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Protein

RAS protein activator like-3

Gene

RASAL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • MAPK cascade Source: Reactome
  • negative regulation of Ras protein signal transduction Source: UniProtKB
  • positive regulation of NK T cell proliferation Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RAS protein activator like-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASAL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105122.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26129 RASAL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616561 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86YV0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64926

Open Targets

More...
OpenTargetsi
ENSG00000105122

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164725297

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RASAL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172046741

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003225661 – 1011RAS protein activator like-3Add BLAST1011

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei166PhosphoserineBy similarity1
Modified residuei167PhosphoserineCombined sources1
Modified residuei170PhosphoserineBy similarity1
Modified residuei224PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphothreonineBy similarity1
Modified residuei787PhosphoserineBy similarity1
Modified residuei790PhosphoserineBy similarity1
Modified residuei988PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86YV0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86YV0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86YV0

PeptideAtlas

More...
PeptideAtlasi
Q86YV0

PRoteomics IDEntifications database

More...
PRIDEi
Q86YV0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70473
70474 [Q86YV0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86YV0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86YV0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in cells of hematopoietic lineages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000105122 Expressed in 179 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86YV0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86YV0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043417

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122348, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q86YV0, 24 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000341905

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86YV0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini197 – 293PHAdd BLAST97
Domaini306 – 384C2Add BLAST79
Domaini458 – 650Ras-GAPPROSITE-ProRule annotationAdd BLAST193

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili888 – 988Sequence analysisAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 31Poly-Gly4
Compositional biasi96 – 133Pro-richAdd BLAST38
Compositional biasi789 – 829Arg-richAdd BLAST41

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3508 Eukaryota
ENOG410XPU1 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161423

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000154074

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86YV0

KEGG Orthology (KO)

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KOi
K17634

Identification of Orthologs from Complete Genome Data

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OMAi
HFQPSQD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G020W

Database for complete collections of gene phylogenies

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PhylomeDBi
Q86YV0

TreeFam database of animal gene trees

More...
TreeFami
TF105303

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035892 C2_domain_sf
IPR039360 Ras_GTPase
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot

The PANTHER Classification System

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PANTHERi
PTHR10194 PTHR10194, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00616 RasGAP, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00323 RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPPSPSRTS QTQPTATSPL TSYRWHTGGG GEKAAGGFRW GRFAGWGRAL
60 70 80 90 100
SHQEPMVSTQ PAPRSIFRRV LSAPPKESRT SRLRLSKALW GRHKNPPPEP
110 120 130 140 150
DPEPEQEAPE LEPEPELEPP TPQIPEAPTP NVPVWDIGGF TLLDGKLVLL
160 170 180 190 200
GGEEEGPRRP RVGSASSEGS IHVAMGNFRD PDRMPGKTEP ETAGPNQVHN
210 220 230 240 250
VRGLLKRLKE KKKARLEPRD GPPSALGSRE SLATLSELDL GAERDVRIWP
260 270 280 290 300
LHPSLLGEPH CFQVTWTGGS RCFSCRSAAE RDRWIEDLRR QFQPTQDNVE
310 320 330 340 350
REETWLSVWV HEAKGLPRAA AGAPGVRAEL WLDGALLART APRAGPGQLF
360 370 380 390 400
WAERFHFEAL PPARRLSLRL RGLGPGSAVL GRVALALEEL DAPRAPAAGL
410 420 430 440 450
ERWFPLLGAP AGAALRARIR ARRLRVLPSE RYKELAEFLT FHYARLCGAL
460 470 480 490 500
EPALPAQAKE ELAAAMVRVL RATGRAQALV TDLGTAELAR CGGREALLFR
510 520 530 540 550
ENTLATKAID EYMKLVAQDY LQETLGQVVR RLCASTEDCE VDPSKCPASE
560 570 580 590 600
LPEHQARLRN SCEEVFETII HSYDWFPAEL GIVFSSWREA CKERGSEVLG
610 620 630 640 650
PRLVCASLFL RLLCPAILAP SLFGLAPDHP APGPARTLTL IAKVIQNLAN
660 670 680 690 700
RAPFGEKEAY MGFMNSFLEE HGPAMQCFLD QVAMVDVDAA PSGYQGSGDL
710 720 730 740 750
ALQLAVLHAQ LCTIFAELDQ TTRDTLEPLP TILRAIEEGQ PVLVSVPMRL
760 770 780 790 800
PLPPAQVHSS LSAGEKPGFL APRDLPKHTP LISKSQSLRS VRRSESWARP
810 820 830 840 850
RPDEERPLRR PRPVQRTQSV PVRRPARRRQ SAGPWPRPKG SLSMGPAPRA
860 870 880 890 900
RPWTRDSASL PRKPSVPWQR QMDQPQDRNQ ALGTHRPVNK LAELQCEVAA
910 920 930 940 950
LREEQKVLSR LVESLSTQIR ALTEQQEQLR GQLQDLDSRL RAGSSEFDSE
960 970 980 990 1000
HNLTSNEGHS LKNLEHRLNE MERTQAQLRD AVQSLQLSPR TRGSWSQPQP
1010
LKAPCLNGDT T
Length:1,011
Mass (Da):111,898
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23A7CA251ED3CE33
GO
Isoform 2 (identifier: Q86YV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     944-1011: Missing.

