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UniProtKB - Q86Y97 (KMT5C_HUMAN)

Entry version 153 (25 May 2022)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
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Protein

Histone-lysine N-methyltransferase KMT5C

Gene

KMT5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273).

In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869).

H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).

Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273).

May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine (A-196) with an IC50 of 144 nM.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=21 µM for H4K20me01 Publication
  2. KM=16 µM for H4K20me11 Publication
  3. KM=0.5 µM for nucleosome1 Publication

pH dependencei

Optimum pH is 8.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei32S-adenosyl-L-methionineCombined sources1 Publication1
Binding sitei121S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenCombined sources1 Publication1
Binding sitei160S-adenosyl-L-methionine; via carbonyl oxygenCombined sources1 Publication1
Binding sitei169S-adenosyl-L-methionineCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi185ZincCombined sources1 Publication1
Metal bindingi229ZincCombined sources1 Publication1
Binding sitei230S-adenosyl-L-methionine; via amide nitrogenCombined sources1 Publication1
Metal bindingi231ZincCombined sources1 Publication1
Metal bindingi234ZincCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.361, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86Y97

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214841, PKMTs methylate histone lysines

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q86Y97

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q86Y97

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase KMT5CCurated
Alternative name(s):
Lysine N-methyltransferase 5C
Lysine-specific methyltransferase 5CImported
Suppressor of variegation 4-20 homolog 2
Short name:
Su(var)4-20 homolog 2
Short name:
Suv4-20h2
[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5BCurated (EC:2.1.1.3622 Publications)
[histone H4]-lysine20 N-methyltransferase KMT5BCurated (EC:2.1.1.3611 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KMT5CImported
Synonyms:SUV420H2
ORF Names:PP7130
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28405, KMT5C

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613198, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86Y97

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000133247

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		84787

Open Targets

More...OpenTargetsi		ENSG00000133247

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134934307

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86Y97, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2321644

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2718

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KMT5C

Domain mapping of disease mutations (DMDM)

More...DMDMi		74727906

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002817931 – 462Histone-lysine N-methyltransferase KMT5CAdd BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei416PhosphothreonineCombined sources1
Modified residuei422PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86Y97

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86Y97

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86Y97

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86Y97

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86Y97

PeptideAtlas

More...PeptideAtlasi		Q86Y97

PRoteomics IDEntifications database

More...PRIDEi		Q86Y97

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70387 [Q86Y97-1]
70388 [Q86Y97-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86Y97

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86Y97

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000133247, Expressed in layer of synovial tissue and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86Y97, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86Y97, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000133247, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with HP1 proteins CBX1, CBX3 and CBX5.

Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124257, 38 interactors

Protein interaction database and analysis system

More...IntActi		Q86Y97, 30 interactors

Molecular INTeraction database

More...MINTi		Q86Y97

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000255613

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q86Y97

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86Y97, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q86Y97

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86Y97

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 218SETPROSITE-ProRule annotationAdd BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni114 – 117S-adenosyl-L-methionine bindingCombined sources1 Publication4
Regioni182 – 183S-adenosyl-L-methionine bindingCombined sources1 Publication2
Regioni325 – 348DisorderedSequence analysisAdd BLAST24
Regioni346 – 435Required for heterochromatin localizationBy similarityAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi329 – 346Basic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2589, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161700

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_040002_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86Y97

Identification of Orthologs from Complete Genome Data

More...OMAi		GGWTAHY

Database of Orthologous Groups

More...OrthoDBi		236983at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86Y97

TreeFam database of animal gene trees

More...TreeFami		TF106433

Family and domain databases

Conserved Domains Database

More...CDDi		cd19185, SET_KMT5C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.1700, 1 hit
2.170.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041938, Hist-Lys_N-MTase_N
IPR044425, KMT5C_SET
IPR001214, SET_dom
IPR046341, SET_dom_sf
IPR039977, Suv4-20/Set9
IPR025790, Suv4-20_animal

