RAB43

Functionⁱ

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.4 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	25 – 32	GTP	8
Nucleotide bindingⁱ	73 – 77	GTPBy similarity	5
Nucleotide bindingⁱ	131 – 134	GTP	4
Nucleotide bindingⁱ	163 – 164	GTP	2

GO - Molecular functionⁱ

GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17562788
- 24891604
GTP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to interferon-gamma Source: Ensembl
ER to Golgi vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Golgi organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17684057
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phagosome maturation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21255211
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retrograde transport, plasma membrane to Golgi
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17562788
toxin transport Source: Ensembl
virion assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21680502

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-8873719 RAB geranylgeranylation

Reactomeⁱ

R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-43 Alternative name(s): Ras-related protein Rab-41
Gene namesⁱ	Name:RAB43 Synonyms:RAB41
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172780.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19983 RAB43
neXtProtⁱ	NX_Q86YS6

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	32	T → N: Abolishes activity. Disrupts Golgi structure. 2 Publications		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000172780
PharmGKBⁱ	PA134968262

Polymorphism and mutation databases

BioMutaⁱ	RAB43
DMDMⁱ	74727944

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000244615	1 – 212	Ras-related protein Rab-43Add BLAST		212

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	49	PhosphoserineBy similarity	1
Modified residueⁱ	193	PhosphoserineCombined sources	1
Lipidationⁱ	210	S-geranylgeranyl cysteineBy similarity	1
Modified residueⁱ	212	Cysteine methyl esterBy similarity	1
Lipidationⁱ	212	S-geranylgeranyl cysteineBy similarity	1

Keywords - PTMⁱ

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDⁱ	Q86YS6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86YS6
PaxDbⁱ	Q86YS6
PeptideAtlas More...PeptideAtlasⁱ	Q86YS6
PRIDEⁱ	Q86YS6
ProteomicsDBⁱ	70463

PTM databases

iPTMnetⁱ	Q86YS6
PhosphoSitePlusⁱ	Q86YS6

Expressionⁱ

Tissue specificityⁱ

Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000172780 Expressed in 84 organ(s), highest expression level in blood
CleanExⁱ	HS_RAB41 HS_RAB43
ExpressionAtlasⁱ	Q86YS6 baseline and differential
Genevisibleⁱ	Q86YS6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046840 HPA060085

HPAⁱ

HPA046840
HPA060085

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
HSPB1	P04792	2	EBI-4401730,EBI-352682

With

Entry

#Exp.

IntAct

Notes

HSPB1

P04792

2

EBI-4401730,EBI-352682

Protein-protein interaction databases

BioGridⁱ	130830, 31 interactors
IntActⁱ	Q86YS6, 5 interactors
STRINGⁱ	9606.ENSP00000319781

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	17 – 25	Combined sources	9
Helixⁱ	31 – 40	Combined sources	10
Beta strandⁱ	55 – 62	Combined sources	8
Beta strandⁱ	65 – 72	Combined sources	8
Helixⁱ	78 – 80	Combined sources	3
Helixⁱ	81 – 88	Combined sources	8
Beta strandⁱ	92 – 99	Combined sources	8
Helixⁱ	103 – 107	Combined sources	5
Helixⁱ	109 – 119	Combined sources	11
Beta strandⁱ	125 – 131	Combined sources	7
Helixⁱ	136 – 138	Combined sources	3
Helixⁱ	143 – 152	Combined sources	10
Beta strandⁱ	156 – 160	Combined sources	5
Turnⁱ	163 – 166	Combined sources	4
Helixⁱ	169 – 183	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	Q86YS6
SMRⁱ	Q86YS6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q86YS6

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	47 – 55	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0084 Eukaryota ENOG410XQN5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140786
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q86YS6
KEGG Orthology (KO) More...KOⁱ	K07930
OMAⁱ	MFVMETS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HS5
PhylomeDBⁱ	Q86YS6
TreeFamⁱ	TF300097

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q86YS6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPGPGPGD PDEQYDFLFK LVLVGDASVG KTCVVQRFKT GAFSERQGST 
        60         70         80         90        100
IGVDFTMKTL EIQGKRVKLQ IWDTAGQERF RTITQSYYRS ANGAILAYDI 
       110        120        130        140        150
TKRSSFLSVP HWIEDVRKYA GSNIVQLLIG NKSDLSELRE VSLAEAQSLA 
       160        170        180        190        200
EHYDILCAIE TSAKDSSNVE EAFLRVATEL IMRHGGPLFS EKSPDHIQLN 
       210 
SKDIGEGWGC GC

Length:212

Mass (Da):23,339

Last modified:June 1, 2003 - v1

Checksum:ⁱ087EE3802B7159C9

GO

Isoform 2 (identifier: Q9ULR0-1) [UniParc]FASTA Add to basket

Also known as: ISY1-RAB43

The sequence of this isoform can be found in the external entry Q9ULR0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Based on a readthrough transcript which may produce a ISY1-RAB43 fusion protein. No experimental confirmation available.

Length:331

Mass (Da):37,567

GO

Isoform 3 (identifier: Q86YS6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
130-155: GNKSDLSELREVSLAEAQSLAEHYDI → EMQSCYVAQADLELLASSNPPASTSK
156-212: Missing.

« Hide

        10         20         30         40         50
MAGPGPGPGD PDEQYDFLFK LVLVGDASVG KTCVVQRFKT GAFSERQGST 
        60         70         80         90        100
IGVDFTMKTL EIQGKRVKLQ IWDTAGQERF RTITQSYYRS ANGAILAYDI 
       110        120        130        140        150
TKRSSFLSVP HWIEDVRKYA GSNIVQLLIE MQSCYVAQAD LELLASSNPP 

ASTSK

Note: Gene prediction based on EST data. No experimental confirmation available.

Show »

Length:155

Mass (Da):17,074

Checksum:ⁱCC4EA3C8FD5E005D

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9JFM7	C9JFM7_HUMAN		Ras-related protein Rab-43 Ras-related protein Rab-43	RAB43	86	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054030	130 – 155	GNKSD…EHYDI → EMQSCYVAQADLELLASSNP PASTSK in isoform 3. CuratedAdd BLAST		26
Alternative sequenceⁱVSP_054031	156 – 212	Missing in isoform 3. CuratedAdd BLAST		57

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY166852 mRNA Translation: AAO17291.1 AK291014 mRNA Translation: BAF83703.1 AC108673 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79283.1 BC062319 mRNA Translation: AAH62319.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33850.1 [Q86YS6-1] CCDS56275.1 [Q86YS6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001191812.1, NM_001204883.1 [Q86YS6-1] NP_001191813.1, NM_001204884.1 [Q86YS6-1] NP_001191814.1, NM_001204885.1 [Q86YS6-1] NP_001191815.1, NM_001204886.1 [Q86YS6-1] NP_001191816.1, NM_001204887.1 [Q86YS6-2] NP_940892.1, NM_198490.2 [Q86YS6-1]
UniGeneⁱ	Hs.381132 Hs.512661 Hs.546542

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q86YS6	RAB43 isoform 2		PANTR		212	UniRef100_Q86YS6
Ras-related protein Rab-43 isoform a		MACMU		212
RAB43 isoform 1		PONAB		212
Uncharacterized protein		CERAT		212
Uncharacterized protein		RHIRO		212
+11
Q86YS6-2	RAB43 isoform 5		PANTR		155	UniRef100_A0A2J8KAK8
Uncharacterized protein		MACMU		155
Uncharacterized protein		CERAT		155
Uncharacterized protein		PANPA		155
RAB43, member RAS oncogene family		GORGO		155
+2

Protein	Similar proteins		Species	Score	Length	Source
Q86YS6	Ras-related protein Rab-43		RAT		210	UniRef90_Q86YS6
RAB43 isoform 2		PANTR		212
Ras-related protein Rab-43 isoform a		MACMU		212
RAB43 isoform 1		PONAB		212
Uncharacterized protein		CERAT		212
+100
Q9ULR0-1	Pre-mRNA-splicing factor ISY1 homolog	)	HUMAN		285	UniRef90_Q9ULR0
Pre-mRNA-splicing factor ISY1 homolog	)	MOUSE		285
Pre-mRNA-splicing factor ISY1 homolog		RAT		284
ISY1 splicing factor homolog		GORGO		285
Uncharacterized protein (Fragment)		MACMU		351
+78
Q86YS6-2	RAB43 isoform 5		PANTR		155	UniRef90_A0A2J8KAK8
Uncharacterized protein		MACMU		155
Uncharacterized protein		CERAT		155
Uncharacterized protein		PANPA		155
RAB43, member RAS oncogene family		GORGO		155
+15

