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UniProtKB - Q86Y37 (CACL1_HUMAN)
Protein
CDK2-associated and cullin domain-containing protein 1
Gene
CACUL1
Organism
Homo sapiens (Human)
Status
Functioni
Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.
1 PublicationGO - Molecular functioni
- protein kinase binding Source: UniProtKB
- ubiquitin protein ligase binding Source: InterPro
GO - Biological processi
- G1/S transition of mitotic cell cycle Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of protein kinase activity Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Biological process | Cell cycle |
Enzyme and pathway databases
PathwayCommonsi | Q86Y37 |
SignaLinki | Q86Y37 |
Names & Taxonomyi
Protein namesi | Recommended name: CDK2-associated and cullin domain-containing protein 1Alternative name(s): Cdk-associated cullin 1 |
Gene namesi | Name:CACUL1 Synonyms:C10orf46, CAC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23727, CACUL1 |
MIMi | 618764, gene |
neXtProti | NX_Q86Y37 |
VEuPathDBi | HostDB:ENSG00000151893 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 143384 |
OpenTargetsi | ENSG00000151893 |
PharmGKBi | PA134869023 |
Miscellaneous databases
Pharosi | Q86Y37, Tbio |
Genetic variation databases
BioMutai | CACUL1 |
DMDMi | 67460542 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119817 | 1 – 369 | CDK2-associated and cullin domain-containing protein 1Add BLAST | 369 |
Proteomic databases
EPDi | Q86Y37 |
jPOSTi | Q86Y37 |
MassIVEi | Q86Y37 |
MaxQBi | Q86Y37 |
PaxDbi | Q86Y37 |
PeptideAtlasi | Q86Y37 |
PRIDEi | Q86Y37 |
ProteomicsDBi | 70367 [Q86Y37-1] 70368 [Q86Y37-2] 70369 [Q86Y37-4] |
PTM databases
GlyGeni | Q86Y37, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q86Y37 |
PhosphoSitePlusi | Q86Y37 |
Expressioni
Tissue specificityi
Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase.1 Publication
Gene expression databases
Bgeei | ENSG00000151893, Expressed in epithelium of mammary gland and 223 other tissues |
Genevisiblei | Q86Y37, HS |
Organism-specific databases
HPAi | ENSG00000151893, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CDK2.
1 PublicationBinary interactionsi
Q86Y37
With | #Exp. | IntAct |
---|---|---|
ESR1 [P03372] | 5 | EBI-8168227,EBI-78473 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- ubiquitin protein ligase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 126801, 22 interactors |
IntActi | Q86Y37, 3 interactors |
MINTi | Q86Y37 |
STRINGi | 9606.ENSP00000358147 |
Miscellaneous databases
RNActi | Q86Y37, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 56 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 342 – 369 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 33 – 49 | Pro residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the cullin family.Curated
Phylogenomic databases
eggNOGi | KOG2166, Eukaryota |
GeneTreei | ENSGT00390000000403 |
HOGENOMi | CLU_062250_1_0_1 |
InParanoidi | Q86Y37 |
OMAi | HNHNYRA |
OrthoDBi | 991620at2759 |
PhylomeDBi | Q86Y37 |
TreeFami | TF329263 |
Family and domain databases
InterProi | View protein in InterPro IPR042652, CACUL1 IPR001373, Cullin_N IPR016159, Cullin_repeat-like_dom_sf |
PANTHERi | PTHR46636, PTHR46636, 1 hit |
Pfami | View protein in Pfam PF00888, Cullin, 1 hit |
SUPFAMi | SSF74788, SSF74788, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q86Y37-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR
60 70 80 90 100
EPPGGQLLAV PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV
110 120 130 140 150
AKAAPAPTAS STININTSTS KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ
160 170 180 190 200
SPGDYIPISY EQIYSCVYKC VCQQHSEQMY SDLIKKITNH LERVSKELQA
210 220 230 240 250
SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL NRDLKDDLIK
260 270 280 290 300
LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPEWVQM
310 320 330 340 350
APTLFSKFIP NILPPAVESE LSEYAAQDQK FQRELIQNGF TRGDQSRKRA
360
GDELAYNSSS ACASSRGYR
Sequence cautioni