Show »
Length:943
Mass (Da):104,243
Checksum:i2DD6F0CCA9FCA2A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QX12M0QX12_HUMAN
RAS protein activator-like-3
RASAL3
445Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYD1V9GYD1_HUMAN
RAS protein activator-like-3
RASAL3
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH30281 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15064 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC56928 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC56928 differs from that shown. Reason: Erroneous termination at position 723. Translated as Arg.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061179251L → V. Corresponds to variant dbSNP:rs58123634Ensembl.1
Natural variantiVAR_061180594R → C. Corresponds to variant dbSNP:rs56209154Ensembl.1
Natural variantiVAR_061181825P → T. Corresponds to variant dbSNP:rs57208996Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033824944 – 1011Missing in isoform 2. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK122587 mRNA Translation: BAC56928.1 Sequence problems.
AC011492 Genomic DNA No translation available.
AK025091 mRNA Translation: BAB15064.1 Different initiation.
BC030281 mRNA Translation: AAH30281.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46006.1 [Q86YV0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001334956.1, NM_001348027.1
NP_001334957.1, NM_001348028.1
NP_075055.1, NM_022904.2 [Q86YV0-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.136979

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343625; ENSP00000341905; ENSG00000105122 [Q86YV0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64926

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64926

UCSC genome browser

More...
UCSCi
uc002nbe.3 human [Q86YV0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122587 mRNA Translation: BAC56928.1 Sequence problems.
AC011492 Genomic DNA No translation available.
AK025091 mRNA Translation: BAB15064.1 Different initiation.
BC030281 mRNA Translation: AAH30281.1 Different initiation.
CCDSiCCDS46006.1 [Q86YV0-1]
RefSeqiNP_001334956.1, NM_001348027.1
NP_001334957.1, NM_001348028.1
NP_075055.1, NM_022904.2 [Q86YV0-1]
UniGeneiHs.136979

3D structure databases

ProteinModelPortaliQ86YV0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122348, 2 interactors
IntActiQ86YV0, 24 interactors
STRINGi9606.ENSP00000341905

PTM databases

iPTMnetiQ86YV0
PhosphoSitePlusiQ86YV0

Polymorphism and mutation databases

BioMutaiRASAL3
DMDMi172046741

Proteomic databases

EPDiQ86YV0
MaxQBiQ86YV0
PaxDbiQ86YV0
PeptideAtlasiQ86YV0
PRIDEiQ86YV0
ProteomicsDBi70473
70474 [Q86YV0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343625; ENSP00000341905; ENSG00000105122 [Q86YV0-1]
GeneIDi64926
KEGGihsa:64926
UCSCiuc002nbe.3 human [Q86YV0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64926
DisGeNETi64926
EuPathDBiHostDB:ENSG00000105122.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RASAL3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0202731
HGNCiHGNC:26129 RASAL3
HPAiHPA043417
MIMi616561 gene
neXtProtiNX_Q86YV0
OpenTargetsiENSG00000105122
PharmGKBiPA164725297

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3508 Eukaryota
ENOG410XPU1 LUCA
GeneTreeiENSGT00940000161423
HOGENOMiHOG000154074
InParanoidiQ86YV0
KOiK17634
OMAiHFQPSQD
OrthoDBiEOG091G020W
PhylomeDBiQ86YV0
TreeFamiTF105303

Enzyme and pathway databases

ReactomeiR-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RASAL3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64926

Protein Ontology

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PROi
PR:Q86YV0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000105122 Expressed in 179 organ(s), highest expression level in blood
ExpressionAtlasiQ86YV0 baseline and differential
GenevisibleiQ86YV0 HS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR039360 Ras_GTPase
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
PANTHERiPTHR10194 PTHR10194, 1 hit
PfamiView protein in Pfam
PF00616 RasGAP, 2 hits
SMARTiView protein in SMART
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86YV0
Secondary accession number(s): Q8N2T9, Q9H735
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: December 5, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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