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Protein

Mitochondrial import inner membrane translocase subunit TIM44

Gene

tim44

Organism
Neurospora crassa
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, TranslocationUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM44UniRule annotation
Gene namesi
Name:tim44Imported
ORF Names:GE21DRAFT_1289Imported
OrganismiNeurospora crassaImported
Taxonomic identifieri5141 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000053122 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi5141.EFNCRP00000003005

Structurei

3D structure databases

ProteinModelPortaliQ873Q7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini366 – 520Tim44InterPro annotationAdd BLAST155

Sequence similaritiesi

Belongs to the Tim44 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2580 Eukaryota
ENOG410Y5IK LUCA
HOGENOMiHOG000208172
PhylomeDBiQ873Q7

Family and domain databases

InterProiView protein in InterPro
IPR032710 NTF2-like_dom_sf
IPR017303 Tim44
IPR039544 Tim44-like
IPR007379 Tim44-like_dom
PANTHERiPTHR10721 PTHR10721, 1 hit
PfamiView protein in Pfam
PF04280 Tim44, 1 hit
PIRSFiPIRSF037871 TIM44, 1 hit
SMARTiView protein in SMART
SM00978 Tim44, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit

Sequencei

Sequence statusi: Complete.

Q873Q7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAYRHVLRT SPGAPLRATA VPHTTHVRSP ATSRLLSSRA SRVNTTESRI
60 70 80 90 100
SPATPISAQE IPLLRSPFTP NAIQARSFHA SFRALQQQEQ PKQQTPETEP
110 120 130 140 150
KAQEEPTGKK ESKSEEAKEE GEKSEGEPKK EKKEDAPPPP PHGDKTPWQV
160 170 180 190 200
FMETMQTEFK QSQEWNESTK ALAASANQIA ESEAIRRARQ AYEATSGTVS
210 220 230 240 250
STAGKVVKTT ATAVGKGAQW TWETPVMKGV RKGANITGEV LDKATKPIRE
260 270 280 290 300
TEAYKNVKDV IDDGSSSRYG GWAEKEERRK RREKWLKESA GKGPQILEED
310 320 330 340 350
PNAGTNVTLH KDAAWKEAWR DFRDSNKFVQ NVFGLKTVYE ESENPLISTA
360 370 380 390 400
RSITDKIGSF FAENETAQVI KKLRELDPGF NMENFLMELR EYILPEVLEA
410 420 430 440 450
YVKGDVETLK LWLSEAQYSV YEALTKQYLQ AGLKSDGRIL DIRGVDVLKA
460 470 480 490 500
RMLEPGDIPV FVITCRTQEV HVYKNAKTGK LAAGMEDKVQ LVTYAIGITR
510 520
IPEDVNNPET RGWRLIEMQK SGRDYI
Length:526
Mass (Da):58,990
Last modified:June 1, 2003 - v1
Checksum:i2E7A4E8532AD31CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212507 mRNA Translation: AAO72335.1
KN389697 Genomic DNA Translation: KHE82976.1

Genome annotation databases

EnsemblFungiiKHE82976; KHE82976; GE21DRAFT_1289

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212507 mRNA Translation: AAO72335.1
KN389697 Genomic DNA Translation: KHE82976.1

3D structure databases

ProteinModelPortaliQ873Q7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5141.EFNCRP00000003005

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiKHE82976; KHE82976; GE21DRAFT_1289

Phylogenomic databases

eggNOGiKOG2580 Eukaryota
ENOG410Y5IK LUCA
HOGENOMiHOG000208172
PhylomeDBiQ873Q7

Family and domain databases

InterProiView protein in InterPro
IPR032710 NTF2-like_dom_sf
IPR017303 Tim44
IPR039544 Tim44-like
IPR007379 Tim44-like_dom
PANTHERiPTHR10721 PTHR10721, 1 hit
PfamiView protein in Pfam
PF04280 Tim44, 1 hit
PIRSFiPIRSF037871 TIM44, 1 hit
SMARTiView protein in SMART
SM00978 Tim44, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ873Q7_NEUCS
AccessioniPrimary (citable) accession number: Q873Q7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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