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Entry version 142 (18 Sep 2019)
Sequence version 4 (01 Oct 2014)
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Protein

Inactive tyrosine-protein kinase PRAG1

Gene

PRAG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity).By similarity

Caution

Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP, suggesting that it has no protein kinase activity.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q86YV5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive tyrosine-protein kinase PRAG1Curated
Alternative name(s):
PEAK1-related kinase-activating pseudokinase 1
Pragmin1 Publication
Sugen kinase 2231 Publication
Short name:
SgK223
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRAG1Imported
Synonyms:SGK223
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25438 PRAG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617344 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86YV5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi955L → A: Decreases homodimerization. Abolished interaction with PEAK1. No effect on cell migration. 1 Publication1
Mutagenesisi966L → A: Decreases homodimerization. Abolished interaction with PEAK1. Decreases cell migration. 1 Publication1
Mutagenesisi1243I → A: No effect on homodimerization. Decreases oligomerization. Decreases interaction with PEAK1. 1 Publication1
Mutagenesisi1271F → A: Decreases homodimerization. Decreases interaction with PEAK1. 1 Publication1
Mutagenesisi1278R → A: Decreases homodimerization. 1 Publication1
Mutagenesisi1282Y → A: No effect on homodimerization. Decreases oligomerization. Decreases interaction with PEAK1. No effect on cell migration. 1 Publication1
Mutagenesisi1366F → A: Decreases homodimerization. Abolished interaction with PEAK1. Decreases cell migration. 1 Publication1
Mutagenesisi1382W → A: Decreases homodimerization. Abolished interaction with PEAK1. Decreases cell migration. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
157285

Open Targets

More...
OpenTargetsi
ENSG00000275342

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRAG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478560

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002630081 – 1406Inactive tyrosine-protein kinase PRAG1Add BLAST1406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei148PhosphoserineCombined sources1
Modified residuei253PhosphotyrosineBy similarity1
Modified residuei365PhosphotyrosineBy similarity1
Modified residuei413PhosphotyrosineBy similarity1
Modified residuei696PhosphoserineCombined sources1
Modified residuei745PhosphoserineCombined sources1
Modified residuei782PhosphoserineCombined sources1
Modified residuei826PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CSK on Tyr-253, Tyr-365, and Tyr-413; Tyr-413 is a primary site of phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86YV5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86YV5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86YV5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86YV5

PeptideAtlas

More...
PeptideAtlasi
Q86YV5

PRoteomics IDEntifications database

More...
PRIDEi
Q86YV5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70475

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86YV5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86YV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000275342 Expressed in 199 organ(s), highest expression level in cerebellar vermis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86YV5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012066

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:29079850). Dimerization leads to the catalytic activation of CSK (By similarity).

Interacts (via C-terminus) with RND2 (By similarity).

Interacts with CSK (via SH2 domain) in a Tyr-413 phosphorylation-dependent manner; this interaction potentiates kinase activity of CSK (By similarity).

Interacts with PEAK1 (PubMed:29079850).

Interacts with NOTCH1 intracellular domain (N1ICD) (By similarity).

Forms a complex with N1ICD and MAML1, in a MAML1-dependent manner (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127591, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q86YV5, 9 interactors

Molecular INTeraction database

More...
MINTi
Q86YV5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000481109

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86YV5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini978 – 1329Protein kinasePROSITE-ProRule annotationAdd BLAST352

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni933 – 976Required for homodimerizationBy similarityAdd BLAST44
Regioni1331 – 1406Required for homodimerizationBy similarityAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 58Poly-Pro4
Compositional biasi713 – 718Poly-Pro6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The dimerization region encompasses helices both from the N- and C-terminal of the protein kinase domain.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJMD Eukaryota
ENOG4110SRP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157066

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168455

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86YV5

KEGG Orthology (KO)

