UniProtKB - Q86YS7 (C2CD5_HUMAN)

BLAST

>sp|Q86YS7|C2CD5_HUMAN C2 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=C2CD5 PE=1 SV=1
MPGKLKVKIVAGRHLPVMDRASDLTDAFVEVKFGNTTFKTDVYLKSLNPQWNSEWFKFEV
DDEDLQDEPLQITVLDHDTYSANDAIGKVYIDIDPLLYSEAATVISGWFPIYDTIHGIRG
EINVVVKVDLFNDLNRFRQSSCGVKFFCTTSIPKCYRAVIIHGFVEELVVNEDPEYQWID
RIRTPRASNEARQRLISLMSGELQRKIGLKVLEMRGNAVVGYLQCFDLEGESGLVVRAIG
TACTLDKLSSPAAFLPACNSPSKEMKEIPFNEDPNPNTHSSGPSTPLKNQTYSFSPSKSY
SRQSSSSDTDLSLTPKTGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPPGF
LVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSI
CEEVCILSASGTAAVLNPRFLQDGTVEGCLEQRLEENLPTRCGFCHIPYDELNMPFPAHL
TYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQAEANATAISNLLPF
MEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGK
TPNDGSYEQHISHMQKKINDTIAKNKELYEINPPEISEEIIGSPIPEPRQRSRLLRSQSE
SSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNWTS
EIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLP
EDELIQVTVTAVAITFDKNQALQTTKTPVEKSLQRASTDNEELLQFPLELCSDSLPSHPF
PPAKAMTVEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFI
RETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGNAVVSYIMKQCVFMENPNKNQAQC
LINVSGDAVVFVRESDLEVVSSQQPTTNCQSSCTEGEVTT

Align

Format
Add to basket Added to basket
History
Entry version 133 (12 Sep 2018)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

C2 domain-containing protein 5

Gene

C2CD5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.1 Publication

Cofactorⁱ

Ca²⁺Note: Binds 2 calcium ions per subunit. The ions are bound to the C2 domains.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	13 – 27	1; low affinityAdd BLAST		15
Calcium bindingⁱ	75 – 86	2; high affinityAdd BLAST		12

GO - Molecular functionⁱ

calcium-dependent phospholipid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21907143
calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21907143

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to insulin stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 21907143
insulin receptor signaling pathway via phosphatidylinositol 3-kinase Source: UniProtKB
intracellular protein transmembrane transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21907143
positive regulation of glucose import in response to insulin stimulus Source: Ensembl
positive regulation of glucose transmembrane transport Source: UniProtKB
positive regulation of protein targeting to membrane
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21907143
positive regulation of vesicle fusion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21907143
protein localization to plasma membrane Source: Ensembl
vesicle fusion Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport
Ligand	Calcium, Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane

Reactomeⁱ

R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C2 domain-containing protein 5 Alternative name(s): C2 domain-containing phosphoprotein of 138 kDa
Gene namesⁱ	Name:C2CD5 Synonyms:CDP138, KIAA0528
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111731.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29062 C2CD5
neXtProtⁱ	NX_Q86YS7

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	19	D → A: Reduces calcium-binding, phospholipid membrane-binding and insulin-stimulated SLC2A4/GLUT4 translocation; when associated with A-26; A-76; A-78 and A-84. 1 Publication	1
Mutagenesisⁱ	26	D → A: Reduces calcium-binding, phospholipid membrane-binding and insulin-stimulated SLC2A4/GLUT4 translocation; when associated with A-19; A-76; A-78 and A-84. 1 Publication	1
Mutagenesisⁱ	76	D → A: Reduces calcium-binding, phospholipid membrane-binding and insulin-stimulated SLC2A4/GLUT4 translocation; when associated with A-19; A-26; A-78 and A-84. 1 Publication	1
Mutagenesisⁱ	78	D → A: Reduces calcium-binding, phospholipid membrane-binding and insulin-stimulated SLC2A4/GLUT4 translocation; when associated with A-19; A-26; A-76 and A-84. 1 Publication	1
Mutagenesisⁱ	84	D → A: Reduces calcium-binding, phospholipid membrane-binding and insulin-stimulated SLC2A4/GLUT4 translocation; when associated with A-19; A-26; A-76 and A-78. 1 Publication	1
Mutagenesisⁱ	197	S → A: Inhibits insulin-stimulated AKT2-induced phosphorylation, SLC2A4/GLUT4 translocation to the cell surface and GSV-PM fusion. 1 Publication	1
Mutagenesisⁱ	200	S → A: Does not inhibit insulin-stimulated SLC2A4/GLUT4 translocation. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000111731
PharmGKBⁱ	PA143485515

