UniProtKB - Q86YT6 (MIB1_HUMAN)
E3 ubiquitin-protein ligase MIB1
MIB1
Functioni
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity).
Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
By similarity1 PublicationMiscellaneous
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 85 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 88 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 100 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 103 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 109 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 112 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 118 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 122 | Zinc 2PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 80 – 132 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 53 | |
Zinc fingeri | 819 – 854 | RING-type 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 866 – 901 | RING-type 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 963 – 996 | RING-type 3PROSITE-ProRule annotationAdd BLAST | 34 |
GO - Molecular functioni
- ubiquitin-protein transferase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- blood vessel development Source: Ensembl
- endocytosis Source: GO_Central
- heart looping Source: Ensembl
- in utero embryonic development Source: Ensembl
- negative regulation of neuron differentiation Source: Ensembl
- neural tube formation Source: Ensembl
- Notch signaling pathway Source: GO_Central
- positive regulation of endocytosis Source: Ensembl
- protein ubiquitination Source: GO_Central
- somitogenesis Source: Ensembl
- ubiquitin-dependent protein catabolic process Source: CACAO
Keywordsi
Molecular function | Transferase |
Biological process | Notch signaling pathway, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q86YT6 |
Reactomei | R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2691232, Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus |
SignaLinki | Q86YT6 |
SIGNORi | Q86YT6 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase MIB1 (EC:2.3.2.27)Alternative name(s): DAPK-interacting protein 1 Short name: DIP-1 Mind bomb homolog 1 RING-type E3 ubiquitin transferase MIB1Curated Zinc finger ZZ type with ankyrin repeat domain protein 2 |
Gene namesi | Name:MIB1 Synonyms:DIP1, KIAA1323, ZZANK2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21086, MIB1 |
MIMi | 608677, gene |
neXtProti | NX_Q86YT6 |
VEuPathDBi | HostDB:ENSG00000101752 |
Subcellular locationi
Cytoskeleton
- centriolar satellite 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Plasma membrane
- Cell membrane By similarity
Note: Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.By similarity
Cytoskeleton
- centrosome Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
- cytoplasmic vesicle Source: Ensembl
- postsynaptic density Source: Ensembl
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Involvement in diseasei
Left ventricular non-compaction 7 (LVNC7)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069620 | 943 | V → F in LVNC7. 1 PublicationCorresponds to variant dbSNP:rs200035428EnsemblClinVar. | 1 |
Keywords - Diseasei
Cardiomyopathy, Disease variantOrganism-specific databases
DisGeNETi | 57534 |
MalaCardsi | MIB1 |
MIMi | 615092, phenotype |
OpenTargetsi | ENSG00000101752 |
Orphaneti | 54260, Left ventricular noncompaction |
PharmGKBi | PA134862722 |
Miscellaneous databases
Pharosi | Q86YT6, Tbio |
Genetic variation databases
BioMutai | MIB1 |
DMDMi | 68565512 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055943 | 1 – 1006 | E3 ubiquitin-protein ligase MIB1Add BLAST | 1006 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 408 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q86YT6 |
jPOSTi | Q86YT6 |
MassIVEi | Q86YT6 |
MaxQBi | Q86YT6 |
PaxDbi | Q86YT6 |
PeptideAtlasi | Q86YT6 |
PRIDEi | Q86YT6 |
ProteomicsDBi | 70468 |
PTM databases
iPTMneti | Q86YT6 |
PhosphoSitePlusi | Q86YT6 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000101752, Expressed in kidney and 226 other tissues |
Genevisiblei | Q86YT6, HS |
Organism-specific databases
HPAi | ENSG00000101752, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CEP131 and PCM1.
