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Protein

Kinesin-like protein KIF18B

Gene

KIF18B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.2 Publications

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 125ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • kinesin binding Source: UniProtKB
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: GO_Central
  • motor activity Source: UniProtKB

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • microtubule-based movement Source: GO_Central
  • microtubule depolymerization Source: UniProtKB
  • mitotic cell cycle Source: UniProtKB
  • mitotic sister chromatid segregation Source: GO_Central
  • regulation of cell division Source: UniProtKB

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF18B
Gene namesi
Name:KIF18B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000186185.13
HGNCiHGNC:27102 KIF18B
MIMi614570 gene
neXtProtiNX_Q86Y91

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi146909
OpenTargetsiENSG00000186185

Polymorphism and mutation databases

BioMutaiKIF18B
DMDMi325511395

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189691 – 864Kinesin-like protein KIF18BAdd BLAST864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei413PhosphoserineCombined sources1
Modified residuei438PhosphothreonineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Modified residuei645PhosphoserineCombined sources1
Modified residuei651PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei686PhosphothreonineCombined sources1
Modified residuei834PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86Y91
MaxQBiQ86Y91
PaxDbiQ86Y91
PeptideAtlasiQ86Y91
PRIDEiQ86Y91
ProteomicsDBi70383
70384 [Q86Y91-2]
70385 [Q86Y91-3]
70386 [Q86Y91-4]

PTM databases

iPTMnetiQ86Y91
PhosphoSitePlusiQ86Y91

Expressioni

Tissue specificityi

Shows a prominent expression in the amygdala.1 Publication

Developmental stagei

Regulated in a cell cycle-dependent manner. Not expressed in the G1 phase. In G2, sequestered in the nucleus. Maximal levels seen at late G2/M phase and early prometaphase. Degraded at the metaphase-anaphase transition (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000186185
CleanExiHS_KIF18B
ExpressionAtlasiQ86Y91 baseline and differential

Organism-specific databases

HPAiHPA024205

Interactioni

Subunit structurei

Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MAPRE1Q156913EBI-10965357,EBI-1004115

GO - Molecular functioni

  • kinesin binding Source: UniProtKB
  • microtubule binding Source: InterPro

Protein-protein interaction databases

BioGridi127024, 24 interactors
IntActiQ86Y91, 9 interactors
STRINGi9606.ENSP00000341466

Structurei

3D structure databases

ProteinModelPortaliQ86Y91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 360Kinesin motorPROSITE-ProRule annotationAdd BLAST345

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni723 – 748KIF2C-bindingAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili375 – 402Sequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi636 – 644Nuclear localization signalCurated9
Motifi665 – 668MAPRE1-binding4
Motifi786 – 789MAPRE1-binding4
Motifi812 – 815MAPRE1-binding4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi405 – 445Pro-richAdd BLAST41

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0242 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00920000148953
HOGENOMiHOG000231436
HOVERGENiHBG108062
InParanoidiQ86Y91
PhylomeDBiQ86Y91

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86Y91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHPGVTTVM AVEDSTLQVV VRVRPPTPRE LDSQRRPVVQ VVDERVLVFN
60 70 80 90 100
PEEPDGGFPG LKWGGTHDGP KKKGKDLTFV FDRVFGEAAT QQDVFQHTTH
110 120 130 140 150
SVLDSFLQGY NCSVFAYGAT GAGKTHTMLG REGDPGIMYL TTVELYRRLE
160 170 180 190 200
ARQQEKHFEV LISYQEVYNE QIHDLLEPKG PLAIREDPDK GVVVQGLSFH
210 220 230 240 250
QPASAEQLLE ILTRGNRNRT QHPTDANATS SRSHAIFQIF VKQQDRVPGL
260 270 280 290 300
TQAVQVAKMS LIDLAGSERA SSTHAKGERL REGANINRSL LALINVLNAL
310 320 330 340 350
ADAKGRKTHV PYRDSKLTRL LKDSLGGNCR TVMIAAISPS SLTYEDTYNT
360 370 380 390 400
LKYADRAKEI RLSLKSNVTS LDCHISQYAT ICQQLQAEVA ALRKKLQVYE
410 420 430 440 450
GGGQPPPQDL PGSPKSGPPP EHLPSSPLPP HPPSQPCTPE LPAGPRALQE
460 470 480 490 500
ESLGMEAQVE RAMEGNSSDQ EQSPEDEDEG PAEEVPTQMP EQNPTHALPE
510 520 530 540 550
SPRLTLQPKP VVGHFSAREL DGDRSKQLAL KVLCVAQRQY SLLQAANLLT
560 570 580 590 600
PDMITEFETL QQLVQEEKIE PGAEALRTSG LARGAPLAQE LCSESKPPGY
610 620 630 640 650
TGPVTRTMAR RLSGPLHTLG IPPGPNCTPA QGSRWPMEKK RRRPSALEAD
660 670 680 690 700
SPMAPKRGTK RQRQSFLPCL RRGSLPDTQP SQGPSTPKGE RASSPCHSPR
710 720 730 740 750
VCPATVIKSR VPLGPSAMQN CSTPLALPTR DLNATFDLSE EPPSKPSFHE
760 770 780 790 800
CIGWDKIPQE LSRLDQPFIP RAPVPLFTMK GPKPTSSLPG TSACKKKRVA
810 820 830 840 850
SSSVSHGRSR IARLPSSTLK RPAGPLVLPE LPLSPLCPSN RRNGKDLIRV
860
GRALSAGNGV TKVS
Length:864
Mass (Da):94,223
Last modified:March 8, 2011 - v3
Checksum:iEC1A26D345B8BFB1
GO
Isoform 2 (identifier: Q86Y91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-596: K → IPVPSPLCPE
     830-833: ELPL → GDWH
     834-864: Missing.

Note: No experimental confirmation available.
Show »
Length:842
Mass (Da):91,965
Checksum:i1E24BBDD57D8A255
GO
Isoform 3 (identifier: Q86Y91-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-434: Missing.
     596-596: K → IPVPSPLCPE

Show »
Length:861
Mass (Da):93,921
Checksum:iB19CFE7979A60F92
GO
Isoform 4 (identifier: Q86Y91-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-596: K → IPVPSPLCPE

Show »
Length:873
Mass (Da):95,128
Checksum:i07F8B6B01D35B435
GO

Sequence cautioni

The sequence AAI36591 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI44272 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038925527Q → R. Corresponds to variant dbSNP:rs17546822Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040705423 – 434Missing in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_040706596K → IPVPSPLCPE in isoform 2, isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_040707830 – 833ELPL → GDWH in isoform 2. 2 Publications4
Alternative sequenceiVSP_040708834 – 864Missing in isoform 2. 2 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU808359 mRNA Translation: ADE43428.1
AC015936 Genomic DNA No translation available.
BC044933 mRNA Translation: AAH44933.1
BC136590 mRNA Translation: AAI36591.1 Different initiation.
BC144271 mRNA Translation: AAI44272.1 Different initiation.
RefSeqiNP_001251503.1, NM_001264573.1
NP_001252506.1, NM_001265577.1
UniGeneiHs.135094

Genome annotation databases

EnsembliENST00000590129; ENSP00000465501; ENSG00000186185 [Q86Y91-2]
GeneIDi146909
KEGGihsa:146909
UCSCiuc010wjh.4 human [Q86Y91-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKI18B_HUMAN
AccessioniPrimary (citable) accession number: Q86Y91
Secondary accession number(s): A6NJI2
, B7ZM49, B9EGM8, D5L6I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 8, 2011
Last modified: July 18, 2018
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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