CACUL1

Functionⁱ

Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.1 Publication

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19829063
ubiquitin protein ligase binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G1/S transition of mitotic cell cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19829063
positive regulation of cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19829063
positive regulation of protein kinase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19829063
ubiquitin-dependent protein catabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle

Biological process

Cell cycle

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CDK2-associated and cullin domain-containing protein 1 Alternative name(s): Cdk-associated cullin1
Gene namesⁱ	Name:CACUL1 Synonyms:C10orf46, CAC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151893.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23727 CACUL1
neXtProtⁱ	NX_Q86Y37

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	143384
Open Targets More...OpenTargetsⁱ	ENSG00000151893
PharmGKBⁱ	PA134869023

Polymorphism and mutation databases

BioMutaⁱ	CACUL1
DMDMⁱ	67460542

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000119817	1 – 369	CDK2-associated and cullin domain-containing protein 1Add BLAST		369

Proteomic databases

EPDⁱ	Q86Y37
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86Y37
PaxDbⁱ	Q86Y37
PeptideAtlas More...PeptideAtlasⁱ	Q86Y37
PRIDEⁱ	Q86Y37
ProteomicsDBⁱ	70367 70368 [Q86Y37-2] 70369 [Q86Y37-4]

PTM databases

iPTMnetⁱ	Q86Y37
PhosphoSitePlusⁱ	Q86Y37

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000151893 Expressed in 206 organ(s), highest expression level in epithelium of mammary gland
CleanExⁱ	HS_C10orf46
Genevisibleⁱ	Q86Y37 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA050611

HPAⁱ

HPA050611

Interactionⁱ

Subunit structureⁱ

Interacts with CDK2.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ESR1	P03372	5	EBI-8168227,EBI-78473

With

Entry

#Exp.

IntAct

Notes

ESR1

P03372

5

EBI-8168227,EBI-78473

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19829063
ubiquitin protein ligase binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	126801, 4 interactors
IntActⁱ	Q86Y37, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q86Y37
STRINGⁱ	9606.ENSP00000358147

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86Y37
SMRⁱ	Q86Y37
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	35 – 82	Pro-richAdd BLAST		48
Compositional biasⁱ	96 – 106	Poly-AlaAdd BLAST		11

Sequence similaritiesⁱ

Belongs to the cullin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2166 Eukaryota COG5647 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000403
HOGENOMⁱ	HOG000111684
HOVERGENⁱ	HBG059519
InParanoidⁱ	Q86Y37
OMAⁱ	WVQMAPA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EJ6
PhylomeDBⁱ	Q86Y37
TreeFamⁱ	TF329263

Family and domain databases

InterProⁱ	View protein in InterPro IPR001373 Cullin_N IPR016159 Cullin_repeat-like_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00888 Cullin, 1 hit
SUPFAMⁱ	SSF74788 SSF74788, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q86Y37-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR 
        60         70         80         90        100
EPPGGQLLAV PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV 
       110        120        130        140        150
AKAAPAPTAS STININTSTS KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ 
       160        170        180        190        200
SPGDYIPISY EQIYSCVYKC VCQQHSEQMY SDLIKKITNH LERVSKELQA 
       210        220        230        240        250
SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL NRDLKDDLIK 
       260        270        280        290        300
LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPEWVQM 
       310        320        330        340        350
APTLFSKFIP NILPPAVESE LSEYAAQDQK FQRELIQNGF TRGDQSRKRA 
       360 
GDELAYNSSS ACASSRGYR

Length:369

Mass (Da):41,064

Last modified:June 1, 2003 - v1

Checksum:ⁱ7ABA2F6846C4F737

GO

Isoform 2 (identifier: Q86Y37-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
296-303: EWVQMAPT → VSQNFTAV
304-369: Missing.

« Hide

        10         20         30         40         50
MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR 
        60         70         80         90        100
EPPGGQLLAV PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV 
       110        120        130        140        150
AKAAPAPTAS STININTSTS KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ 
       160        170        180        190        200
SPGDYIPISY EQIYSCVYKC VCQQHSEQMY SDLIKKITNH LERVSKELQA 
       210        220        230        240        250
SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL NRDLKDDLIK 
       260        270        280        290        300
LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPVSQNF 

TAV

Show »

Length:303

Mass (Da):33,584

Checksum:ⁱE868EE20EEDC574A

GO

Isoform 4 (identifier: Q86Y37-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-123: Missing.

« Hide

        10         20         30         40         50
MNVITIEDYK STYWPKLDGA IDQLLTQSPG DYIPISYEQI YSCVYKCVCQ 
        60         70         80         90        100
QHSEQMYSDL IKKITNHLER VSKELQASPP DLYIERFNIA LGQYMGALQS 
       110        120        130        140        150
IVPLFIYMNK FYIETKLNRD LKDDLIKLFT EHVAEKHIYS LMPLLLEAQS 
       160        170        180        190        200
TPFQVTPSTM ANIVKGLYTL RPEWVQMAPT LFSKFIPNIL PPAVESELSE 
       210        220        230        240 
YAAQDQKFQR ELIQNGFTRG DQSRKRAGDE LAYNSSSACA SSRGYR

Show »

Length:246

Mass (Da):28,293

Checksum:ⁱF89A36DE19D2A4A6

GO

Sequence cautionⁱ

The sequence AAU89709 differs from that shown. Reason: Frameshift at position 296.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_013933	1 – 123	Missing in isoform 4. 1 PublicationAdd BLAST	123
Alternative sequenceⁱVSP_013936	296 – 303	EWVQMAPT → VSQNFTAV in isoform 2. 1 Publication	8
Alternative sequenceