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Protein

Copine-8

Gene

CPNE8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.By similarity

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-8Curated
Alternative name(s):
Copine VIIIImported
Gene namesi
Name:CPNE8Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139117.13
HGNCiHGNC:23498 CPNE8
neXtProtiNX_Q86YQ8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi144402
OpenTargetsiENSG00000139117
PharmGKBiPA134980029

Polymorphism and mutation databases

BioMutaiCPNE8
DMDMi115502379

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448491 – 564Copine-8Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei260PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86YQ8
MaxQBiQ86YQ8
PaxDbiQ86YQ8
PeptideAtlasiQ86YQ8
PRIDEiQ86YQ8
ProteomicsDBi70451

PTM databases

iPTMnetiQ86YQ8
PhosphoSitePlusiQ86YQ8
SwissPalmiQ86YQ8

Expressioni

Gene expression databases

BgeeiENSG00000139117 Expressed in 183 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_CPNE8
ExpressionAtlasiQ86YQ8 baseline and differential
GenevisibleiQ86YQ8 HS

Organism-specific databases

HPAiHPA038600

Interactioni

Protein-protein interaction databases

BioGridi126848, 16 interactors
IntActiQ86YQ8, 9 interactors
STRINGi9606.ENSP00000329748

Structurei

3D structure databases

ProteinModelPortaliQ86YQ8
SMRiQ86YQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 117C2 1PROSITE-ProRule annotationAdd BLAST108
Domaini144 – 249C2 2PROSITE-ProRule annotationAdd BLAST106
Domaini309 – 510VWFAPROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Belongs to the copine family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiQ86YQ8
OMAiFDAMIEL
OrthoDBiEOG091G05IT
PhylomeDBiQ86YQ8
TreeFamiTF316419

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50234 VWFA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSRYNSTAG IGDLNQLSAA IPATRVEVSV SCRNLLDRDT FSKSDPICVL
60 70 80 90 100
YVQGVGNKEW REFGRTEVID NTLNPDFVRK FILDYFFEER ENLRFDLYDV
110 120 130 140 150
DSKSPNLSKH DFLGQVFCTL GEIVGSQGSR LEKPIVGIPG KKCGTIILTA
160 170 180 190 200
EELNCCRDAV LMQFCANKLD KKDFFGKSDP FLVFYRSNED GSFTICHKTE
210 220 230 240 250
VVKNTLNPVW QAFKISVRAL CNGDYDRTIK VEVYDWDRDG SHDFIGEFTT
260 270 280 290 300
SYRELSRGQS QFNVYEVVNP KKKGKKKKYT NSGTVTLLSF LVETEVSFLD
310 320 330 340 350
YIKGGTQINF TVAIDFTASN GNPAQPTSLH YMNPYQLNAY GMALKAVGEI
360 370 380 390 400
VQDYDSDKMF PALGFGAKLP PDGRISHEFA LNGNPQNPYC DGIEGVMEAY
410 420 430 440 450
YRSLKSVQLY GPTNFAPVIN HVARYASSVK DGSQYFVLLI VTDGVISDMA
460 470 480 490 500
QTKESIVNAS KLPMSIIIVG VGPAEFDAMV ELDGDDVRVS SRGKYAERDI
510 520 530 540 550
VQFVPFRDYI DRSGNHILSM ARLAKDVLAE IPEQFLSYMR ARGIKPSPAP
560
PPYTPPTHVL QTQI
Length:564
Mass (Da):63,108
Last modified:October 3, 2006 - v2
Checksum:iBD12DAA905F03692
GO
Isoform 2 (identifier: Q86YQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.

Show »
Length:233
Mass (Da):25,664
Checksum:iC3967F2002727D2C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ENV7E7ENV7_HUMAN
Copine-8
CPNE8
552Annotation score:
F8VZB5F8VZB5_HUMAN
Copine-8
CPNE8
12Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti445V → I in AAO21123 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562871 – 331Missing in isoform 2. 2 PublicationsAdd BLAST331

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177785 mRNA Translation: AAO21123.1
AK094998 mRNA Translation: BAG52968.1
AC023795 Genomic DNA No translation available.
AC067735 Genomic DNA No translation available.
AC069442 Genomic DNA No translation available.
AC087897 Genomic DNA No translation available.
BC046366 mRNA Translation: AAH46366.1
BC110577 mRNA Translation: AAI10578.1
BC110578 mRNA Translation: AAI10579.1
CCDSiCCDS8733.1 [Q86YQ8-1]
RefSeqiNP_705898.1, NM_153634.2 [Q86YQ8-1]
XP_016874340.1, XM_017018851.1
UniGeneiHs.40910

Genome annotation databases

EnsembliENST00000331366; ENSP00000329748; ENSG00000139117 [Q86YQ8-1]
ENST00000538596; ENSP00000439237; ENSG00000139117 [Q86YQ8-2]
GeneIDi144402
KEGGihsa:144402
UCSCiuc001rls.2 human [Q86YQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177785 mRNA Translation: AAO21123.1
AK094998 mRNA Translation: BAG52968.1
AC023795 Genomic DNA No translation available.
AC067735 Genomic DNA No translation available.
AC069442 Genomic DNA No translation available.
AC087897 Genomic DNA No translation available.
BC046366 mRNA Translation: AAH46366.1
BC110577 mRNA Translation: AAI10578.1
BC110578 mRNA Translation: AAI10579.1
CCDSiCCDS8733.1 [Q86YQ8-1]
RefSeqiNP_705898.1, NM_153634.2 [Q86YQ8-1]
XP_016874340.1, XM_017018851.1
UniGeneiHs.40910

3D structure databases

ProteinModelPortaliQ86YQ8
SMRiQ86YQ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126848, 16 interactors
IntActiQ86YQ8, 9 interactors
STRINGi9606.ENSP00000329748

PTM databases

iPTMnetiQ86YQ8
PhosphoSitePlusiQ86YQ8
SwissPalmiQ86YQ8

Polymorphism and mutation databases

BioMutaiCPNE8
DMDMi115502379

Proteomic databases

EPDiQ86YQ8
MaxQBiQ86YQ8
PaxDbiQ86YQ8
PeptideAtlasiQ86YQ8
PRIDEiQ86YQ8
ProteomicsDBi70451

Protocols and materials databases

DNASUi144402
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331366; ENSP00000329748; ENSG00000139117 [Q86YQ8-1]
ENST00000538596; ENSP00000439237; ENSG00000139117 [Q86YQ8-2]
GeneIDi144402
KEGGihsa:144402
UCSCiuc001rls.2 human [Q86YQ8-1]

Organism-specific databases

CTDi144402
DisGeNETi144402
EuPathDBiHostDB:ENSG00000139117.13
GeneCardsiCPNE8
HGNCiHGNC:23498 CPNE8
HPAiHPA038600
neXtProtiNX_Q86YQ8
OpenTargetsiENSG00000139117
PharmGKBiPA134980029
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiQ86YQ8
OMAiFDAMIEL
OrthoDBiEOG091G05IT
PhylomeDBiQ86YQ8
TreeFamiTF316419

Miscellaneous databases

ChiTaRSiCPNE8 human
GeneWikiiCPNE8
GenomeRNAii144402
PROiPR:Q86YQ8

Gene expression databases

BgeeiENSG00000139117 Expressed in 183 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_CPNE8
ExpressionAtlasiQ86YQ8 baseline and differential
GenevisibleiQ86YQ8 HS

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPNE8_HUMAN
AccessioniPrimary (citable) accession number: Q86YQ8
Secondary accession number(s): Q2TB41, Q86VY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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