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UniProtKB - Q86Y91 (KI18B_HUMAN)

Entry version 118 (13 Feb 2019)
Sequence version 3 (08 Mar 2011)
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Protein

Kinesin-like protein KIF18B

Gene

KIF18B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.2 Publications

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi118 – 125ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
  • kinesin binding Source: UniProtKB
  • microtubule binding Source: GO_Central
  • microtubule motor activity Source: GO_Central
  • motor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF18B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF18B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000186185.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:27102 KIF18B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614570 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86Y91

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		146909

Open Targets

More...OpenTargetsi		ENSG00000186185

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KIF18B

Domain mapping of disease mutations (DMDM)

More...DMDMi		325511395

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003189691 – 864Kinesin-like protein KIF18BAdd BLAST864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei413PhosphoserineCombined sources1
Modified residuei438PhosphothreonineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Modified residuei645PhosphoserineCombined sources1
Modified residuei651PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei686PhosphothreonineCombined sources1
Modified residuei834PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86Y91

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86Y91

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86Y91

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86Y91

PeptideAtlas

More...PeptideAtlasi		Q86Y91

PRoteomics IDEntifications database

More...PRIDEi		Q86Y91

ProteomicsDB human proteome resource

More...ProteomicsDBi		70383
70384 [Q86Y91-2]
70385 [Q86Y91-3]
70386 [Q86Y91-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86Y91

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86Y91

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Shows a prominent expression in the amygdala.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Regulated in a cell cycle-dependent manner. Not expressed in the G1 phase. In G2, sequestered in the nucleus. Maximal levels seen at late G2/M phase and early prometaphase. Degraded at the metaphase-anaphase transition (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186185 Expressed in 136 organ(s), highest expression level in trabecular bone tissue

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86Y91 baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA024205

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		127024, 24 interactors

Protein interaction database and analysis system

More...IntActi		Q86Y91, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000341466

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q86Y91

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 360Kinesin motorPROSITE-ProRule annotationAdd BLAST345

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni723 – 748KIF2C-bindingAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili375 – 402Sequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi636 – 644Nuclear localization signalCurated9
Motifi665 – 668MAPRE1-binding4
Motifi786 – 789MAPRE1-binding4
Motifi812 – 815MAPRE1-binding4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi405 – 445Pro-richAdd BLAST41

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0242 Eukaryota
COG5059 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161200

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231436

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG108062

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86Y91

Database of Orthologous Groups

More...OrthoDBi		703086at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86Y91

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR24115 PTHR24115, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00225 Kinesin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00380 KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00129 KISc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86Y91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSHPGVTTVM AVEDSTLQVV VRVRPPTPRE LDSQRRPVVQ VVDERVLVFN 
        60         70         80         90        100
PEEPDGGFPG LKWGGTHDGP KKKGKDLTFV FDRVFGEAAT QQDVFQHTTH 
       110        120        130        140        150
SVLDSFLQGY NCSVFAYGAT GAGKTHTMLG REGDPGIMYL TTVELYRRLE 
       160        170        180        190        200
ARQQEKHFEV LISYQEVYNE QIHDLLEPKG PLAIREDPDK GVVVQGLSFH 
       210        220        230        240        250
QPASAEQLLE ILTRGNRNRT QHPTDANATS SRSHAIFQIF VKQQDRVPGL 
       260        270        280        290        300
TQAVQVAKMS LIDLAGSERA SSTHAKGERL REGANINRSL LALINVLNAL 
       310        320        330        340        350
ADAKGRKTHV PYRDSKLTRL LKDSLGGNCR TVMIAAISPS SLTYEDTYNT 
       360        370        380        390        400
LKYADRAKEI RLSLKSNVTS LDCHISQYAT ICQQLQAEVA ALRKKLQVYE 
       410        420        430        440        450
GGGQPPPQDL PGSPKSGPPP EHLPSSPLPP HPPSQPCTPE LPAGPRALQE 
       460        470        480        490        500
ESLGMEAQVE RAMEGNSSDQ EQSPEDEDEG PAEEVPTQMP EQNPTHALPE 
       510        520        530        540        550
SPRLTLQPKP VVGHFSAREL DGDRSKQLAL KVLCVAQRQY SLLQAANLLT 
       560        570        580        590        600
PDMITEFETL QQLVQEEKIE PGAEALRTSG LARGAPLAQE LCSESKPPGY 
       610        620        630        640        650
TGPVTRTMAR RLSGPLHTLG IPPGPNCTPA QGSRWPMEKK RRRPSALEAD 
       660        670        680        690        700
SPMAPKRGTK RQRQSFLPCL RRGSLPDTQP SQGPSTPKGE RASSPCHSPR 
       710        720        730        740        750
VCPATVIKSR VPLGPSAMQN CSTPLALPTR DLNATFDLSE EPPSKPSFHE 
       760        770        780        790        800
CIGWDKIPQE LSRLDQPFIP RAPVPLFTMK GPKPTSSLPG TSACKKKRVA 
       810        820        830        840        850
SSSVSHGRSR IARLPSSTLK RPAGPLVLPE LPLSPLCPSN RRNGKDLIRV 
       860 
GRALSAGNGV TKVS
Length:864
Mass (Da):94,223
Last modified:March 8, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC1A26D345B8BFB1
GO
Isoform 2 (identifier: Q86Y91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-596: K → IPVPSPLCPE
     830-833: ELPL → GDWH
     834-864: Missing.

