Peroxisome proliferator-activated receptor gamma coactivator 1-beta

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• AF-2 domain binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 11854298
• estrogen receptor binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 11854298
• ligand-dependent nuclear receptor transcription coactivator activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 11854298
• RNA binding Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 11854298
• transcription coregulator activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 11854298
• transcription factor binding Source: GO_Central

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• actin filament organization Source: Ensembl
• bone trabecula formation Source: Ensembl
• cellular response to reactive oxygen species Source: Ensembl
• intracellular estrogen receptor signaling pathway Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 11854298
• mitochondrial transcription Source: Ensembl
• negative regulation of transcription, DNA-templated Source: Ensembl
• ossification Source: Ensembl
• positive regulation of alkaline phosphatase activity Source: Ensembl
• positive regulation of bone resorption Source: Ensembl
• positive regulation of DNA binding transcription factor activity Source: GO_Central
• positive regulation of osteoclast differentiation Source: Ensembl
• positive regulation of phosphorylation Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 11854298
• regulation of transcription, DNA-templated Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 23836911
• response to cAMP Source: Ensembl
• response to glucocorticoid Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• AF-2 domain binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 11854298
• estrogen receptor binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 11854298
• transcription factor binding Source: GO_Central

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MAGNDCGALL DEELSSFFLN YLADTQGGGS GEEQLYADFP ELDLSQLDAS 
        60         70         80         90        100
DFDSATCFGE LQWCPENSET EPNQYSPDDS ELFQIDSENE ALLAELTKTL 
       110        120        130        140        150
DDIPEDDVGL AAFPALDGGD ALSCTSASPA PSSAPPSPAP EKPSAPAPEV 
       160        170        180        190        200
DELSLLQKLL LATSYPTSSS DTQKEGTAWR QAGLRSKSQR PCVKADSTQD 
       210        220        230        240        250
KKAPMMQSQS RSCTELHKHL TSAQCCLQDR GLQPPCLQSP RLPAKEDKEP 
       260        270        280        290        300
GEDCPSPQPA PASPRDSLAL GRADPGAPVS QEDMQAMVQL IRYMHTYCLP 
       310        320        330        340        350
QRKLPPQTPE PLPKACSNPS QQVRSRPWSR HHSKASWAEF SILRELLAQD 
       360        370        380        390        400
VLCDVSKPYR LATPVYASLT PRSRPRPPKD SQASPGRPSS VEEVRIAASP 
       410        420        430        440        450
KSTGPRPSLR PLRLEVKREV RRPARLQQQE EEDEEEEEEE EEEEKEEEEE 
       460        470        480        490        500
WGRKRPGRGL PWTKLGRKLE SSVCPVRRSR RLNPELGPWL TFADEPLVPS 
       510        520        530        540        550
EPQGALPSLC LAPKAYDVER ELGSPTDEDS GQDQQLLRGP QIPALESPCE 
       560        570        580        590        600
SGCGDMDEDP SCPQLPPRDS PRCLMLALSQ SDPTFGKKSF EQTLTVELCG 
       610        620        630        640        650
TAGLTPPTTP PYKPTEEDPF KPDIKHSLGK EIALSLPSPE GLSLKATPGA 
       660        670        680        690        700
AHKLPKKHPE RSELLSHLRH ATAQPASQAG QKRPFSCSFG DHDYCQVLRP 
       710        720        730        740        750
EGVLQRKVLR SWEPSGVHLE DWPQQGAPWA EAQAPGREED RSCDAGAPPK 
       760        770        780        790        800
DSTLLRDHEI RASLTKHFGL LETALEEEDL ASCKSPEYDT VFEDSSSSSG 
       810        820        830        840        850
ESSFLPEEEE EEGEEEEEDD EEEDSGVSPT CSDHCPYQSP PSKANRQLCS 
       860        870        880        890        900
RSRSSSGSSP CHSWSPATRR NFRCESRGPC SDRTPSIRHA RKRREKAIGE 
       910        920        930        940        950
GRVVYIQNLS SDMSSRELKR RFEVFGEIEE CEVLTRNRRG EKYGFITYRC 
       960        970        980        990       1000
SEHAALSLTK GAALRKRNEP SFQLSYGGLR HFCWPRYTDY DSNSEEALPA 
      1010       1020 
SGKSKYEAMD FDSLLKEAQQ SLH                              

