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Protein

Prostate tumor-overexpressed gene 1 protein

Gene

PTOV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.3 Publications

Caution

Despite sequence similarity to MED25, to date this protein has not been identified as a component of the Mediator complex.Curated

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate tumor-overexpressed gene 1 protein
Short name:
PTOV-1
Alternative name(s):
Activator interaction domain-containing protein 2
Gene namesi
Name:PTOV1
Synonyms:ACID2
ORF Names:PP642, UNQ6127/PRO20092
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104960.15
HGNCiHGNC:9632 PTOV1
MIMi610195 gene
neXtProtiNX_Q86YD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi53635
OpenTargetsiENSG00000104960
PharmGKBiPA33976

Polymorphism and mutation databases

BioMutaiPTOV1
DMDMi74762466

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049651 – 416Prostate tumor-overexpressed gene 1 proteinAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86YD1
MaxQBiQ86YD1
PaxDbiQ86YD1
PeptideAtlasiQ86YD1
PRIDEiQ86YD1
ProteomicsDBi70397
70398 [Q86YD1-2]
70399 [Q86YD1-3]

PTM databases

iPTMnetiQ86YD1
PhosphoSitePlusiQ86YD1

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine.1 Publication

Developmental stagei

Expressed at low levels in quiescent cells. Expression rises upon entry into S-phase.1 Publication

Inductioni

By testosterone.1 Publication

Gene expression databases

BgeeiENSG00000104960 Expressed in 232 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_PTOV1
ExpressionAtlasiQ86YD1 baseline and differential
GenevisibleiQ86YD1 HS

Organism-specific databases

HPAiHPA051812
HPA075125

Interactioni

Subunit structurei

May interact with CREBBP. Interacts with FLOT1.2 Publications

Protein-protein interaction databases

BioGridi119792, 26 interactors
IntActiQ86YD1, 11 interactors
MINTiQ86YD1
STRINGi9606.ENSP00000375717

Structurei

3D structure databases

ProteinModelPortaliQ86YD1
SMRiQ86YD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni184 – 416Interaction with FLOT11 PublicationAdd BLAST233

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IHD9 Eukaryota
ENOG410Z0HI LUCA
GeneTreeiENSGT00520000055653
HOGENOMiHOG000115777
HOVERGENiHBG108306
InParanoidiQ86YD1
OMAiELDCLTH
OrthoDBiEOG091G04LS
PhylomeDBiQ86YD1
TreeFamiTF329598

Family and domain databases

Gene3Di2.40.290.30, 2 hits
InterProiView protein in InterPro
IPR021394 Med25_PTOV
IPR038196 PTOV_dom_sf
PfamiView protein in Pfam
PF11232 Med25, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRPRRAPYR SGAGGPLGGR GRPPRPLVVR AVRSRSWPAS PRGPQPPRIR
60 70 80 90 100
ARSAPPMEGA RVFGALGPIG PSSPGLTLGG LAVSEHRLSN KLLAWSGVLE
110 120 130 140 150
WQEKRRPYSD STAKLKRTLP CQAYVNQGEN LETDQWPQKL IMQLIPQQLL
160 170 180 190 200
TTLGPLFRNS QLAQFHFTNR DCDSLKGLCR IMGNGFAGCM LFPHISPCEV
210 220 230 240 250
RVLMLLYSSK KKIFMGLIPY DQSGFVSAIR QVITTRKQAV GPGGVNSGPV
260 270 280 290 300
QIVNNKFLAW SGVMEWQEPR PEPNSRSKRW LPSHVYVNQG EILRTEQWPR
310 320 330 340 350
KLYMQLIPQQ LLTTLVPLFR NSRLVQFHFT KDLETLKSLC RIMDNGFAGC
360 370 380 390 400
VHFSYKASCE IRVLMLLYSS EKKIFIGLIP HDQGNFVNGI RRVIANQQQV
410
LQRNLEQEQQ QRGMGG
Length:416
Mass (Da):46,869
Last modified:June 1, 2003 - v1
Checksum:i888573E714E75180
GO
Isoform 2 (identifier: Q86YD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
     33-57: RSRSWPASPRGPQPPRIRARSAPPM → MRSPAVPTPARGQLGVAFVLLPPHS
     348-397: AGCVHFSYKA...NGIRRVIANQ → RRKSSLASSP...NEGWGGSGYP

Show »
Length:384
Mass (Da):42,777
Checksum:iE6E36282C1744757
GO
Isoform 3 (identifier: Q86YD1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: Missing.