Polymorphism and mutation databases

DMDMⁱ	74750574

DMDMⁱ

74750574

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000247450	1 – 1000	C2 domain-containing protein 5Add BLAST		1000

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	197	Phosphoserine; by PKB/AKT21 Publication	1
Modified residueⁱ	200	Phosphoserine1 Publication	1
Modified residueⁱ	260	PhosphoserineCombined sources	1
Modified residueⁱ	293	PhosphoserineCombined sources	1
Modified residueⁱ	295	PhosphoserineCombined sources	1
Modified residueⁱ	304	PhosphoserineBy similarity	1
Modified residueⁱ	305	PhosphoserineCombined sources	1
Modified residueⁱ	306	PhosphoserineBy similarity	1
Modified residueⁱ	317	PhosphothreonineCombined sources	1
Modified residueⁱ	323	PhosphoserineCombined sources	1
Modified residueⁱ	601	PhosphothreonineCombined sources	1
Modified residueⁱ	643	PhosphoserineCombined sources	1
Modified residueⁱ	657	PhosphoserineBy similarity	1
Modified residueⁱ	659	PhosphoserineCombined sources	1
Modified residueⁱ	661	PhosphoserineBy similarity	1
Modified residueⁱ	662	PhosphoserineCombined sources	1
Modified residueⁱ	666	PhosphothreonineCombined sources	1
Modified residueⁱ	671	PhosphoserineCombined sources	1
Modified residueⁱ	807	PhosphothreonineCombined sources	1
Modified residueⁱ	817	PhosphoserineBy similarity	1
Modified residueⁱ	852	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated on Ser-197 by active myristoylated kinase AKT2; insulin-stimulated phosphorylation by AKT2 regulates SLC2A4/GLUT4 translocation into the plasma membrane.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q86YS7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86YS7
PaxDbⁱ	Q86YS7
PeptideAtlas More...PeptideAtlasⁱ	Q86YS7
PRIDEⁱ	Q86YS7
ProteomicsDBⁱ	70464 70465 [Q86YS7-2]

PTM databases

iPTMnetⁱ	Q86YS7
PhosphoSitePlusⁱ	Q86YS7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000111731 Expressed in 232 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_KIAA0528
ExpressionAtlasⁱ	Q86YS7 baseline and differential
Genevisibleⁱ	Q86YS7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046194

HPAⁱ

HPA046194

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115182, 38 interactors
IntActⁱ	Q86YS7, 21 interactors
STRINGⁱ	9606.ENSP00000334229

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86YS7
SMRⁱ	Q86YS7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 90	C2PROSITE-ProRule annotationAdd BLAST		90

Domainⁱ

The C2 domain binds to calcium and membrane lipids.

Phylogenomic databases

eggNOGⁱ	KOG1031 Eukaryota ENOG410XQDE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000212
HOGENOMⁱ	HOG000006746
HOVERGENⁱ	HBG081824
InParanoidⁱ	Q86YS7
OMAⁱ	CANSTVG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FX6
PhylomeDBⁱ	Q86YS7
TreeFamⁱ	TF323431