1 PublicationBinary interactionsi
Q86YT6
Protein-protein interaction databases
BioGRIDi | 121593, 335 interactors |
IntActi | Q86YT6, 58 interactors |
MINTi | Q86YT6 |
STRINGi | 9606.ENSP00000261537 |
Miscellaneous databases
RNActi | Q86YT6, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q86YT6 |
SMRi | Q86YT6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 74 | MIB/HERC2 1PROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 143 – 221 | MIB/HERC2 2PROSITE-ProRule annotationAdd BLAST | 79 | |
Repeati | 430 – 460 | ANK 1Add BLAST | 31 | |
Repeati | 463 – 492 | ANK 2Add BLAST | 30 | |
Repeati | 496 – 525 | ANK 3Add BLAST | 30 | |
Repeati | 529 – 558 | ANK 4Add BLAST | 30 | |
Repeati | 562 – 591 | ANK 5Add BLAST | 30 | |
Repeati | 595 – 627 | ANK 6Add BLAST | 33 | |
Repeati | 631 – 661 | ANK 7Add BLAST | 31 | |
Repeati | 665 – 694 | ANK 8Add BLAST | 30 | |
Repeati | 698 – 729 | ANK 9Add BLAST | 32 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 935 – 962 | Sequence analysisAdd BLAST | 28 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 80 – 132 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 53 | |
Zinc fingeri | 819 – 854 | RING-type 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 866 – 901 | RING-type 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 963 – 996 | RING-type 3PROSITE-ProRule annotationAdd BLAST | 34 |
Keywords - Domaini
ANK repeat, Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0504, Eukaryota KOG4582, Eukaryota |
GeneTreei | ENSGT00940000156781 |
HOGENOMi | CLU_007287_1_0_1 |
InParanoidi | Q86YT6 |
OMAi | CCGGIGR |
OrthoDBi | 220300at2759 |
PhylomeDBi | Q86YT6 |
TreeFami | TF324147 |
Family and domain databases
CDDi | cd02339, ZZ_Mind_bomb, 1 hit |
Gene3Di | 1.25.40.20, 4 hits 3.30.40.10, 3 hits 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR042056, MIB1/2_ZZ IPR010606, Mib_Herc2 IPR037252, Mib_Herc2_sf IPR040847, SH3_15 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF13637, Ank_4, 1 hit PF06701, MIB_HERC2, 2 hits PF18346, SH3_15, 2 hits PF00569, ZZ, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 9 hits SM00184, RING, 3 hits SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF159034, SSF159034, 2 hits SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 6 hits PS51416, MIB_HERC2, 2 hits PS50089, ZF_RING_2, 3 hits PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSNSRNNRVM VEGVGARVVR GPDWKWGKQD GGEGHVGTVR SFESPEEVVV
60 70 80 90 100
VWDNGTAANY RCSGAYDLRI LDSAPTGIKH DGTMCDTCRQ QPIIGIRWKC
110 120 130 140 150
AECTNYDLCT VCYHGDKHHL RHRFYRITTP GSERVLLESR RKSKKITARG
160 170 180 190 200
IFAGARVVRG VDWQWEDQDG GNGRRGKVTE IQDWSASSPH SAAYVLWDNG
210 220 230 240 250
AKNLYRVGFE GMSDLKCVQD AKGGSFYRDH CPVLGEQNGN RNPGGLQIGD
260 270 280 290 300
LVNIDLDLEI VQSLQHGHGG WTDGMFETLT TTGTVCGIDE DHDIVVQYPS
310 320 330 340 350
GNRWTFNPAV LTKANIVRSG DAAQGAEGGT SQFQVGDLVQ VCYDLERIKL
360 370 380 390 400
LQRGHGEWAE AMLPTLGKVG RVQQIYSDSD LKVEVCGTSW TYNPAAVSKV
410 420 430 440 450
ASAGSAISNA SGERLSQLLK KLFETQESGD LNEELVKAAA NGDVAKVEDL
