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Entry version 153 (11 Dec 2019)
Sequence version 4 (03 Sep 2014)
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Protein

Zinc finger protein 573

Gene

ZNF573

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri134 – 156C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri162 – 184C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri582 – 604C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri610 – 632C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri638 – 660C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 573
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF573
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000189144.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26420 ZNF573

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86YE8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000189144

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134883623

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86YE8 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF573

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811478

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002748771 – 665Zinc finger protein 573Add BLAST665

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86YE8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86YE8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86YE8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86YE8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86YE8

PeptideAtlas

More...
PeptideAtlasi
Q86YE8

PRoteomics IDEntifications database

More...
PRIDEi
Q86YE8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70406 [Q86YE8-1]
70407 [Q86YE8-2]
70408 [Q86YE8-3]
70409 [Q86YE8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86YE8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86YE8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000189144 Expressed in 228 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86YE8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86YE8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042776

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125967, 4 interactors

Protein interaction database and analysis system

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IntActi
Q86YE8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000440464

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86YE8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86YE8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 100KRABPROSITE-ProRule annotationAdd BLAST73

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 156C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri162 – 184C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri582 – 604C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri610 – 632C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri638 – 660C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163768

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86YE8

Identification of Orthologs from Complete Genome Data

More...
OMAi
VISYVEM

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

TreeFam database of animal gene trees

More...
TreeFami
TF341817

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 17 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPVLEPHQV GLIRSYNSKT MTCFQELVTF RDVAIDFSRQ EWEYLDPNQR
60 70 80 90 100
DLYRDVMLEN YRNLVSLGGH SISKPVVVDL LERGKEPWMI LREETQFTDL
110 120 130 140 150
DLQCEIISYI EVPTYETDIS STQLQSIYKR EKLYECKKCQ KKFSSGYQLI
160 170 180 190 200
LHHRFHVIER PYECKECGKN FRSGYQLTLH QRFHTGEKPY ECTECGKNFR
210 220 230 240 250
SGYQLTVHQR FHTGEKTYEC RQCGKAFIYA SHIVQHERIH TGGKPYECQE
260 270 280 290 300
CGRAFSQGGH LRIHQRVHTG EKPYKCKECG KTFSRRSNLV EHGQFHTDEK
310 320 330 340 350
PYICEKCGKA FRRGHQLTVH QRVHTGKKPY ECKECGKGYT TASYFLLHQR
360 370 380 390 400
IHKGGKPYEC KECKKTFTLY RNLTRHQNIH TGEKLFECKQ CGKTYTTGSK
410 420 430 440 450
LFQHQKTHTG EKPYECKECG KAFSLYGYLK QHQKIHTGMK HFECKECKKT
460 470 480 490 500
FTLYRNLTRH QNIHTGKKLF ECQECGKAYS TGSNLIQHRK THTGEKPYKC
510 520 530 540 550
KECGKTFSLH GYLNQHQKIH TGMKPYECKV CRKTFTFYRN LTLHQSIHTD
560 570 580 590 600
EKPFECKECG KTFRRSSHLT AHQSIHADKK PYECKECGKA FKMYGYLTQH
610 620 630 640 650
QKIHTGGKPY ECKECGKAFS RASNLVQHER IHTGEKPYVC KQCGKTFRYG
660
SALKAHQRIH RSIKV
Length:665
Mass (Da):78,181
Last modified:September 3, 2014 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3BC0CDF3ADD2241
GO
Isoform 2 (identifier: Q86YE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Show »
Length:577
Mass (Da):67,782
Checksum:i6C4035AEC4264743
GO
Isoform 3 (identifier: Q86YE8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MFPVLEPHQV...WMILREETQF → MESCSVAQAG...SCHSLQVAGI

Show »
Length:607
Mass (Da):70,843
Checksum:i3D334D27E866B5EB
GO
Isoform 4 (identifier: Q86YE8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     68-98: Missing.

Show »
Length:578
Mass (Da):67,866
Checksum:i43E2AE3301CA6BAF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EM14K7EM14_HUMAN
Zinc finger protein 573
ZNF573
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQQ2K7EQQ2_HUMAN
Zinc finger protein 573
ZNF573
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERS7K7ERS7_HUMAN
Zinc finger protein 573
ZNF573
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRV5A0A0A0MRV5_HUMAN
Zinc finger protein 573
ZNF573
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL03K7EL03_HUMAN
Zinc finger protein 573
ZNF573
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM47K7EM47_HUMAN
Zinc finger protein 573
ZNF573
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH42170 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti129K → E in BAB70929 (PubMed:14702039).Curated1
Sequence conflicti329P → L in BAB70929 (PubMed:14702039).Curated1
Sequence conflicti523M → V in AAH15418 (PubMed:15489334).Curated1
Sequence conflicti523M → V in AAH42170 (PubMed:15489334).Curated1
Sequence conflicti523M → V in AAH51263 (PubMed:15489334).Curated1
Sequence conflicti523M → V in AAH64962 (PubMed:15489334).Curated1
Sequence conflicti591F → L in BAC11047 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030356186G → A. Corresponds to variant dbSNP:rs3752365Ensembl.1
Natural variantiVAR_057426224G → A. Corresponds to variant dbSNP:rs3752365Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0228941 – 97MFPVL…EETQF → MESCSVAQAGVQWPDLSSLQ PPPPRFKQFSCHSLQVAGI in isoform 3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_0228951 – 88Missing in isoform 2. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0228961 – 56Missing in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_02289768 – 98Missing in isoform 4. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055483 mRNA Translation: BAB70929.1
AK074539 mRNA Translation: BAC11047.1
AC093227 Genomic DNA No translation available.
AC016582 Genomic DNA No translation available.
BC015418 mRNA Translation: AAH15418.1
BC042170 mRNA Translation: AAH42170.2 Different initiation.
BC051263 mRNA Translation: AAH51263.1
BC064962 mRNA Translation: AAH64962.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12508.1 [Q86YE8-3]
CCDS54260.1 [Q86YE8-2]
CCDS59381.1 [Q86YE8-1]

