nuoG

Functionⁱ

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityⁱ

NADH + a quinone = NAD⁺ + a quinol.

Cofactorⁱ

Protein has several cofactor binding sites:

[2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit.By similarity
[4Fe-4S] clusterBy similarityNote: Binds 3 [4Fe-4S] clusters per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	34	Iron-sulfur 1 (2Fe-2S)By similarity	1
Metal bindingⁱ	45	Iron-sulfur 1 (2Fe-2S)By similarity	1
Metal bindingⁱ	48	Iron-sulfur 1 (2Fe-2S)By similarity	1
Metal bindingⁱ	67	Iron-sulfur 1 (2Fe-2S)By similarity	1
Metal bindingⁱ	99	Iron-sulfur 2 (4Fe-4S); via tele nitrogenPROSITE-ProRule annotation	1
Metal bindingⁱ	103	Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation	1
Metal bindingⁱ	106	Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation	1
Metal bindingⁱ	112	Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation	1
Metal bindingⁱ	151	Iron-sulfur 3 (4Fe-4S)By similarity	1
Metal bindingⁱ	154	Iron-sulfur 3 (4Fe-4S)By similarity	1
Metal bindingⁱ	157	Iron-sulfur 3 (4Fe-4S)By similarity	1
Metal bindingⁱ	201	Iron-sulfur 3 (4Fe-4S)By similarity	1
Metal bindingⁱ	228	Iron-sulfur 4 (4Fe-4S)Sequence analysis	1
Metal bindingⁱ	231	Iron-sulfur 4 (4Fe-4S)Sequence analysis	1
Metal bindingⁱ	235	Iron-sulfur 4 (4Fe-4S)Sequence analysis	1
Metal bindingⁱ	263	Iron-sulfur 4 (4Fe-4S)Sequence analysis	1

GO - Molecular functionⁱ

2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
electron transfer activity Source: InterPro
metal ion binding Source: UniProtKB-KW
NADH dehydrogenase (ubiquinone) activity
Source: JCVI
Inferred from sequence or structural similarityⁱ
- 12928499
quinone binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ATP synthesis coupled electron transport Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

BioCycⁱ	PSYR223283:G1G0D-3425-MONOMER

BioCycⁱ

PSYR223283:G1G0D-3425-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NADH-quinone oxidoreductase subunit G (EC:1.6.5.11) Alternative name(s): NADH dehydrogenase I subunit G NDH-1 subunit G
Gene namesⁱ	Name:nuoG Ordered Locus Names:PSPTO_3370
Organismⁱ	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Taxonomic identifierⁱ	223283 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas syringae group › Pseudomonas syringae pv. tomato
Proteomesⁱ	UP000002515 Componentⁱ: Chromosome

Subcellular locationⁱ

GO - Cellular componentⁱ

membrane Source: InterPro

View the complete GO annotation on QuickGO ...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000118552	1 – 905	NADH-quinone oxidoreductase subunit GAdd BLAST		905

Keywords - PTMⁱ

Quinone

Interactionⁱ

Subunit structureⁱ

Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.

Protein-protein interaction databases

STRINGⁱ	223283.PSPTO_3370

STRINGⁱ

223283.PSPTO_3370

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q87ZQ4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 83	2Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST	83
Domainⁱ	83 – 122	4Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	221 – 277	4Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST	57

Sequence similaritiesⁱ

Belongs to the complex I 75 kDa subunit family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4108IEH Bacteria COG1034 LUCA
HOGENOMⁱ	HOG000276177
KEGG Orthology (KO) More...KOⁱ	K00336
OMAⁱ	GYGYVNR
Database of Orthologous Groups More...OrthoDBⁱ	POG091H09RP
PhylomeDBⁱ	Q87ZQ4

