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Protein

Zinc finger protein 280B

Gene

ZNF280B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri343 – 366C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri373 – 396C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri432 – 454C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 483C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 280B
Alternative name(s):
5'OY11.1
Suppressor of hairy wing homolog 2
Zinc finger protein 279
Zinc finger protein 632
Gene namesi
Name:ZNF280B
Synonyms:SUHW2, ZNF279, ZNF632
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000275004.3
HGNCiHGNC:23022 ZNF280B
neXtProtiNX_Q86YH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409948

Polymorphism and mutation databases

BioMutaiZNF280B
DMDMi313104081

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470561 – 543Zinc finger protein 280BAdd BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki247Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki261Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ86YH2
MaxQBiQ86YH2
PaxDbiQ86YH2
PeptideAtlasiQ86YH2
PRIDEiQ86YH2
ProteomicsDBi70414

PTM databases

iPTMnetiQ86YH2
PhosphoSitePlusiQ86YH2

Expressioni

Gene expression databases

BgeeiENSG00000275004 Expressed in 133 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZNF280B
ExpressionAtlasiQ86YH2 baseline and differential
GenevisibleiQ86YH2 HS

Organism-specific databases

HPAiHPA059519

Interactioni

Protein-protein interaction databases

BioGridi126751, 3 interactors
STRINGi9606.ENSP00000353586

Structurei

3D structure databases

ProteinModelPortaliQ86YH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri343 – 366C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri373 – 396C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri432 – 454C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 483C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000013047
HOVERGENiHBG060885
InParanoidiQ86YH2
OrthoDBiEOG091G01UE
PhylomeDBiQ86YH2
TreeFamiTF331707

Family and domain databases

InterProiView protein in InterPro
IPR025243 DUF4195
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF13836 DUF4195, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86YH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQSCEEEKE PEPQKNIQET KQVDDEDAEL IFVGVEHVNE DAELIFVGVT
60 70 80 90 100
SNSKPVVSNI LNRVTPGSWS RRKKYDHLRK DTARKLQPKS HETVTSEAVT
110 120 130 140 150
VLPASQLESR STDSPIIIEP LSKPDYRNSS PQVVPNNSSE LPSPLITFTD
160 170 180 190 200
SLHHPVSTAL SVGGINESPR VSKQLSTFEV NSINPKRAKL RDGIIEGNSS
210 220 230 240 250
ASFPSDTFHT MNTQQSTPSN NVHTSLSHVQ NGAPFPAAFP KDNIHFKPIN
260 270 280 290 300
TNLDRENELA KTDILSLTSQ NKTFDPKKEN PIVLLSDFYY GQHKGEGQPE
310 320 330 340 350
QKTHTTFKCL SCVKVLKNVK FMNHVKHHLE FEKQRNDSWE NHTTCQHCHR
360 370 380 390 400
QFPTPFQLQC HIENVHTAQE PSTVCKICEL SFETDQVLLQ HMKDHHKPGE
410 420 430 440 450
MPYVCQVCHY RSSVFADVET HFRTCHENTK NLLCPFCLKI FKTATPYMCH
460 470 480 490 500
YRGHWGKSAH QCSKCRLQFL TFKEKMEHKT QCHQMFKKPK QLEGLPPETK
510 520 530 540
VTIQVSLEPL QPGSVDVASI TVSTSDSEPS LPRSKSKISK KSH
Length:543
Mass (Da):61,584
Last modified:November 30, 2010 - v2
Checksum:iF39D795E8478DAD7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SEJ8A0A0D9SEJ8_HUMAN
Suppressor of hairy wing homolog 2 ...
ZNF280B SUHW2, hCG_1783609
543Annotation score:

Sequence cautioni

The sequence BAA20005 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028013256E → ACombined sources2 PublicationsCorresponds to variant dbSNP:rs2236729Ensembl.1
Natural variantiVAR_028014522V → G. Corresponds to variant dbSNP:rs12484816Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87009 Genomic DNA Translation: BAA20005.1 Different initiation.
CR456614 mRNA Translation: CAG30500.1
BC040020 mRNA Translation: AAH40020.1
CCDSiCCDS13799.1
RefSeqiNP_542942.2, NM_080764.3
XP_011528195.1, XM_011529893.2
XP_011528197.1, XM_011529895.2
XP_011528198.1, XM_011529896.2
XP_011528199.1, XM_011529897.2
UniGeneiHs.43834

Genome annotation databases

EnsembliENST00000613655; ENSP00000481008; ENSG00000275004
ENST00000619852; ENSP00000480958; ENSG00000275004
GeneIDi140883
KEGGihsa:140883
UCSCiuc032qhv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87009 Genomic DNA Translation: BAA20005.1 Different initiation.
CR456614 mRNA Translation: CAG30500.1
BC040020 mRNA Translation: AAH40020.1
CCDSiCCDS13799.1
RefSeqiNP_542942.2, NM_080764.3
XP_011528195.1, XM_011529893.2
XP_011528197.1, XM_011529895.2
XP_011528198.1, XM_011529896.2
XP_011528199.1, XM_011529897.2
UniGeneiHs.43834

3D structure databases

ProteinModelPortaliQ86YH2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126751, 3 interactors
STRINGi9606.ENSP00000353586

PTM databases

iPTMnetiQ86YH2
PhosphoSitePlusiQ86YH2

Polymorphism and mutation databases

BioMutaiZNF280B
DMDMi313104081

Proteomic databases

EPDiQ86YH2
MaxQBiQ86YH2
PaxDbiQ86YH2
PeptideAtlasiQ86YH2
PRIDEiQ86YH2
ProteomicsDBi70414

Protocols and materials databases

DNASUi140883
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000613655; ENSP00000481008; ENSG00000275004
ENST00000619852; ENSP00000480958; ENSG00000275004
GeneIDi140883
KEGGihsa:140883
UCSCiuc032qhv.2 human

Organism-specific databases

CTDi140883
EuPathDBiHostDB:ENSG00000275004.3
GeneCardsiZNF280B
HGNCiHGNC:23022 ZNF280B
HPAiHPA059519
neXtProtiNX_Q86YH2
PharmGKBiPA162409948
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000013047
HOVERGENiHBG060885
InParanoidiQ86YH2
OrthoDBiEOG091G01UE
PhylomeDBiQ86YH2
TreeFamiTF331707

Miscellaneous databases

ChiTaRSiZNF280B human
GenomeRNAii140883
PROiPR:Q86YH2

Gene expression databases

BgeeiENSG00000275004 Expressed in 133 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZNF280B
ExpressionAtlasiQ86YH2 baseline and differential
GenevisibleiQ86YH2 HS

Family and domain databases

InterProiView protein in InterPro
IPR025243 DUF4195
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF13836 DUF4195, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZ280B_HUMAN
AccessioniPrimary (citable) accession number: Q86YH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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