460 470 480 490 500
LKRPDVDVNG QCAGHTAMQA ASQNGHVDIL KLLLKQNVDV EAEDKDGDRA
510 520 530 540 550
VHHAAFGDEG AVIEVLHRGS ADLNARNKRR QTPLHIAVNK GHLQVVKTLL
560 570 580 590 600
DFGCHPSLQD SEGDTPLHDA ISKKRDDILA VLLEAGADVT ITNNNGFNAL
610 620 630 640 650
HHAALRGNPS AMRVLLSKLP RPWIVDEKKD DGYTALHLAA LNNHVEVAEL
660 670 680 690 700
LVHQGNANLD IQNVNQQTAL HLAVERQHTQ IVRLLVRAGA KLDIQDKDGD
710 720 730 740 750
TPLHEALRHH TLSQLRQLQD MQDVGKVDAA WEPSKNTLIM GLGTQGAEKK
760 770 780 790 800
SAASIACFLA ANGADLSIRN KKGQSPLDLC PDPNLCKALA KCHKEKVSGQ
810 820 830 840 850
VGSRSPSMIS NDSETLEECM VCSDMKRDTL FGPCGHIATC SLCSPRVKKC
860 870 880 890 900
LICKEQVQSR TKIEECVVCS DKKAAVLFQP CGHMCACENC ANLMKKCVQC
910 920 930 940 950
RAVVERRVPF IMCCGGKSSE DATDDISSGN IPVLQKDKDN TNVNADVQKL
960 970 980 990 1000
QQQLQDIKEQ TMCPVCLDRL KNMIFLCGHG TCQLCGDRMS ECPICRKAIE
RRILLY
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 327 | E → K in AAN18023 (Ref. 2) Curated | 1 | |
Sequence conflicti | 398 | S → F in AAN18023 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069385 | 174 | R → H Found in a patient with severe mental retardation, psychomotor delay, no speech, sleep disturbances, feeding problems, abnormal breething, deep-set eyes and short philtrum. 1 PublicationCorresponds to variant dbSNP:rs755375969Ensembl. | 1 | |
Natural variantiVAR_069620 | 943 | V → F in LVNC7. 1 PublicationCorresponds to variant dbSNP:rs200035428EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY149908 mRNA Translation: AAN75493.1 AY147849 mRNA Translation: AAN18023.1 Frameshift. EF444995 Genomic DNA Translation: ACA06016.1 BC022403 mRNA Translation: AAH22403.1 Different initiation. BC110581 mRNA Translation: AAI10582.1 BC110582 mRNA Translation: AAI10583.1 CR749635 mRNA Translation: CAH18429.1 AL713705 mRNA Translation: CAD28502.1 AB037744 mRNA Translation: BAA92561.1 AK075157 mRNA Translation: BAC11439.1 Different initiation. |
CCDSi | CCDS11871.1 |
RefSeqi | NP_065825.1, NM_020774.3 |
Genome annotation databases
Ensembli | ENST00000261537.7; ENSP00000261537.6; ENSG00000101752.12 |
GeneIDi | 57534 |
KEGGi | hsa:57534 |
MANE-Selecti | ENST00000261537.7; ENSP00000261537.6; NM_020774.4; NP_065825.1 |
UCSCi | uc002ktq.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY149908 mRNA Translation: AAN75493.1 AY147849 mRNA Translation: AAN18023.1 Frameshift. EF444995 Genomic DNA Translation: ACA06016.1 BC022403 mRNA Translation: AAH22403.1 Different initiation. BC110581 mRNA Translation: AAI10582.1 BC110582 mRNA Translation: AAI10583.1 CR749635 mRNA Translation: CAH18429.1 AL713705 mRNA Translation: CAD28502.1 AB037744 mRNA Translation: BAA92561.1 AK075157 mRNA Translation: BAC11439.1 Different initiation. |
CCDSi | CCDS11871.1 |
RefSeqi | NP_065825.1, NM_020774.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4TSE | X-ray | 2.06 | A/B | 239-409 | [»] | |
4XI6 | X-ray | 2.04 | A | 8-402 | [»] | |
4XI7 | X-ray | 2.05 | A | 8-402 | [»] | |
4XIB | X-ray | 2.15 | A | 8-402 | [»] | |
AlphaFoldDBi | Q86YT6 | |||||
