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Protein

Myosin light chain kinase family member 4

Gene

MYLK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei135ATPPROSITE-ProRule annotation1
Active sitei227Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi112 – 120ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • myosin light chain kinase activity Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ86YV6

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain kinase family member 4 (EC:2.7.11.1)
Alternative name(s):
Sugen kinase 85
Short name:
SgK085
Gene namesi
Name:MYLK4
Synonyms:SGK085
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000145949.9
HGNCiHGNC:27972 MYLK4
neXtProtiNX_Q86YV6

Pathology & Biotechi

Organism-specific databases

DisGeNETi340156
OpenTargetsiENSG00000145949
PharmGKBiPA162396406

Chemistry databases

ChEMBLiCHEMBL5426

Polymorphism and mutation databases

BioMutaiMYLK4
DMDMi118573873

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002610301 – 388Myosin light chain kinase family member 4Add BLAST388

Proteomic databases

MaxQBiQ86YV6
PaxDbiQ86YV6
PeptideAtlasiQ86YV6
PRIDEiQ86YV6
ProteomicsDBi70476
70477 [Q86YV6-2]

Expressioni

Gene expression databases

BgeeiENSG00000145949 Expressed in 115 organ(s), highest expression level in biceps brachii
CleanExiHS_MYLK4
GenevisibleiQ86YV6 HS

Organism-specific databases

HPAiHPA015860

Interactioni

Protein-protein interaction databases

BioGridi131005, 8 interactors
IntActiQ86YV6, 2 interactors
STRINGi9606.ENSP00000274643

Chemistry databases

BindingDBiQ86YV6

Structurei

Secondary structure

1388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ86YV6
SMRiQ86YV6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86YV6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 361Protein kinasePROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118877
HOGENOMiHOG000233016
HOVERGENiHBG095569
InParanoidiQ86YV6
KOiK00907
OMAiLIKEKCW
OrthoDBiEOG091G005W
PhylomeDBiQ86YV6
TreeFamiTF314166

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YV6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKVKRLEEF NTCYNSNQLE KMAFFQCREE VEKVKCFLEK NSGDQDSRSG
60 70 80 90 100
HNEAKEVWSN ADLTERMPVK SKRTSALAVD IPAPPAPFDH RIVTAKQGAV
110 120 130 140 150
NSFYTVSKTE ILGGGRFGQV HKCEETATGL KLAAKIIKTR GMKDKEEVKN
160 170 180 190 200
EISVMNQLDH ANLIQLYDAF ESKNDIVLVM EYVDGGELFD RIIDESYNLT
210 220 230 240 250
ELDTILFMKQ ICEGIRHMHQ MYILHLDLKP ENILCVNRDA KQIKIIDFGL
260 270 280 290 300
ARRYKPREKL KVNFGTPEFL APEVVNYDFV SFPTDMWSVG VIAYMLLSGL
310 320 330 340 350
SPFLGDNDAE TLNNILACRW DLEDEEFQDI SEEAKEFISK LLIKEKSWRI
360 370 380
SASEALKHPW LSDHKLHSRL NAQKKKNRGS DAQDFVTK
Note: No experimental confirmation available.
Length:388
Mass (Da):44,508
Last modified:November 28, 2006 - v2
Checksum:iEF710F6145DFC3C9
GO
Isoform 2 (identifier: Q86YV6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-252: LCVNRDAKQIKIIDFGLAR → QCSRFLIDTSILPLCLLNC

