PPARGC1B

Functionⁱ

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.4 Publications

GO - Molecular functionⁱ

AF-2 domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11854298
estrogen receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11854298
nuclear receptor transcription coactivator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11854298
RNA binding
Source: UniProtKB
Non-traceable author statementⁱ
- 11854298
transcription coregulator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11854298
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament organization Source: Ensembl
bone trabecula formation Source: Ensembl
cellular response to reactive oxygen species Source: Ensembl
intracellular estrogen receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11854298
mitochondrial transcription Source: Ensembl
negative regulation of transcription, DNA-templated Source: Ensembl
ossification Source: Ensembl
positive regulation of alkaline phosphatase activity Source: Ensembl
positive regulation of bone resorption Source: Ensembl
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 17090215
positive regulation of DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of osteoclast differentiation Source: Ensembl
positive regulation of phosphorylation Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 11854298
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 23836911
response to cAMP Source: Ensembl
response to glucocorticoid Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, RNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-8939902 Regulation of RUNX2 expression and activity

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-8939902 Regulation of RUNX2 expression and activity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peroxisome proliferator-activated receptor gamma coactivator 1-beta Short name: PGC-1-beta Short name: PPAR-gamma coactivator 1-beta Short name: PPARGC-1-beta Alternative name(s): PGC-1-related estrogen receptor alpha coactivator
Gene namesⁱ	Name:PPARGC1B Synonyms:PERC, PGC1, PGC1B, PPARGC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000155846.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30022 PPARGC1B
MIMⁱ	608886 gene
neXtProtⁱ	NX_Q86YN6

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	92 – 96	LLAEL → AAAEA: Reduces DNA transcriptional activity. 1 Publication	5
Mutagenesisⁱ	155 – 160	LLQKLL → AAQKAA: Reduces interaction and activation of ESR1. Loss of interaction and activation of ESR1; when associated with 343-AREAA-347. 1 Publication	6
Mutagenesisⁱ	343 – 347	LRELL → AREAA: Reduces interaction and activation of ESR1. Loss of interaction and activation of ESR1; when associated with 155-AAQKAA-160. 1 Publication	5

Organism-specific databases

DisGeNET More...DisGeNETⁱ	133522
MalaCards human disease database More...MalaCardsⁱ	PPARGC1B
Open Targets More...OpenTargetsⁱ	ENSG00000155846
PharmGKBⁱ	PA134953410

Polymorphism and mutation databases

BioMutaⁱ	PPARGC1B
DMDMⁱ	116242724

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000240158	1 – 1023	Peroxisome proliferator-activated receptor gamma coactivator 1-betaAdd BLAST		1023

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	384	PhosphoserineCombined sources	1
Modified residueⁱ	524	PhosphoserineCombined sources	1
Modified residueⁱ	638	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86YN6
PaxDbⁱ	Q86YN6
PeptideAtlas More...PeptideAtlasⁱ	Q86YN6
PRIDEⁱ	Q86YN6
ProteomicsDBⁱ	70440 70441 [Q86YN6-2] 70442 [Q86YN6-3] 70443 [Q86YN6-4] 70444 [Q86YN6-5] 70445 [Q86YN6-6]

PTM databases

iPTMnetⁱ	Q86YN6
PhosphoSitePlusⁱ	Q86YN6

Expressionⁱ

Tissue specificityⁱ

Ubiquitous with higher expression in heart, brain and skeletal muscle.2 Publications

Inductionⁱ

Repressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as well as in pre-diabetics.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000155846 Expressed in 166 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_PPARGC1B
ExpressionAtlasⁱ	Q86YN6 baseline and differential
Genevisibleⁱ	Q86YN6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA050543

HPAⁱ

HPA050543

Interactionⁱ

Subunit structureⁱ

Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity). Interacts with estrogen receptor alpha/ESR1.By similarity1 Publication

GO - Molecular functionⁱ

AF-2 domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11854298
estrogen receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11854298
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	126361, 20 interactors
IntActⁱ	Q86YN6, 1 interactor
STRINGⁱ	9606.ENSP00000312649

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	155 – 162	Combined sources		8
Helixⁱ	1011 – 1021	Combined sources		11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q86YN6
SMRⁱ	Q86YN6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q86YN6

EvolutionaryTraceⁱ

Q86YN6

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	902 – 976	RRMPROSITE-ProRule annotationAdd BLAST		75

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 91	Abolishes DNA transcriptional activity when missingAdd BLAST		91