        10         20         30         40         50
MGVYKGGGSG EEQLYADFPE LDLSQLDASD FDSATCFGEL QWCPENSETE 
        60         70         80         90        100
PNQYSPDDSE LFQIDSENEA LLAELTKTLD DIPEDDVGLA AFPALDGGDA 
       110        120        130        140        150
LSCTSASPAP SSAPPSPAPE KPSAPAPEVD ELSLLQKLLL ATSYPTSSSD 
       160        170        180        190        200
TQKEGTAWRQ AGLRSKSQRP CVKADSTQDK KAPMMQSQSR SCTELHKHLT 
       210        220        230        240        250
SAQCCLQDRG LQPPCLQSPR LPAKEDKEPG EDCPSPQPAP ASPRDSLALG 
       260        270        280        290        300
RADPGAPVSQ EDMQAMVQLI RYMHTYCLPQ RKLPPQTPEP LPKACSNPSQ 
       310        320        330        340        350
QVRSRPWSRH HSKASWAEFS ILRELLAQDV LCDVSKPYRL ATPVYASLTP 
       360        370        380        390        400
RSRPRPPKDS QASPGRPSSV EEVRIAASPK STGPRPSLRP LRLEVKREVR 
       410        420        430        440        450
RPARLQQQEE EDEEEEEEEE EEEKEEEEEW GRKRPGRGLP WTKLGRKLES 
       460        470        480        490        500
SVCPVRRSRR LNPELGPWLT FADEPLVPSE PQGALPSLCL APKAYDVERE 
       510        520        530        540        550
LGSPTDEDSG QDQQLLRGPQ IPALESPCES GCGDMDEDPS CPQLPPRDSP 
       560        570        580        590        600
RCLMLALSQS DPTFGKKSFE QTLTVELCGT AGLTPPTTPP YKPTEEDPFK 
       610        620        630        640        650
PDIKHSLGKE IALSLPSPEG LSLKATPGAA HKLPKKHPER SELLSHLRHA 
       660        670        680        690        700
TAQPASQAGQ KRPFSCSFGD HDYCQVLRPE GVLQRKVLRS WEPSGVHLED 
       710        720        730        740        750
WPQQGAPWAE AQAPGREEDR SCDAGAPPKD STLLRDHEIR ASLTKHFGLL 
       760        770        780        790        800
ETALEEEDLA SCKSPEYDTV FEDSSSSSGE SSFLPEEEEE EGEEEEEDDE 
       810        820        830        840        850
EEDSGVSPTC SDHCPYQSPP SKANRQLCSR SRSSSGSSPC HSWSPATRRN 
       860        870        880        890        900
FRCESRGPCS DRTPSIRHAR KRREKAIGEG RVVYIQNLSS DMSSRELKRR 
       910        920        930        940        950
FEVFGEIEEC EVLTRNRRGE KYGFITYRCS EHAALSLTKG AALRKRNEPS 
       960        970        980        990       1000
FQLSYGGLRH FCWPRYTDYD SNSEEALPAS GKSKYEAMDF DSLLKEAQQS 

