UniProtKB - Q86Y91 (KI18B_HUMAN)
Kinesin-like protein KIF18B
KIF18B
Functioni
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 109 – 116 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: GO_Central
- cytoskeletal motor activity Source: UniProtKB
- kinesin binding Source: UniProtKB
- microtubule binding Source: GO_Central
- microtubule motor activity Source: GO_Central
- plus-end-directed microtubule motor activity Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- microtubule-based movement Source: GO_Central
- microtubule depolymerization Source: UniProtKB
- mitotic cell cycle Source: UniProtKB
- mitotic sister chromatid segregation Source: GO_Central
- regulation of cell division Source: UniProtKB
Keywordsi
Molecular function | Motor protein |
Biological process | Cell cycle, Cell division, Mitosis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q86Y91 |
Reactomei | R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189, Kinesins |
SignaLinki | Q86Y91 |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like protein KIF18B |
Gene namesi | Name:KIF18B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27102, KIF18B |
MIMi | 614570, gene |
neXtProti | NX_Q86Y91 |
VEuPathDBi | HostDB:ENSG00000186185 |
Subcellular locationi
Cytoplasm and Cytosol
Cytoskeleton
Nucleus
Note: Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase.
Cytoskeleton
- astral microtubule Source: UniProtKB
- kinesin complex Source: GO_Central
- microtubule Source: GO_Central
- microtubule end Source: HPA
- microtubule plus-end Source: UniProtKB
- mitotic spindle astral microtubule Source: GO_Central
- mitotic spindle midzone Source: GO_Central
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Microtubule, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 146909 |
OpenTargetsi | ENSG00000186185 |
Miscellaneous databases
Pharosi | Q86Y91, Tbio |
Genetic variation databases
BioMutai | KIF18B |
DMDMi | 325511395 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318969 | 1 – 852 | Kinesin-like protein KIF18BAdd BLAST | 852 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 404 | PhosphoserineCombined sources | 1 | |
Modified residuei | 417 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 452 | PhosphoserineCombined sources | 1 | |
Modified residuei | 480 | PhosphoserineCombined sources | 1 | |
Modified residuei | 558 | PhosphoserineCombined sources | 1 | |
Modified residuei | 633 | PhosphoserineCombined sources | 1 | |
Modified residuei | 639 | PhosphoserineCombined sources | 1 | |
Modified residuei | 662 | PhosphoserineCombined sources | 1 | |
Modified residuei | 674 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 822 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q86Y91 |
jPOSTi | Q86Y91 |
MassIVEi | Q86Y91 |
MaxQBi | Q86Y91 |
PaxDbi | Q86Y91 |
PeptideAtlasi | Q86Y91 |
PRIDEi | Q86Y91 |
PTM databases
GlyGeni | Q86Y91, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q86Y91 |
PhosphoSitePlusi | Q86Y91 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000186185, Expressed in ventricular zone and 147 other tissues |
ExpressionAtlasi | Q86Y91, baseline and differential |
Organism-specific databases
HPAi | ENSG00000186185, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends.
Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.