The PANTHER Classification System

More...PANTHERi		PTHR12977, PTHR12977, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82199, SSF82199, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51570, SAM_MT43_SUVAR420_2, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86Y97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPDRVTARE LCENDDLATS LVLDPYLGFR THKMNVSPVP PLRRQQHLRS 
        60         70         80         90        100
ALETFLRQRD LEAAYRALTL GGWTARYFQS RGPRQEAALK THVYRYLRAF 
       110        120        130        140        150
LPESGFTILP CTRYSMETNG AKIVSTRAWK KNEKLELLVG CIAELREADE 
       160        170        180        190        200
GLLRAGENDF SIMYSTRKRS AQLWLGPAAF INHDCKPNCK FVPADGNAAC 
       210        220        230        240        250
VKVLRDIEPG DEVTCFYGEG FFGEKNEHCE CHTCERKGEG AFRTRPREPA 
       260        270        280        290        300
LPPRPLDKYQ LRETKRRLQQ GLDSGSRQGL LGPRACVHPS PLRRDPFCAA 
       310        320        330        340        350
CQPLRLPACS ARPDTSPLWL QWLPQPQPRV RPRKRRRPRP RRAPVLSTHH 
       360        370        380        390        400
AARVSLHRWG GCGPHCRLRG EALVALGQPP HARWAPQQDW HWARRYGLPY 
       410        420        430        440        450
VVRVDLRRLA PAPPATPAPA GTPGPILIPK QALAFAPFSP PKRLRLVVSH 
       460 
GSIDLDVGGE EL
Length:462
Mass (Da):52,113
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6814F7BDFA109070
GO
Isoform 2 (identifier: Q86Y97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-97: SPVPPLRRQQ...ALKTHVYRYL → RSIATSVPSC...QSCGRQMRGC
     98-462: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:97
Mass (Da):10,821
Checksum:i8E4BE260BF16E819
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SF94A0A0D9SF94_HUMAN
[histone H4]-N-methyl-L-lysine20 N-...
KMT5C SUV420H2, hCG_38236
347Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH05842 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAL55766 differs from that shown. Probable cloning artifact.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04394737 – 97SPVPP…VYRYL → RSIATSVPSCRKVALPSCPA RATPWRPTGPRSCPLVLGKR MRSWSCWWAALQSCGRQMRG C in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_04394898 – 462Missing in isoform 2. 1 PublicationAdd BLAST365

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC020922 Genomic DNA No translation available.
BC005842 mRNA Translation: AAH05842.1 Sequence problems.
BC019313 mRNA Translation: AAH19313.1
BC044889 mRNA Translation: AAH44889.1
AF289582 mRNA Translation: AAL55766.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12922.1 [Q86Y97-1]

NCBI Reference Sequences

More...RefSeqi		NP_116090.2, NM_032701.3 [Q86Y97-1]
XP_005259395.1, XM_005259338.3
XP_006723505.1, XM_006723442.3
XP_011525717.1, XM_011527415.2 [Q86Y97-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000255613.8; ENSP00000255613.3; ENSG00000133247.14
ENST00000445196.5; ENSP00000397296.1; ENSG00000133247.14 [Q86Y97-2]
ENST00000592631.5; ENSP00000467499.1; ENSG00000133247.14 [Q86Y97-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84787

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84787

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000255613.8; ENSP00000255613.3; NM_032701.4; NP_116090.2

UCSC genome browser

More...UCSCi		uc002qkj.5, human [Q86Y97-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020922 Genomic DNA No translation available.
BC005842 mRNA Translation: AAH05842.1 Sequence problems.
BC019313 mRNA Translation: AAH19313.1
BC044889 mRNA Translation: AAH44889.1
AF289582 mRNA Translation: AAL55766.1 Sequence problems.
CCDSiCCDS12922.1 [Q86Y97-1]
RefSeqiNP_116090.2, NM_032701.3 [Q86Y97-1]
XP_005259395.1, XM_005259338.3
XP_006723505.1, XM_006723442.3
XP_011525717.1, XM_011527415.2 [Q86Y97-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RQ4X-ray1.80A2-248[»]
AlphaFoldDBiQ86Y97
SMRiQ86Y97
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124257, 38 interactors
IntActiQ86Y97, 30 interactors
MINTiQ86Y97
STRINGi9606.ENSP00000255613

Chemistry databases

BindingDBiQ86Y97
ChEMBLiCHEMBL2321644
GuidetoPHARMACOLOGYi2718

PTM databases

iPTMnetiQ86Y97
PhosphoSitePlusiQ86Y97

Genetic variation databases

BioMutaiKMT5C
DMDMi74727906

Proteomic databases

EPDiQ86Y97
jPOSTiQ86Y97
MassIVEiQ86Y97
MaxQBiQ86Y97
PaxDbiQ86Y97
PeptideAtlasiQ86Y97
PRIDEiQ86Y97
ProteomicsDBi70387 [Q86Y97-1]
70388 [Q86Y97-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q86Y97, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		46420, 80 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		84787

Genome annotation databases

EnsembliENST00000255613.8; ENSP00000255613.3; ENSG00000133247.14
ENST00000445196.5; ENSP00000397296.1; ENSG00000133247.14 [Q86Y97-2]
ENST00000592631.5; ENSP00000467499.1; ENSG00000133247.14 [Q86Y97-2]
GeneIDi84787
KEGGihsa:84787
MANE-SelectiENST00000255613.8; ENSP00000255613.3; NM_032701.4; NP_116090.2
UCSCiuc002qkj.5, human [Q86Y97-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84787
DisGeNETi84787

GeneCards: human genes, protein and diseases

More...GeneCardsi		KMT5C
HGNCiHGNC:28405, KMT5C
HPAiENSG00000133247, Low tissue specificity
MIMi613198, gene
neXtProtiNX_Q86Y97
OpenTargetsiENSG00000133247
PharmGKBiPA134934307
VEuPathDBiHostDB:ENSG00000133247

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2589, Eukaryota
GeneTreeiENSGT00940000161700
HOGENOMiCLU_040002_0_0_1
InParanoidiQ86Y97
OMAiGGWTAHY
OrthoDBi236983at2759
PhylomeDBiQ86Y97
TreeFamiTF106433

Enzyme and pathway databases

BRENDAi2.1.1.361, 2681
PathwayCommonsiQ86Y97
ReactomeiR-HSA-3214841, PKMTs methylate histone lysines
SignaLinkiQ86Y97
SIGNORiQ86Y97

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84787, 11 hits in 1090 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KMT5C, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84787
PharosiQ86Y97, Tchem

Protein Ontology

More...PROi		PR:Q86Y97
RNActiQ86Y97, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000133247, Expressed in layer of synovial tissue and 221 other tissues
ExpressionAtlasiQ86Y97, baseline and differential
GenevisibleiQ86Y97, HS

Family and domain databases

CDDicd19185, SET_KMT5C, 1 hit
Gene3Di1.10.10.1700, 1 hit
2.170.270.10, 1 hit
InterProiView protein in InterPro
IPR041938, Hist-Lys_N-MTase_N
IPR044425, KMT5C_SET
IPR001214, SET_dom
IPR046341, SET_dom_sf
IPR039977, Suv4-20/Set9
IPR025790, Suv4-20_animal
PANTHERiPTHR12977, PTHR12977, 1 hit
PfamiView protein in Pfam
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM00317, SET, 1 hit
SUPFAMiSSF82199, SSF82199, 1 hit
PROSITEiView protein in PROSITE
PS51570, SAM_MT43_SUVAR420_2, 1 hit
PS50280, SET, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKMT5C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86Y97
Secondary accession number(s): Q8WZ10, Q9BRZ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2003
Last modified: May 25, 2022
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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