LH                                                     

        10         20         30         40         50
MAGNDCGALL DEELSSFFLN YLADTQGGGS GEEQLYADFP ELDLSQLDAS 
        60         70         80         90        100
DFDSATCFGE LQWCPENSET EPNQYSPDDS ELFQIDSENE ALLAELTKTL 
       110        120        130        140        150
DDIPEDDVGL AAFPALDGGD ALSCTSASPA PSSAPPSPAP EKPSAPAPEV 
       160        170        180        190        200
DELSLLQKLL LATSYPTSSS DTQKEGTAWR QAGLRSKSQR PCVKADSTQD 
       210        220        230        240        250
KKAPMMQSQS RSCTELHKHL TSAQCCLQDR GLQPPCLQSP RLPAKEDKEP 
       260        270        280        290        300
GEDCPSPQPA PASPRDSLAL GRADPGAPVS QEDMQAMVQL IRYMHTYCLP 
       310        320        330        340        350
QRKLPPQTPE PLPKACSNPS QQVRSRPWSR HHSKASWAEF SILRELLAQD 
       360        370        380        390        400
VLCDVSKPYR LATPVYASLT PRSRPRPPKD SQASPGRPSS VEEVRIAASP 
       410        420        430        440        450
KSTGPRPSLR PLRLEVKREV RRPARLQQQE EEDEEEEEEE EEEEKEEEEE 
       460        470        480        490        500
WGRKRPGRGL PWTKLGRKLE SSVCPVRRSR RLNPELGPWL TFADEPLVPS 
       510        520        530        540        550
EPQGALPSLC LAPKAYDVER ELGSPTDEDS GQDQQLLRGP QIPALESPCE 
       560        570        580        590        600
SGCGDMDEDP SCPQLPPRDS PRCLMLALSQ SDPTFGKKSF EQTLTVELCG 
       610        620        630        640        650
TAGLTPPTTP PYKPTEEDPF KPDIKHSLGK EIALSLPSPE GLSLKATPGA 
       660        670        680        690        700
AHKLPKKHPE RSELLSHLRH ATAQPASQAG QKRPFSCSFG DHDYCQVLRP 
       710        720        730        740        750
EGVLQRKVLR SWEPSGVHLE DWPQQGAPWA EAQAPGREED RSCDAGAPPK 
       760        770        780        790        800
DSTLLRDHEI RASLTKHFGL LETALEEEDL ASCKSPEYDT VFEDSSSSSG 
       810        820        830        840        850
ESSFLPEEEE EEGEEEEEDD EEEDSGVSPT CSDHCPYQSP PSKANRQLCS 
       860        870        880        890        900
RSRSSSGSSP CHSWSPATRR NFRCESRGPC SDRTPSIRHA RKRREKAIGE 
       910        920        930        940        950
GRVVYIQNLS SDMSSRELKR RFEVFGEIEE CEVLTRNRRG EKYGFITYRC 
       960        970        980        990       1000
SEHAALSLTK GAALRKRNEP SFQLSYGGLR HFCWPRYTDY GKPLKPSHSL 
      1010 
VRLKAWEAVP SLNKTQS                                     

