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UniProtKB - Q86YW5 (TRML1_HUMAN)
Protein
Trem-like transcript 1 protein
Gene
TREML1
Organism
Homo sapiens (Human)
Status
Functioni
Cell surface receptor that may play a role in the innate and adaptive immune response.
1 PublicationGO - Molecular functioni
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- calcium-mediated signaling Source: UniProtKB
- innate immune response Source: UniProtKB
- platelet activation Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | Q86YW5 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
SignaLinki | Q86YW5 |
Names & Taxonomyi
Protein namesi | Recommended name: Trem-like transcript 1 proteinShort name: TLT-1 Alternative name(s): Triggering receptor expressed on myeloid cells-like protein 1 |
Gene namesi | Name:TREML1 Synonyms:TLT1 ORF Names:UNQ1825/PRO3438 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20434, TREML1 |
MIMi | 609714, gene |
neXtProti | NX_Q86YW5 |
VEuPathDBi | HostDB:ENSG00000161911 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nuclear speck Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cell surface Source: UniProtKB
- integral component of membrane Source: UniProtKB
- platelet alpha granule Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 16 – 162 | ExtracellularSequence analysisAdd BLAST | 147 | |
Transmembranei | 163 – 183 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 184 – 311 | CytoplasmicSequence analysisAdd BLAST | 128 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 340205 |
OpenTargetsi | ENSG00000161911 |
PharmGKBi | PA134878709 |
Miscellaneous databases
Pharosi | Q86YW5, Tbio |
Genetic variation databases
BioMutai | TREML1 |
DMDMi | 116256098 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_0000253855 | 16 – 311 | Trem-like transcript 1 proteinAdd BLAST | 296 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 38 ↔ 104 | 1 Publication | ||
Disulfide bondi | 52 ↔ 59 | 1 Publication | ||
Lipidationi | 196 | S-palmitoyl cysteine1 Publication | 1 |
Post-translational modificationi
Phosphorylated on tyrosine residues.1 Publication
Keywords - PTMi
Disulfide bond, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
MassIVEi | Q86YW5 |
PaxDbi | Q86YW5 |
PeptideAtlasi | Q86YW5 |
PRIDEi | Q86YW5 |
ProteomicsDBi | 70482 [Q86YW5-1] 70483 [Q86YW5-2] 70484 [Q86YW5-3] |
PTM databases
GlyGeni | Q86YW5, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q86YW5 |
PhosphoSitePlusi | Q86YW5 |
SwissPalmi | Q86YW5 |
Expressioni
Tissue specificityi
Detected in platelets, monocytic leukemia and in T-cell leukemia.4 Publications
Gene expression databases
Bgeei | ENSG00000161911, Expressed in monocyte and 103 other tissues |
Genevisiblei | Q86YW5, HS |
Organism-specific databases
HPAi | ENSG00000161911, Tissue enhanced (bone marrow, brain, lymphoid tissue) |
Interactioni
Subunit structurei
When phosphorylated, interacts with PTPN6 (By similarity). When phosphorylated, interacts with PTPN11.
By similarity1 PublicationBinary interactionsi
Q86YW5
With | #Exp. | IntAct |
---|---|---|
TMBIM6 [P55061] | 3 | EBI-17245072,EBI-1045825 |
Protein-protein interaction databases
BioGRIDi | 131013, 7 interactors |
ELMi | Q86YW5 |
IntActi | Q86YW5, 2 interactors |
STRINGi | 9606.ENSP00000402855 |
Miscellaneous databases
RNActi | Q86YW5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q86YW5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q86YW5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 121 | Ig-like V-typeAdd BLAST | 106 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 229 – 263 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 287 – 311 | DisorderedSequence analysisAdd BLAST | 25 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 279 – 284 | ITIM | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 237 – 253 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 295 – 311 | Polar residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SRZV, Eukaryota |
GeneTreei | ENSGT00470000042300 |
HOGENOMi | CLU_077694_1_0_1 |
InParanoidi | Q86YW5 |
OMAi | GCQPLVT |
OrthoDBi | 1390184at2759 |
PhylomeDBi | Q86YW5 |
TreeFami | TF337145 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF48726, SSF48726, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q86YW5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLTLLLLLL LGLEGQGIVG SLPEVLQAPV GSSILVQCHY RLQDVKAQKV
60 70 80 90 100
WCRFLPEGCQ PLVSSAVDRR APAGRRTFLT DLGGGLLQVE MVTLQEEDAG
110 120 130 140 150
EYGCMVDGAR GPQILHRVSL NILPPEEEEE THKIGSLAEN AFSDPAGSAN
160 170 180 190 200
PLEPSQDEKS IPLIWGAVLL VGLLVAAVVL FAVMAKRKQG NRLGVCGRFL
210 220 230 240 250
SSRVSGMNPS SVVHHVSDSG PAAELPLDVP HIRLDSPPSF DNTTYTSLPL
260 270 280 290 300
DSPSGKPSLP APSSLPPLPP KVLVCSKPVT YATVIFPGGN KGGGTSCGPA
310
QNPPNNQTPS S
