STX12

Functionⁱ

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).By similarity

GO - Molecular functionⁱ

SNAP receptor activity Source: GO_Central
SNARE binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagosome assembly
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 24095276
cholesterol efflux
Source: BHF-UCL
Inferred from direct assayⁱ
- 15469992
intracellular protein transport Source: GO_Central
protein stabilization
Source: BHF-UCL
Inferred from direct assayⁱ
- 15469992
vesicle docking Source: GO_Central
vesicle fusion Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Syntaxin-12
Gene namesⁱ	Name:STX12
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000117758.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11430 STX12
MIMⁱ	606892 gene
neXtProtⁱ	NX_Q86Y82

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	2 – 248	CytoplasmicSequence analysisAdd BLAST	247
Transmembraneⁱ	249 – 269	Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	270 – 276	VesicularSequence analysis	7

Keywords - Cellular componentⁱ

Endosome, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23673
Open Targets More...OpenTargetsⁱ	ENSG00000117758
PharmGKBⁱ	PA36230

Polymorphism and mutation databases

BioMutaⁱ	STX12
DMDMⁱ	47117211

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000210223	2 – 276	Syntaxin-12Add BLAST		275

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	139	PhosphoserineBy similarity	1
Modified residueⁱ	142	PhosphoserineCombined sources	1
Modified residueⁱ	218	PhosphoserineBy similarity	1
Modified residueⁱ	225	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q86Y82
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86Y82
PaxDbⁱ	Q86Y82
PeptideAtlas More...PeptideAtlasⁱ	Q86Y82
PRIDEⁱ	Q86Y82
ProteomicsDBⁱ	70382

PTM databases

iPTMnetⁱ	Q86Y82
PhosphoSitePlusⁱ	Q86Y82
SwissPalmⁱ	Q86Y82

Miscellaneous databases

PMAP-CutDBⁱ	Q86Y82

PMAP-CutDBⁱ

Q86Y82

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000117758
CleanExⁱ	HS_STX12
ExpressionAtlasⁱ	Q86Y82 baseline and differential
Genevisibleⁱ	Q86Y82 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041038 HPA055300

HPAⁱ

HPA041038
HPA055300

Interactionⁱ

Subunit structureⁱ

Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Associates with the BLOC-1 complex (PubMed:19546860). Interacts with BLOC1S6 (PubMed:19546860). Interacts with GRIPAP1 (By similarity). Forms a complex with GRIP1, GRIA2 and NSG1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Interacts with NSG1 (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ABCA1	O95477	9	EBI-2691717,EBI-784112
DTX2	Q86UW9	5	EBI-2691717,EBI-740376
SNAP29	O95721	4	EBI-2691717,EBI-490676
STX4	Q12846	5	EBI-2691717,EBI-744942

Show more details

GO - Molecular functionⁱ

SNAP receptor activity Source: GO_Central
SNARE binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117191, 101 interactors
CORUMⁱ	Q86Y82
Database of interacting proteins More...DIPⁱ	DIP-44225N
IntActⁱ	Q86Y82, 47 interactors
Molecular INTeraction database More...MINTⁱ	Q86Y82
STRINGⁱ	9606.ENSP00000363054

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	22 – 50	Combined sources	29
Beta strandⁱ	52 – 54	Combined sources	3
Helixⁱ	57 – 86	Combined sources	30
Helixⁱ	93 – 132	Combined sources	40

3D structure databases

ProteinModelPortalⁱ	Q86Y82
SMRⁱ	Q86Y82
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q86Y82

EvolutionaryTraceⁱ

Q86Y82

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	178 – 240	t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST		63

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	33 – 131	Sequence analysisAdd BLAST		99

Sequence similaritiesⁱ

Belongs to the syntaxin family.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0811 Eukaryota COG5325 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00450000040239
HOGENOMⁱ	HOG000188453
HOVERGENⁱ	HBG053083
InParanoidⁱ	Q86Y82
KEGG Orthology (KO) More...KOⁱ	K13813
OMAⁱ	EREPINN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HKZ
PhylomeDBⁱ	Q86Y82
TreeFamⁱ	TF315607

Family and domain databases

InterProⁱ	View protein in InterPro IPR010989 SNARE IPR006012 Syntaxin/epimorphin_CS IPR006011 Syntaxin_N IPR000727 T_SNARE_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05739 SNARE, 1 hit PF14523 Syntaxin_2, 1 hit
SMARTⁱ	View protein in SMART SM00503 SynN, 1 hit SM00397 t_SNARE, 1 hit
SUPFAMⁱ	SSF47661 SSF47661, 1 hit
PROSITEⁱ	View protein in PROSITE PS00914 SYNTAXIN, 1 hit PS50192 T_SNARE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q86Y82-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSYGPLDMYR NPGPSGPQLR DFSSIIQTCS GNIQRISQAT AQIKNLMSQL 
        60         70         80         90        100
GTKQDSSKLQ ENLQQLQHST NQLAKETNEL LKELGSLPLP LSTSEQRQQR 
       110        120        130        140        150
LQKERLMNDF SAALNNFQAV QRRVSEKEKE SIARARAGSR LSAEERQREE 
       160        170        180        190        200
QLVSFDSHEE WNQMQSQEDE VAITEQDLEL IKERETAIRQ LEADILDVNQ 
       210        220        230        240        250
IFKDLAMMIH DQGDLIDSIE ANVESSEVHV ERATEQLQRA AYYQKKSRKK 
       260        270 
MCILVLVLSV IILILGLIIW LVYKTK

