Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q86YJ6 (THNS2_HUMAN)

Entry version 124 (10 Feb 2021)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Threonine synthase-like 2

Gene

THNSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).By similarity
Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphateBy similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86YJ6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q86YJ6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Threonine synthase-like 2 (EC:4.2.3.-)
Short name:
TSH2
Alternative name(s):
Secreted osteoclastogenic factor of activated T-cells
Short name:
SOFAT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THNSL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25602, THNSL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611261, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86YJ6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000144115.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55258

Open Targets

More...OpenTargetsi		ENSG00000144115

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162405692

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86YJ6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		THNSL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104279

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003064071 – 484Threonine synthase-like 2Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei113N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86YJ6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86YJ6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86YJ6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86YJ6

PeptideAtlas

More...PeptideAtlasi		Q86YJ6

PRoteomics IDEntifications database

More...PRIDEi		Q86YJ6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70421 [Q86YJ6-1]
70422 [Q86YJ6-2]
70423 [Q86YJ6-3]
70424 [Q86YJ6-4]
70425 [Q86YJ6-5]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86YJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000144115, Expressed in adenohypophysis and 204 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86YJ6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86YJ6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000144115, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120549, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q86YJ6, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000327323

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86YJ6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86YJ6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2616, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158503

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015170_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86YJ6

Identification of Orthologs from Complete Genome Data

More...OMAi		TYYFYSY

Database of Orthologous Groups

More...OrthoDBi		1361511at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86YJ6

TreeFam database of animal gene trees

More...TreeFami		TF329641

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1100, 2 hits
3.90.1380.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001926, PLP-dep
IPR029144, Thr_synth_N
IPR037158, Thr_synth_N_sf
IPR004450, Thr_synthase-like
IPR036052, Trypto_synt_PLP_dependent

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00291, PALP, 1 hit
PF14821, Thr_synth_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53686, SSF53686, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00260, thrC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWYVSTRGVA PRVNFEGALF SGYAPDGGLF MPEELPQLDR GTLCQWSTLS 
        60         70         80         90        100
YPGLVKELCA LFIGSELLPK DELNDLIDRA FSRFRHREVV HLSRLRNGLN 
       110        120        130        140        150
VLELWHGVTY AFKDLSLSCT TQFLQYFLEK REKHVTVVVG TSGDTGSAAI 
       160        170        180        190        200
ESVQGAKNMD IIVLLPKGHC TKIQELQMTT VLKQNVHVFG VEGNSDELDE 
       210        220        230        240        250
PIKTVFADVA FVKKHNLMSL NSINWSRVLV QMAHHFFAYF QCTPSLDTHP 
       260        270        280        290        300
LPLVEVVVPT GAAGNLAAGY IAQKIGLPIR LVVAVNRNDI IHRTVQQGDF 
       310        320        330        340        350
SLSEAVKSTL ASAMDIQVPY NMERVFWLLS GSDSQVTRAL MEQFERTQSV 
       360        370        380        390        400
NLPKELHSKL SEAVTSVSVS DEAITQTMGR CWDENQYLLC PHSAVAVNYH 
       410        420        430        440        450
YQQIDRQQPS TPRCCLAPAS AAKFPEAVLA AGLTPETPAE IVALEHKETR 
       460        470        480 
CTLMRRGDNW MLMLRDTIED LSRQWRSHAL NTSQ
Length:484
Mass (Da):54,116
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF177B2B7DE6E8752
GO
Isoform 2 (identifier: Q86YJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-484: LSEAVTSVSV...WRSHALNTSQ → WERQDYEKMA...PGTAMVRGGG

Show »
Length:405
Mass (Da):45,037
Checksum:i5A2B03980DD1B3ED
GO
Isoform 3 (identifier: Q86YJ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-484: LSEAVTSVSV...WRSHALNTSQ → HSPVLPRPCLCSQVPGSCPGCWPDP

Show »
Length:384
Mass (Da):42,718
Checksum:iBE36DE86123D5733
GO
Isoform 4 (identifier: Q86YJ6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-274: Missing.

Show »
Length:423
Mass (Da):47,428
Checksum:i14A1A6D8308BC93F
GO
Isoform SOFAT (identifier: Q86YJ6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.
     360-484: LSEAVTSVSV...WRSHALNTSQ → WERQDYEKMA...PGTAMVRGGD

Show »
Length:247
Mass (Da):27,414
Checksum:i0124469439FCFD9D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8K0C1A8K0C1_HUMAN
Threonine synthase-like 2
THNSL2
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JU10C9JU10_HUMAN
Threonine synthase-like 2
THNSL2
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3J1C9J3J1_HUMAN
Threonine synthase-like 2
THNSL2
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAX88906 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA91904 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63I → V in BAA91904 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05463541G → E2 PublicationsCorresponds to variant dbSNP:rs4129190Ensembl.1
Natural variantiVAR_054636108V → I. Corresponds to variant dbSNP:rs35541720Ensembl.1
Natural variantiVAR_054637204T → N. Corresponds to variant dbSNP:rs34136143Ensembl.1
Natural variantiVAR_054638324R → G1 PublicationCorresponds to variant dbSNP:rs17855905Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0416591 – 158Missing in isoform SOFAT. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_028468214 – 274Missing in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_028469360 – 484LSEAV…LNTSQ → WERQDYEKMAVMECDGCCVE LCLGNCGPRRGSVTDIPGTA MVRGGG in isoform 2. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_028470360 – 484LSEAV…LNTSQ → HSPVLPRPCLCSQVPGSCPG CWPDP in isoform 3. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_041660360 – 484LSEAV…LNTSQ → WERQDYEKMAVMECDGCCVE LCLGNCGPRRGSVTDIPGTA MVRGGD in isoform SOFAT. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
HM185274 mRNA Translation: ADL14696.1
AK001778 mRNA Translation: BAA91904.1 Different initiation.
AK095303 mRNA Translation: BAG53023.1
AC092836 Genomic DNA Translation: AAX88906.1 Sequence problems.
BC035315 mRNA Translation: AAH35315.1
BC047758 mRNA Translation: AAH47758.2
BC064423 mRNA Translation: AAH64423.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2002.2 [Q86YJ6-1]
CCDS58718.1 [Q86YJ6-2]