        10         20         30         40         50
MGVYKGGGSG EEQLYADFPE LDLSQLDASD FDSATCFGEL QWCPENSETE 
        60         70         80         90        100
PNQYSPDDSE LFQIDSENEA LLAELTKTLD DIPEDDVGLA AFPALDGGDA 
       110        120        130        140        150
LSCTSASPAP SSAPPSPAPE KPSAPAPEVD ELSLLQKLLL ATSYPTSSSD 
       160        170        180        190        200
TQKEGTAWRQ AGLRSKSQRP CVKADSTQDK KAPMMQSQSR SCTELHKHLT 
       210        220        230        240        250
SAQCCLQDRG LQPPCLQSPR LPAKEDKEPG EDCPSPQPAP ASPRDSLALG 
       260        270        280        290        300
RADPGAPVSQ EDMQAMVQLI RYMHTYCLPQ RKLPPQTPEP LPKACSNPSQ 
       310        320        330        340        350
QVRSRPWSRH HSKASWAEFS ILRELLAQDV LCDVSKPYRL ATPVYASLTP 
       360        370        380        390        400
RSRPRPPKDS QASPGRPSSV EEVRIAASPK STGPRPSLRP LRLEVKREVR 
       410        420        430        440        450
RPARLQQQEE EDEEEEEEEE EEEKEEEEEW GRKRPGRGLP WTKLGRKLES 
       460        470        480        490        500
SVCPVRRSRR LNPELGPWLT FADEPLVPSE PQGALPSLCL APKAYDVERE 
       510        520        530        540        550
LGSPTDEDSG QDQQLLRGPQ IPALESPCES GCGDMDEDPS CPQLPPRDSP 
       560        570        580        590        600
RCLMLALSQS DPTFGKKSFE QTLTVELCGT AGLTPPTTPP YKPTEEDPFK 
       610        620        630        640        650
PDIKHSLGKE IALSLPSPEG LSLKATPGAA HKLPKKHPER SELLSHLRHA 
       660        670        680        690        700
TAQPASQAGQ KRPFSCSFGD HDYCQVLRPE GVLQRKVLRS WEPSGVHLED 
       710        720        730        740        750
WPQQGAPWAE AQAPGREEDR SCDAGAPPKD STLLRDHEIR ASLTKHFGLL 
       760        770        780        790        800
ETALEEEDLA SCKSPEYDTV FEDSSSSSGE SSFLPEEEEE EGEEEEEDDE 
       810        820        830        840        850
EEDSGVSPTC SDHCPYQSPP SKANRQLCSR SRSSSGSSPC HSWSPATRRN 
       860        870        880        890        900
FRCESRGPCS DRTPSIRHAR KRREKAIGEG RVVYIQNLSS DMSSRELKRR 
       910        920        930        940        950
FEVFGEIEEC EVLTRNRRGE KYGFITYRCS EHAALSLTKG AALRKRNEPS 
       960        970        980        990 
FQLSYGGLRH FCWPRYTDYG KPLKPSHSLV RLKAWEAVPS LNKTQS     

        10         20         30         40         50
MAGNDCGALL DEELSSFFLN YLADTQGGGS GEEQLYADFP ELDLSQLDAS 
        60         70         80         90        100
DFDSATCFGE LQWCPENSET EPNQYSPDDS ELFQIDSENE ALLAELTKTL 
       110        120        130        140        150
DDIPEDDVGL AAFPALDGGD ALSCTSASPA PSSAPPSPAP EKPSAPAPEV 
       160        170        180        190        200
DELSLADSTQ DKKAPMMQSQ SRSCTELHKH LTSAQCCLQD RGLQPPCLQS 
       210        220        230        240        250
PRLPAKEDKE PGEDCPSPQP APASPRDSLA LGRADPGAPV SQEDMQAMVQ 
       260        270        280        290        300
LIRYMHTYCL PQRKLPPQTP EPLPKACSNP SQQVRSRPWS RHHSKASWAE 
       310        320        330        340        350
FSILRELLAQ DVLCDVSKPY RLATPVYASL TPRSRPRPPK DSQASPGRPS 
       360        370        380        390        400
SVEEVRIAAS PKSTGPRPSL RPLRLEVKRE VRRPARLQQQ EEEDEEEEEE 
       410        420        430        440        450
EEEEEKEEEE EWGRKRPGRG LPWTKLGRKL ESSVCPVRRS RRLNPELGPW 
       460        470        480        490        500
LTFADEPLVP SEPQGALPSL CLAPKAYDVE RELGSPTDED SGQDQQLLRG 
       510        520        530        540        550
PQIPALESPC ESGCGDMDED PSCPQLPPRD SPRCLMLALS QSDPTFGKKS 
       560        570        580        590        600
FEQTLTVELC GTAGLTPPTT PPYKPTEEDP FKPDIKHSLG KEIALSLPSP 
       610        620        630        640        650
EGLSLKATPG AAHKLPKKHP ERSELLSHLR HATAQPASQA GQKRPFSCSF 
       660        670        680        690        700
GDHDYCQVLR PEGVLQRKVL RSWEPSGVHL EDWPQQGAPW AEAQAPGREE 
       710        720        730        740        750
DRSCDAGAPP KDSTLLRDHE IRASLTKHFG LLETALEEED LASCKSPEYD 
       760        770        780        790        800
TVFEDSSSSS GESSFLPEEE EEEGEEEEED DEEEDSGVSP TCSDHCPYQS 
       810        820        830        840        850
PPSKANRQLC SRSRSSSGSS PCHSWSPATR RNFRCESRGP CSDRTPSIRH 
       860        870        880        890        900
ARKRREKAIG EGRVVYIQNL SSDMSSRELK RRFEVFGEIE ECEVLTRNRR 
       910        920        930        940        950
GEKYGFITYR CSEHAALSLT KGAALRKRNE PSFQLSYGGL RHFCWPRYTD 
       960        970        980 
YDSNSEEALP ASGKSKYEAM DFDSLLKEAQ QSLH                  

