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UniProtKB - Q86YB8 (ERO1B_HUMAN)

Entry version 160 (25 May 2022)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
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Protein

ERO1-like protein beta

Gene

ERO1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.

2 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Glutathione may be required to regulate its activity in the endoplasmic reticulum.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei186FADBy similarity1
Binding sitei188FADBy similarity1
Binding sitei199FADBy similarity1
Binding sitei251FADBy similarity1
Binding sitei254FADBy similarity1
Binding sitei286FADBy similarity1
Binding sitei299FADBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
LigandFAD, Flavoprotein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86YB8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-264876, Insulin processing

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q86YB8

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q86YB8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ERO1-like protein beta (EC:1.8.4.-)
Short name:
ERO1-L-beta
Alternative name(s):
Endoplasmic reticulum oxidoreductase betaImported
Endoplasmic reticulum oxidoreductin-1-like protein B
Oxidoreductin-1-L-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERO1BImported
Synonyms:ERO1LB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14355, ERO1B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615437, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86YB8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000086619

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi90C → A: No effect on catalytic activity when DTT is used as an electron donor; when associated with A-95. Loss of catalytic activity when P4HB is used as an electron donor; when associated with A-95. 1 Publication1
Mutagenesisi95C → A: No effect on catalytic activity when DTT is used as an electron donor; when associated with A-90. Loss of catalytic activity when P4HB is used as an electron donor; when associated with A-90. 1 Publication1
Mutagenesisi100C → A: Slightly decrease in activity. Significant increased activity; when associated with A-130. 1 Publication1
Mutagenesisi130C → A: Small increase in activity. Significant increased activity; when associated with A-130. 1 Publication1
Mutagenesisi390C → A: Strong decrease in P4HB-binding. Efficient homodimerization with both wild-type and A-390 mutated protein. 1 Publication1
Mutagenesisi393C → A: Some decrease in P4HB-binding. Efficient homodimerization with wild-type protein. Loss of catalytic activity when DTT or P4HB are used as an electron donor; when associated with A-396. 2 Publications1
Mutagenesisi396C → A: Some decrease in P4HB-binding. Efficient homodimerization with wild-type protein, but loss of homodimerization with A-396 mutated protein. Loss of catalytic activity when DTT or P4HB are used as an electron donor; when associated with A-393. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		56605

Open Targets

More...OpenTargetsi		ENSG00000086619

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134918597

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86YB8, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01902, 1-Ethyl-Pyrrolidine-2,5-Dione
DB03147, Flavin adenine dinucleotide

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ERO1B

Domain mapping of disease mutations (DMDM)

More...DMDMi		116241353

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000841834 – 467ERO1-like protein betaAdd BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi81 ↔ 3901 Publication
Disulfide bondi90 ↔ 130Alternate1 Publication
Disulfide bondi90 ↔ 95Redox-active; alternate1 Publication
Disulfide bondi100 ↔ 2621 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi207 ↔ 2401 Publication
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi393 ↔ 396Redox-active1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.2 Publications
The Cys-90/Cys-95 and Cys-393/Cys-396 disulfide bonds constitute the redox-active center. The Cys-90/Cys-95 disulfide bond accepts electron from P4HB and funnel them to the active site disulfide Cys-393/Cys-396. The Cys-81/Cys-390 disulfide bond may be critical for structural stability. Two long-range disulfide bonds participate in loose feedback regulation. The Cys-90/Cys-130 disulfide bond may be the predominant regulatory switch to modulate the catalytic activity, while the Cys-100/Cys-262 disulfide bond may play an auxiliary regulatory role.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86YB8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86YB8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86YB8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86YB8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86YB8

PeptideAtlas

More...PeptideAtlasi		Q86YB8

PRoteomics IDEntifications database

More...PRIDEi		Q86YB8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4009
70394 [Q86YB8-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1226, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q86YB8, 4 sites, 3 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86YB8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86YB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enzyme-secreting cells (at protein level). Detected at low level in many other tissues.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by inducers of the unfolded protein response (UPR).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000086619, Expressed in body of pancreas and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86YB8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86YB8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000086619, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked. Heterodimer with ERO1A; disulfide-linked. Also detected as monomer. Homodimers may be somewhat less active than monomers.

Interacts with P4HB.

Interacts with ERP44.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121155, 51 interactors

Protein interaction database and analysis system

More...IntActi		Q86YB8, 21 interactors

Molecular INTeraction database

More...MINTi		Q86YB8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346635

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86YB8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q86YB8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86YB8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EROs family.Curated

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2608, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007753

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023061_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86YB8

Identification of Orthologs from Complete Genome Data

More...OMAi		RDYCVPD

Database of Orthologous Groups

More...OrthoDBi		1181226at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86YB8

TreeFam database of animal gene trees

More...TreeFami		TF314471

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007266, Ero1
IPR037192, ERO1-like_sf

The PANTHER Classification System

More...PANTHERi		PTHR12613, PTHR12613, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04137, ERO1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF017205, ERO1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF110019, SSF110019, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQGVRRAGA GQGVAAAVQL LVTLSFLRSV VEAQVTGVLD DCLCDIDSID 
        60         70         80         90        100
NFNTYKIFPK IKKLQERDYF RYYKVNLKRP CPFWAEDGHC SIKDCHVEPC 
       110        120        130        140        150
PESKIPVGIK AGHSNKYLKM ANNTKELEDC EQANKLGAIN STLSNQSKEA 
       160        170        180        190        200
FIDWARYDDS RDHFCELDDE RSPAAQYVDL LLNPERYTGY KGTSAWRVWN 
       210        220        230        240        250
SIYEENCFKP RSVYRPLNPL APSRGEDDGE SFYTWLEGLC LEKRVFYKLI 
       260        270        280        290        300
SGLHASINLH LCANYLLEET WGKPSWGPNI KEFKHRFDPV ETKGEGPRRL 
       310        320        330        340        350
KNLYFLYLIE LRALSKVAPY FERSIVDLYT GNAEEDADTK TLLLNIFQDT 
       360        370        380        390        400
KSFPMHFDEK SMFAGDKKGA KSLKEEFRLH FKNISRIMDC VGCDKCRLWG 
       410        420        430        440        450
KLQTQGLGTA LKILFSEKEI QKLPENSPSK GFQLTRQEIV ALLNAFGRLS 
       460 
TSIRDLQNFK VLLQHSR
Length:467
Mass (Da):53,543
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DA8753DDEE15314
GO
Isoform 2 (identifier: Q86YB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-466: Missing.

