Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Threonine synthase-like 2

Gene

THNSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).By similarity
Isoform SOFAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.1 Publication

Cofactori

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • lyase activity Source: UniProtKB-KW
  • pyridoxal phosphate binding Source: BHF-UCL
  • serine binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionCytokine, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

SignaLinkiQ86YJ6

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase-like 2 (EC:4.2.3.-)
Short name:
TSH2
Alternative name(s):
Secreted osteoclastogenic factor of activated T-cells
Short name:
SOFAT
Gene namesi
Name:THNSL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144115.16
HGNCiHGNC:25602 THNSL2
MIMi611261 gene
neXtProtiNX_Q86YJ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi55258
OpenTargetsiENSG00000144115
PharmGKBiPA162405692

Polymorphism and mutation databases

BioMutaiTHNSL2
DMDMi313104279

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003064071 – 484Threonine synthase-like 2Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

EPDiQ86YJ6
MaxQBiQ86YJ6
PaxDbiQ86YJ6
PeptideAtlasiQ86YJ6
PRIDEiQ86YJ6
ProteomicsDBi70421
70422 [Q86YJ6-2]
70423 [Q86YJ6-3]
70424 [Q86YJ6-4]
70425 [Q86YJ6-5]

PTM databases

PhosphoSitePlusiQ86YJ6

Expressioni

Gene expression databases

BgeeiENSG00000144115 Expressed in 190 organ(s), highest expression level in adenohypophysis
CleanExiHS_THNSL2
ExpressionAtlasiQ86YJ6 baseline and differential
GenevisibleiQ86YJ6 HS

Organism-specific databases

HPAiHPA035395

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120549, 1 interactor
IntActiQ86YJ6, 2 interactors
STRINGi9606.ENSP00000327323

Structurei

3D structure databases

ProteinModelPortaliQ86YJ6
SMRiQ86YJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiKOG2616 Eukaryota
COG0498 LUCA
GeneTreeiENSGT00530000063879
HOVERGENiHBG108568
InParanoidiQ86YJ6
KOiK06037
OMAiDIFILHP
OrthoDBiEOG091G08UM
PhylomeDBiQ86YJ6
TreeFamiTF329641

Family and domain databases

Gene3Di3.90.1380.10, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR029144 Thr_synth_N
IPR037158 Thr_synth_N_sf
IPR004450 Thr_synthase-like
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PF14821 Thr_synth_N, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00260 thrC, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWYVSTRGVA PRVNFEGALF SGYAPDGGLF MPEELPQLDR GTLCQWSTLS
60 70 80 90 100
YPGLVKELCA LFIGSELLPK DELNDLIDRA FSRFRHREVV HLSRLRNGLN
110 120 130 140 150
VLELWHGVTY AFKDLSLSCT TQFLQYFLEK REKHVTVVVG TSGDTGSAAI
160 170 180 190 200
ESVQGAKNMD IIVLLPKGHC TKIQELQMTT VLKQNVHVFG VEGNSDELDE
210 220 230 240 250
PIKTVFADVA FVKKHNLMSL NSINWSRVLV QMAHHFFAYF QCTPSLDTHP
260 270 280 290 300
LPLVEVVVPT GAAGNLAAGY IAQKIGLPIR LVVAVNRNDI IHRTVQQGDF
310 320 330 340 350
SLSEAVKSTL ASAMDIQVPY NMERVFWLLS GSDSQVTRAL MEQFERTQSV
360 370 380 390 400
NLPKELHSKL SEAVTSVSVS DEAITQTMGR CWDENQYLLC PHSAVAVNYH
410 420 430 440 450
YQQIDRQQPS TPRCCLAPAS AAKFPEAVLA AGLTPETPAE IVALEHKETR
460 470 480
CTLMRRGDNW MLMLRDTIED LSRQWRSHAL NTSQ
Length:484
Mass (Da):54,116
Last modified:November 30, 2010 - v3
Checksum:iF177B2B7DE6E8752
GO
Isoform 2 (identifier: Q86YJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-484: LSEAVTSVSV...WRSHALNTSQ → WERQDYEKMA...PGTAMVRGGG

Note: No experimental confirmation available.
Show »
Length:405
Mass (Da):45,037
Checksum:i5A2B03980DD1B3ED
GO
Isoform 3 (identifier: Q86YJ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-484: LSEAVTSVSV...WRSHALNTSQ → HSPVLPRPCLCSQVPGSCPGCWPDP

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):42,718
Checksum:iBE36DE86123D5733
GO
Isoform 4 (identifier: Q86YJ6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-274: Missing.

Note: No experimental confirmation available.
Show »
Length:423
Mass (Da):47,428
Checksum:i14A1A6D8308BC93F
GO
Isoform SOFAT (identifier: Q86YJ6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.
     360-484: LSEAVTSVSV...WRSHALNTSQ → WERQDYEKMA...PGTAMVRGGD

Show »
Length:247
Mass (Da):27,414
Checksum:i0124469439FCFD9D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8K0C1A8K0C1_HUMAN
Threonine synthase-like 2
THNSL2
226Annotation score:
C9J3J1C9J3J1_HUMAN
Threonine synthase-like 2
THNSL2
126Annotation score:
C9JU10C9JU10_HUMAN
Threonine synthase-like 2
THNSL2
258Annotation score:

