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UniProtKB - Q86YD7 (F90A1_HUMAN)

Entry version 123 (07 Apr 2021)
Sequence version 3 (24 Nov 2009)
Previous versions | rss
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Protein

Protein FAM90A1

Gene

FAM90A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86YD7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM90A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM90A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25526, FAM90A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613041, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86YD7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000171847.10

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000171847

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671796

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86YD7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAM90A1

Domain mapping of disease mutations (DMDM)

More...DMDMi		269849691

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002995921 – 464Protein FAM90A1Add BLAST464

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86YD7

PeptideAtlas

More...PeptideAtlasi		Q86YD7

PRoteomics IDEntifications database

More...PRIDEi		Q86YD7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70405

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86YD7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86YD7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171847, Expressed in right hemisphere of cerebellum and 102 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86YD7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86YD7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000171847, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q86YD7
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-6658203,EBI-11096309
ACTN3 [Q08043]3EBI-6658203,EBI-2880652
AKAP9 [Q6PJH3]3EBI-6658203,EBI-11745576
AMOTL2 [Q9Y2J4]3EBI-6658203,EBI-746752
ANKRD23 [Q86SG2]3EBI-6658203,EBI-5661893
ANKRD29 [Q8N6D5]3EBI-6658203,EBI-17439331
AP2M1 [Q96CW1]5EBI-6658203,EBI-297683
ARHGEF9 [O43307]3EBI-6658203,EBI-3447299
ARRDC3 [Q96B67]3EBI-6658203,EBI-2875665
BANP [Q8N9N5]3EBI-6658203,EBI-744695
BANP - isoform 2 [Q8N9N5-2]3EBI-6658203,EBI-11524452
BCAR1 [P56945]3EBI-6658203,EBI-702093
BEGAIN [Q9BUH8]3EBI-6658203,EBI-742722
BHLHB9 [Q6PI77]3EBI-6658203,EBI-11519926
BLZF1 [Q9H2G9]3EBI-6658203,EBI-2548012
CADPS [A2RRN7]3EBI-6658203,EBI-10179719
CALCOCO2 [Q13137]7EBI-6658203,EBI-739580
CARD9 - isoform 2 [Q9H257-2]3EBI-6658203,EBI-11530605
CCDC13 [Q8IYE1]3EBI-6658203,EBI-10961312
CCDC57 [Q2TAC2]3EBI-6658203,EBI-2808286
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-6658203,EBI-10961624
CCN3 [P48745]3EBI-6658203,EBI-3904822
CCNC [P24863]3EBI-6658203,EBI-395261