Length:276

Mass (Da):31,642

Last modified:June 1, 2003 - v1

Checksum:ⁱ2338061572ED7DA1

GO

Sequence cautionⁱ

The sequence CAA22911 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035643	88	P → R in a breast cancer sample; somatic mutation. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF123769 mRNA Translation: AAP97248.1 AL035306 mRNA Translation: CAA22911.1 Different initiation. AK297585 mRNA Translation: BAG59973.1 AL020997 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07738.1 CH471059 Genomic DNA Translation: EAX07739.1 BC046999 mRNA Translation: AAH46999.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS310.1
NCBI Reference Sequences More...RefSeqⁱ	NP_803173.1, NM_177424.2
UniGeneⁱ	Hs.523855

Genome annotation databases

Ensemblⁱ	ENST00000373943; ENSP00000363054; ENSG00000117758
GeneIDⁱ	23673
KEGGⁱ	hsa:23673
UCSC genome browser More...UCSCⁱ	uc001bou.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q86Y82	STX12 isoform 1		PANTR		276
Syntaxin 12		PANPA		276
Syntaxin 12		GORGO		276
STX12 protein (Fragment)		HUMAN		269

Protein	Similar proteins		Species	Score	Length
Q86Y82	STX12 isoform 1		PANTR		276
Syntaxin 12		PANPA		276
Syntaxin 12		GORGO		276
STX12 protein (Fragment)		HUMAN		269
Syntaxin 12		CALJA		330
+111

Protein	Similar proteins		Species	Score	Length
Q86Y82	STX12 isoform 1		PANTR		276
Syntaxin 12		PANPA		276
Syntaxin 12		GORGO		276
STX12 protein (Fragment)		HUMAN		269
Syntaxin 12		CALJA		330
+114

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF123769 mRNA Translation: AAP97248.1 AL035306 mRNA Translation: CAA22911.1 Different initiation. AK297585 mRNA Translation: BAG59973.1 AL020997 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07738.1 CH471059 Genomic DNA Translation: EAX07739.1 BC046999 mRNA Translation: AAH46999.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS310.1
NCBI Reference Sequences More...RefSeqⁱ	NP_803173.1, NM_177424.2
UniGeneⁱ	Hs.523855

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DNX	NMR	-	A	18-134	[»]
ProteinModelPortalⁱ	Q86Y82
SMRⁱ	Q86Y82
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117191, 101 interactors
CORUMⁱ	Q86Y82
Database of interacting proteins More...DIPⁱ	DIP-44225N
IntActⁱ	Q86Y82, 47 interactors
Molecular INTeraction database More...MINTⁱ	Q86Y82
STRINGⁱ	9606.ENSP00000363054

PTM databases

iPTMnetⁱ	Q86Y82
PhosphoSitePlusⁱ	Q86Y82
SwissPalmⁱ	Q86Y82

Polymorphism and mutation databases

BioMutaⁱ	STX12
DMDMⁱ	47117211

Proteomic databases

EPDⁱ	Q86Y82
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86Y82
PaxDbⁱ	Q86Y82
PeptideAtlas More...PeptideAtlasⁱ	Q86Y82
PRIDEⁱ	Q86Y82
ProteomicsDBⁱ	70382

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23673
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373943; ENSP00000363054; ENSG00000117758
GeneIDⁱ	23673
KEGGⁱ	hsa:23673
UCSC genome browser More...UCSCⁱ	uc001bou.4 human

Organism-specific databases

CTDⁱ	23673
DisGeNET More...DisGeNETⁱ	23673
EuPathDBⁱ	HostDB:ENSG00000117758.13
GeneCardsⁱ	STX12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11430 STX12
Human Protein Atlas More...HPAⁱ	HPA041038 HPA055300
MIMⁱ	606892 gene
neXtProtⁱ	NX_Q86Y82
Open Targets More...OpenTargetsⁱ	ENSG00000117758
PharmGKBⁱ	PA36230
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0811 Eukaryota COG5325 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00450000040239
HOGENOMⁱ	HOG000188453
HOVERGENⁱ	HBG053083
InParanoidⁱ	Q86Y82
KEGG Orthology (KO) More...KOⁱ	K13813
OMAⁱ	EREPINN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HKZ
PhylomeDBⁱ	Q86Y82
TreeFamⁱ	TF315607

Miscellaneous databases

ChiTaRSⁱ	STX12 human
EvolutionaryTraceⁱ	Q86Y82
GeneWikiⁱ	STX12
GenomeRNAiⁱ	23673
PMAP-CutDBⁱ	Q86Y82
Protein Ontology More...PROⁱ	PR:Q86Y82
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000117758
CleanExⁱ	HS_STX12
ExpressionAtlasⁱ	Q86Y82 baseline and differential
Genevisibleⁱ	Q86Y82 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR010989 SNARE IPR006012 Syntaxin/epimorphin_CS IPR006011 Syntaxin_N IPR000727 T_SNARE_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05739 SNARE, 1 hit PF14523 Syntaxin_2, 1 hit
SMARTⁱ	View protein in SMART SM00503 SynN, 1 hit SM00397 t_SNARE, 1 hit
SUPFAMⁱ	SSF47661 SSF47661, 1 hit
PROSITEⁱ	View protein in PROSITE PS00914 SYNTAXIN, 1 hit PS50192 T_SNARE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STX12_HUMAN
Accessionⁱ	Q86Y82Primary (citable) accession number: Q86Y82 Secondary accession number(s): B1AJQ7, O95564
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
	Last sequence update:	June 1, 2003
	Last modified:	July 18, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q86Y82 (STX12_HUMAN)

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Syntaxin-12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endosome

Other locations

Endosome

Golgi apparatus

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