More...
KOi
K17537

Identification of Orthologs from Complete Genome Data

More...
OMAi
VHDESHF

Database of Orthologous Groups

More...
OrthoDBi
49921at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86YV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHQTLCLNPE SLKMSACSDF VEHIWKPGSC KNCFCLRSDH QLVAGPPQPR
60 70 80 90 100
AGSLPPPPRL PPRPENCRLE DEGVNSSPYS KPTIAVKPTM MSSEASDVWT
110 120 130 140 150
EANLSAEVSQ VIWRRAPGKL PLPKQEDAPV VYLGSFRGVQ KPAGPSTSPD
160 170 180 190 200
GNSRCPPAYT MVGLHNLEPR GERNIAFHPV SFPEEKAVHK EKPSFPYQDR
210 220 230 240 250
PSTQESFRQK LAAFAGTTSG CHQGPGPLRE SLPSEDDSDQ RCSPSGDSEG
260 270 280 290 300
GEYCSILDCC PGSPVAKAAS QTAGSRGRHG GRDCSPTCWE QGKCSGPAEQ
310 320 330 340 350
EKRGPSFPKE CCSQGPTAHP SCLGPKKLSL TSEAAISSDG LSCGSGSGSG
360 370 380 390 400
SGASSPFVPH LESDYCSLMK EPAPEKQQDP GCPGVTPSRC LGLTGEPQPP
410 420 430 440 450
AHPREATQPE PIYAESTKRK KAAPVPSKSQ AKIEHAAAAQ GQGQVCTGNA
460 470 480 490 500
WAQKAASGWG RDSPDPTPQV SATITVMAAH PEEDHRTIYL SSPDSAVGVQ
510 520 530 540 550
WPRGPVSQNS EVGEEETSAG QGLSSRESHA HSASESKPKE RPAIPPKLSK
560 570 580 590 600
SSPVGSPVSP SAGGPPVSPL ADLSDGSSGG SSIGPQPPSQ GPADPAPSCR
610 620 630 640 650
TNGVAISDPS RCPQPAASSA SEQRRPRFQA GTWSRQCRIE EEEEVEQELL
660 670 680 690 700
SHSWGRETKN GPTDHSNSTT WHRLHPTDGS SGQNSKVGTG MSKSASFAFE
710 720 730 740 750
FPKDRSGIET FSPPPPPPKS RHLLKMNKSS SDLEKVSQGS AESLSPSFRG
760 770 780 790 800
VHVSFTTGST DSLASDSRTC SDGGPSSELA HSPTNSGKKL FAPVPFPSGS
810 820 830 840 850
TEDVSPSGPQ QPPPLPQKKI VSRAASSPDG FFWTQGSPKP GTASPKLNLS
860 870 880 890 900
HSETNVHDES HFSYSLSPGN RHHPVFSSSD PLEKAFKGSG HWLPAAGLAG
910 920 930 940 950
NRGGCGSPGL QCKGAPSASS SQLSVSSQAS TGSTQLQLHG LLSNISSKEG
960 970 980 990 1000
TYAKLGGLYT QSLARLVAKC EDLFMGGQKK ELHFNENNWS LFKLTCNKPC
1010 1020 1030 1040 1050
CDSGDAIYYC ATCSEDPGST YAVKICKAPE PKTVSYCSPS VPVHFNIQQD
1060 1070 1080 1090 1100
CGHFVASVPS SMLSSPDAPK DPVPALPTHP PAQEQDCVVV ITREVPHQTA
1110 1120 1130 1140 1150
SDFVRDSAAS HQAEPEAYER RVCFLLLQLC NGLEHLKEHG IIHRDLCLEN
1160 1170 1180 1190 1200
LLLVHCTLQA GPGPAPAPAP APAPAAAAPP CSSAAPPAGG TLSPAAGPAS
1210 1220 1230 1240 1250
PEGPREKQLP RLIISNFLKA KQKPGGTPNL QQKKSQARLA PEIVSASQYR
1260 1270 1280 1290 1300
KFDEFQTGIL IYELLHQPNP FEVRAQLRER DYRQEDLPPL PALSLYSPGL
1310 1320 1330 1340 1350
QQLAHLLLEA DPIKRIRIGE AKRVLQCLLW GPRRELVQQP GTSEEALCGT
1360 1370 1380 1390 1400
LHNWIDMKRA LMMMKFAEKA VDRRRGVELE DWLCCQYLAS AEPGALLQSL

