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Entry version 110 (13 Feb 2019)
Sequence version 3 (30 Nov 2010)
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Protein

Threonine synthase-like 2

Gene

THNSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).By similarity
Isoform SOFAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphateBy similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • lyase activity Source: UniProtKB-KW
  • pyridoxal phosphate binding Source: BHF-UCL
  • serine binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q86YJ6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Threonine synthase-like 2 (EC:4.2.3.-)
Short name:
TSH2
Alternative name(s):
Secreted osteoclastogenic factor of activated T-cells
Short name:
SOFAT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THNSL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000144115.16

Human Gene Nomenclature Database

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HGNCi
HGNC:25602 THNSL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611261 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86YJ6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55258

Open Targets

More...
OpenTargetsi
ENSG00000144115

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162405692

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
THNSL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104279

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003064071 – 484Threonine synthase-like 2Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei113N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86YJ6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86YJ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86YJ6

PeptideAtlas

More...
PeptideAtlasi
Q86YJ6

PRoteomics IDEntifications database

More...
PRIDEi
Q86YJ6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70421
70422 [Q86YJ6-2]
70423 [Q86YJ6-3]
70424 [Q86YJ6-4]
70425 [Q86YJ6-5]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86YJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144115 Expressed in 190 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86YJ6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86YJ6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035395

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120549, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q86YJ6, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000327323

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86YJ6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86YJ6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2616 Eukaryota
COG0498 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158503

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108568

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86YJ6

KEGG Orthology (KO)

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KOi
K06037

Identification of Orthologs from Complete Genome Data

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OMAi
DIFILHP

Database of Orthologous Groups

More...
OrthoDBi
1361511at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86YJ6

TreeFam database of animal gene trees

More...
TreeFami
TF329641

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1380.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001926 PLP-dep
IPR029144 Thr_synth_N
IPR037158 Thr_synth_N_sf
IPR004450 Thr_synthase-like
IPR036052 Trypto_synt_PLP_dependent

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00291 PALP, 1 hit
PF14821 Thr_synth_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53686 SSF53686, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00260 thrC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWYVSTRGVA PRVNFEGALF SGYAPDGGLF MPEELPQLDR GTLCQWSTLS
60 70 80 90 100
YPGLVKELCA LFIGSELLPK DELNDLIDRA FSRFRHREVV HLSRLRNGLN
110 120 130 140 150
VLELWHGVTY AFKDLSLSCT TQFLQYFLEK REKHVTVVVG TSGDTGSAAI
160 170 180 190 200
ESVQGAKNMD IIVLLPKGHC TKIQELQMTT VLKQNVHVFG VEGNSDELDE
210 220 230 240 250
PIKTVFADVA FVKKHNLMSL NSINWSRVLV QMAHHFFAYF QCTPSLDTHP
260 270 280 290 300
LPLVEVVVPT GAAGNLAAGY IAQKIGLPIR LVVAVNRNDI IHRTVQQGDF
310 320 330 340 350
SLSEAVKSTL ASAMDIQVPY NMERVFWLLS GSDSQVTRAL MEQFERTQSV
360 370 380 390 400
NLPKELHSKL SEAVTSVSVS DEAITQTMGR CWDENQYLLC PHSAVAVNYH
410 420 430 440 450
YQQIDRQQPS TPRCCLAPAS AAKFPEAVLA AGLTPETPAE IVALEHKETR
460 470 480
CTLMRRGDNW MLMLRDTIED LSRQWRSHAL NTSQ
Length:484
Mass (Da):54,116
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF177B2B7DE6E8752
GO
Isoform 2 (identifier: Q86YJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-484: LSEAVTSVSV...WRSHALNTSQ → WERQDYEKMA...PGTAMVRGGG

Note: No experimental confirmation available.
Show »
Length:405
Mass (Da):45,037
Checksum:i5A2B03980DD1B3ED
GO
Isoform 3 (identifier: Q86YJ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-484: LSEAVTSVSV...WRSHALNTSQ → HSPVLPRPCLCSQVPGSCPGCWPDP

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):42,718
Checksum:iBE36DE86123D5733
GO
Isoform 4 (identifier: Q86YJ6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-274: Missing.

Note: No experimental confirmation available.
Show »
Length:423
Mass (Da):47,428
Checksum:i14A1A6D8308BC93F
GO
Isoform SOFAT (identifier: Q86YJ6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.
     360-484: LSEAVTSVSV...WRSHALNTSQ → WERQDYEKMA...PGTAMVRGGD