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	156 – 160	LXXLL motif 1	5
Motifⁱ	343 – 347	LXXLL motif 2	5
Motifⁱ	691 – 694	HCFC1-binding-motif (HBM)	4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	430 – 450	Glu-richAdd BLAST		21
Compositional biasⁱ	772 – 823	Glu-richAdd BLAST		52

Domainⁱ

Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.By similarity

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IIJJ Eukaryota ENOG4111PZ5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063196
HOGENOMⁱ	HOG000236356
HOVERGENⁱ	HBG080730
InParanoidⁱ	Q86YN6
KEGG Orthology (KO) More...KOⁱ	K17962
OMAⁱ	DYCQVLK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G029M
PhylomeDBⁱ	Q86YN6
TreeFamⁱ	TF343068

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12356 RRM_PPARGC1B, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR034605 PGC-1 IPR034621 PGC-1beta IPR034177 PPARGC1B_RRM IPR035979 RBD_domain_sf IPR000504 RRM_dom
PANTHERⁱ	PTHR15528 PTHR15528, 1 hit PTHR15528:SF12 PTHR15528:SF12, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q86YN6-1) [UniParc]FASTA Add to basket

Also known as: PGC1beta-1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGNDCGALL DEELSSFFLN YLADTQGGGS GEEQLYADFP ELDLSQLDAS 
        60         70         80         90        100
DFDSATCFGE LQWCPENSET EPNQYSPDDS ELFQIDSENE ALLAELTKTL 
       110        120        130        140        150
DDIPEDDVGL AAFPALDGGD ALSCTSASPA PSSAPPSPAP EKPSAPAPEV 
       160        170        180        190        200
DELSLLQKLL LATSYPTSSS DTQKEGTAWR QAGLRSKSQR PCVKADSTQD 
       210        220        230        240        250
KKAPMMQSQS RSCTELHKHL TSAQCCLQDR GLQPPCLQSP RLPAKEDKEP 
       260        270        280        290        300
GEDCPSPQPA PASPRDSLAL GRADPGAPVS QEDMQAMVQL IRYMHTYCLP 
       310        320        330        340        350
QRKLPPQTPE PLPKACSNPS QQVRSRPWSR HHSKASWAEF SILRELLAQD 
       360        370        380        390        400
VLCDVSKPYR LATPVYASLT PRSRPRPPKD SQASPGRPSS VEEVRIAASP 
       410        420        430        440        450
KSTGPRPSLR PLRLEVKREV RRPARLQQQE EEDEEEEEEE EEEEKEEEEE 
       460        470        480        490        500
WGRKRPGRGL PWTKLGRKLE SSVCPVRRSR RLNPELGPWL TFADEPLVPS 
       510        520        530        540        550
EPQGALPSLC LAPKAYDVER ELGSPTDEDS GQDQQLLRGP QIPALESPCE 
       560        570        580        590        600
SGCGDMDEDP SCPQLPPRDS PRCLMLALSQ SDPTFGKKSF EQTLTVELCG 
       610        620        630        640        650
TAGLTPPTTP PYKPTEEDPF KPDIKHSLGK EIALSLPSPE GLSLKATPGA 
       660        670        680        690        700
AHKLPKKHPE RSELLSHLRH ATAQPASQAG QKRPFSCSFG DHDYCQVLRP 
       710        720        730        740        750
EGVLQRKVLR SWEPSGVHLE DWPQQGAPWA EAQAPGREED RSCDAGAPPK 
       760        770        780        790        800
DSTLLRDHEI RASLTKHFGL LETALEEEDL ASCKSPEYDT VFEDSSSSSG 
       810        820        830        840        850
ESSFLPEEEE EEGEEEEEDD EEEDSGVSPT CSDHCPYQSP PSKANRQLCS 
       860        870        880        890        900
RSRSSSGSSP CHSWSPATRR NFRCESRGPC SDRTPSIRHA RKRREKAIGE 
       910        920        930        940        950
GRVVYIQNLS SDMSSRELKR RFEVFGEIEE CEVLTRNRRG EKYGFITYRC 
       960        970        980        990       1000
SEHAALSLTK GAALRKRNEP SFQLSYGGLR HFCWPRYTDY DSNSEEALPA 
      1010       1020 
SGKSKYEAMD FDSLLKEAQQ SLH

