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Entry version 151 (22 Apr 2020)
Sequence version 2 (15 Mar 2004)
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Protein

Hornerin

Gene

HRNR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the epidermal cornified cell envelopes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi19 – 321PROSITE-ProRule annotationAdd BLAST14
Calcium bindingi62 – 732PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processKeratinization
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hornerin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HRNR
Synonyms:S100A18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20846 HRNR

Online Mendelian Inheritance in Man (OMIM)

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MIMi
616293 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86YZ3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
388697

Open Targets

More...
OpenTargetsi
ENSG00000197915

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134936141

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86YZ3 Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HRNR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
45476906

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001440381 – 2850HornerinAdd BLAST2850

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei659PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei890PhosphoserineCombined sources1
Modified residuei993PhosphoserineCombined sources1
Modified residuei1008PhosphoserineCombined sources1
Modified residuei1205Omega-N-methylarginineBy similarity1
Modified residuei1463PhosphoserineCombined sources1
Modified residuei1478PhosphoserineCombined sources1
Modified residuei1712PhosphoserineCombined sources1
Modified residuei1714PhosphoserineCombined sources1
Modified residuei1829PhosphoserineCombined sources1
Modified residuei1831PhosphoserineCombined sources1
Modified residuei1933PhosphoserineCombined sources1
Modified residuei1948PhosphoserineCombined sources1
Modified residuei2299PhosphoserineCombined sources1
Modified residuei2301PhosphoserineCombined sources1
Modified residuei2403PhosphoserineCombined sources1
Modified residuei2418PhosphoserineCombined sources1
Modified residuei2652PhosphoserineCombined sources1
Modified residuei2654PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Processed during the process of epidermal differentiation.By similarity
Forms covalent cross-links mediated by transglutaminase TGM3, between glutamine and the epsilon-amino group of lysine residues (in vitro).1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86YZ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86YZ3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86YZ3

PeptideAtlas

More...
PeptideAtlasi
Q86YZ3

PRoteomics IDEntifications database

More...
PRIDEi
Q86YZ3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70490

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
Q86YZ3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86YZ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86YZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cornified epidermis, psoriatic and regenerating skin after wounding. Found in the upper granular layer and in the entire cornified layer of epidermis.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By UV-B irradiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197915 Expressed in lower esophagus mucosa and 48 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197915 Tissue enhanced (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
132814, 55 interactors

Protein interaction database and analysis system

More...
IntActi
Q86YZ3, 29 interactors

Molecular INTeraction database

More...
MINTi
Q86YZ3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357791

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86YZ3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86YZ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini49 – 84EF-hand 2PROSITE-ProRule annotationAdd BLAST36
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati97 – 1871Add BLAST91
Repeati188 – 2782Add BLAST91
Repeati279 – 3693Add BLAST91
Repeati370 – 4604Add BLAST91
Repeati474 – 5665Add BLAST93
Repeati593 – 6836Add BLAST91
Repeati685 – 7477Add BLAST63
Repeati748 – 8368Add BLAST89
Repeati839 – 8759Add BLAST37
Repeati876 – 96510Add BLAST90
Repeati966 – 100411Add BLAST39
Repeati1007 – 109712Add BLAST91
Repeati1098 – 118813Add BLAST91
Repeati1215 – 130514Add BLAST91
Repeati1332 – 142215Add BLAST91
Repeati1423 – 147416Add BLAST52
Repeati1477 – 156717Add BLAST91
Repeati1568 – 165818Add BLAST91
Repeati1685 – 177519Add BLAST91
Repeati1802 – 189220Add BLAST91
Repeati1893 – 194421Add BLAST52
Repeati1947 – 203722Add BLAST91
Repeati2038 – 212823Add BLAST91
Repeati2155 – 224524Add BLAST91
Repeati2272 – 236225Add BLAST91
Repeati2363 – 241426Add BLAST52
Repeati2417 – 250727Add BLAST91
Repeati2508 – 259828Add BLAST91
Repeati2625 – 271529Add BLAST91
Repeati2716 – 280630Add BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 81S-100-likeAdd BLAST81

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the S100-fused protein family.Curated
In the N-terminal section; belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IX7U Eukaryota
ENOG410ZH9F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154467

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_226653_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86YZ3

KEGG Orthology (KO)

More...
KOi
K23757

Identification of Orthologs from Complete Genome Data

More...
OMAi
THGQHGS

Database of Orthologous Groups

More...
OrthoDBi
30610at2759

TreeFam database of animal gene trees

More...
TreeFami
TF338665

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00213 S-100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR033201 HRNR
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub

The PANTHER Classification System

More...
PANTHERi
PTHR22571:SF25 PTHR22571:SF25, 9 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01023 S_100, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01394 S_100, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86YZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKLLQGVIT VIDVFYQYAT QHGEYDTLNK AELKELLENE FHQILKNPND
60 70 80 90 100
PDTVDIILQS LDRDHNKKVD FTEYLLMIFK LVQARNKIIG KDYCQVSGSK
110 120 130 140 150
LRDDTHQHQE EQEETEKEEN KRQESSFSHS SWSAGENDSY SRNVRGSLKP
160 170 180 190 200
GTESISRRLS FQRDFSGQHN SYSGQSSSYG EQNSDSHQSS GRGQCGSGSG
210 220 230 240 250
QSPNYGQHGS GSGQSSSNDT HGSGSGQSSG FSQHKSSSGQ SSGYSQHGSG
260 270 280 290 300
SGHSSGYGQH GSRSGQSSRG ERHRSSSGSS SSYGQHGSGS RQSLGHGRQG
310 320 330 340 350
SGSRQSPSHV RHGSGSGHSS SHGQHGSGSS YSYSRGHYES GSGQTSGFGQ
360 370 380 390 400
HESGSGQSSG YSKHGSGSGH SSSQGQHGST SGQASSSGQH GSSSRQSSSY
410 420 430 440 450
GQHESASRHS SGRGQHSSGS GQSPGHGQRG SGSGQSPSSG QHGTGFGRSS
460 470 480 490 500
SSGPYVSGSG YSSGFGHHES SSEHSSGYTQ HGSGSGHSSG HGQHGSRSGQ
510 520 530 540 550
SSRGERQGSS AGSSSSYGQH GSGSRQSLGH SRHGSGSGQS PSPSRGRHES
560 570 580 590 600
GSRQSSSYGP HGYGSGRSSS RGPYESGSGH SSGLGHQESR SGQSSGYGQH
610 620 630 640 650
GSSSGHSSTH GQHGSTSGQS SSCGQHGATS GQSSSHGQHG SGSSQSSRYG
660 670 680 690 700
QQGSGSGQSP SRGRHGSDFG HSSSYGQHGS GSGWSSSNGP HGSVSGQSSG
710 720 730 740 750
FGHKSGSGQS SGYSQHGSGS SHSSGYRKHG SRSGQSSRSE QHGSSSGLSS
760 770 780 790 800
SYGQHGSGSH QSSGHGRQGS GSGHSPSRVR HGSSSGHSSS HGQHGSGTSC
810 820 830 840 850
SSSCGHYESG SGQASGFGQH ESGSGQGYSQ HGSASGHFSS QGRHGSTSGQ
860 870 880 890 900
SSSSGQHDSS SGQSSSYGQH ESASHHASGR GRHGSGSGQS PGHGQRGSGS
910 920 930 940 950
GQSPSYGRHG SGSGRSSSSG RHGSGSGQSS GFGHKSSSGQ SSGYTQHGSG
960 970 980 990 1000
SGHSSSYEQH GSRSGQSSRS EQHGSSSGSS SSYGQHGSGS RQSLGHGQHG
1010 1020 1030 1040 1050
SGSGQSPSPS RGRHGSGSGQ SSSYGPYRSG SGWSSSRGPY ESGSGHSSGL
1060 1070 1080 1090 1100
GHRESRSGQS SGYGQHGSSS GHSSTHGQHG STSGQSSSCG QHGASSGQSS
1110 1120 1130 1140 1150
SHGQHGSGSS QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS YGRHGSGSGR
1160 1170 1180 1190 1200
SSSSGQHGSG LGESSGFGHH ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS
1210 1220 1230 1240 1250
GQSSRGERHG SSSGSSSHYG QHGSGSRQSS GHGRQGSGSG HSPSRGRHGS
1260 1270 1280 1290 1300
GLGHSSSHGQ HGSGSGRSSS RGPYESRSGH SSVFGQHESG SGHSSAYSQH
1310 1320 1330 1340 1350
GSGSGHFCSQ GQHGSTSGQS STFDQEGSST GQSSSYGHRG SGSSQSSGYG
1360 1370 1380 1390 1400
RHGAGSGQSP SRGRHGSGSG HSSSYGQHGS GSGWSSSSGR HGSGSGQSSG
1410 1420 1430 1440 1450
FGHHESSSWQ SSGCTQHGSG SGHSSSYEQH GSRSGQSSRG ERHGSSSGSS
1460 1470 1480 1490 1500
SSYGQHGSGS RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ SSSYSPYGSG
1510 1520 1530 1540 1550
SGWSSSRGPY ESGSSHSSGL GHRESRSGQS SGYGQHGSSS GHSSTHGQHG
1560 1570 1580 1590 1600
STSGQSSSCG QHGASSGQSS SHGQHGSGSS QSSGYGRQGS GSGQSPGHGQ
1610 1620 1630 1640 1650
RGSGSRQSPS YGRHGSGSGR SSSSGQHGSG LGESSGFGHH ESSSGQSSSY
1660 1670 1680 1690 1700
SQHGSGSGHS SGYGQHGSRS GQSSRGERHG SSSRSSSRYG QHGSGSRQSS
1710 1720 1730 1740 1750
GHGRQGSGSG QSPSRGRHGS GLGHSSSHGQ HGSGSGRSSS RGPYESRSGH
1760 1770 1780 1790 1800
SSVFGQHESG SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS STFDQEGSST
1810 1820 1830 1840 1850
GQSSSHGQHG SGSSQSSSYG QQGSGSGQSP SRGRHGSGSG HSSSYGQHGS
1860 1870 1880 1890 1900
GSGWSSSSGR HGSGSGQSSG FGHHESSSWQ SSGYTQHGSG SGHSSSYEQH
1910 1920 1930 1940 1950