        10         20         30         40         50
MGGGSGEEQL YADFPELDLS QLDASDFDSA TCFGELQWCP ENSETEPNQY 
        60         70         80         90        100
SPDDSELFQI DSENEALLAE LTKTLDDIPE DDVGLAAFPA LDGGDALSCT 
       110        120        130        140        150
SASPAPSSAP PSPAPEKPSA PAPEVDELSL ADSTQDKKAP MMQSQSRSCT 
       160        170        180        190        200
ELHKHLTSAQ CCLQDRGLQP PCLQSPRLPA KEDKEPGEDC PSPQPAPASP 
       210        220        230        240        250
RDSLALGRAD PGAPVSQEDM QAMVQLIRYM HTYCLPQRKL PPQTPEPLPK 
       260        270        280        290        300
ACSNPSQQVR SRPWSRHHSK ASWAEFSILR ELLAQDVLCD VSKPYRLATP 
       310        320        330        340        350
VYASLTPRSR PRPPKDSQAS PGRPSSVEEV RIAASPKSTG PRPSLRPLRL 
       360        370        380        390        400
EVKREVRRPA RLQQQEEEDE EEEEEEEEEE KEEEEEWGRK RPGRGLPWTK 
       410        420        430        440        450
LGRKLESSVC PVRRSRRLNP ELGPWLTFAD EPLVPSEPQG ALPSLCLAPK 
       460        470        480        490        500
AYDVERELGS PTDEDSGQDQ QLLRGPQIPA LESPCESGCG DMDEDPSCPQ 
       510        520        530        540        550
LPPRDSPRCL MLALSQSDPT FGKKSFEQTL TVELCGTAGL TPPTTPPYKP 
       560        570        580        590        600
TEEDPFKPDI KHSLGKEIAL SLPSPEGLSL KATPGAAHKL PKKHPERSEL 
       610        620        630        640        650
LSHLRHATAQ PASQAGQKRP FSCSFGDHDY CQVLRPEGVL QRKVLRSWEP 
       660        670        680        690        700
SGVHLEDWPQ QGAPWAEAQA PGREEDRSCD AGAPPKDSTL LRDHEIRASL 
       710        720        730        740        750
TKHFGLLETA LEEEDLASCK SPEYDTVFED SSSSSGESSF LPEEEEEEGE 
       760        770        780        790        800
EEEEDDEEED SGVSPTCSDH CPYQSPPSKA NRQLCSRSRS SSGSSPCHSW 
       810        820        830        840        850
SPATRRNFRC ESRGPCSDRT PSIRHARKRR EKAIGEGRVV YIQNLSSDMS 
       860        870        880        890        900
SRELKRRFEV FGEIEECEVL TRNRRGEKYG FITYRCSEHA ALSLTKGAAL 
       910        920        930        940        950
RKRNEPSFQL SYGGLRHFCW PRYTDYDSNS EEALPASGKS KYEAMDFDSL 

LKEAQQSLH                                              

Experimental Info

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismⁱ

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 5
   Human chromosome 5: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references