1 PublicationGO - Molecular functioni
- kinesin binding Source: UniProtKB
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 127024, 55 interactors |
IntActi | Q86Y91, 19 interactors |
MINTi | Q86Y91 |
STRINGi | 9606.ENSP00000465992 |
Miscellaneous databases
RNActi | Q86Y91, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 351 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 345 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 390 – 424 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 437 – 485 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 575 – 594 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 602 – 689 | DisorderedSequence analysisAdd BLAST | 88 | |
Regioni | 711 – 736 | KIF2C-bindingAdd BLAST | 26 | |
Regioni | 767 – 798 | DisorderedSequence analysisAdd BLAST | 32 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 366 – 393 | Sequence analysisAdd BLAST | 28 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 624 – 632 | Nuclear localization signalCurated | 9 | |
Motifi | 653 – 656 | MAPRE1-binding | 4 | |
Motifi | 774 – 777 | MAPRE1-binding | 4 | |
Motifi | 800 – 803 | MAPRE1-binding | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 398 – 418 | Pro residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 449 – 463 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 663 – 680 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 772 – 798 | Polar residuesSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0242, Eukaryota |
GeneTreei | ENSGT00940000161200 |
HOGENOMi | CLU_001485_21_5_1 |
InParanoidi | Q86Y91 |
OMAi | HQEEKRF |
OrthoDBi | 703086at2759 |
PhylomeDBi | Q86Y91 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVEDSTLQV VVRVRPPTPR ELDSQRRPVV QVVDERVLVF NPEEPDGGFP
60 70 80 90 100
GLKWGGTHDG PKKKGKDLTF VFDRVFGEAA TQQDVFQHTT HSVLDSFLQG
110 120 130 140 150
YNCSVFAYGA TGAGKTHTML GREGDPGIMY LTTVELYRRL EARQQEKHFE
160 170 180 190 200
VLISYQEVYN EQIHDLLEPK GPLAIREDPD KGVVVQGLSF HQPASAEQLL
210 220 230 240 250
EILTRGNRNR TQHPTDANAT SSRSHAIFQI FVKQQDRVPG LTQAVQVAKM
260 270 280 290 300
SLIDLAGSER ASSTHAKGER LREGANINRS LLALINVLNA LADAKGRKTH
310 320 330 340 350
VPYRDSKLTR LLKDSLGGNC RTVMIAAISP SSLTYEDTYN TLKYADRAKE
360 370 380 390 400
IRLSLKSNVT SLDCHISQYA TICQQLQAEV AALRKKLQVY EGGGQPPPQD
410 420 430 440 450
LPGSPKSGPP PEHQPCTPEL PAGPRALQEE SLGMEAQVER AMEGNSSDQE
460 470 480 490 500
QSPEDEDEGP AEEVPTQMPE QNPTHALPES PRLTLQPKPV VGHFSARELD
510 520 530 540 550
GDRSKQLALK VLCVAQRQYS LLQAANLLTP DMITEFETLQ QLVQEEKIEP
560 570 580 590 600
GAEALRTSGL ARGAPLAQEL CSESIPVPSP LCPEPPGYTG PVTRTMARRL
610 620 630 640 650
SGPLHTLGIP PGPNCTPAQG SRWPMEKKRR RPSALEADSP MAPKRGTKRQ
660 670 680 690 700
RQSFLPCLRR GSLPDTQPSQ GPSTPKGERA SSPCHSPRVC PATVIKSRVP
710 720 730 740 750
LGPSAMQNCS TPLALPTRDL NATFDLSEEP PSKPSFHECI GWDKIPQELS
760 770 780 790 800
RLDQPFIPRA PVPLFTMKGP KPTSSLPGTS ACKKKRVASS SVSHGRSRIA
810 820 830 840 850
RLPSSTLKRP AGPLVLPELP LSPLCPSNRR NGKDLIRVGR ALSAGNGVTK
VS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A494BYR6 | A0A494BYR6_HUMAN | Kinesin-like protein | KIF18B | 842 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038925 | 506 | Q → R. Corresponds to variant dbSNP:rs17546822Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060111 | 413 | H → HLPSSPLPPHPPS in isoform 2. | 1 | |
Alternative sequenceiVSP_060112 | 818 – 821 | ELPL → GDWH in isoform 2. | 4 | |