The sequence AAU89709 differs from that shown. Reason: Frameshift.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013933 | 1 – 123 | Missing in isoform 4. 1 PublicationAdd BLAST | 123 | |
Alternative sequenceiVSP_013936 | 296 – 303 | EWVQMAPT → VSQNFTAV in isoform 2. 1 Publication | 8 | |
Alternative sequenceiVSP_013937 | 304 – 369 | Missing in isoform 2. 1 PublicationAdd BLAST | 66 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ544771 mRNA Translation: CAD67614.1 AY743663 mRNA Translation: AAU89709.1 Frameshift. AK097728 mRNA Translation: BAC05153.1 AL139407 Genomic DNA No translation available. BC038294 mRNA Translation: AAH38294.1 |
CCDSi | CCDS41570.1 [Q86Y37-1] |
RefSeqi | NP_722517.3, NM_153810.4 [Q86Y37-1] |
Genome annotation databases
Ensembli | ENST00000369151.8; ENSP00000358147.2; ENSG00000151893.15 ENST00000493518.5; ENSP00000431329.1; ENSG00000151893.15 [Q86Y37-2] |
GeneIDi | 143384 |
KEGGi | hsa:143384 |
MANE-Selecti | ENST00000369151.8; ENSP00000358147.2; NM_153810.5; NP_722517.3 |
UCSCi | uc001lds.2, human [Q86Y37-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ544771 mRNA Translation: CAD67614.1 AY743663 mRNA Translation: AAU89709.1 Frameshift. AK097728 mRNA Translation: BAC05153.1 AL139407 Genomic DNA No translation available. BC038294 mRNA Translation: AAH38294.1 |
CCDSi | CCDS41570.1 [Q86Y37-1] |
RefSeqi | NP_722517.3, NM_153810.4 [Q86Y37-1] |
3D structure databases
AlphaFoldDBi | Q86Y37 |
SMRi | Q86Y37 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126801, 22 interactors |
IntActi | Q86Y37, 3 interactors |
MINTi | Q86Y37 |
STRINGi | 9606.ENSP00000358147 |
PTM databases
GlyGeni | Q86Y37, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q86Y37 |
PhosphoSitePlusi | Q86Y37 |
Genetic variation databases
BioMutai | CACUL1 |
DMDMi | 67460542 |
Proteomic databases
EPDi | Q86Y37 |
jPOSTi | Q86Y37 |
MassIVEi | Q86Y37 |
MaxQBi | Q86Y37 |
PaxDbi | Q86Y37 |
PeptideAtlasi | Q86Y37 |
PRIDEi | Q86Y37 |
ProteomicsDBi | 70367 [Q86Y37-1] 70368 [Q86Y37-2] 70369 [Q86Y37-4] |
Protocols and materials databases
Antibodypediai | 32069, 137 antibodies from 22 providers |
DNASUi | 143384 |
Genome annotation databases
Ensembli | ENST00000369151.8; ENSP00000358147.2; ENSG00000151893.15 ENST00000493518.5; ENSP00000431329.1; ENSG00000151893.15 [Q86Y37-2] |
GeneIDi | 143384 |
KEGGi | hsa:143384 |
MANE-Selecti | ENST00000369151.8; ENSP00000358147.2; NM_153810.5; NP_722517.3 |
UCSCi | uc001lds.2, human [Q86Y37-1] |
Organism-specific databases
CTDi | 143384 |
DisGeNETi | 143384 |
GeneCardsi | CACUL1 |
HGNCi | HGNC:23727, CACUL1 |
HPAi | ENSG00000151893, Low tissue specificity |
MIMi | 618764, gene |
neXtProti | NX_Q86Y37 |
OpenTargetsi | ENSG00000151893 |
PharmGKBi | PA134869023 |
VEuPathDBi | HostDB:ENSG00000151893 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2166, Eukaryota |
GeneTreei | ENSGT00390000000403 |
HOGENOMi | CLU_062250_1_0_1 |
InParanoidi | Q86Y37 |
OMAi | HNHNYRA |
OrthoDBi | 991620at2759 |
PhylomeDBi | Q86Y37 |
TreeFami | TF329263 |
Enzyme and pathway databases
PathwayCommonsi | Q86Y37 |
SignaLinki | Q86Y37 |
Miscellaneous databases
BioGRID-ORCSi | 143384, 13 hits in 1082 CRISPR screens |
ChiTaRSi | CACUL1, human |
GenomeRNAii | 143384 |
Pharosi | Q86Y37, Tbio |
PROi | PR:Q86Y37 |
RNActi | Q86Y37, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151893, Expressed in epithelium of mammary gland and 223 other tissues |
Genevisiblei | Q86Y37, HS |
Family and domain databases
InterProi | View protein in InterPro IPR042652, CACUL1 IPR001373, Cullin_N IPR016159, Cullin_repeat-like_dom_sf |
PANTHERi | PTHR46636, PTHR46636, 1 hit |
Pfami | View protein in Pfam PF00888, Cullin, 1 hit |
SUPFAMi | SSF74788, SSF74788, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CACL1_HUMAN | |
Accessioni | Q86Y37Primary (citable) accession number: Q86Y37 Secondary accession number(s): Q5XPL7, Q8IY11, Q8N7S4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families