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08688 C2_KIAA0528-like, 1 hit
Gene3Dⁱ	2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR037785 C2_C2CD5 IPR000008 C2_dom IPR035892 C2_domain_sf IPR038983 C2CD5
PANTHERⁱ	PTHR37412 PTHR37412, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 1 hit
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004 C2, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q86YS7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGKLKVKIV AGRHLPVMDR ASDLTDAFVE VKFGNTTFKT DVYLKSLNPQ 
        60         70         80         90        100
WNSEWFKFEV DDEDLQDEPL QITVLDHDTY SANDAIGKVY IDIDPLLYSE 
       110        120        130        140        150
AATVISGWFP IYDTIHGIRG EINVVVKVDL FNDLNRFRQS SCGVKFFCTT 
       160        170        180        190        200
SIPKCYRAVI IHGFVEELVV NEDPEYQWID RIRTPRASNE ARQRLISLMS 
       210        220        230        240        250
GELQRKIGLK VLEMRGNAVV GYLQCFDLEG ESGLVVRAIG TACTLDKLSS 
       260        270        280        290        300
PAAFLPACNS PSKEMKEIPF NEDPNPNTHS SGPSTPLKNQ TYSFSPSKSY 
       310        320        330        340        350
SRQSSSSDTD LSLTPKTGMG SGSAGKEGGP FKALLRQQTQ SALEQREFPF 
       360        370        380        390        400
FTLTAFPPGF LVHVGGVVSA RSVKLLDRIH NPDEPETRDA WWAEIRQEIK 
       410        420        430        440        450
SHAKALGCHA VVGYSESTSI CEEVCILSAS GTAAVLNPRF LQDGTVEGCL 
       460        470        480        490        500
EQRLEENLPT RCGFCHIPYD ELNMPFPAHL TYCYNCRKQK VPDVLFTTID 
       510        520        530        540        550
LPTDATVIGK GCLIQARLCR LKKKAQAEAN ATAISNLLPF MEYEVHTQLM 
       560        570        580        590        600
NKLKLKGMNA LFGLRIQITV GENMLMGLAS ATGVYLAALP TPGGIQIAGK 
       610        620        630        640        650
TPNDGSYEQH ISHMQKKIND TIAKNKELYE INPPEISEEI IGSPIPEPRQ 
       660        670        680        690        700
RSRLLRSQSE SSDEVTELDL SHGKKDAFVL EIDDTDAMED VHSLLTDVPP 
       710        720        730        740        750
PSGFYSCNTE IMPGINNWTS EIQMFTSVRV IRLSSLNLTN QALNKNFNDL 
       760        770        780        790        800
CENLLKSLYF KLRSMIPCCL CHVNFTVSLP EDELIQVTVT AVAITFDKNQ 
       810        820        830        840        850
ALQTTKTPVE KSLQRASTDN EELLQFPLEL CSDSLPSHPF PPAKAMTVEK 
       860        870        880        890        900
ASPVGDGNFR NRSAPPCANS TVGVVKMTPL SFIPGAKITK YLGIINMFFI 
       910        920        930        940        950
RETTSLREEG GVSGFLHAFI AEVFAMVRAH VAALGGNAVV SYIMKQCVFM 
       960        970        980        990       1000
ENPNKNQAQC LINVSGDAVV FVRESDLEVV SSQQPTTNCQ SSCTEGEVTT

Length:1,000

Mass (Da):110,447

Last modified:June 1, 2003 - v1

Checksum:ⁱ7C51961F54CBBACD

Isoform 2 (identifier: Q86YS7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
268-316: IPFNEDPNPN...SDTDLSLTPK → SPLVHPPSHG...FSVSVPTLIY
845-845: A → EHLESASSNSGIPAAQRATSVDYSSFADRCSSWIELIKLKAQTIRRGSIKTT

