UniProtKB - Q86Y82 (STX12_HUMAN)
Syntaxin-12
STX12
Functioni
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: GO_Central
GO - Biological processi
- autophagosome assembly Source: ParkinsonsUK-UCL
- cholesterol efflux Source: BHF-UCL
- intracellular protein transport Source: GO_Central
- protein stabilization Source: BHF-UCL
- vesicle docking Source: GO_Central
- vesicle fusion Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q86Y82 |
Names & Taxonomyi
Protein namesi | Recommended name: Syntaxin-12 |
Gene namesi | Name:STX12 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11430, STX12 |
MIMi | 606892, gene |
neXtProti | NX_Q86Y82 |
VEuPathDBi | HostDB:ENSG00000117758.13 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane ; Single-pass type IV membrane protein By similarity
Endosome
- Endosome membrane ; Single-pass type IV membrane protein By similarity
- Early endosome membrane By similarity; Single-pass type IV membrane protein Curated
- Recycling endosome membrane By similarity; Single-pass type IV membrane protein By similarity
Other locations
- Endomembrane system Curated; Single-pass type IV membrane protein Curated; Cytoplasmic side Curated
Endosome
- early endosome membrane Source: UniProtKB-SubCell
- postsynaptic recycling endosome Source: GO_Central
- recycling endosome membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- endomembrane system Source: GO_Central
- integral component of membrane Source: GO_Central
- integral component of synaptic vesicle membrane Source: GO_Central
- membrane raft Source: BHF-UCL
- phagocytic vesicle Source: BHF-UCL
- phagophore assembly site Source: ParkinsonsUK-UCL
- SNARE complex Source: UniProtKB
- synaptic vesicle Source: GO_Central
- vesicle Source: ParkinsonsUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 248 | CytoplasmicSequence analysisAdd BLAST | 247 | |
Transmembranei | 249 – 269 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 270 – 276 | VesicularSequence analysis | 7 |
Keywords - Cellular componenti
Endosome, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23673 |
OpenTargetsi | ENSG00000117758 |
PharmGKBi | PA36230 |
Miscellaneous databases
Pharosi | Q86Y82, Tbio |
Genetic variation databases
BioMutai | STX12 |
DMDMi | 47117211 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000210223 | 2 – 276 | Syntaxin-12Add BLAST | 275 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 139 | PhosphoserineBy similarity | 1 | |
Modified residuei | 142 | PhosphoserineCombined sources | 1 | |
Modified residuei | 218 | PhosphoserineBy similarity | 1 | |
Modified residuei | 225 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q86Y82 |
jPOSTi | Q86Y82 |
MassIVEi | Q86Y82 |
MaxQBi | Q86Y82 |
PaxDbi | Q86Y82 |
PeptideAtlasi | Q86Y82 |
PRIDEi | Q86Y82 |
ProteomicsDBi | 70382 |
PTM databases
iPTMneti | Q86Y82 |
PhosphoSitePlusi | Q86Y82 |
SwissPalmi | Q86Y82 |
Expressioni
Gene expression databases
Bgeei | ENSG00000117758, Expressed in left lobe of thyroid gland and 243 other tissues |
ExpressionAtlasi | Q86Y82, baseline and differential |
Genevisiblei | Q86Y82, HS |
Organism-specific databases
HPAi | ENSG00000117758, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with NAPA and SNAP23.
Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Associates with the BLOC-1 complex (PubMed:19546860).
Interacts with BLOC1S6 (PubMed:19546860).
Interacts with GRIPAP1 (By similarity).
Forms a complex with GRIP1, GRIA2 and NSG1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Interacts with NSG1 (By similarity).
