEH Bacteria
COG1034 LUCA
HOGENOMiHOG000276177
KOiK00336
OMAiGYGYVNR
OrthoDBiPOG091H09RP
PhylomeDBiQ87ZQ4

Family and domain databases

CDDicd00207 fer2, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR009010 Asp_de-COase-like_dom_sf
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS
IPR010228 NADH_UbQ_OxRdtase_Gsu
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
PfamiView protein in Pfam
PF04879 Molybdop_Fe4S4, 1 hit
PF00384 Molybdopterin, 1 hit
PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTiView protein in SMART
SM00926 Molybdop_Fe4S4, 1 hit
SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMiSSF50692 SSF50692, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR01973 NuoG, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS51839 4FE4S_HC3, 1 hit
PS51669 4FE4S_MOW_BIS_MGD, 1 hit
PS00641 COMPLEX1_75K_1, 1 hit
PS00642 COMPLEX1_75K_2, 1 hit
PS00643 COMPLEX1_75K_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q87ZQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATIHVDGKA LEVDGADNLL QACLSLGLDI PYFCWHPALG SVGACRQCAV
60 70 80 90 100
KQYTDENDTR GRIVMSCMTP ATDNTWISIE DDESKAFRAS VVEWLMTNHP
110 120 130 140 150
HDCPVCEEGG HCHLQDMTVM TGHNERRYRF TKRTHQNQEL GPFIAHEMNR
160 170 180 190 200
CIACYRCVRF YKDYAGGTDL GVYGAHDNVY FGRVEDGTLE SEFSGNLTEV
210 220 230 240 250
CPTGVFTDKT HSERYNRKWD MQFSPSICHG CSSGCNISPG ERYGELRRIE
260 270 280 290 300
NRYNGSVNQY FLCDRGRFGY GYVNRTDRPR QPLLVDGQVK LSLDEALDKA
310 320 330 340 350
ADLLRGRNIV GIGSPRASLE SNYALRELVG AEHFYSGIEA GELERVRLIL
360 370 380 390 400
KVLNDSPLPI PTLRDIEDHD AIFVLGEDLT QTAARMALGL RQAVKGKAED
410 420 430 440 450
MAAAMKVQPW LDAAVKNIGQ HELNPLFIAS LAETRLDDIA EECVHAAPDD
460 470 480 490 500
LARIGFAVAH ALDASAPAVE GLDSEALELA QRIADALLAA KRPLIISGSS
510 520 530 540 550
LGSTALIEAA ANIAKALKLR DKQGSISLIV PEANSMGLAM FGGDSVDAAL
560 570 580 590 600
QAVISGKADA IVVLENDLYR RVDAKIVDAA LSAAKVVIVA DHQKTPTSDR
610 620 630 640 650
AHLVLPAASF AEGDGTLVSQ EGRAQRFFQV FDPTYLDASI LVHEGWRWLH
660 670 680 690 700
ALRATLLNKP VDWTQLDHVT EACAGSTAQL AGIVNAAPSA SFRIKGLKLA
710 720 730 740 750
REPLRYSGRT AMRANISVHE PRTSQDIDTA FSFSMEGYSG SAEPRQQVPF
760 770 780 790 800
AWSPGWNSPQ AWNKFQDEVG GHLRAGDPGT RLIESQGDGL SWFSSVPRAF
810 820 830 840 850
SPERGTWQVV PFFHLFGSDE TSSLAAPVQE RIPQAYVAVA KSEADRLGVN
860 870 880 890 900
DGALLSLSIG GETLTLPLRI SEELGAGLVA LPAGLPGIPP ALFGKSVDGL

QEAAQ
Length:905
Mass (Da):98,334
Last modified:June 1, 2003 - v1
Checksum:i53716244354E40DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA Translation: AAO56848.1
RefSeqiNP_793153.1, NC_004578.1
WP_007246028.1, NC_004578.1

Genome annotation databases

EnsemblBacteriaiAAO56848; AAO56848; PSPTO_3370
GeneIDi1185029
KEGGipst:PSPTO_3370
PATRICifig|223283.9.peg.3450

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA Translation: AAO56848.1
RefSeqiNP_793153.1, NC_004578.1
WP_007246028.1, NC_004578.1

3D structure databases

ProteinModelPortaliQ87ZQ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi223283.PSPTO_3370

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO56848; AAO56848; PSPTO_3370
GeneIDi1185029
KEGGipst:PSPTO_3370
PATRICifig|223283.9.peg.3450

Phylogenomic databases

eggNOGiENOG4108IEH Bacteria
COG1034 LUCA
HOGENOMiHOG000276177
KOiK00336
OMAiGYGYVNR
OrthoDBiPOG091H09RP
PhylomeDBiQ87ZQ4

Enzyme and pathway databases

BioCyciPSYR223283:G1G0D-3425-MONOMER

Family and domain databases

CDDicd00207 fer2, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR009010 Asp_de-COase-like_dom_sf
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS
IPR010228 NADH_UbQ_OxRdtase_Gsu
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
PfamiView protein in Pfam
PF04879 Molybdop_Fe4S4, 1 hit
PF00384 Molybdopterin, 1 hit
PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTiView protein in SMART
SM00926 Molybdop_Fe4S4, 1 hit
SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMiSSF50692 SSF50692, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR01973 NuoG, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS51839 4FE4S_HC3, 1 hit
PS51669 4FE4S_MOW_BIS_MGD, 1 hit
PS00641 COMPLEX1_75K_1, 1 hit
PS00642 COMPLEX1_75K_2, 1 hit
PS00643 COMPLEX1_75K_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUOG_PSESM
AccessioniPrimary (citable) accession number: Q87ZQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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