GSRSGQSSRG EQHGSSSGSS SSYGQHGSGS RQSLGHGQHG SGSGQSPSPS
1960 1970 1980 1990 2000
RGRHGSGSGQ SSSYGPYGSG SGWSSSRGPY ESGSGHSSGL GHRESRSGQS
2010 2020 2030 2040 2050
SGYGQHGSSS GHSSTHGQHG SASGQSSSCG QHGASSGQSS SHGQHGSGSS
2060 2070 2080 2090 2100
QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS YGRHGSGSGR SSSSGQHGPG
2110 2120 2130 2140 2150
LGESSGFGHH ESSSGQSSSY SQHGSGSGHS SGYGQHGSRS GQSSRGERHG
2160 2170 2180 2190 2200
SSSGSSSRYG QHGSGSRQSS GHGRQGSGSG HSPSRGRHGS GSGHSSSHGQ
2210 2220 2230 2240 2250
HGSGSGRSSS RGPYESRSGH SSVFGQHESG SGHSSAYSQH GSGSGHFCSQ
2260 2270 2280 2290 2300
GQHGSTSGQS STFDQEGSST GQSSSHGQHG SGSSQSSSYG QQGSGSGQSP
2310 2320 2330 2340 2350
SRGRHGSGSG HSSSYGQHGS GSGWSSSSGR HGSGSGQSSG FGHHESSSWQ
2360 2370 2380 2390 2400
SSGYTQHGSG SGHSSSYEQH GSRSGQSSRG ERHGSSSGSS SSYGQHGSGS
2410 2420 2430 2440 2450
RQSLGHGQHG SGSGQSPSPS RGRHGSGSGQ SSSYSPYGSG SGWSSSRGPY
2460 2470 2480 2490 2500
ESGSGHSSGL GHRESRSGQS SGYGQHGSSS GHSSTHGQHG STSGQSSSCG
2510 2520 2530 2540 2550
QHGASSGQSS SHGQHGSGSS QSSGYGRQGS GSGQSPGHGQ RGSGSRQSPS
2560 2570 2580 2590 2600
YGRHGSGSGR SSSSGQHGSG LGESSGFGHH ESSSGQSSSY SQHGSGSGHS
2610 2620 2630 2640 2650
SGYGQHGSRS GQSSRGERHG SSSGSSSHYG QHGSGSRQSS GHGRQGSGSG
2660 2670 2680 2690 2700
QSPSRGRHGS GLGHSSSHGQ HGSGSGRSSS RGPYESRLGH SSVFGQHESG
2710 2720 2730 2740 2750
SGHSSAYSQH GSGSGHFCSQ GQHGSTSGQS STFDQEGSST GQSSSYGHRG
2760 2770 2780 2790 2800
SGSSQSSGYG RHGAGSGQSL SHGRHGSGSG QSSSYGQHGS GSGQSSGYSQ
2810 2820 2830 2840 2850
HGSGSGQDGY SYCKGGSNHD GGSSGSYFLS FPSSTSPYEY VQEQRCYFYQ
Length:2,850
Mass (Da):282,390
Last modified:March 15, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF25D8028C5AB6701
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti271E → D in AAR91619 (Ref. 2) Curated1
Sequence conflicti2382R → Q in BAC57496 (PubMed:15507446).Curated1
Sequence conflicti2539G → S in BAC57496 (PubMed:15507446).Curated1
Sequence conflicti2688L → S in BAC57496 (PubMed:15507446).Curated1
Sequence conflicti2837P → T in AAR91619 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04849485R → H1 PublicationCorresponds to variant dbSNP:rs11204937Ensembl.1
Natural variantiVAR_061053122R → W. Corresponds to variant dbSNP:rs57277761Ensembl.1
Natural variantiVAR_048495167G → D. Corresponds to variant dbSNP:rs12741518Ensembl.1
Natural variantiVAR_059174273H → Q. Corresponds to variant dbSNP:rs7545406Ensembl.1
Natural variantiVAR_061054376Q → R. Corresponds to variant dbSNP:rs6587649Ensembl.1
Natural variantiVAR_061055427G → D. Corresponds to variant dbSNP:rs6666097Ensembl.1
Natural variantiVAR_048496473E → G. Corresponds to variant dbSNP:rs6587648Ensembl.1
Natural variantiVAR_048497492G → R. Corresponds to variant dbSNP:rs6587647Ensembl.1
Natural variantiVAR_061056517Y → C. Corresponds to variant dbSNP:rs41266134Ensembl.1
Natural variantiVAR_048498664R → Q. Corresponds to variant dbSNP:rs7520249Ensembl.1
Natural variantiVAR_048499799S → T. Corresponds to variant dbSNP:rs6662450Ensembl.1
Natural variantiVAR_0591752435S → G. Corresponds to variant dbSNP:rs78949172Ensembl.1
Natural variantiVAR_0591762461G → S. Corresponds to variant dbSNP:rs6659183Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB104446 mRNA Translation: BAC57496.1
BR000036 mRNA Translation: FAA00004.1
AY396741 mRNA Translation: AAR91619.1
AL589986 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30859.1