By similarity1 PublicationBinary interactionsi
Hide detailsQ86Y82
GO - Molecular functioni
- SNARE binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 117191, 156 interactors |
CORUMi | Q86Y82 |
DIPi | DIP-44225N |
IntActi | Q86Y82, 112 interactors |
MINTi | Q86Y82 |
STRINGi | 9606.ENSP00000363054 |
Miscellaneous databases
RNActi | Q86Y82, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q86Y82 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q86Y82 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 178 – 240 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 33 – 131 | Sequence analysisAdd BLAST | 99 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0811, Eukaryota |
GeneTreei | ENSGT01000000214440 |
HOGENOMi | CLU_059257_1_1_1 |
InParanoidi | Q86Y82 |
OMAi | HQIQHYT |
OrthoDBi | 1204812at2759 |
PhylomeDBi | Q86Y82 |
TreeFami | TF315607 |
Family and domain databases
CDDi | cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF14523, Syntaxin_2, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSYGPLDMYR NPGPSGPQLR DFSSIIQTCS GNIQRISQAT AQIKNLMSQL
60 70 80 90 100
GTKQDSSKLQ ENLQQLQHST NQLAKETNEL LKELGSLPLP LSTSEQRQQR
110 120 130 140 150
LQKERLMNDF SAALNNFQAV QRRVSEKEKE SIARARAGSR LSAEERQREE
160 170 180 190 200
QLVSFDSHEE WNQMQSQEDE VAITEQDLEL IKERETAIRQ LEADILDVNQ
210 220 230 240 250
IFKDLAMMIH DQGDLIDSIE ANVESSEVHV ERATEQLQRA AYYQKKSRKK
260 270
MCILVLVLSV IILILGLIIW LVYKTK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1AJQ6 | B1AJQ6_HUMAN | Syntaxin-12 | STX12 | 215 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035643 | 88 | P → R in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF123769 mRNA Translation: AAP97248.1 AL035306 mRNA Translation: CAA22911.1 Different initiation. AK297585 mRNA Translation: BAG59973.1 AL020997 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07738.1 CH471059 Genomic DNA Translation: EAX07739.1 BC046999 mRNA Translation: AAH46999.1 |
CCDSi | CCDS310.1 |
RefSeqi | NP_803173.1, NM_177424.2 |
Genome annotation databases
Ensembli | ENST00000373943; ENSP00000363054; ENSG00000117758 |
GeneIDi | 23673 |
KEGGi | hsa:23673 |
UCSCi | uc001bou.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF123769 mRNA Translation: AAP97248.1 AL035306 mRNA Translation: CAA22911.1 Different initiation. AK297585 mRNA Translation: BAG59973.1 AL020997 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07738.1 CH471059 Genomic DNA Translation: EAX07739.1 BC046999 mRNA Translation: AAH46999.1 |
CCDSi | CCDS310.1 |
RefSeqi | NP_803173.1, NM_177424.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DNX | NMR | - | A | 18-134 | [»] | |
SMRi | Q86Y82 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117191, 156 interactors |
CORUMi | Q86Y82 |
DIPi | DIP-44225N |
IntActi | Q86Y82, 112 interactors |
MINTi | Q86Y82 |
STRINGi | 9606.ENSP00000363054 |
PTM databases
iPTMneti | Q86Y82 |
PhosphoSitePlusi | Q86Y82 |
SwissPalmi | Q86Y82 |
Genetic variation databases
BioMutai | STX12 |
DMDMi | 47117211 |
Proteomic databases
EPDi | Q86Y82 |
jPOSTi | Q86Y82 |
MassIVEi | Q86Y82 |
MaxQBi | Q86Y82 |
PaxDbi | Q86Y82 |
PeptideAtlasi | Q86Y82 |
PRIDEi | Q86Y82 |
ProteomicsDBi | 70382 |
Protocols and materials databases
Antibodypediai | 30837, 171 antibodies |
DNASUi | 23673 |
Genome annotation databases
Ensembli | ENST00000373943; ENSP00000363054; ENSG00000117758 |
GeneIDi | 23673 |
KEGGi | hsa:23673 |
UCSCi | uc001bou.4, human |
Organism-specific databases
CTDi | 23673 |
DisGeNETi | 23673 |
GeneCardsi | STX12 |
HGNCi | HGNC:11430, STX12 |
HPAi | ENSG00000117758, Low tissue specificity |
MIMi | 606892, gene |
neXtProti | NX_Q86Y82 |
OpenTargetsi | ENSG00000117758 |
PharmGKBi | PA36230 |
VEuPathDBi | HostDB:ENSG00000117758.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0811, Eukaryota |
GeneTreei | ENSGT01000000214440 |
HOGENOMi | CLU_059257_1_1_1 |
InParanoidi | Q86Y82 |
OMAi | HQIQHYT |
OrthoDBi | 1204812at2759 |
PhylomeDBi | Q86Y82 |
TreeFami | TF315607 |
Enzyme and pathway databases
PathwayCommonsi | Q86Y82 |
Miscellaneous databases
BioGRID-ORCSi | 23673, 8 hits in 876 CRISPR screens |
ChiTaRSi | STX12, human |
EvolutionaryTracei | Q86Y82 |
GeneWikii | STX12 |
GenomeRNAii | 23673 |
Pharosi | Q86Y82, Tbio |
PROi | PR:Q86Y82 |
RNActi | Q86Y82, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000117758, Expressed in left lobe of thyroid gland and 243 other tissues |
ExpressionAtlasi | Q86Y82, baseline and differential |
Genevisiblei | Q86Y82, HS |
Family and domain databases
CDDi | cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF14523, Syntaxin_2, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STX12_HUMAN | |
Accessioni | Q86Y82Primary (citable) accession number: Q86Y82 Secondary accession number(s): B1AJQ7, O95564 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families