Length:1,023

Mass (Da):113,222

Last modified:October 17, 2006 - v2

Checksum:ⁱDC37FCDE4D3CD239

GO

Isoform 2 (identifier: Q86YN6-2) [UniParc]FASTA Add to basket

Also known as: PGC1beta-2a

The sequence of this isoform differs from the canonical sequence as follows:
1-26: MAGNDCGALLDEELSSFFLNYLADTQ → MGVYK

« Hide

        10         20         30         40         50
MGVYKGGGSG EEQLYADFPE LDLSQLDASD FDSATCFGEL QWCPENSETE 
        60         70         80         90        100
PNQYSPDDSE LFQIDSENEA LLAELTKTLD DIPEDDVGLA AFPALDGGDA 
       110        120        130        140        150
LSCTSASPAP SSAPPSPAPE KPSAPAPEVD ELSLLQKLLL ATSYPTSSSD 
       160        170        180        190        200
TQKEGTAWRQ AGLRSKSQRP CVKADSTQDK KAPMMQSQSR SCTELHKHLT 
       210        220        230        240        250
SAQCCLQDRG LQPPCLQSPR LPAKEDKEPG EDCPSPQPAP ASPRDSLALG 
       260        270        280        290        300
RADPGAPVSQ EDMQAMVQLI RYMHTYCLPQ RKLPPQTPEP LPKACSNPSQ 
       310        320        330        340        350
QVRSRPWSRH HSKASWAEFS ILRELLAQDV LCDVSKPYRL ATPVYASLTP 
       360        370        380        390        400
RSRPRPPKDS QASPGRPSSV EEVRIAASPK STGPRPSLRP LRLEVKREVR 
       410        420        430        440        450
RPARLQQQEE EDEEEEEEEE EEEKEEEEEW GRKRPGRGLP WTKLGRKLES 
       460        470        480        490        500
SVCPVRRSRR LNPELGPWLT FADEPLVPSE PQGALPSLCL APKAYDVERE 
       510        520        530        540        550
LGSPTDEDSG QDQQLLRGPQ IPALESPCES GCGDMDEDPS CPQLPPRDSP 
       560        570        580        590        600
RCLMLALSQS DPTFGKKSFE QTLTVELCGT AGLTPPTTPP YKPTEEDPFK 
       610        620        630        640        650
PDIKHSLGKE IALSLPSPEG LSLKATPGAA HKLPKKHPER SELLSHLRHA 
       660        670        680        690        700
TAQPASQAGQ KRPFSCSFGD HDYCQVLRPE GVLQRKVLRS WEPSGVHLED 
       710        720        730        740        750
WPQQGAPWAE AQAPGREEDR SCDAGAPPKD STLLRDHEIR ASLTKHFGLL 
       760        770        780        790        800
ETALEEEDLA SCKSPEYDTV FEDSSSSSGE SSFLPEEEEE EGEEEEEDDE 
       810        820        830        840        850
EEDSGVSPTC SDHCPYQSPP SKANRQLCSR SRSSSGSSPC HSWSPATRRN 
       860        870        880        890        900
FRCESRGPCS DRTPSIRHAR KRREKAIGEG RVVYIQNLSS DMSSRELKRR 
       910        920        930        940        950
FEVFGEIEEC EVLTRNRRGE KYGFITYRCS EHAALSLTKG AALRKRNEPS 
       960        970        980        990       1000
FQLSYGGLRH FCWPRYTDYD SNSEEALPAS GKSKYEAMDF DSLLKEAQQS 

LH

Show »

Length:1,002

Mass (Da):110,981

Checksum:ⁱ8ACBD368E172B27E

GO

Isoform 3 (identifier: Q86YN6-3) [UniParc]FASTA Add to basket

Also known as: PGC1beta-1b

The sequence of this isoform differs from the canonical sequence as follows:
991-1023: DSNSEEALPASGKSKYEAMDFDSLLKEAQQSLH → GKPLKPSHSLVRLKAWEAVPSLNKTQS