« Hide

        10         20         30         40         50
MPGKLKVKIV AGRHLPVMDR ASDLTDAFVE VKFGNTTFKT DVYLKSLNPQ 
        60         70         80         90        100
WNSEWFKFEV DDEDLQDEPL QITVLDHDTY SANDAIGKVY IDIDPLLYSE 
       110        120        130        140        150
AATVISGWFP IYDTIHGIRG EINVVVKVDL FNDLNRFRQS SCGVKFFCTT 
       160        170        180        190        200
SIPKCYRAVI IHGFVEELVV NEDPEYQWID RIRTPRASNE ARQRLISLMS 
       210        220        230        240        250
GELQRKIGLK VLEMRGNAVV GYLQCFDLEG ESGLVVRAIG TACTLDKLSS 
       260        270        280        290        300
PAAFLPACNS PSKEMKESPL VHPPSHGCRS THNSPIHTAT GSRLTQNFSV 
       310        320        330        340        350
SVPTLIYTGM GSGSAGKEGG PFKALLRQQT QSALEQREFP FFTLTAFPPG 
       360        370        380        390        400
FLVHVGGVVS ARSVKLLDRI HNPDEPETRD AWWAEIRQEI KSHAKALGCH 
       410        420        430        440        450
AVVGYSESTS ICEEVCILSA SGTAAVLNPR FLQDGTVEGC LEQRLEENLP 
       460        470        480        490        500
TRCGFCHIPY DELNMPFPAH LTYCYNCRKQ KVPDVLFTTI DLPTDATVIG 
       510        520        530        540        550
KGCLIQARLC RLKKKAQAEA NATAISNLLP FMEYEVHTQL MNKLKLKGMN 
       560        570        580        590        600
ALFGLRIQIT VGENMLMGLA SATGVYLAAL PTPGGIQIAG KTPNDGSYEQ 
       610        620        630        640        650
HISHMQKKIN DTIAKNKELY EINPPEISEE IIGSPIPEPR QRSRLLRSQS 
       660        670        680        690        700
ESSDEVTELD LSHGKKDAFV LEIDDTDAME DVHSLLTDVP PPSGFYSCNT 
       710        720        730        740        750
EIMPGINNWT SEIQMFTSVR VIRLSSLNLT NQALNKNFND LCENLLKSLY 
       760        770        780        790        800
FKLRSMIPCC LCHVNFTVSL PEDELIQVTV TAVAITFDKN QALQTTKTPV 
       810        820        830        840        850
EKSLQRASTD NEELLQFPLE LCSDSLPSHP FPPAKEHLES ASSNSGIPAA 
       860        870        880        890        900
QRATSVDYSS FADRCSSWIE LIKLKAQTIR RGSIKTTMTV EKASPVGDGN 
       910        920        930        940        950
FRNRSAPPCA NSTVGVVKMT PLSFIPGAKI TKYLGIINMF FIRETTSLRE 
       960        970        980        990       1000
EGGVSGFLHA FIAEVFAMVR AHVAALGGNA VVSYIMKQCV FMENPNKNQA 
      1010       1020       1030       1040 
QCLINVSGDA VVFVRESDLE VVSSQQPTTN CQSSCTEGEV TT

Note: No experimental confirmation available.

Show »

Length:1,042

Mass (Da):114,994

Checksum:ⁱ23C91754C1A61236

Isoform 3 (identifier: Q86YS7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
845-845: A → EHLESASSNSGIPAAQRATSVDYSSFADRCSSWIELIKLKAQTIRRGSIKTT

« Hide

        10         20         30         40         50
MPGKLKVKIV AGRHLPVMDR ASDLTDAFVE VKFGNTTFKT DVYLKSLNPQ 
        60         70         80         90        100
WNSEWFKFEV DDEDLQDEPL QITVLDHDTY SANDAIGKVY IDIDPLLYSE 
       110        120        130        140        150
AATVISGWFP IYDTIHGIRG EINVVVKVDL FNDLNRFRQS SCGVKFFCTT 
       160        170        180        190        200
SIPKCYRAVI IHGFVEELVV NEDPEYQWID RIRTPRASNE ARQRLISLMS 
       210        220        230        240        250
GELQRKIGLK VLEMRGNAVV GYLQCFDLEG ESGLVVRAIG TACTLDKLSS 
       260        270        280        290        300
PAAFLPACNS PSKEMKEIPF NEDPNPNTHS SGPSTPLKNQ TYSFSPSKSY 
       310        320        330        340        350
SRQSSSSDTD LSLTPKTGMG SGSAGKEGGP FKALLRQQTQ SALEQREFPF 
       360        370        380        390        400
FTLTAFPPGF LVHVGGVVSA RSVKLLDRIH NPDEPETRDA WWAEIRQEIK 
       410        420        430        440        450
SHAKALGCHA VVGYSESTSI CEEVCILSAS GTAAVLNPRF LQDGTVEGCL 
       460        470        480        490        500
EQRLEENLPT RCGFCHIPYD ELNMPFPAHL TYCYNCRKQK VPDVLFTTID 
       510        520        530        540        550
LPTDATVIGK GCLIQARLCR LKKKAQAEAN ATAISNLLPF MEYEVHTQLM 
       560        570        580        590        600
NKLKLKGMNA LFGLRIQITV GENMLMGLAS ATGVYLAALP TPGGIQIAGK 
       610        620        630        640        650
TPNDGSYEQH ISHMQKKIND TIAKNKELYE INPPEISEEI IGSPIPEPRQ 
       660        670        680        690        700
RSRLLRSQSE SSDEVTELDL SHGKKDAFVL EIDDTDAMED VHSLLTDVPP 
       710        720        730        740        750
PSGFYSCNTE IMPGINNWTS EIQMFTSVRV IRLSSLNLTN QALNKNFNDL 
       760        770        780        790        800
CENLLKSLYF KLRSMIPCCL CHVNFTVSLP EDELIQVTVT AVAITFDKNQ 
       810        820        830        840        850
ALQTTKTPVE KSLQRASTDN EELLQFPLEL CSDSLPSHPF PPAKEHLESA 
       860        870        880        890        900
SSNSGIPAAQ RATSVDYSSF ADRCSSWIEL IKLKAQTIRR GSIKTTMTVE 
       910        920        930        940        950
KASPVGDGNF RNRSAPPCAN STVGVVKMTP LSFIPGAKIT KYLGIINMFF 
       960        970        980        990       1000
IRETTSLREE GGVSGFLHAF IAEVFAMVRA HVAALGGNAV VSYIMKQCVF 
      1010       1020       1030       1040       1050
MENPNKNQAQ CLINVSGDAV VFVRESDLEV VSSQQPTTNC QSSCTEGEVT 

