Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homer protein homolog 1

Gene

HOMER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled glutamate receptor binding Source: GO_Central
  • ion channel binding Source: BHF-UCL
  • signaling adaptor activity Source: BHF-UCL

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins
SignaLinkiQ86YM7

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 1Curated
Short name:
Homer-1
Gene namesi
Name:HOMER1Imported
Synonyms:SYN471 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000152413.14
HGNCiHGNC:17512 HOMER1
MIMi604798 gene
neXtProtiNX_Q86YM7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi9456
OpenTargetsiENSG00000152413
PharmGKBiPA134972608

Polymorphism and mutation databases

DMDMi38604765

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001910052 – 354Homer protein homolog 1Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei306PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ86YM7
MaxQBiQ86YM7
PaxDbiQ86YM7
PeptideAtlasiQ86YM7
PRIDEiQ86YM7
ProteomicsDBi70435
70436 [Q86YM7-2]
70437 [Q86YM7-3]

PTM databases

iPTMnetiQ86YM7
PhosphoSitePlusiQ86YM7

Expressioni

Gene expression databases

BgeeiENSG00000152413 Expressed in 234 organ(s), highest expression level in caudate nucleus
CleanExiHS_HOMER1
ExpressionAtlasiQ86YM7 baseline and differential
GenevisibleiQ86YM7 HS

Organism-specific databases

HPAiCAB004437
HPA036521
HPA036522

Interactioni

Subunit structurei

Tetramer; this tetrameric structure is critical for forming the high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2 and SHANK3. Interacts with IFT57 and OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Interacts with SHANK1; forms high-order polymerized complex with a mesh-like network structure, at least composed of SHANK1, HOMER1 and DLGAP1; the complex formation is SHANK1 multimerization dependent.Interacts with SHANK1; forms high-order polymerized complex with a mesh-like network structure, at least composed of SHANK1, HOMER1 and DLGAP1; the complex formation is SHANK1 multimerization dependent (By similarity).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114845, 51 interactors
IntActiQ86YM7, 24 interactors
MINTiQ86YM7
STRINGi9606.ENSP00000334382

Structurei

3D structure databases

ProteinModelPortaliQ86YM7
SMRiQ86YM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 110WH1PROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni290 – 354Required for tetramerizationBy similarityAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili181 – 352Sequence analysisAdd BLAST172

Domaini

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3. The coiled-Coil domain forms an antiparallel tetrameric arrangement (By similarity).By similarity

Sequence similaritiesi

Belongs to the Homer family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGRQ Eukaryota
ENOG410XQWT LUCA
GeneTreeiENSGT00390000017850
HOGENOMiHOG000006979
HOVERGENiHBG051918
InParanoidiQ86YM7
KOiK15010
OMAiQNSEPRP
OrthoDBiEOG091G0CQ0
PhylomeDBiQ86YM7
TreeFamiTF325627

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS50229 WH1, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YM7-1) [UniParc]FASTAAdd to basket
Also known as: 1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL
60 70 80 90 100
DGSKAIINST ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA
110 120 130 140 150
EKFQEFKEAA RLAKEKSQEK MELTSTPSQE SAGGDLQSPL TPESINGTDD
160 170 180 190 200
ERTPDVTQNS EPRAEPTQNA LPFSHSSAIS KHWEAELATL KGNNAKLTAA
210 220 230 240 250
LLESTANVKQ WKQQLAAYQE EAERLHKRVT ELECVSSQAN AVHTHKTELN
260 270 280 290 300
QTIQELEETL KLKEEEIERL KQEIDNAREL QEQRDSLTQK LQEVEIRNKD
310 320 330 340 350
LEGQLSDLEQ RLEKSQNEQE AFRNNLKTLL EILDGKIFEL TELRDNLAKL

LECS
Length:354
Mass (Da):40,277
Last modified:November 28, 2003 - v2
Checksum:i8C68A56224C98033
GO
Isoform 2 (identifier: Q86YM7-2) [UniParc]FASTAAdd to basket
Also known as: 1e

The sequence of this isoform differs from the canonical sequence as follows:
     99-228: Missing.

Show »
Length:224
Mass (Da):25,843
Checksum:iF94F6A9AB2682629
GO
Isoform 3 (identifier: Q86YM7-3) [UniParc]FASTAAdd to basket
Also known as: 1h

The sequence of this isoform differs from the canonical sequence as follows:
     176-177: SS → RK
     178-354: Missing.