« Hide

        10         20         30         40         50
MAGNDCGALL DEELSSFFLN YLADTQGGGS GEEQLYADFP ELDLSQLDAS 
        60         70         80         90        100
DFDSATCFGE LQWCPENSET EPNQYSPDDS ELFQIDSENE ALLAELTKTL 
       110        120        130        140        150
DDIPEDDVGL AAFPALDGGD ALSCTSASPA PSSAPPSPAP EKPSAPAPEV 
       160        170        180        190        200
DELSLLQKLL LATSYPTSSS DTQKEGTAWR QAGLRSKSQR PCVKADSTQD 
       210        220        230        240        250
KKAPMMQSQS RSCTELHKHL TSAQCCLQDR GLQPPCLQSP RLPAKEDKEP 
       260        270        280        290        300
GEDCPSPQPA PASPRDSLAL GRADPGAPVS QEDMQAMVQL IRYMHTYCLP 
       310        320        330        340        350
QRKLPPQTPE PLPKACSNPS QQVRSRPWSR HHSKASWAEF SILRELLAQD 
       360        370        380        390        400
VLCDVSKPYR LATPVYASLT PRSRPRPPKD SQASPGRPSS VEEVRIAASP 
       410        420        430        440        450
KSTGPRPSLR PLRLEVKREV RRPARLQQQE EEDEEEEEEE EEEEKEEEEE 
       460        470        480        490        500
WGRKRPGRGL PWTKLGRKLE SSVCPVRRSR RLNPELGPWL TFADEPLVPS 
       510        520        530        540        550
EPQGALPSLC LAPKAYDVER ELGSPTDEDS GQDQQLLRGP QIPALESPCE 
       560        570        580        590        600
SGCGDMDEDP SCPQLPPRDS PRCLMLALSQ SDPTFGKKSF EQTLTVELCG 
       610        620        630        640        650
TAGLTPPTTP PYKPTEEDPF KPDIKHSLGK EIALSLPSPE GLSLKATPGA 
       660        670        680        690        700
AHKLPKKHPE RSELLSHLRH ATAQPASQAG QKRPFSCSFG DHDYCQVLRP 
       710        720        730        740        750
EGVLQRKVLR SWEPSGVHLE DWPQQGAPWA EAQAPGREED RSCDAGAPPK 
       760        770        780        790        800
DSTLLRDHEI RASLTKHFGL LETALEEEDL ASCKSPEYDT VFEDSSSSSG 
       810        820        830        840        850
ESSFLPEEEE EEGEEEEEDD EEEDSGVSPT CSDHCPYQSP PSKANRQLCS 
       860        870        880        890        900
RSRSSSGSSP CHSWSPATRR NFRCESRGPC SDRTPSIRHA RKRREKAIGE 
       910        920        930        940        950
GRVVYIQNLS SDMSSRELKR RFEVFGEIEE CEVLTRNRRG EKYGFITYRC 
       960        970        980        990       1000
SEHAALSLTK GAALRKRNEP SFQLSYGGLR HFCWPRYTDY GKPLKPSHSL 
      1010 
VRLKAWEAVP SLNKTQS

Show »

Length:1,017

Mass (Da):112,568

Checksum:ⁱF2229A0A356A2148

GO

Isoform 4 (identifier: Q86YN6-4) [UniParc]FASTA Add to basket

Also known as: PGC1beta-2b

The sequence of this isoform differs from the canonical sequence as follows:
1-26: MAGNDCGALLDEELSSFFLNYLADTQ → MGVYK
991-1023: DSNSEEALPASGKSKYEAMDFDSLLKEAQQSLH → GKPLKPSHSLVRLKAWEAVPSLNKTQS

