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Entry version 139 (07 Apr 2021)
Sequence version 1 (01 Jun 2003)
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Protein

Prostate tumor-overexpressed gene 1 protein

Gene

PTOV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.3 Publications

Caution

Despite sequence similarity to MED25, to date this protein has not been identified as a component of the Mediator complex.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86YD1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostate tumor-overexpressed gene 1 protein
Short name:
PTOV-1
Alternative name(s):
Activator interaction domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTOV1
Synonyms:ACID2
ORF Names:PP642, UNQ6127/PRO20092
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9632, PTOV1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610195, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86YD1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000104960.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
53635

Open Targets

More...
OpenTargetsi
ENSG00000104960

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33976

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86YD1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTOV1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762466

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003049651 – 416Prostate tumor-overexpressed gene 1 proteinAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei53PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86YD1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86YD1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86YD1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86YD1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86YD1

PeptideAtlas

More...
PeptideAtlasi
Q86YD1

PRoteomics IDEntifications database

More...
PRIDEi
Q86YD1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70397 [Q86YD1-1]
70398 [Q86YD1-2]
70399 [Q86YD1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86YD1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86YD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at low levels in quiescent cells. Expression rises upon entry into S-phase.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By testosterone.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104960, Expressed in cerebellar hemisphere and 242 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86YD1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86YD1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000104960, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with CREBBP.

Interacts with FLOT1.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119792, 35 interactors

Protein interaction database and analysis system

More...
IntActi
Q86YD1, 18 interactors

Molecular INTeraction database

More...
MINTi
Q86YD1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375717

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86YD1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86YD1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni184 – 416Interaction with FLOT11 PublicationAdd BLAST233

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SS25, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161923

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_045342_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86YD1

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELDCLTH

Database of Orthologous Groups

More...
OrthoDBi
340324at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86YD1

TreeFam database of animal gene trees

More...
TreeFami
TF329598

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.290.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021394, Med25_PTOV
IPR038196, PTOV_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11232, Med25, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRPRRAPYR SGAGGPLGGR GRPPRPLVVR AVRSRSWPAS PRGPQPPRIR
60 70 80 90 100
ARSAPPMEGA RVFGALGPIG PSSPGLTLGG LAVSEHRLSN KLLAWSGVLE
110 120 130 140 150
WQEKRRPYSD STAKLKRTLP CQAYVNQGEN LETDQWPQKL IMQLIPQQLL
160 170 180 190 200
TTLGPLFRNS QLAQFHFTNR DCDSLKGLCR IMGNGFAGCM LFPHISPCEV
210 220 230 240 250
RVLMLLYSSK KKIFMGLIPY DQSGFVSAIR QVITTRKQAV GPGGVNSGPV
260 270 280 290 300
QIVNNKFLAW SGVMEWQEPR PEPNSRSKRW LPSHVYVNQG EILRTEQWPR
310 320 330 340 350
KLYMQLIPQQ LLTTLVPLFR NSRLVQFHFT KDLETLKSLC RIMDNGFAGC
360 370 380 390 400
VHFSYKASCE IRVLMLLYSS EKKIFIGLIP HDQGNFVNGI RRVIANQQQV
410
LQRNLEQEQQ QRGMGG
Length:416
Mass (Da):46,869
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i888573E714E75180
GO
Isoform 2 (identifier: Q86YD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
     33-57: RSRSWPASPRGPQPPRIRARSAPPM → MRSPAVPTPARGQLGVAFVLLPPHS
     348-397: AGCVHFSYKA...NGIRRVIANQ → RRKSSLASSP...NEGWGGSGYP

Show »
Length:384
Mass (Da):42,777
Checksum:iE6E36282C1744757
GO
Isoform 3 (identifier: Q86YD1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: Missing.