T

Note: No experimental confirmation available.

Show »

Length:1,051

Mass (Da):116,027

Checksum:ⁱ2C4D059D41F01BE8

Isoform 4 (identifier: Q86YS7-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-316: IPFNEDPNPN...SDTDLSLTPK → SPLVHPPSHG...FSVSVPTLIY
     345-345: Q → QRGGSPHRFCRR
     845-845: A → EHLESASSNSGIPAAQRATSVDYSSFADRCSSWIELIKLKAQTIRRGSIKTT

« Hide

        10         20         30         40         50
MPGKLKVKIV AGRHLPVMDR ASDLTDAFVE VKFGNTTFKT DVYLKSLNPQ 
        60         70         80         90        100
WNSEWFKFEV DDEDLQDEPL QITVLDHDTY SANDAIGKVY IDIDPLLYSE 
       110        120        130        140        150
AATVISGWFP IYDTIHGIRG EINVVVKVDL FNDLNRFRQS SCGVKFFCTT 
       160        170        180        190        200
SIPKCYRAVI IHGFVEELVV NEDPEYQWID RIRTPRASNE ARQRLISLMS 
       210        220        230        240        250
GELQRKIGLK VLEMRGNAVV GYLQCFDLEG ESGLVVRAIG TACTLDKLSS 
       260        270        280        290        300
PAAFLPACNS PSKEMKESPL VHPPSHGCRS THNSPIHTAT GSRLTQNFSV 
       310        320        330        340        350
SVPTLIYTGM GSGSAGKEGG PFKALLRQQT QSALEQRGGS PHRFCRRREF 
       360        370        380        390        400
PFFTLTAFPP GFLVHVGGVV SARSVKLLDR IHNPDEPETR DAWWAEIRQE 
       410        420        430        440        450
IKSHAKALGC HAVVGYSEST SICEEVCILS ASGTAAVLNP RFLQDGTVEG 
       460        470        480        490        500
CLEQRLEENL PTRCGFCHIP YDELNMPFPA HLTYCYNCRK QKVPDVLFTT 
       510        520        530        540        550
IDLPTDATVI GKGCLIQARL CRLKKKAQAE ANATAISNLL PFMEYEVHTQ 
       560        570        580        590        600
LMNKLKLKGM NALFGLRIQI TVGENMLMGL ASATGVYLAA LPTPGGIQIA 
       610        620        630        640        650
GKTPNDGSYE QHISHMQKKI NDTIAKNKEL YEINPPEISE EIIGSPIPEP 
       660        670        680        690        700
RQRSRLLRSQ SESSDEVTEL DLSHGKKDAF VLEIDDTDAM EDVHSLLTDV 
       710        720        730        740        750
PPPSGFYSCN TEIMPGINNW TSEIQMFTSV RVIRLSSLNL TNQALNKNFN 
       760        770        780        790        800
DLCENLLKSL YFKLRSMIPC CLCHVNFTVS LPEDELIQVT VTAVAITFDK 
       810        820        830        840        850
NQALQTTKTP VEKSLQRAST DNEELLQFPL ELCSDSLPSH PFPPAKEHLE 
       860        870        880        890        900
SASSNSGIPA AQRATSVDYS SFADRCSSWI ELIKLKAQTI RRGSIKTTMT 
       910        920        930        940        950
VEKASPVGDG NFRNRSAPPC ANSTVGVVKM TPLSFIPGAK ITKYLGIINM 
       960        970        980        990       1000
FFIRETTSLR EEGGVSGFLH AFIAEVFAMV RAHVAALGGN AVVSYIMKQC 
      1010       1020       1030       1040       1050
VFMENPNKNQ AQCLINVSGD AVVFVRESDL EVVSSQQPTT NCQSSCTEGE 