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035526 | 6 | L → V in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_049950 | 231 | H → P. Corresponds to variant dbSNP:rs34254490Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021124 | 15 – 125 | Missing in isoform 3. 1 PublicationAdd BLAST | 111 | |
Alternative sequenceiVSP_021125 | 190 – 199 | GNRLGVCGRF → ESLLSGPPRQ in isoform 2. 2 Publications | 10 | |
Alternative sequenceiVSP_021126 | 200 – 311 | Missing in isoform 2. 2 PublicationsAdd BLAST | 112 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF508193 mRNA Translation: AAO37827.1 Different termination. AF534822 mRNA Translation: AAO15020.1 AF534823 mRNA Translation: AAO15021.1 AY358357 mRNA Translation: AAQ88723.1 AL133404 Genomic DNA No translation available. BC100944 mRNA Translation: AAI00945.1 BC100945 mRNA Translation: AAI00946.1 BC100946 mRNA Translation: AAI00947.1 |
CCDSi | CCDS4851.1 [Q86YW5-1] CCDS64420.1 [Q86YW5-3] CCDS64421.1 [Q86YW5-2] |
RefSeqi | NP_001258736.1, NM_001271807.1 [Q86YW5-2] NP_001258737.1, NM_001271808.1 [Q86YW5-3] NP_835468.1, NM_178174.3 [Q86YW5-1] XP_016866312.1, XM_017010823.1 [Q86YW5-1] XP_016866313.1, XM_017010824.1 [Q86YW5-1] |
Genome annotation databases
Ensembli | ENST00000373127; ENSP00000362219; ENSG00000161911 [Q86YW5-2] ENST00000426005; ENSP00000402855; ENSG00000161911 ENST00000437044; ENSP00000400405; ENSG00000161911 [Q86YW5-3] |
GeneIDi | 340205 |
KEGGi | hsa:340205 |
MANE-Selecti | ENST00000426005.7; ENSP00000402855.2; NM_178174.4; NP_835468.1 |
UCSCi | uc003opx.5, human [Q86YW5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF508193 mRNA Translation: AAO37827.1 Different termination. AF534822 mRNA Translation: AAO15020.1 AF534823 mRNA Translation: AAO15021.1 AY358357 mRNA Translation: AAQ88723.1 AL133404 Genomic DNA No translation available. BC100944 mRNA Translation: AAI00945.1 BC100945 mRNA Translation: AAI00946.1 BC100946 mRNA Translation: AAI00947.1 |
CCDSi | CCDS4851.1 [Q86YW5-1] CCDS64420.1 [Q86YW5-3] CCDS64421.1 [Q86YW5-2] |
RefSeqi | NP_001258736.1, NM_001271807.1 [Q86YW5-2] NP_001258737.1, NM_001271808.1 [Q86YW5-3] NP_835468.1, NM_178174.3 [Q86YW5-1] XP_016866312.1, XM_017010823.1 [Q86YW5-1] XP_016866313.1, XM_017010824.1 [Q86YW5-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FRG | X-ray | 1.19 | P | 20-125 | [»] | |
SMRi | Q86YW5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 131013, 7 interactors |
ELMi | Q86YW5 |
IntActi | Q86YW5, 2 interactors |
STRINGi | 9606.ENSP00000402855 |
PTM databases
GlyGeni | Q86YW5, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q86YW5 |
PhosphoSitePlusi | Q86YW5 |
SwissPalmi | Q86YW5 |
Genetic variation databases
BioMutai | TREML1 |
DMDMi | 116256098 |
Proteomic databases
MassIVEi | Q86YW5 |
PaxDbi | Q86YW5 |
PeptideAtlasi | Q86YW5 |
PRIDEi | Q86YW5 |
ProteomicsDBi | 70482 [Q86YW5-1] 70483 [Q86YW5-2] 70484 [Q86YW5-3] |
Protocols and materials databases
ABCDi | Q86YW5, 6 sequenced antibodies |
Antibodypediai | 2655, 290 antibodies from 31 providers |
DNASUi | 340205 |
Genome annotation databases
Ensembli | ENST00000373127; ENSP00000362219; ENSG00000161911 [Q86YW5-2] ENST00000426005; ENSP00000402855; ENSG00000161911 ENST00000437044; ENSP00000400405; ENSG00000161911 [Q86YW5-3] |
GeneIDi | 340205 |
KEGGi | hsa:340205 |
MANE-Selecti | ENST00000426005.7; ENSP00000402855.2; NM_178174.4; NP_835468.1 |
UCSCi | uc003opx.5, human [Q86YW5-1] |
Organism-specific databases
CTDi | 340205 |
DisGeNETi | 340205 |
GeneCardsi | TREML1 |
HGNCi | HGNC:20434, TREML1 |
HPAi | ENSG00000161911, Tissue enhanced (bone marrow, brain, lymphoid tissue) |
MIMi | 609714, gene |
neXtProti | NX_Q86YW5 |
OpenTargetsi | ENSG00000161911 |
PharmGKBi | PA134878709 |
VEuPathDBi | HostDB:ENSG00000161911 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SRZV, Eukaryota |
GeneTreei | ENSGT00470000042300 |
HOGENOMi | CLU_077694_1_0_1 |
InParanoidi | Q86YW5 |
OMAi | GCQPLVT |
OrthoDBi | 1390184at2759 |
PhylomeDBi | Q86YW5 |
TreeFami | TF337145 |
Enzyme and pathway databases
PathwayCommonsi | Q86YW5 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
SignaLinki | Q86YW5 |
Miscellaneous databases
BioGRID-ORCSi | 340205, 4 hits in 1027 CRISPR screens |
EvolutionaryTracei | Q86YW5 |
GeneWikii | TREML1 |
GenomeRNAii | 340205 |
Pharosi | Q86YW5, Tbio |
PROi | PR:Q86YW5 |
RNActi | Q86YW5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161911, Expressed in monocyte and 103 other tissues |
Genevisiblei | Q86YW5, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF48726, SSF48726, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRML1_HUMAN | |
Accessioni | Q86YW5Primary (citable) accession number: Q86YW5 Secondary accession number(s): Q496B3, Q8IWY1, Q8IWY2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 23, 2022 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references