CCNL2 - isoform 5 [Q96S94-5]3EBI-6658203,EBI-12024864
CDR2 [Q01850]3EBI-6658203,EBI-1181367
CEP55 [Q53EZ4]6EBI-6658203,EBI-747776
CEP70 [Q8NHQ1]3EBI-6658203,EBI-739624
CEP72 [Q9P209]3EBI-6658203,EBI-739498
CEP76 [Q8TAP6]6EBI-6658203,EBI-742887
CHRDL2 - isoform 2 [Q6WN34-2]3EBI-6658203,EBI-12593838
COG6 [Q9Y2V7]5EBI-6658203,EBI-3866319
CYSRT1 [A8MQ03]3EBI-6658203,EBI-3867333
DTX3 [Q8N9I9]5EBI-6658203,EBI-2340258
DVL3 [Q92997]3EBI-6658203,EBI-739789
EFEMP2 [O95967]3EBI-6658203,EBI-743414
ENKD1 [Q9H0I2]3EBI-6658203,EBI-744099
EXOSC8 [Q96B26]6EBI-6658203,EBI-371922
FAM228A [Q86W67]3EBI-6658203,EBI-12958227
FHL3 [Q13643]7EBI-6658203,EBI-741101
FHL3 [Q96C98]3EBI-6658203,EBI-10229248
FLACC1 - isoform 2 [Q96Q35-2]3EBI-6658203,EBI-11533409
FLOT1 [O75955]3EBI-6658203,EBI-603643
FOSB [P53539]3EBI-6658203,EBI-2806743
FSD2 [A1L4K1]6EBI-6658203,EBI-5661036
FXR1 - isoform 2 [P51114-2]3EBI-6658203,EBI-11022345
FXR2 [P51116]3EBI-6658203,EBI-740459
FYN - isoform 3 [P06241-3]3EBI-6658203,EBI-10691738
GABPB1 [Q06547]3EBI-6658203,EBI-618165
GCSAML [Q5JQS6]3EBI-6658203,EBI-17857617
GNPTAB [Q3T906]3EBI-6658203,EBI-1104907
GOLGA2 [Q08379]8EBI-6658203,EBI-618309
GOPC [Q9HD26]3EBI-6658203,EBI-349832
GPSM1 - isoform 3 [Q86YR5-3]3EBI-6658203,EBI-10261098
GRIPAP1 [Q4V328]3EBI-6658203,EBI-717919
HAND2 - isoform 2 [P61296-2]3EBI-6658203,EBI-13086076
HMBOX1 [Q6NT76]3EBI-6658203,EBI-2549423
HOMER3 [Q9NSC5]3EBI-6658203,EBI-748420
HOOK2 - isoform 2 [Q96ED9-2]3EBI-6658203,EBI-10961706
HSF2BP [O75031]3EBI-6658203,EBI-7116203
ISY1 [Q9ULR0]3EBI-6658203,EBI-2557660
KANK2 [Q63ZY3]3EBI-6658203,EBI-2556193
KASH5 [Q8N6L0]3EBI-6658203,EBI-749265
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-6658203,EBI-14069005
KLHL12 [Q53G59]3EBI-6658203,EBI-740929
KPNA3 [O00505]3EBI-6658203,EBI-358297
KPNA6 [O60684]3EBI-6658203,EBI-359923
KRT31 [Q15323]6EBI-6658203,EBI-948001
KRT34 [O76011]3EBI-6658203,EBI-1047093
KRT38 [O76015]3EBI-6658203,EBI-1047263
KRT40 [Q6A162]6EBI-6658203,EBI-10171697
KRTAP1-1 [Q07627]3EBI-6658203,EBI-11959885
KRTAP10-8 [P60410]3EBI-6658203,EBI-10171774
LDOC1 [O95751]6EBI-6658203,EBI-740738
LHX6 [Q9UPM6]3EBI-6658203,EBI-10258746
LIMS1 - isoform 3 [P48059-3]3EBI-6658203,EBI-12864460
LMO2 - isoform 3 [P25791-3]5EBI-6658203,EBI-11959475
LNX1 [Q8TBB1]3EBI-6658203,EBI-739832
LRP2BP [Q9P2M1]3EBI-6658203,EBI-18273118
LZTS1 [Q9Y250]3EBI-6658203,EBI-1216080
LZTS2 [Q9BRK4]3EBI-6658203,EBI-741037
MAD1L1 [Q9Y6D9]3EBI-6658203,EBI-742610
MDFI [Q99750]3EBI-6658203,EBI-724076
MEIS3 - isoform 3 [Q99687-3]3EBI-6658203,EBI-18582591
MID2 - isoform 2 [Q9UJV3-2]6EBI-6658203,EBI-10172526
MIPOL1 [Q8TD10]3EBI-6658203,EBI-2548751
MLH1 [P40692]3EBI-6658203,EBI-744248
MORN3 [Q6PF18]3EBI-6658203,EBI-9675802
MSS51 [Q4VC12]3EBI-6658203,EBI-11599933
MTUS2 [Q5JR59]3EBI-6658203,EBI-742948
