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Protein

Transmembrane protein 25

Gene

TMEM25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 25
Gene namesi
Name:TMEM25
ORF Names:UNQ2531/PRO6030
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149582.15
HGNCiHGNC:25890 TMEM25
MIMi613934 gene
neXtProtiNX_Q86YD3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 232ExtracellularSequence analysisAdd BLAST206
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 366CytoplasmicSequence analysisAdd BLAST113

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi84866
OpenTargetsiENSG00000149582
PharmGKBiPA134919013

Polymorphism and mutation databases

BioMutaiTMEM25

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000001498427 – 366Transmembrane protein 25Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 107PROSITE-ProRule annotation
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86YD3
PeptideAtlasiQ86YD3
PRIDEiQ86YD3
ProteomicsDBi70400
70401 [Q86YD3-2]
70402 [Q86YD3-3]
70403 [Q86YD3-4]

PTM databases

iPTMnetiQ86YD3
PhosphoSitePlusiQ86YD3

Expressioni

Gene expression databases

BgeeiENSG00000149582 Expressed in 150 organ(s), highest expression level in cerebellum
CleanExiHS_TMEM25
ExpressionAtlasiQ86YD3 baseline and differential
GenevisibleiQ86YD3 HS

Organism-specific databases

HPAiHPA012163
HPA051562

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi124311, 89 interactors
IntActiQ86YD3, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ86YD3
SMRiQ86YD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 123Ig-likeAdd BLAST94

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF2Y Eukaryota
ENOG410ZNWF LUCA
GeneTreeiENSGT00390000003414
HOGENOMiHOG000261622
HOVERGENiHBG057137
InParanoidiQ86YD3
KOiK22652
PhylomeDBiQ86YD3
TreeFamiTF333068

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q86YD3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALPPGPAAL RHTLLLLPAL LSSGWGELEP QIDGQTWAER ALRENERHAF
60 70 80 90 100
TCRVAGGPGT PRLAWYLDGQ LQEASTSRLL SVGGEAFSGG TSTFTVTAHR
110 120 130 140 150
AQHELNCSLQ DPRSGRSANA SVILNVQFKP EIAQVGAKYQ EAQGPGLLVV
160 170 180 190 200
LFALVRANPP ANVTWIDQDG PVTVNTSDFL VLDAQNYPWL TNHTVQLQLR
210 220 230 240 250
SLAHNLSVVA TNDVGVTSAS LPAPGLLATR VEVPLLGIVV AAGLALGTLV
260 270 280 290 300
GFSTLVACLV CRKEKKTKGP SRHPSLISSD SNNLKLNNVR LPRENMSLPS
310 320 330 340 350
NLQLNDLTPD SRAVKPADRQ MAQNNSRPEL LDPEPGGLLT SQGFIRLPVL
360
GYIYRVSSVS SDEIWL
Length:366
Mass (Da):39,285
Last modified:June 1, 2003 - v1
Checksum:i82B06A7B55A10129
GO
Isoform 2 (identifier: Q86YD3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-268: Missing.

Show »
Length:322
Mass (Da):34,793
Checksum:i91F6B96B4D992B35
GO
Isoform 3 (identifier: Q86YD3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-128: GWGELEPQID...NASVILNVQF → V
     225-268: Missing.

Show »
Length:218
Mass (Da):23,526
Checksum:iDC027919F836EDA2
GO
Isoform 4 (identifier: Q86YD3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-366: FIRLPVLGYIYRVSSVSSDEIWL → RRNQDKDA

Show »
Length:351
Mass (Da):37,574
Checksum:iEC41C2A68831855A
GO
Isoform 5 (identifier: Q86YD3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-268: Missing.
     313-313: Missing.
     344-366: FIRLPVLGYIYRVSSVSSDEIWL → RRNQDKDA