NCBI Reference Sequences

More...
RefSeqi
NP_001009931.1, NM_001009931.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368801; ENSP00000357791; ENSG00000197915

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
388697

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:388697

UCSC genome browser

More...
UCSCi
uc001ezt.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB104446 mRNA Translation: BAC57496.1
BR000036 mRNA Translation: FAA00004.1
AY396741 mRNA Translation: AAR91619.1
AL589986 Genomic DNA No translation available.
CCDSiCCDS30859.1
RefSeqiNP_001009931.1, NM_001009931.2

3D structure databases

SMRiQ86YZ3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi132814, 55 interactors
IntActiQ86YZ3, 29 interactors
MINTiQ86YZ3
STRINGi9606.ENSP00000357791

Chemistry databases

DrugBankiDB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

PTM databases

iPTMnetiQ86YZ3
PhosphoSitePlusiQ86YZ3

Polymorphism and mutation databases

BioMutaiHRNR
DMDMi45476906

2D gel databases

UCD-2DPAGEiQ86YZ3

Proteomic databases

jPOSTiQ86YZ3
MassIVEiQ86YZ3
PaxDbiQ86YZ3
PeptideAtlasiQ86YZ3
PRIDEiQ86YZ3
ProteomicsDBi70490

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34085 90 antibodies

Genome annotation databases

EnsembliENST00000368801; ENSP00000357791; ENSG00000197915
GeneIDi388697
KEGGihsa:388697
UCSCiuc001ezt.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
388697
DisGeNETi388697

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HRNR
HGNCiHGNC:20846 HRNR
HPAiENSG00000197915 Tissue enhanced (skin)
MIMi616293 gene
neXtProtiNX_Q86YZ3
OpenTargetsiENSG00000197915
PharmGKBiPA134936141

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IX7U Eukaryota
ENOG410ZH9F LUCA
GeneTreeiENSGT00940000154467
HOGENOMiCLU_226653_0_0_1
InParanoidiQ86YZ3
KOiK23757
OMAiTHGQHGS
OrthoDBi30610at2759
TreeFamiTF338665

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
388697
PharosiQ86YZ3 Tbio

Protein Ontology

More...
PROi
PR:Q86YZ3
RNActiQ86YZ3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197915 Expressed in lower esophagus mucosa and 48 other tissues

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR033201 HRNR
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR22571:SF25 PTHR22571:SF25, 9 hits
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHORN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86YZ3
Secondary accession number(s): Q5DT20, Q5U1F4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: April 22, 2020
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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