Protein	Similar proteins		Species	Score	Length	Source
Q86YS6	Ras-related protein Rab-43		RAT		210	UniRef50_Q86YS6
Ras-related protein Rab-43		MOUSE		210
RAB43 isoform 2		PANTR		212
Ras-related protein Rab-43 isoform a		MACMU		212
RAB43 isoform 1		PONAB		212
+156
Q9ULR0-1	Pre-mRNA-splicing factor ISY1 homolog	)	HUMAN		285	UniRef50_Q9ULR0
Pre-mRNA-splicing factor ISY1 homolog	)	MOUSE		285
Pre-mRNA-splicing factor ISY1 homolog		RAT		284
ISY1 splicing factor homolog		GORGO		285
Uncharacterized protein (Fragment)		MACMU		351
+118
Q86YS6-2	RAB43 isoform 5		PANTR		155	UniRef50_A0A2J8KAK8
Uncharacterized protein		MACMU		155
Uncharacterized protein		CERAT		155
Uncharacterized protein		PANPA		155
RAB43, member RAS oncogene family		GORGO		155
+22

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY166852 mRNA Translation: AAO17291.1 AK291014 mRNA Translation: BAF83703.1 AC108673 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79283.1 BC062319 mRNA Translation: AAH62319.1
CCDSⁱ	CCDS33850.1 [Q86YS6-1] CCDS56275.1 [Q86YS6-2]
RefSeqⁱ	NP_001191812.1, NM_001204883.1 [Q86YS6-1] NP_001191813.1, NM_001204884.1 [Q86YS6-1] NP_001191814.1, NM_001204885.1 [Q86YS6-1] NP_001191815.1, NM_001204886.1 [Q86YS6-1] NP_001191816.1, NM_001204887.1 [Q86YS6-2] NP_940892.1, NM_198490.2 [Q86YS6-1]
UniGeneⁱ	Hs.381132 Hs.512661 Hs.546542

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2HUP	X-ray	2.05	A/B	9-190	[»]
ProteinModelPortalⁱ	Q86YS6
SMRⁱ	Q86YS6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	130830, 31 interactors
IntActⁱ	Q86YS6, 5 interactors
STRINGⁱ	9606.ENSP00000319781

PTM databases

iPTMnetⁱ	Q86YS6
PhosphoSitePlusⁱ	Q86YS6

Polymorphism and mutation databases

BioMutaⁱ	RAB43
DMDMⁱ	74727944

Proteomic databases

EPDⁱ	Q86YS6
MaxQBⁱ	Q86YS6
PaxDbⁱ	Q86YS6
PeptideAtlasⁱ	Q86YS6
PRIDEⁱ	Q86YS6
ProteomicsDBⁱ	70463

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000315150; ENSP00000319781; ENSG00000172780 [Q86YS6-1] ENST00000393304; ENSP00000376981; ENSG00000172780 [Q86YS6-1] ENST00000393305; ENSP00000376982; ENSG00000172780 [Q86YS6-1] ENST00000393307; ENSP00000376984; ENSG00000172780 [Q86YS6-1] ENST00000393308; ENSP00000376985; ENSG00000172780 [Q86YS6-1] ENST00000476465; ENSP00000427632; ENSG00000172780 [Q86YS6-2] ENST00000615093; ENSP00000481399; ENSG00000172780 [Q86YS6-2]
GeneIDⁱ	339122
KEGGⁱ	hsa:339122
UCSCⁱ	uc003eln.3 human [Q86YS6-1]

Organism-specific databases

CTDⁱ	339122
EuPathDBⁱ	HostDB:ENSG00000172780.16
GeneCardsⁱ	RAB43
HGNCⁱ	HGNC:19983 RAB43
HPAⁱ	HPA046840 HPA060085
neXtProtⁱ	NX_Q86YS6
OpenTargetsⁱ	ENSG00000172780
PharmGKBⁱ	PA134968262
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0084 Eukaryota ENOG410XQN5 LUCA
GeneTreeⁱ	ENSGT00900000140786
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q86YS6
KOⁱ	K07930
OMAⁱ	MFVMETS
OrthoDBⁱ	EOG091G0HS5
PhylomeDBⁱ	Q86YS6
TreeFamⁱ	TF300097

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-8873719 RAB geranylgeranylation

Reactomeⁱ

R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

EvolutionaryTraceⁱ	Q86YS6
GenomeRNAiⁱ	339122
Protein Ontology More...PROⁱ	PR:Q86YS6

Gene expression databases

Bgeeⁱ	ENSG00000172780 Expressed in 84 organ(s), highest expression level in blood
CleanExⁱ	HS_RAB41 HS_RAB43
ExpressionAtlasⁱ	Q86YS6 baseline and differential
Genevisibleⁱ	Q86YS6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAB43_HUMAN
Accessionⁱ	Q86YS6Primary (citable) accession number: Q86YS6 Secondary accession number(s): A8K4P9, E9PBQ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	June 1, 2003
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q86YS6 (RAB43_HUMAN)

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Ras-related protein Rab-43

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Other locations

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