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00207 fer2, 1 hit
InterProⁱ	View protein in InterPro IPR036010 2Fe-2S_ferredoxin-like_sf IPR001041 2Fe-2S_ferredoxin-type IPR009010 Asp_de-COase-like_dom_sf IPR006656 Mopterin_OxRdtase IPR006963 Mopterin_OxRdtase_4Fe-4S_dom IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS IPR010228 NADH_UbQ_OxRdtase_Gsu IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04879 Molybdop_Fe4S4, 1 hit PF00384 Molybdopterin, 1 hit PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTⁱ	View protein in SMART SM00926 Molybdop_Fe4S4, 1 hit SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMⁱ	SSF50692 SSF50692, 1 hit SSF54292 SSF54292, 1 hit
TIGRFAMsⁱ	TIGR01973 NuoG, 1 hit
PROSITEⁱ	View protein in PROSITE PS51085 2FE2S_FER_2, 1 hit PS51839 4FE4S_HC3, 1 hit PS51669 4FE4S_MOW_BIS_MGD, 1 hit PS00641 COMPLEX1_75K_1, 1 hit PS00642 COMPLEX1_75K_2, 1 hit PS00643 COMPLEX1_75K_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q87ZQ4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATIHVDGKA LEVDGADNLL QACLSLGLDI PYFCWHPALG SVGACRQCAV 
        60         70         80         90        100
KQYTDENDTR GRIVMSCMTP ATDNTWISIE DDESKAFRAS VVEWLMTNHP 
       110        120        130        140        150
HDCPVCEEGG HCHLQDMTVM TGHNERRYRF TKRTHQNQEL GPFIAHEMNR 
       160        170        180        190        200
CIACYRCVRF YKDYAGGTDL GVYGAHDNVY FGRVEDGTLE SEFSGNLTEV 
       210        220        230        240        250
CPTGVFTDKT HSERYNRKWD MQFSPSICHG CSSGCNISPG ERYGELRRIE 
       260        270        280        290        300
NRYNGSVNQY FLCDRGRFGY GYVNRTDRPR QPLLVDGQVK LSLDEALDKA 
       310        320        330        340        350
ADLLRGRNIV GIGSPRASLE SNYALRELVG AEHFYSGIEA GELERVRLIL 
       360        370        380        390        400
KVLNDSPLPI PTLRDIEDHD AIFVLGEDLT QTAARMALGL RQAVKGKAED 
       410        420        430        440        450
MAAAMKVQPW LDAAVKNIGQ HELNPLFIAS LAETRLDDIA EECVHAAPDD 
       460        470        480        490        500
LARIGFAVAH ALDASAPAVE GLDSEALELA QRIADALLAA KRPLIISGSS 
       510        520        530        540        550
LGSTALIEAA ANIAKALKLR DKQGSISLIV PEANSMGLAM FGGDSVDAAL 
       560        570        580        590        600
QAVISGKADA IVVLENDLYR RVDAKIVDAA LSAAKVVIVA DHQKTPTSDR 
       610        620        630        640        650
AHLVLPAASF AEGDGTLVSQ EGRAQRFFQV FDPTYLDASI LVHEGWRWLH 
       660        670        680        690        700
ALRATLLNKP VDWTQLDHVT EACAGSTAQL AGIVNAAPSA SFRIKGLKLA 
       710        720        730        740        750
REPLRYSGRT AMRANISVHE PRTSQDIDTA FSFSMEGYSG SAEPRQQVPF 
       760        770        780        790        800
AWSPGWNSPQ AWNKFQDEVG GHLRAGDPGT RLIESQGDGL SWFSSVPRAF 
       810        820        830        840        850
SPERGTWQVV PFFHLFGSDE TSSLAAPVQE RIPQAYVAVA KSEADRLGVN 
       860        870        880        890        900
DGALLSLSIG GETLTLPLRI SEELGAGLVA LPAGLPGIPP ALFGKSVDGL 

QEAAQ

Length:905

Mass (Da):98,334

Last modified:June 1, 2003 - v1

Checksum:ⁱ53716244354E40DD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE016853 Genomic DNA Translation: AAO56848.1
NCBI Reference Sequences More...RefSeqⁱ	NP_793153.1, NC_004578.1 WP_007246028.1, NC_004578.1

Genome annotation databases

EnsemblBacteriaⁱ	AAO56848; AAO56848; PSPTO_3370
GeneIDⁱ	1185029
KEGGⁱ	pst:PSPTO_3370
PATRICⁱ	fig\|223283.9.peg.3450