Note: Sequence incomplete. No experimental confirmation available.
Show »
Length:388
Mass (Da):44,487
Checksum:i126A576FFF4E5A86
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y4U5A0A2R8Y4U5_HUMAN
Myosin light chain kinase family me...
MYLK4
382Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04086430E → Q in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_05165039E → A. Corresponds to variant dbSNP:rs7770402Ensembl.1
Natural variantiVAR_04086550G → R2 PublicationsCorresponds to variant dbSNP:rs2296356Ensembl.1
Natural variantiVAR_04086678A → S in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs762093504Ensembl.1
Natural variantiVAR_040867126T → M1 PublicationCorresponds to variant dbSNP:rs34953021Ensembl.1
Natural variantiVAR_040868217H → L in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040869318C → Y1 PublicationCorresponds to variant dbSNP:rs35609073Ensembl.1
Natural variantiVAR_040870373Q → R1 PublicationCorresponds to variant dbSNP:rs35211631Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026948234 – 252LCVNR…FGLAR → QCSRFLIDTSILPLCLLNC in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138876 Genomic DNA No translation available.
AL139092 Genomic DNA No translation available.
BC132831 mRNA Translation: AAI32832.1
BC132833 mRNA Translation: AAI32834.1
AK122581 mRNA Translation: BAC56922.1
CCDSiCCDS34330.1 [Q86YV6-1]
RefSeqiNP_001012418.2, NM_001012418.4 [Q86YV6-1]
NP_001334801.1, NM_001347872.1
XP_005249136.1, XM_005249079.2 [Q86YV6-1]
XP_016866308.1, XM_017010819.1
UniGeneiHs.127830

Genome annotation databases

EnsembliENST00000274643; ENSP00000274643; ENSG00000145949 [Q86YV6-1]
GeneIDi340156
KEGGihsa:340156
UCSCiuc003mty.5 human [Q86YV6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138876 Genomic DNA No translation available.
AL139092 Genomic DNA No translation available.
BC132831 mRNA Translation: AAI32832.1
BC132833 mRNA Translation: AAI32834.1
AK122581 mRNA Translation: BAC56922.1
CCDSiCCDS34330.1 [Q86YV6-1]
RefSeqiNP_001012418.2, NM_001012418.4 [Q86YV6-1]
NP_001334801.1, NM_001347872.1
XP_005249136.1, XM_005249079.2 [Q86YV6-1]
XP_016866308.1, XM_017010819.1
UniGeneiHs.127830

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X4FX-ray2.67A/B40-388[»]
ProteinModelPortaliQ86YV6
SMRiQ86YV6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131005, 8 interactors
IntActiQ86YV6, 2 interactors
STRINGi9606.ENSP00000274643

Chemistry databases

BindingDBiQ86YV6
ChEMBLiCHEMBL5426

Polymorphism and mutation databases

BioMutaiMYLK4
DMDMi118573873

Proteomic databases

MaxQBiQ86YV6
PaxDbiQ86YV6
PeptideAtlasiQ86YV6
PRIDEiQ86YV6
ProteomicsDBi70476
70477 [Q86YV6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274643; ENSP00000274643; ENSG00000145949 [Q86YV6-1]
GeneIDi340156
KEGGihsa:340156
UCSCiuc003mty.5 human [Q86YV6-1]

Organism-specific databases

CTDi340156
DisGeNETi340156
EuPathDBiHostDB:ENSG00000145949.9
GeneCardsiMYLK4
H-InvDBiHIX0018128
HGNCiHGNC:27972 MYLK4
HPAiHPA015860
neXtProtiNX_Q86YV6
OpenTargetsiENSG00000145949
PharmGKBiPA162396406
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118877
HOGENOMiHOG000233016
HOVERGENiHBG095569
InParanoidiQ86YV6
KOiK00907
OMAiLIKEKCW
OrthoDBiEOG091G005W
PhylomeDBiQ86YV6
TreeFamiTF314166

Enzyme and pathway databases

SignaLinkiQ86YV6

Miscellaneous databases

ChiTaRSiMYLK4 human
EvolutionaryTraceiQ86YV6
GenomeRNAii340156
PROiPR:Q86YV6

Gene expression databases

BgeeiENSG00000145949 Expressed in 115 organ(s), highest expression level in biceps brachii
CleanExiHS_MYLK4
GenevisibleiQ86YV6 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYLK4_HUMAN
AccessioniPrimary (citable) accession number: Q86YV6
Secondary accession number(s): A2RUC0, Q5TAW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 7, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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