Show »
Length:247
Mass (Da):27,414
Checksum:i0124469439FCFD9D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8K0C1A8K0C1_HUMAN
Threonine synthase-like 2
THNSL2
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JU10C9JU10_HUMAN
Threonine synthase-like 2
THNSL2
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3J1C9J3J1_HUMAN
Threonine synthase-like 2
THNSL2
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAX88906 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA91904 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63I → V in BAA91904 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05463541G → E2 PublicationsCorresponds to variant dbSNP:rs4129190Ensembl.1
Natural variantiVAR_054636108V → I. Corresponds to variant dbSNP:rs35541720Ensembl.1
Natural variantiVAR_054637204T → N. Corresponds to variant dbSNP:rs34136143Ensembl.1
Natural variantiVAR_054638324R → G1 PublicationCorresponds to variant dbSNP:rs17855905Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0416591 – 158Missing in isoform SOFAT. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_028468214 – 274Missing in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_028469360 – 484LSEAV…LNTSQ → WERQDYEKMAVMECDGCCVE LCLGNCGPRRGSVTDIPGTA MVRGGG in isoform 2. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_028470360 – 484LSEAV…LNTSQ → HSPVLPRPCLCSQVPGSCPG CWPDP in isoform 3. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_041660360 – 484LSEAV…LNTSQ → WERQDYEKMAVMECDGCCVE LCLGNCGPRRGSVTDIPGTA MVRGGD in isoform SOFAT. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HM185274 mRNA Translation: ADL14696.1
AK001778 mRNA Translation: BAA91904.1 Different initiation.
AK095303 mRNA Translation: BAG53023.1
AC092836 Genomic DNA Translation: AAX88906.1 Sequence problems.
BC035315 mRNA Translation: AAH35315.1
BC047758 mRNA Translation: AAH47758.2
BC064423 mRNA Translation: AAH64423.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2002.2 [Q86YJ6-1]
CCDS58718.1 [Q86YJ6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001231605.1, NM_001244676.1 [Q86YJ6-2]
NP_060741.3, NM_018271.4 [Q86YJ6-1]
XP_005264457.1, XM_005264400.4 [Q86YJ6-1]
XP_005264458.1, XM_005264401.4 [Q86YJ6-1]
XP_005264460.1, XM_005264403.4 [Q86YJ6-3]
XP_006712106.1, XM_006712043.2 [Q86YJ6-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.739080
Hs.740434

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324166; ENSP00000327323; ENSG00000144115 [Q86YJ6-1]
ENST00000343544; ENSP00000339563; ENSG00000144115 [Q86YJ6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55258

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55258

UCSC genome browser

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UCSCi
uc002ssw.5 human [Q86YJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM185274 mRNA Translation: ADL14696.1
AK001778 mRNA Translation: BAA91904.1 Different initiation.
AK095303 mRNA Translation: BAG53023.1
AC092836 Genomic DNA Translation: AAX88906.1 Sequence problems.
BC035315 mRNA Translation: AAH35315.1
BC047758 mRNA Translation: AAH47758.2
BC064423 mRNA Translation: AAH64423.1
CCDSiCCDS2002.2 [Q86YJ6-1]
CCDS58718.1 [Q86YJ6-2]
RefSeqiNP_001231605.1, NM_001244676.1 [Q86YJ6-2]
NP_060741.3, NM_018271.4 [Q86YJ6-1]
XP_005264457.1, XM_005264400.4 [Q86YJ6-1]
XP_005264458.1, XM_005264401.4 [Q86YJ6-1]
XP_005264460.1, XM_005264403.4 [Q86YJ6-3]
XP_006712106.1, XM_006712043.2 [Q86YJ6-2]
UniGeneiHs.739080
Hs.740434

3D structure databases

ProteinModelPortaliQ86YJ6
SMRiQ86YJ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120549, 1 interactor
IntActiQ86YJ6, 2 interactors
STRINGi9606.ENSP00000327323

PTM databases

PhosphoSitePlusiQ86YJ6

Polymorphism and mutation databases

BioMutaiTHNSL2
DMDMi313104279

Proteomic databases

EPDiQ86YJ6
MaxQBiQ86YJ6
PaxDbiQ86YJ6
PeptideAtlasiQ86YJ6
PRIDEiQ86YJ6
ProteomicsDBi70421
70422 [Q86YJ6-2]
70423 [Q86YJ6-3]
70424 [Q86YJ6-4]
70425 [Q86YJ6-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324166; ENSP00000327323; ENSG00000144115 [Q86YJ6-1]
ENST00000343544; ENSP00000339563; ENSG00000144115 [Q86YJ6-2]
GeneIDi55258
KEGGihsa:55258
UCSCiuc002ssw.5 human [Q86YJ6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55258
DisGeNETi55258
EuPathDBiHostDB:ENSG00000144115.16

GeneCards: human genes, protein and diseases

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GeneCardsi
THNSL2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0002247
HGNCiHGNC:25602 THNSL2
HPAiHPA035395
MIMi611261 gene
neXtProtiNX_Q86YJ6
OpenTargetsiENSG00000144115
PharmGKBiPA162405692

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2616 Eukaryota
COG0498 LUCA
GeneTreeiENSGT00940000158503
HOVERGENiHBG108568
InParanoidiQ86YJ6
KOiK06037
OMAiDIFILHP
OrthoDBi1361511at2759
PhylomeDBiQ86YJ6
TreeFamiTF329641

Enzyme and pathway databases

SignaLinkiQ86YJ6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
THNSL2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55258

Protein Ontology

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PROi
PR:Q86YJ6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000144115 Expressed in 190 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiQ86YJ6 baseline and differential
GenevisibleiQ86YJ6 HS

Family and domain databases

Gene3Di3.90.1380.10, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR029144 Thr_synth_N
IPR037158 Thr_synth_N_sf
IPR004450 Thr_synthase-like
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PF14821 Thr_synth_N, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00260 thrC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHNS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86YJ6
Secondary accession number(s): B3KTB1
, B5MDX8, B7WPF8, D9ZZB8, Q6P2M7, Q6PI27, Q9NV54
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 30, 2010
Last modified: February 13, 2019
This is version 110 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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