Protein	Similar proteins		Species	Score	Length	Source
Q87ZQ4	NADH-quinone oxidoreductase		PSEUB		905	UniRef100_Q87ZQ4
NADH-quinone oxidoreductase		PSEYM		905
NADH-quinone oxidoreductase		Pseudomonas syringae pv. berberidis		905
NADH dehydrogenase subunit G (Fragment)		Pseudomonas syringae pv. japonica str. M301072		87
NADH-quinone oxidoreductase		Pseudomonas syringae pv. coryli		194
+2

Protein	Similar proteins		Species	Score	Length	Source
Q87ZQ4	NADH-quinone oxidoreductase		PSEUB		905	UniRef90_Q87ZQ4
NADH-quinone oxidoreductase		PSEYM		905
NADH-quinone oxidoreductase		Pseudomonas syringae pv. berberidis		905
NADH dehydrogenase subunit G (Fragment)		Pseudomonas syringae pv. japonica str. M301072		87
NADH-quinone oxidoreductase		Pseudomonas syringae pv. coryli		194
+488

Protein	Similar proteins		Species	Score	Length	Source
Q87ZQ4	NADH-quinone oxidoreductase subunit G		ECOLI		908	UniRef50_P33602
NADH-quinone oxidoreductase subunit G		SHIFL		908
NADH-quinone oxidoreductase subunit G		ECO57		908
NADH-quinone oxidoreductase subunit G		ECOL6		908
NADH-quinone oxidoreductase subunit G		SALTI		908
+4739

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE016853 Genomic DNA Translation: AAO56848.1
RefSeqⁱ	NP_793153.1, NC_004578.1 WP_007246028.1, NC_004578.1

3D structure databases

ProteinModelPortalⁱ	Q87ZQ4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	223283.PSPTO_3370

STRINGⁱ

223283.PSPTO_3370

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAO56848; AAO56848; PSPTO_3370
GeneIDⁱ	1185029
KEGGⁱ	pst:PSPTO_3370
PATRICⁱ	fig\|223283.9.peg.3450

Phylogenomic databases

eggNOGⁱ	ENOG4108IEH Bacteria COG1034 LUCA
HOGENOMⁱ	HOG000276177
KOⁱ	K00336
OMAⁱ	GYGYVNR
OrthoDBⁱ	POG091H09RP
PhylomeDBⁱ	Q87ZQ4

Enzyme and pathway databases

BioCycⁱ	PSYR223283:G1G0D-3425-MONOMER

BioCycⁱ

PSYR223283:G1G0D-3425-MONOMER

Family and domain databases

CDDⁱ	cd00207 fer2, 1 hit
InterProⁱ	View protein in InterPro IPR036010 2Fe-2S_ferredoxin-like_sf IPR001041 2Fe-2S_ferredoxin-type IPR009010 Asp_de-COase-like_dom_sf IPR006656 Mopterin_OxRdtase IPR006963 Mopterin_OxRdtase_4Fe-4S_dom IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS IPR010228 NADH_UbQ_OxRdtase_Gsu IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
Pfamⁱ	View protein in Pfam PF04879 Molybdop_Fe4S4, 1 hit PF00384 Molybdopterin, 1 hit PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTⁱ	View protein in SMART SM00926 Molybdop_Fe4S4, 1 hit SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMⁱ	SSF50692 SSF50692, 1 hit SSF54292 SSF54292, 1 hit
TIGRFAMsⁱ	TIGR01973 NuoG, 1 hit
PROSITEⁱ	View protein in PROSITE PS51085 2FE2S_FER_2, 1 hit PS51839 4FE4S_HC3, 1 hit PS51669 4FE4S_MOW_BIS_MGD, 1 hit PS00641 COMPLEX1_75K_1, 1 hit PS00642 COMPLEX1_75K_2, 1 hit PS00643 COMPLEX1_75K_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NUOG_PSESM
Accessionⁱ	Q87ZQ4Primary (citable) accession number: Q87ZQ4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
	Last sequence update:	June 1, 2003
	Last modified:	February 28, 2018
	This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

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UniProtKB - Q87ZQ4 (NUOG_PSESM)

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NADH-quinone oxidoreductase subunit G

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