« Hide

        10         20         30         40         50
MGVYKGGGSG EEQLYADFPE LDLSQLDASD FDSATCFGEL QWCPENSETE 
        60         70         80         90        100
PNQYSPDDSE LFQIDSENEA LLAELTKTLD DIPEDDVGLA AFPALDGGDA 
       110        120        130        140        150
LSCTSASPAP SSAPPSPAPE KPSAPAPEVD ELSLLQKLLL ATSYPTSSSD 
       160        170        180        190        200
TQKEGTAWRQ AGLRSKSQRP CVKADSTQDK KAPMMQSQSR SCTELHKHLT 
       210        220        230        240        250
SAQCCLQDRG LQPPCLQSPR LPAKEDKEPG EDCPSPQPAP ASPRDSLALG 
       260        270        280        290        300
RADPGAPVSQ EDMQAMVQLI RYMHTYCLPQ RKLPPQTPEP LPKACSNPSQ 
       310        320        330        340        350
QVRSRPWSRH HSKASWAEFS ILRELLAQDV LCDVSKPYRL ATPVYASLTP 
       360        370        380        390        400
RSRPRPPKDS QASPGRPSSV EEVRIAASPK STGPRPSLRP LRLEVKREVR 
       410        420        430        440        450
RPARLQQQEE EDEEEEEEEE EEEKEEEEEW GRKRPGRGLP WTKLGRKLES 
       460        470        480        490        500
SVCPVRRSRR LNPELGPWLT FADEPLVPSE PQGALPSLCL APKAYDVERE 
       510        520        530        540        550
LGSPTDEDSG QDQQLLRGPQ IPALESPCES GCGDMDEDPS CPQLPPRDSP 
       560        570        580        590        600
RCLMLALSQS DPTFGKKSFE QTLTVELCGT AGLTPPTTPP YKPTEEDPFK 
       610        620        630        640        650
PDIKHSLGKE IALSLPSPEG LSLKATPGAA HKLPKKHPER SELLSHLRHA 
       660        670        680        690        700
TAQPASQAGQ KRPFSCSFGD HDYCQVLRPE GVLQRKVLRS WEPSGVHLED 
       710        720        730        740        750
WPQQGAPWAE AQAPGREEDR SCDAGAPPKD STLLRDHEIR ASLTKHFGLL 
       760        770        780        790        800
ETALEEEDLA SCKSPEYDTV FEDSSSSSGE SSFLPEEEEE EGEEEEEDDE 
       810        820        830        840        850
EEDSGVSPTC SDHCPYQSPP SKANRQLCSR SRSSSGSSPC HSWSPATRRN 
       860        870        880        890        900
FRCESRGPCS DRTPSIRHAR KRREKAIGEG RVVYIQNLSS DMSSRELKRR 
       910        920        930        940        950
FEVFGEIEEC EVLTRNRRGE KYGFITYRCS EHAALSLTKG AALRKRNEPS 
       960        970        980        990 
FQLSYGGLRH FCWPRYTDYG KPLKPSHSLV RLKAWEAVPS LNKTQS

Show »

Length:996

Mass (Da):110,327

Checksum:ⁱ5265F3916B919ECC

GO

Isoform 5 (identifier: Q86YN6-5) [UniParc]FASTA Add to basket

Also known as: PERC-s

The sequence of this isoform differs from the canonical sequence as follows:
156-194: Missing.

« Hide

        10         20         30         40         50
MAGNDCGALL DEELSSFFLN YLADTQGGGS GEEQLYADFP ELDLSQLDAS 
        60         70         80         90        100
DFDSATCFGE LQWCPENSET EPNQYSPDDS ELFQIDSENE ALLAELTKTL 
       110        120        130        140        150
DDIPEDDVGL AAFPALDGGD ALSCTSASPA PSSAPPSPAP EKPSAPAPEV 
       160        170        180        190        200
DELSLADSTQ DKKAPMMQSQ SRSCTELHKH LTSAQCCLQD RGLQPPCLQS 
       210        220        230        240        250
PRLPAKEDKE PGEDCPSPQP APASPRDSLA LGRADPGAPV SQEDMQAMVQ 
       260        270        280        290        300
LIRYMHTYCL PQRKLPPQTP EPLPKACSNP SQQVRSRPWS RHHSKASWAE 
       310        320        330        340        350
FSILRELLAQ DVLCDVSKPY RLATPVYASL TPRSRPRPPK DSQASPGRPS 
       360        370        380        390        400
SVEEVRIAAS PKSTGPRPSL RPLRLEVKRE VRRPARLQQQ EEEDEEEEEE 
       410        420        430        440        450
EEEEEKEEEE EWGRKRPGRG LPWTKLGRKL ESSVCPVRRS RRLNPELGPW 
       460        470        480        490        500
LTFADEPLVP SEPQGALPSL CLAPKAYDVE RELGSPTDED SGQDQQLLRG 
       510        520        530        540        550
PQIPALESPC ESGCGDMDED PSCPQLPPRD SPRCLMLALS QSDPTFGKKS 
       560        570        580        590        600
FEQTLTVELC GTAGLTPPTT PPYKPTEEDP FKPDIKHSLG KEIALSLPSP 
       610        620        630        640        650
EGLSLKATPG AAHKLPKKHP ERSELLSHLR HATAQPASQA GQKRPFSCSF 
       660        670        680        690        700
GDHDYCQVLR PEGVLQRKVL RSWEPSGVHL EDWPQQGAPW AEAQAPGREE 
       710        720        730        740        750
DRSCDAGAPP KDSTLLRDHE IRASLTKHFG LLETALEEED LASCKSPEYD 
       760        770        780        790        800
TVFEDSSSSS GESSFLPEEE EEEGEEEEED DEEEDSGVSP TCSDHCPYQS 
       810        820        830        840        850
PPSKANRQLC SRSRSSSGSS PCHSWSPATR RNFRCESRGP CSDRTPSIRH 
       860        870        880        890        900
ARKRREKAIG EGRVVYIQNL SSDMSSRELK RRFEVFGEIE ECEVLTRNRR 
       910        920        930        940        950
GEKYGFITYR CSEHAALSLT KGAALRKRNE PSFQLSYGGL RHFCWPRYTD 
       960        970        980 
YDSNSEEALP ASGKSKYEAM DFDSLLKEAQ QSLH

Note: Lacks LXXLL motif 1 and has a reduced ability to enhance the hormone-dependent activity of estrogen receptor alpha.

