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UniProtKB - Q86YD7 (F90A1_HUMAN)

Entry version 112 (08 May 2019)
Sequence version 3 (24 Nov 2009)
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Protein

Protein FAM90A1

Gene

FAM90A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM90A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM90A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25526 FAM90A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613041 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86YD7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000171847

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671796

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAM90A1

Domain mapping of disease mutations (DMDM)

More...DMDMi		269849691

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002995921 – 464Protein FAM90A1Add BLAST464

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86YD7

PeptideAtlas

More...PeptideAtlasi		Q86YD7

PRoteomics IDEntifications database

More...PRIDEi		Q86YD7

ProteomicsDB human proteome resource

More...ProteomicsDBi		70405

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86YD7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86YD7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171847 Expressed in 82 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86YD7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86YD7 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		120442, 53 interactors

Protein interaction database and analysis system

More...IntActi		Q86YD7, 157 interactors

Molecular INTeraction database

More...MINTi		Q86YD7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000445418

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86YD7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM90 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410JA2C Eukaryota
ENOG4111A8B LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00910000144208

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000015373

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86YD7

Identification of Orthologs from Complete Genome Data

More...OMAi		CDYLRVA

Database of Orthologous Groups

More...OrthoDBi		791998at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86YD7

TreeFam database of animal gene trees

More...TreeFami		TF338572

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039213 FAM90
IPR041670 Znf-CCHC_6

The PANTHER Classification System

More...PANTHERi		PTHR16035 PTHR16035, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15288 zf-CCHC_6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86YD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMARRDPKPG AKRLVRAQTL QKQRRAPVGP RAPPPDEEDP RLKCKNCEAF 
        60         70         80         90        100
GHTARSTRCP MKCWKAALVP PNFGEKEGKE NLKPWKPQVE ANPGPLNKDK 
       110        120        130        140        150
GEKEERPRPQ DPQRKALLHI FSRKPPEKPL PNQKGSTESS DYLRVASGPM 
       160        170        180        190        200
PVHTTSKRPR VDPVLSDRSA TEMSDRGSVL ASLSPLRKAS LSSSSSLGPK 
       210        220        230        240        250
ERQTGAAADI PQTAVRHQGP EPLLVVKPTH SSPAGGCREV PQAASKTHGL 
       260        270        280        290        300
LQAVSPQAQD KRPAVTSQPC PPAATHSLGL GSNLSFGPGA KRSAPAPIQA 
       310        320        330        340        350
CLNFPKKPRL GPFQIPESAI QGGELGAPEN LQPPPAATEL GPRTSPQTGT 
       360        370        380        390        400
RTPAQVLSGD RQPPHSRPCL PTAQACTMSH HPAASHDGAQ PLRVLFRRLE 
       410        420        430        440        450
NGRWSSSLLT APSFHSPEKP GAFLAQSPHV SEKSEGPCVR VPPSVLYEDL 
       460 
QVPSSSEDSD SDLE
Length:464
Mass (Da):49,793
Last modified:November 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9E36FCEE5021250
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H7S5F5H7S5_HUMAN
Protein FAM90A1
FAM90A1
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti254 – 255VS → AR in AAH42608 (PubMed:15489334).Curated2
Sequence conflicti344T → TV in BAA91593 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060293123R → G2 PublicationsCorresponds to variant dbSNP:rs9738115Ensembl.1
Natural variantiVAR_057778234A → E1 PublicationCorresponds to variant dbSNP:rs9668582Ensembl.1
Natural variantiVAR_060294334P → L1 PublicationCorresponds to variant dbSNP:rs17855656Ensembl.1
Natural variantiVAR_060154343R → S. Corresponds to variant dbSNP:rs9668475Ensembl.1
Natural variantiVAR_060295348T → I3 PublicationsCorresponds to variant dbSNP:rs9668474Ensembl.1
Natural variantiVAR_060155410T → A. Corresponds to variant dbSNP:rs11044098Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK001270 mRNA Translation: BAA91593.1
AC092111 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88629.1
CH471116 Genomic DNA Translation: EAW88630.1
BC042608 mRNA Translation: AAH42608.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31738.1

NCBI Reference Sequences

More...RefSeqi		NP_001306911.1, NM_001319982.1
NP_060558.3, NM_018088.3
XP_011519021.1, XM_011520719.1
XP_016875036.1, XM_017019547.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000307435; ENSP00000307798; ENSG00000171847
ENST00000538603; ENSP00000445418; ENSG00000171847

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55138

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55138

UCSC genome browser

More...UCSCi		uc001quh.3 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001270 mRNA Translation: BAA91593.1
AC092111 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88629.1
CH471116 Genomic DNA Translation: EAW88630.1
BC042608 mRNA Translation: AAH42608.1
CCDSiCCDS31738.1
RefSeqiNP_001306911.1, NM_001319982.1
NP_060558.3, NM_018088.3
XP_011519021.1, XM_011520719.1
XP_016875036.1, XM_017019547.1

3D structure databases

SMRiQ86YD7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120442, 53 interactors
IntActiQ86YD7, 157 interactors
MINTiQ86YD7
STRINGi9606.ENSP00000445418

PTM databases

iPTMnetiQ86YD7
PhosphoSitePlusiQ86YD7

Polymorphism and mutation databases

BioMutaiFAM90A1
DMDMi269849691

Proteomic databases

PaxDbiQ86YD7
PeptideAtlasiQ86YD7
PRIDEiQ86YD7
ProteomicsDBi70405

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		55138
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307435; ENSP00000307798; ENSG00000171847
ENST00000538603; ENSP00000445418; ENSG00000171847
GeneIDi55138
KEGGihsa:55138
UCSCiuc001quh.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55138

GeneCards: human genes, protein and diseases

More...GeneCardsi		FAM90A1
HGNCiHGNC:25526 FAM90A1
MIMi613041 gene
neXtProtiNX_Q86YD7
OpenTargetsiENSG00000171847
PharmGKBiPA142671796

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410JA2C Eukaryota
ENOG4111A8B LUCA
GeneTreeiENSGT00910000144208
HOGENOMiHOG000015373
InParanoidiQ86YD7
OMAiCDYLRVA
OrthoDBi791998at2759
PhylomeDBiQ86YD7
TreeFamiTF338572

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55138

Protein Ontology

More...PROi		PR:Q86YD7

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171847 Expressed in 82 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ86YD7 baseline and differential
GenevisibleiQ86YD7 HS

Family and domain databases

InterProiView protein in InterPro
IPR039213 FAM90
IPR041670 Znf-CCHC_6
PANTHERiPTHR16035 PTHR16035, 1 hit
PfamiView protein in Pfam
PF15288 zf-CCHC_6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF90A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86YD7
Secondary accession number(s): D3DUU9, Q9NVZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 24, 2009
Last modified: May 8, 2019
This is version 112 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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