Sequence cautioni

The sequence AAX88906 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA91904 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63I → V in BAA91904 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05463541G → E2 PublicationsCorresponds to variant dbSNP:rs4129190Ensembl.1
Natural variantiVAR_054636108V → I. Corresponds to variant dbSNP:rs35541720Ensembl.1
Natural variantiVAR_054637204T → N. Corresponds to variant dbSNP:rs34136143Ensembl.1
Natural variantiVAR_054638324R → G1 PublicationCorresponds to variant dbSNP:rs17855905Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0416591 – 158Missing in isoform SOFAT. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_028468214 – 274Missing in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_028469360 – 484LSEAV…LNTSQ → WERQDYEKMAVMECDGCCVE LCLGNCGPRRGSVTDIPGTA MVRGGG in isoform 2. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_028470360 – 484LSEAV…LNTSQ → HSPVLPRPCLCSQVPGSCPG CWPDP in isoform 3. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_041660360 – 484LSEAV…LNTSQ → WERQDYEKMAVMECDGCCVE LCLGNCGPRRGSVTDIPGTA MVRGGD in isoform SOFAT. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM185274 mRNA Translation: ADL14696.1
AK001778 mRNA Translation: BAA91904.1 Different initiation.
AK095303 mRNA Translation: BAG53023.1
AC092836 Genomic DNA Translation: AAX88906.1 Sequence problems.
BC035315 mRNA Translation: AAH35315.1
BC047758 mRNA Translation: AAH47758.2
BC064423 mRNA Translation: AAH64423.1
CCDSiCCDS2002.2 [Q86YJ6-1]
CCDS58718.1 [Q86YJ6-2]
RefSeqiNP_001231605.1, NM_001244676.1 [Q86YJ6-2]
NP_060741.3, NM_018271.4 [Q86YJ6-1]
XP_005264457.1, XM_005264400.4 [Q86YJ6-1]
XP_005264458.1, XM_005264401.4 [Q86YJ6-1]
XP_005264460.1, XM_005264403.4 [Q86YJ6-3]
XP_006712106.1, XM_006712043.2 [Q86YJ6-2]
UniGeneiHs.739080
Hs.740434

Genome annotation databases

EnsembliENST00000324166; ENSP00000327323; ENSG00000144115 [Q86YJ6-1]
ENST00000343544; ENSP00000339563; ENSG00000144115 [Q86YJ6-2]
GeneIDi55258
KEGGihsa:55258
UCSCiuc002ssw.5 human [Q86YJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM185274 mRNA Translation: ADL14696.1
AK001778 mRNA Translation: BAA91904.1 Different initiation.
AK095303 mRNA Translation: BAG53023.1
AC092836 Genomic DNA Translation: AAX88906.1 Sequence problems.
BC035315 mRNA Translation: AAH35315.1
BC047758 mRNA Translation: AAH47758.2
BC064423 mRNA Translation: AAH64423.1
CCDSiCCDS2002.2 [Q86YJ6-1]
CCDS58718.1 [Q86YJ6-2]
RefSeqiNP_001231605.1, NM_001244676.1 [Q86YJ6-2]
NP_060741.3, NM_018271.4 [Q86YJ6-1]
XP_005264457.1, XM_005264400.4 [Q86YJ6-1]
XP_005264458.1, XM_005264401.4 [Q86YJ6-1]
XP_005264460.1, XM_005264403.4 [Q86YJ6-3]
XP_006712106.1, XM_006712043.2 [Q86YJ6-2]
UniGeneiHs.739080
Hs.740434

3D structure databases

ProteinModelPortaliQ86YJ6
SMRiQ86YJ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120549, 1 interactor
IntActiQ86YJ6, 2 interactors
STRINGi9606.ENSP00000327323

PTM databases

PhosphoSitePlusiQ86YJ6

Polymorphism and mutation databases

BioMutaiTHNSL2
DMDMi313104279

Proteomic databases

EPDiQ86YJ6
MaxQBiQ86YJ6
PaxDbiQ86YJ6
PeptideAtlasiQ86YJ6
PRIDEiQ86YJ6
ProteomicsDBi70421
70422 [Q86YJ6-2]
70423 [Q86YJ6-3]
70424 [Q86YJ6-4]
70425 [Q86YJ6-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324166; ENSP00000327323; ENSG00000144115 [Q86YJ6-1]
ENST00000343544; ENSP00000339563; ENSG00000144115 [Q86YJ6-2]
GeneIDi55258
KEGGihsa:55258
UCSCiuc002ssw.5 human [Q86YJ6-1]

Organism-specific databases

CTDi55258
DisGeNETi55258
EuPathDBiHostDB:ENSG00000144115.16
GeneCardsiTHNSL2
H-InvDBiHIX0002247
HGNCiHGNC:25602 THNSL2
HPAiHPA035395
MIMi611261 gene
neXtProtiNX_Q86YJ6
OpenTargetsiENSG00000144115
PharmGKBiPA162405692
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2616 Eukaryota
COG0498 LUCA
GeneTreeiENSGT00530000063879
HOVERGENiHBG108568
InParanoidiQ86YJ6
KOiK06037
OMAiDIFILHP
OrthoDBiEOG091G08UM
PhylomeDBiQ86YJ6
TreeFamiTF329641

Enzyme and pathway databases

SignaLinkiQ86YJ6

Miscellaneous databases

ChiTaRSiTHNSL2 human
GenomeRNAii55258
PROiPR:Q86YJ6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144115 Expressed in 190 organ(s), highest expression level in adenohypophysis
CleanExiHS_THNSL2
ExpressionAtlasiQ86YJ6 baseline and differential
GenevisibleiQ86YJ6 HS

Family and domain databases

Gene3Di3.90.1380.10, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR029144 Thr_synth_N
IPR037158 Thr_synth_N_sf
IPR004450 Thr_synthase-like
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PF14821 Thr_synth_N, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00260 thrC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHNS2_HUMAN
AccessioniPrimary (citable) accession number: Q86YJ6
Secondary accession number(s): B3KTB1
, B5MDX8, B7WPF8, D9ZZB8, Q6P2M7, Q6PI27, Q9NV54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 107 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again