VTT

Note: No experimental confirmation available.Curated

Show »

Length:1,053

Mass (Da):116,305

Checksum:ⁱF27416DC231838AA

Isoform 5 (identifier: Q86YS7-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-316: IPFNEDPNPN...SDTDLSLTPK → SPLVHPPSHG...FSVSVPTLIY
     382-382: P → PAFVGIMGNTRSYKLLDWNSFNS
     845-845: A → EHLESASSNSGIPAAQRDRCSSWIELIKLKAQTIRRGSIKTT

« Hide

        10         20         30         40         50
MPGKLKVKIV AGRHLPVMDR ASDLTDAFVE VKFGNTTFKT DVYLKSLNPQ 
        60         70         80         90        100
WNSEWFKFEV DDEDLQDEPL QITVLDHDTY SANDAIGKVY IDIDPLLYSE 
       110        120        130        140        150
AATVISGWFP IYDTIHGIRG EINVVVKVDL FNDLNRFRQS SCGVKFFCTT 
       160        170        180        190        200
SIPKCYRAVI IHGFVEELVV NEDPEYQWID RIRTPRASNE ARQRLISLMS 
       210        220        230        240        250
GELQRKIGLK VLEMRGNAVV GYLQCFDLEG ESGLVVRAIG TACTLDKLSS 
       260        270        280        290        300
PAAFLPACNS PSKEMKESPL VHPPSHGCRS THNSPIHTAT GSRLTQNFSV 
       310        320        330        340        350
SVPTLIYTGM GSGSAGKEGG PFKALLRQQT QSALEQREFP FFTLTAFPPG 
       360        370        380        390        400
FLVHVGGVVS ARSVKLLDRI HNPAFVGIMG NTRSYKLLDW NSFNSDEPET 
       410        420        430        440        450
RDAWWAEIRQ EIKSHAKALG CHAVVGYSES TSICEEVCIL SASGTAAVLN 
       460        470        480        490        500
PRFLQDGTVE GCLEQRLEEN LPTRCGFCHI PYDELNMPFP AHLTYCYNCR 
       510        520        530        540        550
KQKVPDVLFT TIDLPTDATV IGKGCLIQAR LCRLKKKAQA EANATAISNL 
       560        570        580        590        600
LPFMEYEVHT QLMNKLKLKG MNALFGLRIQ ITVGENMLMG LASATGVYLA 
       610        620        630        640        650
ALPTPGGIQI AGKTPNDGSY EQHISHMQKK INDTIAKNKE LYEINPPEIS 
       660        670        680        690        700
EEIIGSPIPE PRQRSRLLRS QSESSDEVTE LDLSHGKKDA FVLEIDDTDA 
       710        720        730        740        750
MEDVHSLLTD VPPPSGFYSC NTEIMPGINN WTSEIQMFTS VRVIRLSSLN 
       760        770        780        790        800
LTNQALNKNF NDLCENLLKS LYFKLRSMIP CCLCHVNFTV SLPEDELIQV 
       810        820        830        840        850
TVTAVAITFD KNQALQTTKT PVEKSLQRAS TDNEELLQFP LELCSDSLPS 
       860        870        880        890        900
HPFPPAKEHL ESASSNSGIP AAQRDRCSSW IELIKLKAQT IRRGSIKTTM 
       910        920        930        940        950
TVEKASPVGD GNFRNRSAPP CANSTVGVVK MTPLSFIPGA KITKYLGIIN 
       960        970        980        990       1000
MFFIRETTSL REEGGVSGFL HAFIAEVFAM VRAHVAALGG NAVVSYIMKQ 
      1010       1020       1030       1040       1050
CVFMENPNKN QAQCLINVSG DAVVFVRESD LEVVSSQQPT TNCQSSCTEG 

