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Protein

RAS protein activator like-3

Gene

RASAL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway.By similarity

GO - Molecular functioni

GO - Biological processi

  • MAPK cascade Source: Reactome
  • negative regulation of Ras protein signal transduction Source: UniProtKB
  • positive regulation of NK T cell proliferation Source: UniProtKB

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants

Names & Taxonomyi

Protein namesi
Recommended name:
RAS protein activator like-3
Gene namesi
Name:RASAL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105122.12
HGNCiHGNC:26129 RASAL3
MIMi616561 gene
neXtProtiNX_Q86YV0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi64926
OpenTargetsiENSG00000105122
PharmGKBiPA164725297

Polymorphism and mutation databases

BioMutaiRASAL3
DMDMi172046741

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003225661 – 1011RAS protein activator like-3Add BLAST1011

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei166PhosphoserineBy similarity1
Modified residuei167PhosphoserineCombined sources1
Modified residuei170PhosphoserineBy similarity1
Modified residuei224PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphothreonineBy similarity1
Modified residuei787PhosphoserineBy similarity1
Modified residuei790PhosphoserineBy similarity1
Modified residuei988PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86YV0
MaxQBiQ86YV0
PaxDbiQ86YV0
PeptideAtlasiQ86YV0
PRIDEiQ86YV0
ProteomicsDBi70473
70474 [Q86YV0-2]

PTM databases

iPTMnetiQ86YV0
PhosphoSitePlusiQ86YV0

Expressioni

Tissue specificityi

Predominantly expressed in cells of hematopoietic lineages.1 Publication

Gene expression databases

BgeeiENSG00000105122 Expressed in 179 organ(s), highest expression level in blood
ExpressionAtlasiQ86YV0 baseline and differential
GenevisibleiQ86YV0 HS

Organism-specific databases

HPAiHPA043417

Interactioni

Protein-protein interaction databases

BioGridi122348, 2 interactors
IntActiQ86YV0, 24 interactors
STRINGi9606.ENSP00000341905

Structurei

3D structure databases

ProteinModelPortaliQ86YV0
SMRiQ86YV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 293PHAdd BLAST97
Domaini306 – 384C2Add BLAST79
Domaini458 – 650Ras-GAPPROSITE-ProRule annotationAdd BLAST193

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili888 – 988Sequence analysisAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 31Poly-Gly4
Compositional biasi96 – 133Pro-richAdd BLAST38
Compositional biasi789 – 829Arg-richAdd BLAST41

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3508 Eukaryota
ENOG410XPU1 LUCA
GeneTreeiENSGT00760000119092
HOGENOMiHOG000154074
InParanoidiQ86YV0
KOiK17634
OMAiGQLFWAE
OrthoDBiEOG091G020W
PhylomeDBiQ86YV0
TreeFamiTF105303

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR039360 Ras_GTPase
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
PANTHERiPTHR10194 PTHR10194, 1 hit
PfamiView protein in Pfam
PF00616 RasGAP, 2 hits
SMARTiView protein in SMART
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPPSPSRTS QTQPTATSPL TSYRWHTGGG GEKAAGGFRW GRFAGWGRAL
60 70 80 90 100
SHQEPMVSTQ PAPRSIFRRV LSAPPKESRT SRLRLSKALW GRHKNPPPEP
110 120 130 140 150
DPEPEQEAPE LEPEPELEPP TPQIPEAPTP NVPVWDIGGF TLLDGKLVLL
160 170 180 190 200
GGEEEGPRRP RVGSASSEGS IHVAMGNFRD PDRMPGKTEP ETAGPNQVHN
210 220 230 240 250
VRGLLKRLKE KKKARLEPRD GPPSALGSRE SLATLSELDL GAERDVRIWP
260 270 280 290 300
LHPSLLGEPH CFQVTWTGGS RCFSCRSAAE RDRWIEDLRR QFQPTQDNVE
310 320 330 340 350
REETWLSVWV HEAKGLPRAA AGAPGVRAEL WLDGALLART APRAGPGQLF
360 370 380 390 400
WAERFHFEAL PPARRLSLRL RGLGPGSAVL GRVALALEEL DAPRAPAAGL
410 420 430 440 450
ERWFPLLGAP AGAALRARIR ARRLRVLPSE RYKELAEFLT FHYARLCGAL
460 470 480 490 500
EPALPAQAKE ELAAAMVRVL RATGRAQALV TDLGTAELAR CGGREALLFR
510 520 530 540 550
ENTLATKAID EYMKLVAQDY LQETLGQVVR RLCASTEDCE VDPSKCPASE
560 570 580 590 600
LPEHQARLRN SCEEVFETII HSYDWFPAEL GIVFSSWREA CKERGSEVLG
610 620 630 640 650
PRLVCASLFL RLLCPAILAP SLFGLAPDHP APGPARTLTL IAKVIQNLAN
660 670 680 690 700
RAPFGEKEAY MGFMNSFLEE HGPAMQCFLD QVAMVDVDAA PSGYQGSGDL
710 720 730 740 750
ALQLAVLHAQ LCTIFAELDQ TTRDTLEPLP TILRAIEEGQ PVLVSVPMRL
760 770 780 790 800
PLPPAQVHSS LSAGEKPGFL APRDLPKHTP LISKSQSLRS VRRSESWARP
810 820 830 840 850
RPDEERPLRR PRPVQRTQSV PVRRPARRRQ SAGPWPRPKG SLSMGPAPRA
860 870 880 890 900
RPWTRDSASL PRKPSVPWQR QMDQPQDRNQ ALGTHRPVNK LAELQCEVAA
910 920 930 940 950
LREEQKVLSR LVESLSTQIR ALTEQQEQLR GQLQDLDSRL RAGSSEFDSE
960 970 980 990 1000
HNLTSNEGHS LKNLEHRLNE MERTQAQLRD AVQSLQLSPR TRGSWSQPQP
1010
LKAPCLNGDT T
Length:1,011
Mass (Da):111,898
Last modified:February 26, 2008 - v2
Checksum:i23A7CA251ED3CE33
GO
Isoform 2 (identifier: Q86YV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     944-1011: Missing.