KLLQLL
Length:1,406
Mass (Da):149,624
Last modified:October 1, 2014 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i941BCF315B826148
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1226G → S in BAC56923 (Ref. 2) Curated1
Sequence conflicti1226G → S in CAD38729 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041803122L → I1 PublicationCorresponds to variant dbSNP:rs55764617Ensembl.1
Natural variantiVAR_041804137R → G1 PublicationCorresponds to variant dbSNP:rs56290960Ensembl.1
Natural variantiVAR_041805139V → I1 PublicationCorresponds to variant dbSNP:rs34346032Ensembl.1
Natural variantiVAR_041806404R → Q2 PublicationsCorresponds to variant dbSNP:rs3896980Ensembl.1
Natural variantiVAR_041807569P → L2 PublicationsCorresponds to variant dbSNP:rs4840955Ensembl.1
Natural variantiVAR_041808578S → C2 PublicationsCorresponds to variant dbSNP:rs4840953Ensembl.1
Natural variantiVAR_041809595P → A1 PublicationCorresponds to variant dbSNP:rs55994745Ensembl.1
Natural variantiVAR_041810662P → T1 PublicationCorresponds to variant dbSNP:rs56351643Ensembl.1
Natural variantiVAR_041811814P → L1 PublicationCorresponds to variant dbSNP:rs56207906Ensembl.1
Natural variantiVAR_041812851H → R1 PublicationCorresponds to variant dbSNP:rs56215812Ensembl.1
Natural variantiVAR_0418131003S → L1 PublicationCorresponds to variant dbSNP:rs56289289Ensembl.1
Natural variantiVAR_0418141041V → M1 PublicationCorresponds to variant dbSNP:rs28533138Ensembl.1
Natural variantiVAR_0418151113A → T3 PublicationsCorresponds to variant dbSNP:rs12549973Ensembl.1
Natural variantiVAR_0418161315R → H1 PublicationCorresponds to variant dbSNP:rs1314830862Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC068353 Genomic DNA No translation available.
AC103957 Genomic DNA No translation available.
AK122582 mRNA Translation: BAC56923.1
AL833872 mRNA Translation: CAD38729.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43706.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074295.2, NM_001080826.2
XP_005272426.2, XM_005272369.4
XP_005272427.2, XM_005272370.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000615670; ENSP00000481109; ENSG00000275342
ENST00000622241; ENSP00000479068; ENSG00000275342

Database of genes from NCBI RefSeq genomes

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GeneIDi
157285

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:157285

UCSC genome browser

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UCSCi
uc064kbu.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068353 Genomic DNA No translation available.
AC103957 Genomic DNA No translation available.
AK122582 mRNA Translation: BAC56923.1
AL833872 mRNA Translation: CAD38729.1
CCDSiCCDS43706.1
RefSeqiNP_001074295.2, NM_001080826.2
XP_005272426.2, XM_005272369.4
XP_005272427.2, XM_005272370.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VE6X-ray2.95A932-1406[»]
SMRiQ86YV5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127591, 9 interactors
IntActiQ86YV5, 9 interactors
MINTiQ86YV5
STRINGi9606.ENSP00000481109

PTM databases

iPTMnetiQ86YV5
PhosphoSitePlusiQ86YV5

Polymorphism and mutation databases

BioMutaiPRAG1
DMDMi327478560

Proteomic databases

EPDiQ86YV5
jPOSTiQ86YV5
MassIVEiQ86YV5
PaxDbiQ86YV5
PeptideAtlasiQ86YV5
PRIDEiQ86YV5
ProteomicsDBi70475

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
157285
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000615670; ENSP00000481109; ENSG00000275342
ENST00000622241; ENSP00000479068; ENSG00000275342
GeneIDi157285
KEGGihsa:157285
UCSCiuc064kbu.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
157285
DisGeNETi157285

GeneCards: human genes, protein and diseases

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GeneCardsi
PRAG1
HGNCiHGNC:25438 PRAG1
HPAiHPA012066
MIMi617344 gene
neXtProtiNX_Q86YV5
OpenTargetsiENSG00000275342

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IJMD Eukaryota
ENOG4110SRP LUCA
GeneTreeiENSGT00940000157066
HOGENOMiHOG000168455
InParanoidiQ86YV5
KOiK17537
OMAiVHDESHF
OrthoDBi49921at2759

Enzyme and pathway databases

SignaLinkiQ86YV5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SGK223 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
157285

Pharos

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Pharosi
Q86YV5

Protein Ontology

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PROi
PR:Q86YV5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000275342 Expressed in 199 organ(s), highest expression level in cerebellar vermis
GenevisibleiQ86YV5 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRAG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86YV5
Secondary accession number(s): Q8N3N5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2014
Last modified: September 18, 2019
This is version 142 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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