Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable peptidyl-tRNA hydrolase

Gene

PTRH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.

GO - Molecular functioni

  • aminoacyl-tRNA hydrolase activity Source: GO_Central
  • RNA binding Source: UniProtKB

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable peptidyl-tRNA hydrolase (EC:3.1.1.29)
Short name:
PTH
Gene namesi
Name:PTRH1
Synonyms:C9orf115
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000187024.13
HGNCiHGNC:27039 PTRH1
neXtProtiNX_Q86Y79

Pathology & Biotechi

Organism-specific databases

DisGeNETi138428
OpenTargetsiENSG00000187024
PharmGKBiPA134917129

Polymorphism and mutation databases

BioMutaiPTRH1
DMDMi74750555

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002404411 – 214Probable peptidyl-tRNA hydrolaseAdd BLAST214

Proteomic databases

EPDiQ86Y79
MaxQBiQ86Y79
PaxDbiQ86Y79
PeptideAtlasiQ86Y79
PRIDEiQ86Y79
ProteomicsDBi70381

PTM databases

iPTMnetiQ86Y79
PhosphoSitePlusiQ86Y79

Expressioni

Gene expression databases

BgeeiENSG00000187024 Expressed in 151 organ(s), highest expression level in left adrenal gland
CleanExiHS_PTRH1
ExpressionAtlasiQ86Y79 baseline and differential
GenevisibleiQ86Y79 HS

Organism-specific databases

HPAiHPA021223

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-2602515,EBI-10175124

Protein-protein interaction databases

BioGridi126512, 3 interactors
IntActiQ86Y79, 5 interactors
STRINGi9606.ENSP00000418661

Structurei

3D structure databases

ProteinModelPortaliQ86Y79
SMRiQ86Y79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH family.Curated

Phylogenomic databases

eggNOGiKOG2255 Eukaryota
COG0193 LUCA
GeneTreeiENSGT00390000004247
HOGENOMiHOG000004797
HOVERGENiHBG067636
InParanoidiQ86Y79
KOiK01056
OMAiRYAHTRH
OrthoDBiEOG091G0L6U
PhylomeDBiQ86Y79
TreeFamiTF332601

Family and domain databases

CDDicd00462 PTH, 1 hit
Gene3Di3.40.50.1470, 1 hit
InterProiView protein in InterPro
IPR001328 Pept_tRNA_hydro
IPR018171 Pept_tRNA_hydro_CS
IPR036416 Pept_tRNA_hydro_sf
PANTHERiPTHR17224 PTHR17224, 1 hit
PfamiView protein in Pfam
PF01195 Pept_tRNA_hydro, 1 hit
SUPFAMiSSF53178 SSF53178, 1 hit
PROSITEiView protein in PROSITE
PS01196 PEPT_TRNA_HYDROL_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q86Y79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPGGFLGAG QRLSRAMSRC VLEPRPPGKR WMVAGLGNPG LPGTRHSVGM
60 70 80 90 100
AVLGQLARRL GVAESWTRDR HCAADLALAP LGDAQLVLLR PRRLMNANGR
110 120 130 140 150
SVARAAELFG LTAEEVYLVH DELDKPLGRL ALKLGGSARG HNGVRSCISC
160 170 180 190 200
LNSNAMPRLR VGIGRPAHPE AVQAHVLGCF SPAEQELLPL LLDRATDLIL
210
DHIRERSQGP SLGP
Length:214
Mass (Da):22,937
Last modified:June 1, 2003 - v1
Checksum:iDBA3959411DA8248
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J7Z1C9J7Z1_HUMAN
Probable peptidyl-tRNA hydrolase
PTRH1
182Annotation score:
A0A096LP22A0A096LP22_HUMAN
Probable peptidyl-tRNA hydrolase
PTRH1
172Annotation score:
A0A096LPA3A0A096LPA3_HUMAN
Probable peptidyl-tRNA hydrolase
PTRH1
162Annotation score:
A0A096LP34A0A096LP34_HUMAN
Probable peptidyl-tRNA hydrolase
PTRH1
137Annotation score:
A0A286YER0A0A286YER0_HUMAN
Probable peptidyl-tRNA hydrolase
PTRH1
35Annotation score:
A0A286YF52A0A286YF52_HUMAN
Probable peptidyl-tRNA hydrolase
PTRH1
159Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047012 mRNA Translation: AAH47012.1
CCDSiCCDS35147.1
RefSeqiNP_001002913.1, NM_001002913.2
UniGeneiHs.653265

Genome annotation databases

EnsembliENST00000419060; ENSP00000418661; ENSG00000187024
ENST00000543175; ENSP00000439469; ENSG00000187024
GeneIDi138428
KEGGihsa:138428
UCSCiuc004bro.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047012 mRNA Translation: AAH47012.1
CCDSiCCDS35147.1
RefSeqiNP_001002913.1, NM_001002913.2
UniGeneiHs.653265

3D structure databases

ProteinModelPortaliQ86Y79
SMRiQ86Y79
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126512, 3 interactors
IntActiQ86Y79, 5 interactors
STRINGi9606.ENSP00000418661

PTM databases

iPTMnetiQ86Y79
PhosphoSitePlusiQ86Y79

Polymorphism and mutation databases

BioMutaiPTRH1
DMDMi74750555

Proteomic databases

EPDiQ86Y79
MaxQBiQ86Y79
PaxDbiQ86Y79
PeptideAtlasiQ86Y79
PRIDEiQ86Y79
ProteomicsDBi70381

Protocols and materials databases

DNASUi138428
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419060; ENSP00000418661; ENSG00000187024
ENST00000543175; ENSP00000439469; ENSG00000187024
GeneIDi138428
KEGGihsa:138428
UCSCiuc004bro.4 human

Organism-specific databases

CTDi138428
DisGeNETi138428
EuPathDBiHostDB:ENSG00000187024.13
GeneCardsiPTRH1
HGNCiHGNC:27039 PTRH1
HPAiHPA021223
neXtProtiNX_Q86Y79
OpenTargetsiENSG00000187024
PharmGKBiPA134917129
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2255 Eukaryota
COG0193 LUCA
GeneTreeiENSGT00390000004247
HOGENOMiHOG000004797
HOVERGENiHBG067636
InParanoidiQ86Y79
KOiK01056
OMAiRYAHTRH
OrthoDBiEOG091G0L6U
PhylomeDBiQ86Y79
TreeFamiTF332601

Miscellaneous databases

GenomeRNAii138428
PROiPR:Q86Y79

Gene expression databases

BgeeiENSG00000187024 Expressed in 151 organ(s), highest expression level in left adrenal gland
CleanExiHS_PTRH1
ExpressionAtlasiQ86Y79 baseline and differential
GenevisibleiQ86Y79 HS

Family and domain databases

CDDicd00462 PTH, 1 hit
Gene3Di3.40.50.1470, 1 hit
InterProiView protein in InterPro
IPR001328 Pept_tRNA_hydro
IPR018171 Pept_tRNA_hydro_CS
IPR036416 Pept_tRNA_hydro_sf
PANTHERiPTHR17224 PTHR17224, 1 hit
PfamiView protein in Pfam
PF01195 Pept_tRNA_hydro, 1 hit
SUPFAMiSSF53178 SSF53178, 1 hit
PROSITEiView protein in PROSITE
PS01196 PEPT_TRNA_HYDROL_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTH_HUMAN
AccessioniPrimary (citable) accession number: Q86Y79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again