Show »
Length:177
Mass (Da):19,861
Checksum:iB1AE94C8E245CAEF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q86YM6Q86YM6_HUMAN
HOMER1F
HOMER1
180Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00905799 – 228Missing in isoform 2. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_009058176 – 177SS → RK in isoform 3. 1 Publication2
Alternative sequenceiVSP_009059178 – 354Missing in isoform 3. 1 PublicationAdd BLAST177

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093262 mRNA Translation: AAC71026.1
Y17829 mRNA Translation: CAA76877.1
AY189939 mRNA Translation: AAO38999.1
AY189941 mRNA Translation: AAO39001.1
BT009846 mRNA Translation: AAP88848.1
AK312481 mRNA Translation: BAG35385.1
CH471084 Genomic DNA Translation: EAW95836.1
BC015502 mRNA Translation: AAH15502.1
CCDSiCCDS43335.1 [Q86YM7-1]
CCDS64188.1 [Q86YM7-2]
CCDS64189.1 [Q86YM7-3]
RefSeqiNP_001264006.1, NM_001277077.1 [Q86YM7-2]
NP_001264007.1, NM_001277078.1 [Q86YM7-3]
NP_004263.1, NM_004272.4 [Q86YM7-1]
UniGeneiHs.591761

Genome annotation databases

EnsembliENST00000282260; ENSP00000282260; ENSG00000152413 [Q86YM7-2]
ENST00000334082; ENSP00000334382; ENSG00000152413 [Q86YM7-1]
ENST00000508576; ENSP00000426651; ENSG00000152413 [Q86YM7-3]
GeneIDi9456
KEGGihsa:9456
UCSCiuc003kfy.5 human [Q86YM7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093262 mRNA Translation: AAC71026.1
Y17829 mRNA Translation: CAA76877.1
AY189939 mRNA Translation: AAO38999.1
AY189941 mRNA Translation: AAO39001.1
BT009846 mRNA Translation: AAP88848.1
AK312481 mRNA Translation: BAG35385.1
CH471084 Genomic DNA Translation: EAW95836.1
BC015502 mRNA Translation: AAH15502.1
CCDSiCCDS43335.1 [Q86YM7-1]
CCDS64188.1 [Q86YM7-2]
CCDS64189.1 [Q86YM7-3]
RefSeqiNP_001264006.1, NM_001277077.1 [Q86YM7-2]
NP_001264007.1, NM_001277078.1 [Q86YM7-3]
NP_004263.1, NM_004272.4 [Q86YM7-1]
UniGeneiHs.591761

3D structure databases

ProteinModelPortaliQ86YM7
SMRiQ86YM7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114845, 51 interactors
IntActiQ86YM7, 24 interactors
MINTiQ86YM7
STRINGi9606.ENSP00000334382

PTM databases

iPTMnetiQ86YM7
PhosphoSitePlusiQ86YM7

Polymorphism and mutation databases

DMDMi38604765

Proteomic databases

EPDiQ86YM7
MaxQBiQ86YM7
PaxDbiQ86YM7
PeptideAtlasiQ86YM7
PRIDEiQ86YM7
ProteomicsDBi70435
70436 [Q86YM7-2]
70437 [Q86YM7-3]

Protocols and materials databases

DNASUi9456
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282260; ENSP00000282260; ENSG00000152413 [Q86YM7-2]
ENST00000334082; ENSP00000334382; ENSG00000152413 [Q86YM7-1]
ENST00000508576; ENSP00000426651; ENSG00000152413 [Q86YM7-3]
GeneIDi9456
KEGGihsa:9456
UCSCiuc003kfy.5 human [Q86YM7-1]

Organism-specific databases

CTDi9456
DisGeNETi9456
EuPathDBiHostDB:ENSG00000152413.14
GeneCardsiHOMER1
HGNCiHGNC:17512 HOMER1
HPAiCAB004437
HPA036521
HPA036522
MIMi604798 gene
neXtProtiNX_Q86YM7
OpenTargetsiENSG00000152413
PharmGKBiPA134972608
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGRQ Eukaryota
ENOG410XQWT LUCA
GeneTreeiENSGT00390000017850
HOGENOMiHOG000006979
HOVERGENiHBG051918
InParanoidiQ86YM7
KOiK15010
OMAiQNSEPRP
OrthoDBiEOG091G0CQ0
PhylomeDBiQ86YM7
TreeFamiTF325627

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins
SignaLinkiQ86YM7

Miscellaneous databases

ChiTaRSiHOMER1 human
GeneWikiiHOMER1
GenomeRNAii9456
PROiPR:Q86YM7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152413 Expressed in 234 organ(s), highest expression level in caudate nucleus
CleanExiHS_HOMER1
ExpressionAtlasiQ86YM7 baseline and differential
GenevisibleiQ86YM7 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS50229 WH1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHOME1_HUMAN
AccessioniPrimary (citable) accession number: Q86YM7
Secondary accession number(s): B2R688, O96003, Q86YM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: October 10, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again