NCBI Reference Sequences

More...RefSeqi		NP_001231605.1, NM_001244676.1 [Q86YJ6-2]
NP_060741.3, NM_018271.4 [Q86YJ6-1]
XP_005264457.1, XM_005264400.4
XP_005264458.1, XM_005264401.4 [Q86YJ6-1]
XP_005264460.1, XM_005264403.4
XP_006712106.1, XM_006712043.2 [Q86YJ6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000324166; ENSP00000327323; ENSG00000144115 [Q86YJ6-1]
ENST00000343544; ENSP00000339563; ENSG00000144115 [Q86YJ6-2]
ENST00000496844; ENSP00000501447; ENSG00000144115 [Q86YJ6-3]
ENST00000674334; ENSP00000501453; ENSG00000144115 [Q86YJ6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55258

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55258

UCSC genome browser

More...UCSCi		uc002ssw.5, human [Q86YJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM185274 mRNA Translation: ADL14696.1
AK001778 mRNA Translation: BAA91904.1 Different initiation.
AK095303 mRNA Translation: BAG53023.1
AC092836 Genomic DNA Translation: AAX88906.1 Sequence problems.
BC035315 mRNA Translation: AAH35315.1
BC047758 mRNA Translation: AAH47758.2
BC064423 mRNA Translation: AAH64423.1
CCDSiCCDS2002.2 [Q86YJ6-1]
CCDS58718.1 [Q86YJ6-2]
RefSeqiNP_001231605.1, NM_001244676.1 [Q86YJ6-2]
NP_060741.3, NM_018271.4 [Q86YJ6-1]
XP_005264457.1, XM_005264400.4
XP_005264458.1, XM_005264401.4 [Q86YJ6-1]
XP_005264460.1, XM_005264403.4
XP_006712106.1, XM_006712043.2 [Q86YJ6-2]

3D structure databases

SMRiQ86YJ6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120549, 1 interactor
IntActiQ86YJ6, 3 interactors
STRINGi9606.ENSP00000327323

PTM databases

PhosphoSitePlusiQ86YJ6

Genetic variation databases

BioMutaiTHNSL2
DMDMi313104279

Proteomic databases

EPDiQ86YJ6
MassIVEiQ86YJ6
MaxQBiQ86YJ6
PaxDbiQ86YJ6
PeptideAtlasiQ86YJ6
PRIDEiQ86YJ6
ProteomicsDBi70421 [Q86YJ6-1]
70422 [Q86YJ6-2]
70423 [Q86YJ6-3]
70424 [Q86YJ6-4]
70425 [Q86YJ6-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32227, 128 antibodies

Genome annotation databases

EnsembliENST00000324166; ENSP00000327323; ENSG00000144115 [Q86YJ6-1]
ENST00000343544; ENSP00000339563; ENSG00000144115 [Q86YJ6-2]
ENST00000496844; ENSP00000501447; ENSG00000144115 [Q86YJ6-3]
ENST00000674334; ENSP00000501453; ENSG00000144115 [Q86YJ6-1]
GeneIDi55258
KEGGihsa:55258
UCSCiuc002ssw.5, human [Q86YJ6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55258
DisGeNETi55258

GeneCards: human genes, protein and diseases

More...GeneCardsi		THNSL2
HGNCiHGNC:25602, THNSL2
HPAiENSG00000144115, Low tissue specificity
MIMi611261, gene
neXtProtiNX_Q86YJ6
OpenTargetsiENSG00000144115
PharmGKBiPA162405692
VEuPathDBiHostDB:ENSG00000144115.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2616, Eukaryota
GeneTreeiENSGT00940000158503
HOGENOMiCLU_015170_1_1_1
InParanoidiQ86YJ6
OMAiTYYFYSY
OrthoDBi1361511at2759
PhylomeDBiQ86YJ6
TreeFamiTF329641

Enzyme and pathway databases

PathwayCommonsiQ86YJ6
SignaLinkiQ86YJ6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55258, 3 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		THNSL2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55258
PharosiQ86YJ6, Tbio

Protein Ontology

More...PROi		PR:Q86YJ6
RNActiQ86YJ6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000144115, Expressed in adenohypophysis and 204 other tissues
ExpressionAtlasiQ86YJ6, baseline and differential
GenevisibleiQ86YJ6, HS

Family and domain databases

Gene3Di3.40.50.1100, 2 hits
3.90.1380.10, 1 hit
InterProiView protein in InterPro
IPR001926, PLP-dep
IPR029144, Thr_synth_N
IPR037158, Thr_synth_N_sf
IPR004450, Thr_synthase-like
IPR036052, Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291, PALP, 1 hit
PF14821, Thr_synth_N, 1 hit
SUPFAMiSSF53686, SSF53686, 1 hit
TIGRFAMsiTIGR00260, thrC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHNS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86YJ6
Secondary accession number(s): B3KTB1
, B5MDX8, B7WPF8, D9ZZB8, Q6P2M7, Q6PI27, Q9NV54
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 30, 2010
Last modified: February 10, 2021
This is version 124 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with genetic variants
    List of human entries with genetic variants
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again