Alternative sequenceiVSP_060113 | 822 – 852 | Missing in isoform 2. Add BLAST | 31 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU808359 mRNA Translation: ADE43428.1 Sequence problems. AC015936 Genomic DNA No translation available. BC044933 mRNA Translation: AAH44933.1 BC136590 mRNA Translation: AAI36591.1 BC144271 mRNA Translation: AAI44272.1 |
CCDSi | CCDS45709.2 [Q86Y91-5] CCDS58555.1 [Q86Y91-6] |
RefSeqi | NP_001251503.1, NM_001264573.1 [Q86Y91-6] NP_001252506.1, NM_001265577.1 [Q86Y91-5] |
Genome annotation databases
Ensembli | ENST00000587309; ENSP00000465377; ENSG00000186185 [Q86Y91-6] ENST00000593135; ENSP00000465992; ENSG00000186185 |
GeneIDi | 146909 |
KEGGi | hsa:146909 |
MANE-Selecti | ENST00000593135.6; ENSP00000465992.1; NM_001265577.2; NP_001252506.1 |
UCSCi | uc010wjh.4, human [Q86Y91-5] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU808359 mRNA Translation: ADE43428.1 Sequence problems. AC015936 Genomic DNA No translation available. BC044933 mRNA Translation: AAH44933.1 BC136590 mRNA Translation: AAI36591.1 BC144271 mRNA Translation: AAI44272.1 |
CCDSi | CCDS45709.2 [Q86Y91-5] CCDS58555.1 [Q86Y91-6] |
RefSeqi | NP_001251503.1, NM_001264573.1 [Q86Y91-6] NP_001252506.1, NM_001265577.1 [Q86Y91-5] |
3D structure databases
SMRi | Q86Y91 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127024, 55 interactors |
IntActi | Q86Y91, 19 interactors |
MINTi | Q86Y91 |
STRINGi | 9606.ENSP00000465992 |
PTM databases
GlyGeni | Q86Y91, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q86Y91 |
PhosphoSitePlusi | Q86Y91 |
Genetic variation databases
BioMutai | KIF18B |
DMDMi | 325511395 |
Proteomic databases
EPDi | Q86Y91 |
jPOSTi | Q86Y91 |
MassIVEi | Q86Y91 |
MaxQBi | Q86Y91 |
PaxDbi | Q86Y91 |
PeptideAtlasi | Q86Y91 |
PRIDEi | Q86Y91 |
Protocols and materials databases
Antibodypediai | 8290, 23 antibodies from 10 providers |
DNASUi | 146909 |
Genome annotation databases
Ensembli | ENST00000587309; ENSP00000465377; ENSG00000186185 [Q86Y91-6] ENST00000593135; ENSP00000465992; ENSG00000186185 |
GeneIDi | 146909 |
KEGGi | hsa:146909 |
MANE-Selecti | ENST00000593135.6; ENSP00000465992.1; NM_001265577.2; NP_001252506.1 |
UCSCi | uc010wjh.4, human [Q86Y91-5] |
Organism-specific databases
CTDi | 146909 |
DisGeNETi | 146909 |
GeneCardsi | KIF18B |
HGNCi | HGNC:27102, KIF18B |
HPAi | ENSG00000186185, Tissue enhanced (bone marrow, lymphoid tissue) |
MIMi | 614570, gene |
neXtProti | NX_Q86Y91 |
OpenTargetsi | ENSG00000186185 |
VEuPathDBi | HostDB:ENSG00000186185 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0242, Eukaryota |
GeneTreei | ENSGT00940000161200 |
HOGENOMi | CLU_001485_21_5_1 |
InParanoidi | Q86Y91 |
OMAi | HQEEKRF |
OrthoDBi | 703086at2759 |
PhylomeDBi | Q86Y91 |
Enzyme and pathway databases
PathwayCommonsi | Q86Y91 |
Reactomei | R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189, Kinesins |
SignaLinki | Q86Y91 |
Miscellaneous databases
BioGRID-ORCSi | 146909, 177 hits in 1051 CRISPR screens |
ChiTaRSi | KIF18B, human |
GenomeRNAii | 146909 |
Pharosi | Q86Y91, Tbio |
PROi | PR:Q86Y91 |
RNActi | Q86Y91, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186185, Expressed in ventricular zone and 147 other tissues |
ExpressionAtlasi | Q86Y91, baseline and differential |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KI18B_HUMAN | |
Accessioni | Q86Y91Primary (citable) accession number: Q86Y91 Secondary accession number(s): A0A0C4DGP2 D5L6I1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | May 8, 2019 | |
Last modified: | February 23, 2022 | |
This is version 137 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families