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Entry version 116 (22 Apr 2020)
Sequence version 1 (01 Jun 2003)
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Protein

Protein transport protein sec31

Gene

sec31

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein sec31
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sec31
ORF Names:B24N11.230, NCU06738
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 6, Linkage Group II, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:NCU06738

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002954421 – 1256Protein transport protein sec31Add BLAST1256

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q873A1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The COPII coat is composed of at least 5 proteins: the sec23/24 complex, the sec13/31 complex, and the protein vtr-7/sar1. Sec13 and sec31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage.

Interacts (via WD 8) with nup-20/sec13 (By similarity).

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q873A1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati5 – 46WD 1Add BLAST42
Repeati65 – 109WD 2Add BLAST45
Repeati117 – 157WD 3Add BLAST41
Repeati161 – 201WD 4Add BLAST41
Repeati204 – 247WD 5Add BLAST44
Repeati251 – 291WD 6Add BLAST41
Repeati294 – 334WD 7Add BLAST41
Repeati375 – 403WD 8; interaction with sec13PROSITE-ProRule annotationAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi823 – 1144Pro-richAdd BLAST322

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat SEC31 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003033_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q873A1

KEGG Orthology (KO)

More...
KOi
K14005

Identification of Orthologs from Complete Genome Data

More...
OMAi
FMIAICG

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR040251 SEC31-like
IPR009917 SRA1-protein/COPII_Sec31
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13923 PTHR13923, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12931 Sec16_C, 1 hit
PF07304 SRA1, 1 hit
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q873A1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRLREIPRT AAFAWSPGAN PLLVTGTRSG AVDADFSDET KLELWDLKLD
60 70 80 90 100
SQEQGLELQP IASITAESRF YDIAWGQPND EHPRGVIAGA MENGSLDLWD
110 120 130 140 150
AEKLIAGEDA LISRTTKHTG PIKALQFNPL RPQVLATAGA KGELFVWDVN
160 170 180 190 200
DTSAPFRLGT AAAHDIDCLA WNPKVANILA TGGAGGFVTV WDLKTKKASL
210 220 230 240 250
TLNNHRKAVS AIAWDPENST KLLTASSDDT APVILLWNLR NSQAPEKTLQ
260 270 280 290 300
GHDQGILSLS WCQQDAGLLL SCGKDNRTLI WNPQTGERYG EFPEATNWTF
310 320 330 340 350
YTRFNPHNPN LSATASFDGK IAIQTLQNTN PSAAPAAQNN LSDDDFFSKA
360 370 380 390 400
ASQPQAASFS LPRAPAWIER PVGVSFGFGG KLVFFNKVET AAGQKRSSKL
410 420 430 440 450
QISSFSIDSD IGSATDKFEQ AIQSGDIASI CEEHIENAKT DEEKAEWQVM
460 470 480 490 500
QTLSESDGRT KIIERLGFIK DEPVEEAKEA ESPMSPEPKQ EDSASLKPNG
510 520 530 540 550
GEAKKHRRVV SMWGDGDDGE DFLSEIAATK GAKTDNPFNL LSVGNTHLED
560 570 580 590 600
QITRALILGK FEKAVEICLK EERWSDAFLI ANCGSKELVE KVQTAYLQQK
610 620 630 640 650
RGSPSYLRLI SSVVAKNLWD IAYNADLADW KETMVTLCTY ADPSEFPDLC
660 670 680 690 700
EALGDRILES GNRKDASFCY LIGSKLEKVV GLWVDELQET EQAALNEEAG
710 720 730 740 750
DSTFSVHAKS LQQFIEKVTI FRHVTKFNDS ETSLTEGWKL AALYDKYLEY
760 770 780 790 800
ADIAAAHGQL SVAQKYLDLL PTSYPPAETA RNRVRLATQK AGAQTAVRQA
810 820 830 840 850
TPAGRTTTTT SSRTAAPVGY QQPSLVPAPA NPSSLNPYAP PVPAPVSAAA
860 870 880 890 900
SNPYAPPLAP VSAAASQYGA SSSTYAPPQN QGYAPSGYTP PTQSYAPTSV
910 920 930 940 950
TGYGVPAQNF GQPSPLGGPP KATAPPVQLK RDGVWNDVPM VTKAPPRRNT
960 970 980 990 1000
PSVAPLTSPF PGQPGIASPP PAGPFQQGAP TPPPPPKGSA PPRNVGAPPT
1010 1020 1030 1040 1050
GPPRPSSVSS NATNPYAPPP PAAGLQPTYG VPPAPRTASP YNPPPSAAAP
1060 1070 1080 1090 1100
PANRYAPAPA TQQYTQGPPS GSGIAPPPAS GAYTPAPPAA SQQYAAAPPP
1110 1120 1130 1140 1150
PRAGFSAPPP ASRPPGGGPP PAAGAPPQQQ APPPAAPPKP RYPPGDRSNI
1160 1170 1180 1190 1200
PEHAKELVDI LSRDMQRVAS KAPASFAPQV KDTQKRLNIL FDHLNNEELI
1210 1220 1230 1240 1250
KTETIDQLAQ LAGALAGKNY DIASKIQVEI SKEKTEECGQ WMVGVKRLIS

MSKATP
Length:1,256
Mass (Da):134,018
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3875155C99C36B3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284751 Genomic DNA Translation: CAD70409.1
CM002237 Genomic DNA Translation: EAA34274.1

NCBI Reference Sequences

More...
RefSeqi
XP_963510.1, XM_958417.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAA34274; EAA34274; NCU06738

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3879671

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ncr:NCU06738

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284751 Genomic DNA Translation: CAD70409.1
CM002237 Genomic DNA Translation: EAA34274.1
RefSeqiXP_963510.1, XM_958417.2

3D structure databases

SMRiQ873A1
ModBaseiSearch...

Proteomic databases

PRIDEiQ873A1

Genome annotation databases

EnsemblFungiiEAA34274; EAA34274; NCU06738
GeneIDi3879671
KEGGincr:NCU06738

Organism-specific databases

EuPathDBiFungiDB:NCU06738

Phylogenomic databases

HOGENOMiCLU_003033_2_0_1
InParanoidiQ873A1
KOiK14005
OMAiFMIAICG

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR040251 SEC31-like
IPR009917 SRA1-protein/COPII_Sec31
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13923 PTHR13923, 1 hit
PfamiView protein in Pfam
PF12931 Sec16_C, 1 hit
PF07304 SRA1, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEC31_NEUCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q873A1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2003
Last modified: April 22, 2020
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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