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Length:984

Mass (Da):108,919

Checksum:ⁱ5D91928FD6D6D104

GO

Isoform 6 (identifier: Q86YN6-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-26: MAGNDCGALLDEELSSFFLNYLADTQ → M
156-194: Missing.

« Hide

        10         20         30         40         50
MGGGSGEEQL YADFPELDLS QLDASDFDSA TCFGELQWCP ENSETEPNQY 
        60         70         80         90        100
SPDDSELFQI DSENEALLAE LTKTLDDIPE DDVGLAAFPA LDGGDALSCT 
       110        120        130        140        150
SASPAPSSAP PSPAPEKPSA PAPEVDELSL ADSTQDKKAP MMQSQSRSCT 
       160        170        180        190        200
ELHKHLTSAQ CCLQDRGLQP PCLQSPRLPA KEDKEPGEDC PSPQPAPASP 
       210        220        230        240        250
RDSLALGRAD PGAPVSQEDM QAMVQLIRYM HTYCLPQRKL PPQTPEPLPK 
       260        270        280        290        300
ACSNPSQQVR SRPWSRHHSK ASWAEFSILR ELLAQDVLCD VSKPYRLATP 
       310        320        330        340        350
VYASLTPRSR PRPPKDSQAS PGRPSSVEEV RIAASPKSTG PRPSLRPLRL 
       360        370        380        390        400
EVKREVRRPA RLQQQEEEDE EEEEEEEEEE KEEEEEWGRK RPGRGLPWTK 
       410        420        430        440        450
LGRKLESSVC PVRRSRRLNP ELGPWLTFAD EPLVPSEPQG ALPSLCLAPK 
       460        470        480        490        500
AYDVERELGS PTDEDSGQDQ QLLRGPQIPA LESPCESGCG DMDEDPSCPQ 
       510        520        530        540        550
LPPRDSPRCL MLALSQSDPT FGKKSFEQTL TVELCGTAGL TPPTTPPYKP 
       560        570        580        590        600
TEEDPFKPDI KHSLGKEIAL SLPSPEGLSL KATPGAAHKL PKKHPERSEL 
       610        620        630        640        650
LSHLRHATAQ PASQAGQKRP FSCSFGDHDY CQVLRPEGVL QRKVLRSWEP 
       660        670        680        690        700
SGVHLEDWPQ QGAPWAEAQA PGREEDRSCD AGAPPKDSTL LRDHEIRASL 
       710        720        730        740        750
TKHFGLLETA LEEEDLASCK SPEYDTVFED SSSSSGESSF LPEEEEEEGE 
       760        770        780        790        800
EEEEDDEEED SGVSPTCSDH CPYQSPPSKA NRQLCSRSRS SSGSSPCHSW 
       810        820        830        840        850
SPATRRNFRC ESRGPCSDRT PSIRHARKRR EKAIGEGRVV YIQNLSSDMS 
       860        870        880        890        900
SRELKRRFEV FGEIEECEVL TRNRRGEKYG FITYRCSEHA ALSLTKGAAL 
       910        920        930        940        950
RKRNEPSFQL SYGGLRHFCW PRYTDYDSNS EEALPASGKS KYEAMDFDSL 

LKEAQQSLH

Note: No experimental confirmation available.