Show »
Length:227
Mass (Da):26,145
Checksum:i2F3BF5F7F6F419F2
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QY25M0QY25_HUMAN
Prostate tumor-overexpressed gene 1...
PTOV1
384Annotation score:
A0A0C4DGR2A0A0C4DGR2_HUMAN
Prostate tumor overexpressed gene 1...
PTOV1 hCG_2039824
374Annotation score:
M0QYH7M0QYH7_HUMAN
Prostate tumor-overexpressed gene 1...
PTOV1
283Annotation score:
M0QZB9M0QZB9_HUMAN
Prostate tumor-overexpressed gene 1...
PTOV1
142Annotation score:
M0QYH6M0QYH6_HUMAN
Prostate tumor-overexpressed gene 1...
PTOV1
111Annotation score:
M0QYQ4M0QYQ4_HUMAN
Prostate tumor overexpressed gene 1...
PTOV1 hCG_2039824
237Annotation score:
M0QX53M0QX53_HUMAN
Prostate tumor-overexpressed gene 1...
PTOV1
42Annotation score:

Sequence cautioni

The sequence AAF70635 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0281531 – 189Missing in isoform 3. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_0281541 – 32Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_02815533 – 57RSRSW…SAPPM → MRSPAVPTPARGQLGVAFVL LPPHS in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_028156348 – 397AGCVH…VIANQ → RRKSSLASSPMTRATLSTAS GVSLPTSSRSCSGTWSRSNS NEGWGGSGYP in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238381 Genomic DNA Translation: AAF70635.1 Sequence problems.
AJ617480 mRNA Translation: CAE84582.1
AF218026 mRNA Translation: AAG17268.1
AY358168 mRNA Translation: AAQ88535.1
CH471177 Genomic DNA Translation: EAW52558.1
BC015172 mRNA Translation: AAH15172.1
BC042921 mRNA Translation: AAH42921.1
CCDSiCCDS12782.1 [Q86YD1-1]
RefSeqiNP_001292034.1, NM_001305105.1 [Q86YD1-1]
NP_001292037.1, NM_001305108.1
NP_059128.2, NM_017432.4 [Q86YD1-1]
UniGeneiHs.587979

Genome annotation databases

EnsembliENST00000391842; ENSP00000375717; ENSG00000104960 [Q86YD1-1]
ENST00000599732; ENSP00000469128; ENSG00000104960 [Q86YD1-1]
ENST00000601675; ENSP00000472816; ENSG00000104960 [Q86YD1-1]
GeneIDi53635
KEGGihsa:53635
UCSCiuc002pqb.5 human [Q86YD1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238381 Genomic DNA Translation: AAF70635.1 Sequence problems.
AJ617480 mRNA Translation: CAE84582.1
AF218026 mRNA Translation: AAG17268.1
AY358168 mRNA Translation: AAQ88535.1
CH471177 Genomic DNA Translation: EAW52558.1
BC015172 mRNA Translation: AAH15172.1
BC042921 mRNA Translation: AAH42921.1
CCDSiCCDS12782.1 [Q86YD1-1]
RefSeqiNP_001292034.1, NM_001305105.1 [Q86YD1-1]
NP_001292037.1, NM_001305108.1
NP_059128.2, NM_017432.4 [Q86YD1-1]
UniGeneiHs.587979

3D structure databases

ProteinModelPortaliQ86YD1
SMRiQ86YD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119792, 26 interactors
IntActiQ86YD1, 11 interactors
MINTiQ86YD1
STRINGi9606.ENSP00000375717

PTM databases

iPTMnetiQ86YD1
PhosphoSitePlusiQ86YD1

Polymorphism and mutation databases

BioMutaiPTOV1
DMDMi74762466

Proteomic databases

EPDiQ86YD1
MaxQBiQ86YD1
PaxDbiQ86YD1
PeptideAtlasiQ86YD1
PRIDEiQ86YD1
ProteomicsDBi70397
70398 [Q86YD1-2]
70399 [Q86YD1-3]

Protocols and materials databases

DNASUi53635
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391842; ENSP00000375717; ENSG00000104960 [Q86YD1-1]
ENST00000599732; ENSP00000469128; ENSG00000104960 [Q86YD1-1]
ENST00000601675; ENSP00000472816; ENSG00000104960 [Q86YD1-1]
GeneIDi53635
KEGGihsa:53635
UCSCiuc002pqb.5 human [Q86YD1-1]

Organism-specific databases

CTDi53635
DisGeNETi53635
EuPathDBiHostDB:ENSG00000104960.15
GeneCardsiPTOV1
HGNCiHGNC:9632 PTOV1
HPAiHPA051812
HPA075125
MIMi610195 gene
neXtProtiNX_Q86YD1
OpenTargetsiENSG00000104960
PharmGKBiPA33976
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHD9 Eukaryota
ENOG410Z0HI LUCA
GeneTreeiENSGT00520000055653
HOGENOMiHOG000115777
HOVERGENiHBG108306
InParanoidiQ86YD1
OMAiELDCLTH
OrthoDBiEOG091G04LS
PhylomeDBiQ86YD1
TreeFamiTF329598

Miscellaneous databases

ChiTaRSiPTOV1 human
GeneWikiiPTOV1
GenomeRNAii53635
PROiPR:Q86YD1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104960 Expressed in 232 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_PTOV1
ExpressionAtlasiQ86YD1 baseline and differential
GenevisibleiQ86YD1 HS

Family and domain databases

Gene3Di2.40.290.30, 2 hits
InterProiView protein in InterPro
IPR021394 Med25_PTOV
IPR038196 PTOV_dom_sf
PfamiView protein in Pfam
PF11232 Med25, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPTOV1_HUMAN
AccessioniPrimary (citable) accession number: Q86YD1
Secondary accession number(s): Q6UXX7
, Q96BU3, Q9HBN4, Q9NYL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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