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Entry version 143 (22 Apr 2020)
Sequence version 1 (01 Jun 2003)
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Protein

Histone-lysine N-methyltransferase KMT5C

Gene

KMT5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine (A-196) with an IC50 of 144 nM.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=21 µM for H4K20me01 Publication
  2. KM=16 µM for H4K20me11 Publication
  3. KM=0.5 µM for nucleosome1 Publication

    pH dependencei

    Optimum pH is 8.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei32S-adenosyl-L-methionineCombined sources1 Publication1
    Binding sitei121S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenCombined sources1 Publication1
    Binding sitei160S-adenosyl-L-methionine; via carbonyl oxygenCombined sources1 Publication1
    Binding sitei169S-adenosyl-L-methionineCombined sources1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi185ZincCombined sources1 Publication1
    Metal bindingi229ZincCombined sources1 Publication1
    Binding sitei230S-adenosyl-L-methionine; via amide nitrogenCombined sources1 Publication1
    Metal bindingi231ZincCombined sources1 Publication1
    Metal bindingi234ZincCombined sources1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionChromatin regulator, Methyltransferase, Repressor, Transferase
    Biological processTranscription, Transcription regulation
    LigandMetal-binding, S-adenosyl-L-methionine, Zinc

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-3214841 PKMTs methylate histone lysines

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase KMT5CCurated
    Alternative name(s):
    Lysine N-methyltransferase 5C
    Lysine-specific methyltransferase 5CImported
    Suppressor of variegation 4-20 homolog 2
    Short name:
    Su(var)4-20 homolog 2
    Short name:
    Suv4-20h2
    [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5BCurated (EC:2.1.1.3622 Publications)
    [histone H4]-lysine20 N-methyltransferase KMT5BCurated (EC:2.1.1.3611 Publication)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:KMT5CImported
    Synonyms:SUV420H2
    ORF Names:PP7130
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:28405 KMT5C

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    613198 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q86Y97

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Chromosome, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    84787

    Open Targets

    More...
    OpenTargetsi
    ENSG00000133247

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134934307

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q86Y97 Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2321644

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2718

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    KMT5C

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74727906

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002817931 – 462Histone-lysine N-methyltransferase KMT5CAdd BLAST462

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei416PhosphothreonineCombined sources1
    Modified residuei422PhosphothreonineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q86Y97

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q86Y97

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q86Y97

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q86Y97

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q86Y97

    PeptideAtlas

    More...
    PeptideAtlasi
    Q86Y97

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q86Y97

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    70387 [Q86Y97-1]
    70388 [Q86Y97-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q86Y97

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q86Y97

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000133247 Expressed in islet of Langerhans and 204 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q86Y97 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q86Y97 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000133247 Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (By similarity).

    Interacts with HP1 proteins CBX1, CBX3 and CBX5.

    Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity).

    By similarity

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    124257, 12 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q86Y97, 5 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q86Y97

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000255613

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q86Y97

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q86Y97 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1462
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q86Y97

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 218SETPROSITE-ProRule annotationAdd BLAST115

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni114 – 117S-adenosyl-L-methionine bindingCombined sources1 Publication4
    Regioni182 – 183S-adenosyl-L-methionine bindingCombined sources1 Publication2
    Regioni346 – 435Required for heterochromatin localizationBy similarityAdd BLAST90

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2589 Eukaryota
    ENOG410XPH8 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000161700

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_040002_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q86Y97

    KEGG Orthology (KO)

    More...
    KOi
    K11429

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    LHRWGGC

    Database of Orthologous Groups

    More...
    OrthoDBi
    236983at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q86Y97