Show »
Length:144
Mass (Da):16,096
Checksum:i05408D9D015C85D8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A8I5KWQ1A0A8I5KWQ1_HUMAN
ERO1-like protein beta
ERO1B
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028012129D → V1 PublicationCorresponds to variant dbSNP:rs2477599Ensembl.1
Natural variantiVAR_019492465H → Q1 PublicationCorresponds to variant dbSNP:rs1055851Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056988144 – 466Missing in isoform 2. 1 PublicationAdd BLAST323

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF252538 mRNA Translation: AAF97547.1
AK293941 mRNA Translation: BAG57318.1
AL139162 Genomic DNA No translation available.
AL450309 Genomic DNA No translation available.
BC032823 mRNA Translation: AAH32823.2
BC044573 mRNA Translation: AAH44573.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31064.1 [Q86YB8-1]

NCBI Reference Sequences

More...RefSeqi		NP_063944.3, NM_019891.3 [Q86YB8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354619.10; ENSP00000346635.5; ENSG00000086619.15

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56605

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56605

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000354619.10; ENSP00000346635.5; NM_019891.4; NP_063944.3

UCSC genome browser

More...UCSCi		uc001hxt.4, human [Q86YB8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252538 mRNA Translation: AAF97547.1
AK293941 mRNA Translation: BAG57318.1
AL139162 Genomic DNA No translation available.
AL450309 Genomic DNA No translation available.
BC032823 mRNA Translation: AAH32823.2
BC044573 mRNA Translation: AAH44573.1
CCDSiCCDS31064.1 [Q86YB8-1]
RefSeqiNP_063944.3, NM_019891.3 [Q86YB8-1]

3D structure databases

AlphaFoldDBiQ86YB8
SMRiQ86YB8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121155, 51 interactors
IntActiQ86YB8, 21 interactors
MINTiQ86YB8
STRINGi9606.ENSP00000346635

Chemistry databases

DrugBankiDB01902, 1-Ethyl-Pyrrolidine-2,5-Dione
DB03147, Flavin adenine dinucleotide

PTM databases

GlyConnecti1226, 3 N-Linked glycans (1 site)
GlyGeniQ86YB8, 4 sites, 3 N-linked glycans (1 site)
iPTMnetiQ86YB8
PhosphoSitePlusiQ86YB8

Genetic variation databases

BioMutaiERO1B
DMDMi116241353

Proteomic databases

EPDiQ86YB8
jPOSTiQ86YB8
MassIVEiQ86YB8
MaxQBiQ86YB8
PaxDbiQ86YB8
PeptideAtlasiQ86YB8
PRIDEiQ86YB8
ProteomicsDBi4009
70394 [Q86YB8-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34698, 199 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		56605

Genome annotation databases

EnsembliENST00000354619.10; ENSP00000346635.5; ENSG00000086619.15
GeneIDi56605
KEGGihsa:56605
MANE-SelectiENST00000354619.10; ENSP00000346635.5; NM_019891.4; NP_063944.3
UCSCiuc001hxt.4, human [Q86YB8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56605
DisGeNETi56605

GeneCards: human genes, protein and diseases

More...GeneCardsi		ERO1B
HGNCiHGNC:14355, ERO1B
HPAiENSG00000086619, Tissue enhanced (pancreas)
MIMi615437, gene
neXtProtiNX_Q86YB8
OpenTargetsiENSG00000086619
PharmGKBiPA134918597
VEuPathDBiHostDB:ENSG00000086619

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2608, Eukaryota
GeneTreeiENSGT00390000007753
HOGENOMiCLU_023061_2_2_1
InParanoidiQ86YB8
OMAiRDYCVPD
OrthoDBi1181226at2759
PhylomeDBiQ86YB8
TreeFamiTF314471

Enzyme and pathway databases

PathwayCommonsiQ86YB8
ReactomeiR-HSA-264876, Insulin processing
SignaLinkiQ86YB8
SIGNORiQ86YB8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56605, 9 hits in 1073 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ERO1B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ERO1LB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56605
PharosiQ86YB8, Tbio

Protein Ontology

More...PROi		PR:Q86YB8
RNActiQ86YB8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000086619, Expressed in body of pancreas and 203 other tissues
ExpressionAtlasiQ86YB8, baseline and differential
GenevisibleiQ86YB8, HS

Family and domain databases

InterProiView protein in InterPro
IPR007266, Ero1
IPR037192, ERO1-like_sf
PANTHERiPTHR12613, PTHR12613, 1 hit
PfamiView protein in Pfam
PF04137, ERO1, 1 hit
PIRSFiPIRSF017205, ERO1, 1 hit
SUPFAMiSSF110019, SSF110019, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERO1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86YB8
Secondary accession number(s): B4DF57
, Q5T1H4, Q8IZ11, Q9NR62
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 17, 2006
Last modified: May 25, 2022
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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