MTUS2 - isoform 2 [Q5JR59-3]3EBI-6658203,EBI-11522433
MYOG [P15173]3EBI-6658203,EBI-3906629
NDUFB7 [P17568]3EBI-6658203,EBI-1246238
NOTCH2NLC [P0DPK4]3EBI-6658203,EBI-22310682
NUDT21 [O43809]3EBI-6658203,EBI-355720
OVOL1 [O14753]3EBI-6658203,EBI-3917713
PBX1 [P40424]3EBI-6658203,EBI-301611
PBX2 [P40425]3EBI-6658203,EBI-348489
PDLIM7 [Q9NR12]3EBI-6658203,EBI-350517
PFDN5 [Q99471]3EBI-6658203,EBI-357275
PICK1 [Q9NRD5]3EBI-6658203,EBI-79165
PIH1D1 [Q9NWS0]5EBI-6658203,EBI-357318
PLAGL2 [Q9UPG8]3EBI-6658203,EBI-2876622
POF1B - isoform 1 [Q8WVV4-1]3EBI-6658203,EBI-11986735
PPP1R13B [Q96KQ4]3EBI-6658203,EBI-1105153
PRDM6 [Q9NQX0]3EBI-6658203,EBI-11320284
PRKAR1B [P31321]3EBI-6658203,EBI-2805516
PRR23B [Q6ZRT6]3EBI-6658203,EBI-12845180
PSTPIP1 [O43586]6EBI-6658203,EBI-1050964
RAB11FIP2 [Q7L804]3EBI-6658203,EBI-1049676
RABEP1 [Q15276]3EBI-6658203,EBI-447043
RBM48 [Q5RL73]3EBI-6658203,EBI-473821
REL - isoform 2 [Q04864-2]3EBI-6658203,EBI-10829018
RHOH [Q15669]3EBI-6658203,EBI-1244971
RINT1 [Q6NUQ1]3EBI-6658203,EBI-726876
ROPN1 [Q9HAT0]3EBI-6658203,EBI-1378139
RPRD1A - isoform 2 [Q96P16-3]3EBI-6658203,EBI-12840198
SH2B2 - isoform 2 [O14492-2]3EBI-6658203,EBI-19952306
SIAH1 [Q8IUQ4]3EBI-6658203,EBI-747107
SMAD3 [P84022]3EBI-6658203,EBI-347161
SMARCB1 - isoform B [Q12824-2]3EBI-6658203,EBI-358436
SNW1 [Q13573]3EBI-6658203,EBI-632715
SPRED1 [Q7Z699]3EBI-6658203,EBI-5235340
STAC3 [Q96MF2]6EBI-6658203,EBI-745680
STMN2 [Q93045]3EBI-6658203,EBI-714194
STX11 [O75558]3EBI-6658203,EBI-714135
TAX1BP1 [Q86VP1]3EBI-6658203,EBI-529518
TEPSIN [Q96N21]3EBI-6658203,EBI-11139477
TFIP11 [Q9UBB9]3EBI-6658203,EBI-1105213
TLE5 - isoform 2 [Q08117-2]3EBI-6658203,EBI-11741437
TRAF2 [Q12933]6EBI-6658203,EBI-355744
TRIB3 [Q96RU7]3EBI-6658203,EBI-492476
TRIM23 [P36406]6EBI-6658203,EBI-740098
TRIM27 [P14373]3EBI-6658203,EBI-719493
TRIM42 [Q8IWZ5]3EBI-6658203,EBI-5235829
TRIM54 [Q9BYV2]3EBI-6658203,EBI-2130429
TRIM69 - isoform 2 [Q86WT6-2]3EBI-6658203,EBI-11525489
TRIM9 [Q9C026]3EBI-6658203,EBI-720828
TRIML2 [Q8N7C3]3EBI-6658203,EBI-11059915
VRTN [Q9H8Y1]3EBI-6658203,EBI-12894399
VWC2 [Q2TAL6]3EBI-6658203,EBI-11957238
ZBTB14 [O43829]3EBI-6658203,EBI-10176632
ZBTB16 [Q05516]3EBI-6658203,EBI-711925
ZBTB7B - isoform 2 [O15156-2]3EBI-6658203,EBI-11522250
ZBTB8A [Q96BR9]3EBI-6658203,EBI-742740
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-6658203,EBI-14104088
ZMYND12 [Q9H0C1]3EBI-6658203,EBI-12030590
ZNF143 [P52747]3EBI-6658203,EBI-2849334
ZNF212 [Q9UDV6]8EBI-6658203,EBI-1640204
ZNF343 [Q6P1L6]3EBI-6658203,EBI-10252492
ZNF526 [Q8TF50]3EBI-6658203,EBI-11035148
ZNF581 [Q9P0T4]3EBI-6658203,EBI-745520
ZNF655 [Q8N720]3EBI-6658203,EBI-625509
ZNF688 [P0C7X2]3EBI-6658203,EBI-4395732
ZNF76 [P36508]3EBI-6658203,EBI-7254550
ZWINT [O95229]3EBI-6658203,EBI-1001132