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106433

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.10.1700, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR041938 Hist-Lys_N-MTase_N
    IPR025790 Hist-Lys_N-MTase_Suvar4-20
    IPR039977 KMT5B/KMT5C/SET9
    IPR001214 SET_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR12977 PTHR12977, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00856 SET, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00317 SET, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51570 SAM_MT43_SUVAR420_2, 1 hit
    PS50280 SET, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q86Y97-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGPDRVTARE LCENDDLATS LVLDPYLGFR THKMNVSPVP PLRRQQHLRS
    60 70 80 90 100
    ALETFLRQRD LEAAYRALTL GGWTARYFQS RGPRQEAALK THVYRYLRAF
    110 120 130 140 150
    LPESGFTILP CTRYSMETNG AKIVSTRAWK KNEKLELLVG CIAELREADE
    160 170 180 190 200
    GLLRAGENDF SIMYSTRKRS AQLWLGPAAF INHDCKPNCK FVPADGNAAC
    210 220 230 240 250
    VKVLRDIEPG DEVTCFYGEG FFGEKNEHCE CHTCERKGEG AFRTRPREPA
    260 270 280 290 300
    LPPRPLDKYQ LRETKRRLQQ GLDSGSRQGL LGPRACVHPS PLRRDPFCAA
    310 320 330 340 350
    CQPLRLPACS ARPDTSPLWL QWLPQPQPRV RPRKRRRPRP RRAPVLSTHH
    360 370 380 390 400
    AARVSLHRWG GCGPHCRLRG EALVALGQPP HARWAPQQDW HWARRYGLPY
    410 420 430 440 450
    VVRVDLRRLA PAPPATPAPA GTPGPILIPK QALAFAPFSP PKRLRLVVSH
    460
    GSIDLDVGGE EL
    Length:462
    Mass (Da):52,113
    Last modified:June 1, 2003 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6814F7BDFA109070
    GO
    Isoform 2 (identifier: Q86Y97-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         37-97: SPVPPLRRQQ...ALKTHVYRYL → RSIATSVPSC...QSCGRQMRGC
         98-462: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
    Show »
    Length:97
    Mass (Da):10,821
    Checksum:i8E4BE260BF16E819
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0D9SF94A0A0D9SF94_HUMAN
    Histone-lysine N-methyltransferase ...
    KMT5C SUV420H2, hCG_38236
    347Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH05842 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
    The sequence AAL55766 differs from that shown. Probable cloning artifact.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04394737 – 97SPVPP…VYRYL → RSIATSVPSCRKVALPSCPA RATPWRPTGPRSCPLVLGKR MRSWSCWWAALQSCGRQMRG C in isoform 2. 1 PublicationAdd BLAST61
    Alternative sequenceiVSP_04394898 – 462Missing in isoform 2. 1 PublicationAdd BLAST365

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AC020922 Genomic DNA No translation available.
    BC005842 mRNA Translation: AAH05842.1 Sequence problems.
    BC019313 mRNA Translation: AAH19313.1
    BC044889 mRNA Translation: AAH44889.1
    AF289582 mRNA Translation: AAL55766.1 Sequence problems.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS12922.1 [Q86Y97-1]

    NCBI Reference Sequences

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    RefSeqi
    NP_116090.2, NM_032701.3 [Q86Y97-1]
    XP_005259395.1, XM_005259338.3
    XP_006723505.1, XM_006723442.3
    XP_011525717.1, XM_011527415.2 [Q86Y97-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000255613; ENSP00000255613; ENSG00000133247 [Q86Y97-1]
    ENST00000445196; ENSP00000397296; ENSG00000133247 [Q86Y97-2]
    ENST00000592631; ENSP00000467499; ENSG00000133247 [Q86Y97-2]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    84787