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Length:959

Mass (Da):106,230

Checksum:ⁱD4E5EF57FC0C2459

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0Y713	H0Y713_HUMAN		Peroxisome proliferator-activated r... Peroxisome proliferator-activated receptor gamma coactivator 1-beta	PPARGC1B	748	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	558	E → G in BAC04541 (PubMed:14702039).Curated		1

Polymorphismⁱ

Variation of PPARGC1B may contribute to the pathogenesis of obesity, with a widespread Ala-203 allele being a risk factor for the development of this common disorders.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_026698	203	A → P1 PublicationCorresponds to variant dbSNP:rs7732671EnsemblClinVar.	1
Natural variantⁱVAR_026699	265	R → Q1 PublicationCorresponds to variant dbSNP:rs45520937Ensembl.	1
Natural variantⁱVAR_026700	279	V → I1 PublicationCorresponds to variant dbSNP:rs17572019Ensembl.	1
Natural variantⁱVAR_026701	292	R → S2 PublicationsCorresponds to variant dbSNP:rs11959820Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_019299	1 – 26	MAGND…LADTQ → MGVYK in isoform 2 and isoform 4. 1 PublicationAdd BLAST	26
Alternative sequenceⁱVSP_043374	1 – 26	MAGND…LADTQ → M in isoform 6. 1 PublicationAdd BLAST	26
Alternative sequenceⁱVSP_019300	156 – 194	Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST	39
Alternative sequenceⁱVSP_019301	991 – 1023	DSNSE…QQSLH → GKPLKPSHSLVRLKAWEAVP SLNKTQS in isoform 3 and isoform 4. 1 PublicationAdd BLAST	33

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF468496 mRNA Translation: AAL78633.1 AF468497 mRNA Translation: AAL78634.1 AY188947 mRNA Translation: AAO40022.1 AY188948 mRNA Translation: AAO40023.1 AY188949 mRNA Translation: AAO40024.1 AY188950 mRNA Translation: AAO40025.1 AK095391 mRNA Translation: BAC04541.1 AK123614 mRNA Translation: BAG53922.1 AC008545 Genomic DNA No translation available. AC022100 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61759.1 BC132971 mRNA Translation: AAI32972.1 BC132973 mRNA Translation: AAI32974.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4298.1 [Q86YN6-1] CCDS54933.1 [Q86YN6-5] CCDS54934.1 [Q86YN6-6]
NCBI Reference Sequences More...RefSeqⁱ	NP_001166169.1, NM_001172698.1 [Q86YN6-5] NP_001166170.1, NM_001172699.1 [Q86YN6-6] NP_573570.3, NM_133263.3 [Q86YN6-1] XP_005268429.1, XM_005268372.4 [Q86YN6-2]
UniGeneⁱ	Hs.483816

Genome annotation databases

Ensemblⁱ	ENST00000309241; ENSP00000312649; ENSG00000155846 [Q86YN6-1] ENST00000360453; ENSP00000353638; ENSG00000155846 [Q86YN6-5] ENST00000394320; ENSP00000377855; ENSG00000155846 [Q86YN6-3] ENST00000403750; ENSP00000384403; ENSG00000155846 [Q86YN6-6]
GeneIDⁱ	133522
KEGGⁱ	hsa:133522
UCSC genome browser More...UCSCⁱ	uc003lrb.3 human [Q86YN6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q86YN6	PPARG coactivator 1 beta		CALJA		1186	UniRef90_Q86YN6
Uncharacterized protein		COLAP		1025
Uncharacterized protein		RHIRO		1024
Uncharacterized protein		RHIBE		1024
Uncharacterized protein		PAPAN		1023
+35
Q86YN6-5	PPARG coactivator 1 beta		CALJA		1147	UniRef90_Q86YN6-5
Uncharacterized protein		COLAP		986
Uncharacterized protein		RHIBE		985
Uncharacterized protein		RHIRO		985
Uncharacterized protein		MACMU		984
+21
Q86YN6-6	Isoform 5 of Peroxisome proliferator-activated receptor gamma coactivator 1-beta		HUMAN		984	UniRef90_Q86YN6-5
PPARG coactivator 1 beta		CALJA		1147
Uncharacterized protein		COLAP		986
Uncharacterized protein		RHIBE		985
Uncharacterized protein		RHIRO		985
+21

Protein	Similar proteins		Species	Score	Length	Source
Q86YN6	PPARG coactivator 1 beta		CALJA		1186	UniRef50_Q86YN6
Uncharacterized protein		COLAP		1025
Uncharacterized protein		RHIBE		1024
Uncharacterized protein		RHIRO		1024
Uncharacterized protein		MACFA		1023
+86