EVTT

Note: No experimental confirmation available.Curated

Show »

Length:1,054

Mass (Da):116,468

Checksum:ⁱ2514DE8DDDBDB3A7

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
H0YGU7	H0YGU7_HUMAN	C2 domain-containing protein 5 C2 domain-containing protein 5	C2CD5	182	Annotation score:
H0YFE9	H0YFE9_HUMAN	C2 domain-containing protein 5 C2 domain-containing protein 5	C2CD5	165	Annotation score:
H0YFC4	H0YFC4_HUMAN	C2 domain-containing protein 5 C2 domain-containing protein 5	C2CD5	283	Annotation score:

Sequence cautionⁱ

The sequence BAA25454 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAG58665 differs from that shown. Reason: Frameshift at position 33.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	997	E → G in BAG58665 (PubMed:14702039).Curated	1
Isoform 4 (identifier: Q86YS7-4)
Sequence conflictⁱ	895	I → F in AAI43879 (PubMed:15489334).Curated	1
Isoform 5 (identifier: Q86YS7-5)
Sequence conflictⁱ	895	S → P in BAG58665 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_028255	268 – 316	IPFNE…SLTPK → SPLVHPPSHGCRSTHNSPIH TATGSRLTQNFSVSVPTLIY in isoform 2, isoform 4 and isoform 5. 2 PublicationsAdd BLAST	49
Alternative sequenceⁱVSP_055638	345	Q → QRGGSPHRFCRR in isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_055639	382	P → PAFVGIMGNTRSYKLLDWNS FNS in isoform 5. 1 Publication	1
Alternative sequenceⁱVSP_028256	845	A → EHLESASSNSGIPAAQRATS VDYSSFADRCSSWIELIKLK AQTIRRGSIKTT in isoform 2, isoform 3 and isoform 4. 2 Publications	1
Alternative sequenceⁱVSP_055640	845	A → EHLESASSNSGIPAAQRDRC SSWIELIKLKAQTIRRGSIK TT in isoform 5. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB011100 mRNA Translation: BAA25454.3 Different initiation. AY166851 mRNA Translation: AAO17290.1 AK295862 mRNA Translation: BAG58665.1 Frameshift. AK299353 mRNA Translation: BAG61349.1 AC053513 Genomic DNA No translation available. BC042498 mRNA Translation: AAH42498.2 BC053885 mRNA Translation: AAH53885.1 BC117143 mRNA Translation: AAI17144.1 BC143878 mRNA Translation: AAI43879.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31758.1 [Q86YS7-1] CCDS66337.1 [Q86YS7-3] CCDS66338.1 [Q86YS7-2] CCDS66339.1 [Q86YS7-5] CCDS66340.1 [Q86YS7-4]
PIRⁱ	T00072
NCBI Reference Sequences More...RefSeqⁱ	NP_001273102.1, NM_001286173.1 [Q86YS7-4] NP_001273103.1, NM_001286174.1 [Q86YS7-3] NP_001273104.1, NM_001286175.1 [Q86YS7-5] NP_001273105.1, NM_001286176.1 [Q86YS7-3] NP_001273106.1, NM_001286177.1 [Q86YS7-2] NP_055617.1, NM_014802.2 [Q86YS7-1]
UniGeneⁱ	Hs.271014