    KEGG: Kyoto Encyclopedia of Genes and Genomes

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    KEGGi
    hsa:84787

    UCSC genome browser

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    UCSCi
    uc002qkj.5 human [Q86Y97-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC020922 Genomic DNA No translation available.
    BC005842 mRNA Translation: AAH05842.1 Sequence problems.
    BC019313 mRNA Translation: AAH19313.1
    BC044889 mRNA Translation: AAH44889.1
    AF289582 mRNA Translation: AAL55766.1 Sequence problems.
    CCDSiCCDS12922.1 [Q86Y97-1]
    RefSeqiNP_116090.2, NM_032701.3 [Q86Y97-1]
    XP_005259395.1, XM_005259338.3
    XP_006723505.1, XM_006723442.3
    XP_011525717.1, XM_011527415.2 [Q86Y97-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3RQ4X-ray1.80A2-248[»]
    SMRiQ86Y97
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi124257, 12 interactors
    IntActiQ86Y97, 5 interactors
    MINTiQ86Y97
    STRINGi9606.ENSP00000255613

    Chemistry databases

    BindingDBiQ86Y97
    ChEMBLiCHEMBL2321644
    GuidetoPHARMACOLOGYi2718

    PTM databases

    iPTMnetiQ86Y97
    PhosphoSitePlusiQ86Y97

    Polymorphism and mutation databases

    BioMutaiKMT5C
    DMDMi74727906

    Proteomic databases

    EPDiQ86Y97
    jPOSTiQ86Y97
    MassIVEiQ86Y97
    MaxQBiQ86Y97
    PaxDbiQ86Y97
    PeptideAtlasiQ86Y97
    PRIDEiQ86Y97
    ProteomicsDBi70387 [Q86Y97-1]
    70388 [Q86Y97-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    46420 60 antibodies

    Genome annotation databases

    EnsembliENST00000255613; ENSP00000255613; ENSG00000133247 [Q86Y97-1]
    ENST00000445196; ENSP00000397296; ENSG00000133247 [Q86Y97-2]
    ENST00000592631; ENSP00000467499; ENSG00000133247 [Q86Y97-2]
    GeneIDi84787
    KEGGihsa:84787
    UCSCiuc002qkj.5 human [Q86Y97-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    84787
    DisGeNETi84787

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    KMT5C
    HGNCiHGNC:28405 KMT5C
    HPAiENSG00000133247 Low tissue specificity
    MIMi613198 gene
    neXtProtiNX_Q86Y97
    OpenTargetsiENSG00000133247
    PharmGKBiPA134934307

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2589 Eukaryota
    ENOG410XPH8 LUCA
    GeneTreeiENSGT00940000161700
    HOGENOMiCLU_040002_0_0_1
    InParanoidiQ86Y97
    KOiK11429
    OMAiLHRWGGC
    OrthoDBi236983at2759
    PhylomeDBiQ86Y97
    TreeFamiTF106433

    Enzyme and pathway databases

    ReactomeiR-HSA-3214841 PKMTs methylate histone lysines

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    KMT5C human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    84787
    PharosiQ86Y97 Tchem

    Protein Ontology

    More...
    PROi
    PR:Q86Y97
    RNActiQ86Y97 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000133247 Expressed in islet of Langerhans and 204 other tissues
    ExpressionAtlasiQ86Y97 baseline and differential
    GenevisibleiQ86Y97 HS

    Family and domain databases

    Gene3Di1.10.10.1700, 1 hit
    InterProiView protein in InterPro
    IPR041938 Hist-Lys_N-MTase_N
    IPR025790 Hist-Lys_N-MTase_Suvar4-20
    IPR039977 KMT5B/KMT5C/SET9
    IPR001214 SET_dom
    PANTHERiPTHR12977 PTHR12977, 1 hit
    PfamiView protein in Pfam
    PF00856 SET, 1 hit
    SMARTiView protein in SMART
    SM00317 SET, 1 hit
    PROSITEiView protein in PROSITE
    PS51570 SAM_MT43_SUVAR420_2, 1 hit
    PS50280 SET, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKMT5C_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86Y97
    Secondary accession number(s): Q8WZ10, Q9BRZ6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: June 1, 2003
    Last modified: April 22, 2020
    This is version 143 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
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