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120442, 179 interactors

Protein interaction database and analysis system

More...IntActi		Q86YD7, 173 interactors

Molecular INTeraction database

More...MINTi		Q86YD7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000445418

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86YD7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86YD7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM90 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RU1C, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00910000144208

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_047915_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86YD7

Identification of Orthologs from Complete Genome Data

More...OMAi		EKSEAPC

Database of Orthologous Groups

More...OrthoDBi		791998at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86YD7

TreeFam database of animal gene trees

More...TreeFami		TF338572

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039213, FAM90
IPR041670, Znf-CCHC_6

The PANTHER Classification System

More...PANTHERi		PTHR16035, PTHR16035, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15288, zf-CCHC_6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86YD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMARRDPKPG AKRLVRAQTL QKQRRAPVGP RAPPPDEEDP RLKCKNCEAF 
        60         70         80         90        100
GHTARSTRCP MKCWKAALVP PNFGEKEGKE NLKPWKPQVE ANPGPLNKDK 
       110        120        130        140        150
GEKEERPRPQ DPQRKALLHI FSRKPPEKPL PNQKGSTESS DYLRVASGPM 
       160        170        180        190        200
PVHTTSKRPR VDPVLSDRSA TEMSDRGSVL ASLSPLRKAS LSSSSSLGPK 
       210        220        230        240        250
ERQTGAAADI PQTAVRHQGP EPLLVVKPTH SSPAGGCREV PQAASKTHGL 
       260        270        280        290        300
LQAVSPQAQD KRPAVTSQPC PPAATHSLGL GSNLSFGPGA KRSAPAPIQA 
       310        320        330        340        350
CLNFPKKPRL GPFQIPESAI QGGELGAPEN LQPPPAATEL GPRTSPQTGT 
       360        370        380        390        400
RTPAQVLSGD RQPPHSRPCL PTAQACTMSH HPAASHDGAQ PLRVLFRRLE 
       410        420        430        440        450
NGRWSSSLLT APSFHSPEKP GAFLAQSPHV SEKSEGPCVR VPPSVLYEDL 
       460 
QVPSSSEDSD SDLE
Length:464
Mass (Da):49,793
Last modified:November 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9E36FCEE5021250
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H7S5F5H7S5_HUMAN
Protein FAM90A1
FAM90A1
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti254 – 255VS → AR in AAH42608 (PubMed:15489334).Curated2
Sequence conflicti344T → TV in BAA91593 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060293123R → G2 PublicationsCorresponds to variant dbSNP:rs9738115Ensembl.1
Natural variantiVAR_057778234A → E1 PublicationCorresponds to variant dbSNP:rs9668582EnsemblClinVar.1
Natural variantiVAR_060294334P → L1 PublicationCorresponds to variant dbSNP:rs17855656Ensembl.1
Natural variantiVAR_060154343R → S. Corresponds to variant dbSNP:rs9668475Ensembl.1
Natural variantiVAR_060295348T → I3 PublicationsCorresponds to variant dbSNP:rs9668474Ensembl.1
Natural variantiVAR_060155410T → A. Corresponds to variant dbSNP:rs11044098Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK001270 mRNA Translation: BAA91593.1
AC092111 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88629.1
CH471116 Genomic DNA Translation: EAW88630.1
BC042608 mRNA Translation: AAH42608.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31738.1

NCBI Reference Sequences

More...RefSeqi		NP_001306911.1, NM_001319982.1
NP_060558.3, NM_018088.3
XP_011519021.1, XM_011520719.1
XP_016875036.1, XM_017019547.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000307435; ENSP00000307798; ENSG00000171847
ENST00000538603; ENSP00000445418; ENSG00000171847

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55138

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55138

UCSC genome browser

More...UCSCi		uc001quh.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001270 mRNA Translation: BAA91593.1
AC092111 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88629.1
CH471116 Genomic DNA Translation: EAW88630.1
BC042608 mRNA Translation: AAH42608.1
CCDSiCCDS31738.1
RefSeqiNP_001306911.1, NM_001319982.1
NP_060558.3, NM_018088.3
XP_011519021.1, XM_011520719.1
XP_016875036.1, XM_017019547.1

3D structure databases

SMRiQ86YD7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120442, 179 interactors
IntActiQ86YD7, 173 interactors
MINTiQ86YD7
STRINGi9606.ENSP00000445418

PTM databases

iPTMnetiQ86YD7
PhosphoSitePlusiQ86YD7

Genetic variation databases

BioMutaiFAM90A1
DMDMi269849691

Proteomic databases

PaxDbiQ86YD7
PeptideAtlasiQ86YD7
PRIDEiQ86YD7
ProteomicsDBi70405

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23050, 34 antibodies

The DNASU plasmid repository

More...DNASUi		55138

Genome annotation databases

EnsembliENST00000307435; ENSP00000307798; ENSG00000171847
ENST00000538603; ENSP00000445418; ENSG00000171847
GeneIDi55138
KEGGihsa:55138
UCSCiuc001quh.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55138

GeneCards: human genes, protein and diseases

More...GeneCardsi		FAM90A1
HGNCiHGNC:25526, FAM90A1
HPAiENSG00000171847, Tissue enhanced (brain)
MIMi613041, gene
neXtProtiNX_Q86YD7
OpenTargetsiENSG00000171847
PharmGKBiPA142671796
VEuPathDBiHostDB:ENSG00000171847.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RU1C, Eukaryota
GeneTreeiENSGT00910000144208
HOGENOMiCLU_047915_0_1_1
InParanoidiQ86YD7
OMAiEKSEAPC
OrthoDBi791998at2759
PhylomeDBiQ86YD7
TreeFamiTF338572

Enzyme and pathway databases

PathwayCommonsiQ86YD7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55138, 6 hits in 981 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM90A1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55138
PharosiQ86YD7, Tdark

Protein Ontology

More...PROi		PR:Q86YD7
RNActiQ86YD7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171847, Expressed in right hemisphere of cerebellum and 102 other tissues
ExpressionAtlasiQ86YD7, baseline and differential
GenevisibleiQ86YD7, HS

Family and domain databases

InterProiView protein in InterPro
IPR039213, FAM90
IPR041670, Znf-CCHC_6
PANTHERiPTHR16035, PTHR16035, 1 hit
PfamiView protein in Pfam
PF15288, zf-CCHC_6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF90A1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86YD7
Secondary accession number(s): D3DUU9, Q9NVZ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 24, 2009
Last modified: April 7, 2021
This is version 123 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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