Note: No experimental confirmation available.
Show »
Length:842
Mass (Da):91,965
Checksum:i1E24BBDD57D8A255
GO
Isoform 3 (identifier: Q86Y91-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-434: Missing.
     596-596: K → IPVPSPLCPE

Show »
Length:861
Mass (Da):93,921
Checksum:iB19CFE7979A60F92
GO
Isoform 4 (identifier: Q86Y91-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-596: K → IPVPSPLCPE

Show »
Length:873
Mass (Da):95,128
Checksum:i07F8B6B01D35B435
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGP5A0A0C4DGP5_HUMAN
Kinesin-like protein
KIF18B
852Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGP2A0A0C4DGP2_HUMAN
Kinesin-like protein
KIF18B
833Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI36591 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI44272 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038925527Q → R. Corresponds to variant dbSNP:rs17546822Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040705423 – 434Missing in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_040706596K → IPVPSPLCPE in isoform 2, isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_040707830 – 833ELPL → GDWH in isoform 2. 2 Publications4
Alternative sequenceiVSP_040708834 – 864Missing in isoform 2. 2 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
GU808359 mRNA Translation: ADE43428.1
AC015936 Genomic DNA No translation available.
BC044933 mRNA Translation: AAH44933.1
BC136590 mRNA Translation: AAI36591.1 Different initiation.
BC144271 mRNA Translation: AAI44272.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_001251503.1, NM_001264573.1
NP_001252506.1, NM_001265577.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.135094

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000590129; ENSP00000465501; ENSG00000186185 [Q86Y91-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		146909

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:146909

UCSC genome browser

More...UCSCi		uc010wjh.4 human [Q86Y91-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU808359 mRNA Translation: ADE43428.1
AC015936 Genomic DNA No translation available.
BC044933 mRNA Translation: AAH44933.1
BC136590 mRNA Translation: AAI36591.1 Different initiation.
BC144271 mRNA Translation: AAI44272.1 Different initiation.
RefSeqiNP_001251503.1, NM_001264573.1
NP_001252506.1, NM_001265577.1
UniGeneiHs.135094

3D structure databases

ProteinModelPortaliQ86Y91
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127024, 24 interactors
IntActiQ86Y91, 9 interactors
STRINGi9606.ENSP00000341466

PTM databases

iPTMnetiQ86Y91
PhosphoSitePlusiQ86Y91

Polymorphism and mutation databases

BioMutaiKIF18B
DMDMi325511395

Proteomic databases

EPDiQ86Y91
jPOSTiQ86Y91
MaxQBiQ86Y91
PaxDbiQ86Y91
PeptideAtlasiQ86Y91
PRIDEiQ86Y91
ProteomicsDBi70383
70384 [Q86Y91-2]
70385 [Q86Y91-3]
70386 [Q86Y91-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000590129; ENSP00000465501; ENSG00000186185 [Q86Y91-2]
GeneIDi146909
KEGGihsa:146909
UCSCiuc010wjh.4 human [Q86Y91-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		146909
DisGeNETi146909
EuPathDBiHostDB:ENSG00000186185.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		KIF18B

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0202540
HGNCiHGNC:27102 KIF18B
HPAiHPA024205
MIMi614570 gene
neXtProtiNX_Q86Y91
OpenTargetsiENSG00000186185

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0242 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00940000161200
HOGENOMiHOG000231436
HOVERGENiHBG108062
InParanoidiQ86Y91
OrthoDBi703086at2759
PhylomeDBiQ86Y91

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KIF18B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		146909

Protein Ontology

More...PROi		PR:Q86Y91

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186185 Expressed in 136 organ(s), highest expression level in trabecular bone tissue
ExpressionAtlasiQ86Y91 baseline and differential

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKI18B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86Y91
Secondary accession number(s): A6NJI2
, B7ZM49, B9EGM8, D5L6I1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 8, 2011
Last modified: February 13, 2019
This is version 118 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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