Genome annotation databases

Ensemblⁱ	ENST00000333957; ENSP00000334229; ENSG00000111731 [Q86YS7-1] ENST00000396028; ENSP00000379345; ENSG00000111731 [Q86YS7-2] ENST00000446597; ENSP00000388756; ENSG00000111731 [Q86YS7-3] ENST00000536386; ENSP00000439392; ENSG00000111731 [Q86YS7-4] ENST00000542676; ENSP00000441951; ENSG00000111731 [Q86YS7-3] ENST00000545552; ENSP00000443204; ENSG00000111731 [Q86YS7-5]
GeneIDⁱ	9847
KEGGⁱ	hsa:9847
UCSC genome browser More...UCSCⁱ	uc001rfq.5 human [Q86YS7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q86YS7	C2 domain-containing protein 5		PONAB		1000	UniRef90_Q86YS7
C2 calcium dependent domain containing 5		CHICK		1081
C2 calcium dependent domain containing 5		PANTR		1000
C2 calcium dependent domain containing 5		PANPA		1000
C2 calcium dependent domain containing 5		MACMU		1000
+90
Q86YS7-2	Isoform 5 of C2 domain-containing protein 5		HUMAN		1054	UniRef90_Q86YS7-5
C2 domain-containing protein 5 isoform X4		TARSY		1063
C2 domain-containing protein 5 isoform X5		ERIEU		1062
C2 calcium dependent domain containing 5		AOTNA		1062
C2 calcium dependent domain containing 5		SAIBB		1058
+342
Q86YS7-3	Isoform 5 of C2 domain-containing protein 5		HUMAN		1054	UniRef90_Q86YS7-5
C2 domain-containing protein 5 isoform X4		TARSY		1063
C2 domain-containing protein 5 isoform X5		ERIEU		1062
C2 calcium dependent domain containing 5		AOTNA		1062
C2 calcium dependent domain containing 5		SAIBB		1058
+342
Q86YS7-4	Isoform 5 of C2 domain-containing protein 5		HUMAN		1054	UniRef90_Q86YS7-5
C2 domain-containing protein 5 isoform X4		TARSY		1063
C2 domain-containing protein 5 isoform X5		ERIEU		1062
C2 calcium dependent domain containing 5		AOTNA		1062
C2 calcium dependent domain containing 5		SAIBB		1058
+342
Q86YS7-5	C2 domain-containing protein 5 isoform X4		TARSY		1063	UniRef90_Q86YS7-5
C2 domain-containing protein 5 isoform X5		ERIEU		1062
C2 calcium dependent domain containing 5		AOTNA		1062
C2 calcium dependent domain containing 5		SAIBB		1058
C2 calcium dependent domain containing 5		PELSI		1055
+342

Protein	Similar proteins		Species	Score	Length	Source
Q86YS7	C2 domain-containing protein 5		PONAB		1000	UniRef50_Q86YS7
C2 calcium dependent domain containing 5		CHICK		1081
C2 calcium dependent domain containing 5		MACMU		1000
C2 calcium dependent domain containing 5		MACFA		1000
C2 calcium dependent domain containing 5		FELCA		1000
+190
Q86YS7-2	Isoform 5 of C2 domain-containing protein 5		HUMAN		1054	UniRef50_Q86YS7-5
C2 domain-containing protein 5 isoform X4		TARSY		1063
C2 calcium dependent domain containing 5		AOTNA		1062
C2 domain-containing protein 5 isoform X5		ERIEU		1062
C2 calcium dependent domain containing 5		SAIBB		1058
+1021
Q86YS7-3	Isoform 5 of C2 domain-containing protein 5		HUMAN		1054	UniRef50_Q86YS7-5
C2 domain-containing protein 5 isoform X4		TARSY		1063
C2 calcium dependent domain containing 5		AOTNA		1062
C2 domain-containing protein 5 isoform X5		ERIEU		1062
C2 calcium dependent domain containing 5		SAIBB		1058
+1021
Q86YS7-4	Isoform 5 of C2 domain-containing protein 5		HUMAN		1054	UniRef50_Q86YS7-5
C2 domain-containing protein 5 isoform X4		TARSY		1063
C2 calcium dependent domain containing 5		AOTNA		1062
C2 domain-containing protein 5 isoform X5		ERIEU		1062
C2 calcium dependent domain containing 5		SAIBB		1058
+1021
Q86YS7-5	C2 domain-containing protein 5 isoform X4		TARSY		1063	UniRef50_Q86YS7-5
C2 calcium dependent domain containing 5		AOTNA		1062
C2 domain-containing protein 5 isoform X5		ERIEU		1062
C2 calcium dependent domain containing 5		SAIBB		1058
C2 calcium dependent domain containing 5		PELSI		1055
+1021

Entry informationⁱ

Entry nameⁱ	C2CD5_HUMAN
Accessionⁱ	Q86YS7Primary (citable) accession number: Q86YS7 Secondary accession number(s): B4DJ03 Q86SU3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
	Last sequence update:	June 1, 2003
	Last modified:	September 12, 2018
	This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q86YS7 (C2CD5_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

C2 domain-containing protein 5

C2CD5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytoskeleton

Cytosol

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