SMRi | Q86YT6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121593, 335 interactors |
IntActi | Q86YT6, 58 interactors |
MINTi | Q86YT6 |
STRINGi | 9606.ENSP00000261537 |
PTM databases
iPTMneti | Q86YT6 |
PhosphoSitePlusi | Q86YT6 |
Genetic variation databases
BioMutai | MIB1 |
DMDMi | 68565512 |
Proteomic databases
EPDi | Q86YT6 |
jPOSTi | Q86YT6 |
MassIVEi | Q86YT6 |
MaxQBi | Q86YT6 |
PaxDbi | Q86YT6 |
PeptideAtlasi | Q86YT6 |
PRIDEi | Q86YT6 |
ProteomicsDBi | 70468 |
Protocols and materials databases
Antibodypediai | 7263, 345 antibodies from 37 providers |
DNASUi | 57534 |
Genome annotation databases
Ensembli | ENST00000261537.7; ENSP00000261537.6; ENSG00000101752.12 |
GeneIDi | 57534 |
KEGGi | hsa:57534 |
MANE-Selecti | ENST00000261537.7; ENSP00000261537.6; NM_020774.4; NP_065825.1 |
UCSCi | uc002ktq.5, human |
Organism-specific databases
CTDi | 57534 |
DisGeNETi | 57534 |
GeneCardsi | MIB1 |
HGNCi | HGNC:21086, MIB1 |
HPAi | ENSG00000101752, Low tissue specificity |
MalaCardsi | MIB1 |
MIMi | 608677, gene 615092, phenotype |
neXtProti | NX_Q86YT6 |
OpenTargetsi | ENSG00000101752 |
Orphaneti | 54260, Left ventricular noncompaction |
PharmGKBi | PA134862722 |
VEuPathDBi | HostDB:ENSG00000101752 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota KOG4582, Eukaryota |
GeneTreei | ENSGT00940000156781 |
HOGENOMi | CLU_007287_1_0_1 |
InParanoidi | Q86YT6 |
OMAi | CCGGIGR |
OrthoDBi | 220300at2759 |
PhylomeDBi | Q86YT6 |
TreeFami | TF324147 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q86YT6 |
Reactomei | R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2691232, Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus |
SignaLinki | Q86YT6 |
SIGNORi | Q86YT6 |
Miscellaneous databases
BioGRID-ORCSi | 57534, 102 hits in 1132 CRISPR screens |
ChiTaRSi | MIB1, human |
GeneWikii | MIB1_(gene) |
GenomeRNAii | 57534 |
Pharosi | Q86YT6, Tbio |
PROi | PR:Q86YT6 |
RNActi | Q86YT6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101752, Expressed in kidney and 226 other tissues |
Genevisiblei | Q86YT6, HS |
Family and domain databases
CDDi | cd02339, ZZ_Mind_bomb, 1 hit |
Gene3Di | 1.25.40.20, 4 hits 3.30.40.10, 3 hits 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR042056, MIB1/2_ZZ IPR010606, Mib_Herc2 IPR037252, Mib_Herc2_sf IPR040847, SH3_15 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF13637, Ank_4, 1 hit PF06701, MIB_HERC2, 2 hits PF18346, SH3_15, 2 hits PF00569, ZZ, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 9 hits SM00184, RING, 3 hits SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF159034, SSF159034, 2 hits SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 6 hits PS51416, MIB_HERC2, 2 hits PS50089, ZF_RING_2, 3 hits PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MIB1_HUMAN | |
Accessioni | Q86YT6Primary (citable) accession number: Q86YT6 Secondary accession number(s): B0YJ38 Q9P2M3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | June 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references