NCBI Reference Sequences

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RefSeqi
NP_001166160.1, NM_001172689.1 [Q86YE8-2]
NP_001166161.1, NM_001172690.1 [Q86YE8-1]
NP_001166162.1, NM_001172691.1
NP_001166163.1, NM_001172692.1 [Q86YE8-2]
NP_689573.3, NM_152360.3 [Q86YE8-3]
XP_016881769.1, XM_017026280.1
XP_016881770.1, XM_017026281.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000339503; ENSP00000340171; ENSG00000189144 [Q86YE8-3]
ENST00000357309; ENSP00000349861; ENSG00000189144 [Q86YE8-2]
ENST00000392138; ENSP00000375983; ENSG00000189144 [Q86YE8-4]
ENST00000536220; ENSP00000440464; ENSG00000189144 [Q86YE8-1]
ENST00000590414; ENSP00000465020; ENSG00000189144 [Q86YE8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
126231

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:126231

UCSC genome browser

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UCSCi
uc002ohe.3 human [Q86YE8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055483 mRNA Translation: BAB70929.1
AK074539 mRNA Translation: BAC11047.1
AC093227 Genomic DNA No translation available.
AC016582 Genomic DNA No translation available.
BC015418 mRNA Translation: AAH15418.1
BC042170 mRNA Translation: AAH42170.2 Different initiation.
BC051263 mRNA Translation: AAH51263.1
BC064962 mRNA Translation: AAH64962.1
CCDSiCCDS12508.1 [Q86YE8-3]
CCDS54260.1 [Q86YE8-2]
CCDS59381.1 [Q86YE8-1]
RefSeqiNP_001166160.1, NM_001172689.1 [Q86YE8-2]
NP_001166161.1, NM_001172690.1 [Q86YE8-1]
NP_001166162.1, NM_001172691.1
NP_001166163.1, NM_001172692.1 [Q86YE8-2]
NP_689573.3, NM_152360.3 [Q86YE8-3]
XP_016881769.1, XM_017026280.1
XP_016881770.1, XM_017026281.1

3D structure databases

SMRiQ86YE8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125967, 4 interactors
IntActiQ86YE8, 1 interactor
STRINGi9606.ENSP00000440464

PTM databases

iPTMnetiQ86YE8
PhosphoSitePlusiQ86YE8

Polymorphism and mutation databases

BioMutaiZNF573
DMDMi143811478

Proteomic databases

EPDiQ86YE8
jPOSTiQ86YE8
MassIVEiQ86YE8
MaxQBiQ86YE8
PaxDbiQ86YE8
PeptideAtlasiQ86YE8
PRIDEiQ86YE8
ProteomicsDBi70406 [Q86YE8-1]
70407 [Q86YE8-2]
70408 [Q86YE8-3]
70409 [Q86YE8-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
126231

Genome annotation databases

EnsembliENST00000339503; ENSP00000340171; ENSG00000189144 [Q86YE8-3]
ENST00000357309; ENSP00000349861; ENSG00000189144 [Q86YE8-2]
ENST00000392138; ENSP00000375983; ENSG00000189144 [Q86YE8-4]
ENST00000536220; ENSP00000440464; ENSG00000189144 [Q86YE8-1]
ENST00000590414; ENSP00000465020; ENSG00000189144 [Q86YE8-1]
GeneIDi126231
KEGGihsa:126231
UCSCiuc002ohe.3 human [Q86YE8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
126231
EuPathDBiHostDB:ENSG00000189144.13

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF573
HGNCiHGNC:26420 ZNF573
HPAiHPA042776
neXtProtiNX_Q86YE8
OpenTargetsiENSG00000189144
PharmGKBiPA134883623

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000163768
InParanoidiQ86YE8
OMAiVISYVEM
OrthoDBi1318335at2759
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF573 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
126231
PharosiQ86YE8 Tdark

Protein Ontology

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PROi
PR:Q86YE8
RNActiQ86YE8 protein

Gene expression databases

BgeeiENSG00000189144 Expressed in 228 organ(s), highest expression level in intestine
ExpressionAtlasiQ86YE8 baseline and differential
GenevisibleiQ86YE8 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 17 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN573_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86YE8
Secondary accession number(s): B7WPE1
, K7EJ45, Q6P1P1, Q7Z7Q3, Q8N2Q1, Q96BM3, Q96NH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: September 3, 2014
Last modified: December 11, 2019
This is version 153 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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