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF468496 mRNA Translation: AAL78633.1 AF468497 mRNA Translation: AAL78634.1 AY188947 mRNA Translation: AAO40022.1 AY188948 mRNA Translation: AAO40023.1 AY188949 mRNA Translation: AAO40024.1 AY188950 mRNA Translation: AAO40025.1 AK095391 mRNA Translation: BAC04541.1 AK123614 mRNA Translation: BAG53922.1 AC008545 Genomic DNA No translation available. AC022100 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61759.1 BC132971 mRNA Translation: AAI32972.1 BC132973 mRNA Translation: AAI32974.1
CCDSⁱ	CCDS4298.1 [Q86YN6-1] CCDS54933.1 [Q86YN6-5] CCDS54934.1 [Q86YN6-6]
RefSeqⁱ	NP_001166169.1, NM_001172698.1 [Q86YN6-5] NP_001166170.1, NM_001172699.1 [Q86YN6-6] NP_573570.3, NM_133263.3 [Q86YN6-1] XP_005268429.1, XM_005268372.4 [Q86YN6-2]
UniGeneⁱ	Hs.483816

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3SP6	X-ray	2.21	B	153-163	[»]
	6D0Y	X-ray	2.68	B	994-1023	[»]
ProteinModelPortalⁱ	Q86YN6
SMRⁱ	Q86YN6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126361, 20 interactors
IntActⁱ	Q86YN6, 1 interactor
STRINGⁱ	9606.ENSP00000312649

PTM databases

iPTMnetⁱ	Q86YN6
PhosphoSitePlusⁱ	Q86YN6

Polymorphism and mutation databases

BioMutaⁱ	PPARGC1B
DMDMⁱ	116242724

Proteomic databases

MaxQBⁱ	Q86YN6
PaxDbⁱ	Q86YN6
PeptideAtlasⁱ	Q86YN6
PRIDEⁱ	Q86YN6
ProteomicsDBⁱ	70440 70441 [Q86YN6-2] 70442 [Q86YN6-3] 70443 [Q86YN6-4] 70444 [Q86YN6-5] 70445 [Q86YN6-6]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000309241; ENSP00000312649; ENSG00000155846 [Q86YN6-1] ENST00000360453; ENSP00000353638; ENSG00000155846 [Q86YN6-5] ENST00000394320; ENSP00000377855; ENSG00000155846 [Q86YN6-3] ENST00000403750; ENSP00000384403; ENSG00000155846 [Q86YN6-6]
GeneIDⁱ	133522
KEGGⁱ	hsa:133522
UCSCⁱ	uc003lrb.3 human [Q86YN6-1]

Organism-specific databases

CTDⁱ	133522
DisGeNETⁱ	133522
EuPathDBⁱ	HostDB:ENSG00000155846.16
GeneCardsⁱ	PPARGC1B
HGNCⁱ	HGNC:30022 PPARGC1B
HPAⁱ	HPA050543
MalaCardsⁱ	PPARGC1B
MIMⁱ	608886 gene
neXtProtⁱ	NX_Q86YN6
OpenTargetsⁱ	ENSG00000155846
PharmGKBⁱ	PA134953410
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIJJ Eukaryota ENOG4111PZ5 LUCA
GeneTreeⁱ	ENSGT00530000063196
HOGENOMⁱ	HOG000236356
HOVERGENⁱ	HBG080730
InParanoidⁱ	Q86YN6
KOⁱ	K17962
OMAⁱ	DYCQVLK
OrthoDBⁱ	EOG091G029M
PhylomeDBⁱ	Q86YN6
TreeFamⁱ	TF343068

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-8939902 Regulation of RUNX2 expression and activity

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-8939902 Regulation of RUNX2 expression and activity

Miscellaneous databases

ChiTaRSⁱ	PPARGC1B human
EvolutionaryTraceⁱ	Q86YN6
GeneWikiⁱ	PPARGC1B
GenomeRNAiⁱ	133522
Protein Ontology More...PROⁱ	PR:Q86YN6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000155846 Expressed in 166 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_PPARGC1B
ExpressionAtlasⁱ	Q86YN6 baseline and differential
Genevisibleⁱ	Q86YN6 HS

Family and domain databases

CDDⁱ	cd12356 RRM_PPARGC1B, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR034605 PGC-1 IPR034621 PGC-1beta IPR034177 PPARGC1B_RRM IPR035979 RBD_domain_sf IPR000504 RRM_dom
PANTHERⁱ	PTHR15528 PTHR15528, 1 hit PTHR15528:SF12 PTHR15528:SF12, 1 hit
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRGC2_HUMAN
Accessionⁱ	Q86YN6Primary (citable) accession number: Q86YN6 Secondary accession number(s): A2RUM8 Q8TDE5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q86YN6 (PRGC2_HUMAN)

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Peroxisome proliferator-activated receptor gamma coactivator 1-beta

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