Show »
Length:943
Mass (Da):104,243
Checksum:i2DD6F0CCA9FCA2A0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QX12M0QX12_HUMAN
RAS protein activator-like-3
RASAL3
445Annotation score:
V9GYD1V9GYD1_HUMAN
RAS protein activator-like-3
RASAL3
228Annotation score:

Sequence cautioni

The sequence AAH30281 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15064 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC56928 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC56928 differs from that shown. Reason: Erroneous termination at position 723. Translated as Arg.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061179251L → V. Corresponds to variant dbSNP:rs58123634Ensembl.1
Natural variantiVAR_061180594R → C. Corresponds to variant dbSNP:rs56209154Ensembl.1
Natural variantiVAR_061181825P → T. Corresponds to variant dbSNP:rs57208996Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033824944 – 1011Missing in isoform 2. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122587 mRNA Translation: BAC56928.1 Sequence problems.
AC011492 Genomic DNA No translation available.
AK025091 mRNA Translation: BAB15064.1 Different initiation.
BC030281 mRNA Translation: AAH30281.1 Different initiation.
CCDSiCCDS46006.1 [Q86YV0-1]
RefSeqiNP_001334956.1, NM_001348027.1
NP_001334957.1, NM_001348028.1
NP_075055.1, NM_022904.2 [Q86YV0-1]
UniGeneiHs.136979

Genome annotation databases

EnsembliENST00000343625; ENSP00000341905; ENSG00000105122 [Q86YV0-1]
GeneIDi64926
KEGGihsa:64926
UCSCiuc002nbe.3 human [Q86YV0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122587 mRNA Translation: BAC56928.1 Sequence problems.
AC011492 Genomic DNA No translation available.
AK025091 mRNA Translation: BAB15064.1 Different initiation.
BC030281 mRNA Translation: AAH30281.1 Different initiation.
CCDSiCCDS46006.1 [Q86YV0-1]
RefSeqiNP_001334956.1, NM_001348027.1
NP_001334957.1, NM_001348028.1
NP_075055.1, NM_022904.2 [Q86YV0-1]
UniGeneiHs.136979

3D structure databases

ProteinModelPortaliQ86YV0
SMRiQ86YV0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122348, 2 interactors
IntActiQ86YV0, 24 interactors
STRINGi9606.ENSP00000341905

PTM databases

iPTMnetiQ86YV0
PhosphoSitePlusiQ86YV0

Polymorphism and mutation databases

BioMutaiRASAL3
DMDMi172046741

Proteomic databases

EPDiQ86YV0
MaxQBiQ86YV0
PaxDbiQ86YV0
PeptideAtlasiQ86YV0
PRIDEiQ86YV0
ProteomicsDBi70473
70474 [Q86YV0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343625; ENSP00000341905; ENSG00000105122 [Q86YV0-1]
GeneIDi64926
KEGGihsa:64926
UCSCiuc002nbe.3 human [Q86YV0-1]

Organism-specific databases

CTDi64926
DisGeNETi64926
EuPathDBiHostDB:ENSG00000105122.12
GeneCardsiRASAL3
H-InvDBiHIX0202731
HGNCiHGNC:26129 RASAL3
HPAiHPA043417
MIMi616561 gene
neXtProtiNX_Q86YV0
OpenTargetsiENSG00000105122
PharmGKBiPA164725297
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3508 Eukaryota
ENOG410XPU1 LUCA
GeneTreeiENSGT00760000119092
HOGENOMiHOG000154074
InParanoidiQ86YV0
KOiK17634
OMAiGQLFWAE
OrthoDBiEOG091G020W
PhylomeDBiQ86YV0
TreeFamiTF105303

Enzyme and pathway databases

ReactomeiR-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants

Miscellaneous databases

ChiTaRSiRASAL3 human
GenomeRNAii64926
PROiPR:Q86YV0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105122 Expressed in 179 organ(s), highest expression level in blood
ExpressionAtlasiQ86YV0 baseline and differential
GenevisibleiQ86YV0 HS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR039360 Ras_GTPase
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
PANTHERiPTHR10194 PTHR10194, 1 hit
PfamiView protein in Pfam
PF00616 RasGAP, 2 hits
SMARTiView protein in SMART
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRASL3_HUMAN
AccessioniPrimary (citable) accession number: Q86YV0
Secondary accession number(s): Q8N2T9, Q9H735
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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