Show »
Length:227
Mass (Da):26,145
Checksum:i2F3BF5F7F6F419F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGR2A0A0C4DGR2_HUMAN
Prostate tumor overexpressed gene 1...
PTOV1 hCG_2039824
374Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYH7M0QYH7_HUMAN
Prostate tumor-overexpressed gene 1...
PTOV1
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY25M0QY25_HUMAN
Prostate tumor-overexpressed gene 1...
PTOV1
384Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZB9M0QZB9_HUMAN
Prostate tumor-overexpressed gene 1...
PTOV1
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYH6M0QYH6_HUMAN
Prostate tumor-overexpressed gene 1...
PTOV1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX53M0QX53_HUMAN
Prostate tumor-overexpressed gene 1...
PTOV1
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYQ4M0QYQ4_HUMAN
Prostate tumor overexpressed gene 1...
PTOV1 hCG_2039824
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF70635 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0281531 – 189Missing in isoform 3. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_0281541 – 32Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_02815533 – 57RSRSW…SAPPM → MRSPAVPTPARGQLGVAFVL LPPHS in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_028156348 – 397AGCVH…VIANQ → RRKSSLASSPMTRATLSTAS GVSLPTSSRSCSGTWSRSNS NEGWGGSGYP in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF238381 Genomic DNA Translation: AAF70635.1 Sequence problems.
AJ617480 mRNA Translation: CAE84582.1
AF218026 mRNA Translation: AAG17268.1
AY358168 mRNA Translation: AAQ88535.1
CH471177 Genomic DNA Translation: EAW52558.1
BC015172 mRNA Translation: AAH15172.1
BC042921 mRNA Translation: AAH42921.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12782.1 [Q86YD1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001292034.1, NM_001305105.1 [Q86YD1-1]
NP_001292037.1, NM_001305108.1
NP_059128.2, NM_017432.4 [Q86YD1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000391842; ENSP00000375717; ENSG00000104960 [Q86YD1-1]
ENST00000599732; ENSP00000469128; ENSG00000104960 [Q86YD1-1]
ENST00000601675; ENSP00000472816; ENSG00000104960 [Q86YD1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
53635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:53635

UCSC genome browser

More...
UCSCi
uc002pqb.5, human [Q86YD1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238381 Genomic DNA Translation: AAF70635.1 Sequence problems.
AJ617480 mRNA Translation: CAE84582.1
AF218026 mRNA Translation: AAG17268.1
AY358168 mRNA Translation: AAQ88535.1
CH471177 Genomic DNA Translation: EAW52558.1
BC015172 mRNA Translation: AAH15172.1
BC042921 mRNA Translation: AAH42921.1
CCDSiCCDS12782.1 [Q86YD1-1]
RefSeqiNP_001292034.1, NM_001305105.1 [Q86YD1-1]
NP_001292037.1, NM_001305108.1
NP_059128.2, NM_017432.4 [Q86YD1-1]

3D structure databases

SMRiQ86YD1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119792, 35 interactors
IntActiQ86YD1, 18 interactors
MINTiQ86YD1
STRINGi9606.ENSP00000375717

PTM databases

iPTMnetiQ86YD1
PhosphoSitePlusiQ86YD1

Genetic variation databases

BioMutaiPTOV1
DMDMi74762466

Proteomic databases

EPDiQ86YD1
jPOSTiQ86YD1
MassIVEiQ86YD1
MaxQBiQ86YD1
PaxDbiQ86YD1
PeptideAtlasiQ86YD1
PRIDEiQ86YD1
ProteomicsDBi70397 [Q86YD1-1]
70398 [Q86YD1-2]
70399 [Q86YD1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
18733, 126 antibodies

The DNASU plasmid repository

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DNASUi
53635

Genome annotation databases

EnsembliENST00000391842; ENSP00000375717; ENSG00000104960 [Q86YD1-1]
ENST00000599732; ENSP00000469128; ENSG00000104960 [Q86YD1-1]
ENST00000601675; ENSP00000472816; ENSG00000104960 [Q86YD1-1]
GeneIDi53635
KEGGihsa:53635
UCSCiuc002pqb.5, human [Q86YD1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
53635
DisGeNETi53635

GeneCards: human genes, protein and diseases

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GeneCardsi
PTOV1
HGNCiHGNC:9632, PTOV1
HPAiENSG00000104960, Low tissue specificity
MIMi610195, gene
neXtProtiNX_Q86YD1
OpenTargetsiENSG00000104960
PharmGKBiPA33976
VEuPathDBiHostDB:ENSG00000104960.15

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502SS25, Eukaryota
GeneTreeiENSGT00940000161923
HOGENOMiCLU_045342_0_0_1
InParanoidiQ86YD1
OMAiELDCLTH
OrthoDBi340324at2759
PhylomeDBiQ86YD1
TreeFamiTF329598

Enzyme and pathway databases

PathwayCommonsiQ86YD1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
53635, 3 hits in 957 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PTOV1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PTOV1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
53635
PharosiQ86YD1, Tbio

Protein Ontology

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PROi
PR:Q86YD1
RNActiQ86YD1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000104960, Expressed in cerebellar hemisphere and 242 other tissues
ExpressionAtlasiQ86YD1, baseline and differential
GenevisibleiQ86YD1, HS

Family and domain databases

Gene3Di2.40.290.30, 2 hits
InterProiView protein in InterPro
IPR021394, Med25_PTOV
IPR038196, PTOV_dom_sf
PfamiView protein in Pfam
PF11232, Med25, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTOV1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86YD1
Secondary accession number(s): Q6UXX7
, Q96BU3, Q9HBN4, Q9NYL1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2003
Last modified: April 7, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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