Note: No experimental confirmation available.
Show »
Length:306
Mass (Da):33,011
Checksum:i49AA63E43E178145
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKP3E9PKP3_HUMAN
Transmembrane protein 25
TMEM25
381Annotation score:
E9PIE6E9PIE6_HUMAN
Transmembrane protein 25
TMEM25
167Annotation score:
H0YC87H0YC87_HUMAN
Transmembrane protein 25
TMEM25
200Annotation score:
E9PIT4E9PIT4_HUMAN
Transmembrane protein 25
TMEM25
168Annotation score:
E9PI73E9PI73_HUMAN
Transmembrane protein 25
TMEM25
138Annotation score:
E9PIR4E9PIR4_HUMAN
Transmembrane protein 25
TMEM25
170Annotation score:
E9PK88E9PK88_HUMAN
Transmembrane protein 25
TMEM25
40Annotation score:
E9PK43E9PK43_HUMAN
Transmembrane protein 25
TMEM25
49Annotation score:
H0YD63H0YD63_HUMAN
Transmembrane protein 25
TMEM25
194Annotation score:
E9PID6E9PID6_HUMAN
Transmembrane protein 25
TMEM25
37Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti277I → V in BAC11620 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03362325W → C. Corresponds to variant dbSNP:rs35915434Ensembl.1
Natural variantiVAR_021391342Q → R2 PublicationsCorresponds to variant dbSNP:rs12289253Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01293924 – 128GWGEL…LNVQF → V in isoform 3. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_012940225 – 268Missing in isoform 2, isoform 3 and isoform 5. 4 PublicationsAdd BLAST44
Alternative sequenceiVSP_045635313Missing in isoform 5. 1 Publication1
Alternative sequenceiVSP_012941344 – 366FIRLP…DEIWL → RRNQDKDA in isoform 4 and isoform 5. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358919 mRNA Translation: AAQ89278.1
AK027305 mRNA Translation: BAB55029.1
AK056325 mRNA Translation: BAB71151.1
AK292359 mRNA Translation: BAF85048.1
AK075437 mRNA Translation: BAC11620.1
EF445037 Genomic DNA Translation: ACA06084.1
EF445037 Genomic DNA Translation: ACA06085.1
EF445037 Genomic DNA Translation: ACA06086.1
EF445037 Genomic DNA Translation: ACA06087.1
AP000941 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67388.1
CH471065 Genomic DNA Translation: EAW67389.1
CH471065 Genomic DNA Translation: EAW67393.1
BC042896 mRNA Translation: AAH42896.1
BC051841 mRNA Translation: AAH51841.1
CCDSiCCDS44745.1 [Q86YD3-4]
CCDS44746.1 [Q86YD3-5]
CCDS44747.1 [Q86YD3-2]
CCDS44748.1 [Q86YD3-3]
CCDS8398.1 [Q86YD3-1]
RefSeqiNP_001137506.1, NM_001144034.1 [Q86YD3-2]
NP_001137507.1, NM_001144035.1 [Q86YD3-2]
NP_001137508.1, NM_001144036.1 [Q86YD3-3]
NP_001137509.1, NM_001144037.1 [Q86YD3-4]
NP_001137510.1, NM_001144038.1 [Q86YD3-5]
NP_001305684.1, NM_001318755.1
NP_001305686.1, NM_001318757.1
NP_116169.2, NM_032780.3 [Q86YD3-1]
XP_016873911.1, XM_017018422.1 [Q86YD3-1]
UniGeneiHs.564188

Genome annotation databases

EnsembliENST00000313236; ENSP00000315635; ENSG00000149582 [Q86YD3-1]
ENST00000354064; ENSP00000278959; ENSG00000149582 [Q86YD3-3]
ENST00000354284; ENSP00000346237; ENSG00000149582 [Q86YD3-4]
ENST00000359862; ENSP00000352924; ENSG00000149582 [Q86YD3-2]
ENST00000411589; ENSP00000411882; ENSG00000149582 [Q86YD3-2]
ENST00000442938; ENSP00000416071; ENSG00000149582 [Q86YD3-5]
ENST00000524725; ENSP00000431205; ENSG00000149582 [Q86YD3-2]
GeneIDi84866
KEGGihsa:84866
UCSCiuc001pth.4 human [Q86YD3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTMM25_HUMAN
AccessioniPrimary (citable) accession number: Q86YD3
Secondary accession number(s): A8K8J4
, B0YJA6, B0YJA7, B0YJA9, G5E9U4, Q6UW89, Q86UA7, Q8NBL5, Q96KA6, Q96MW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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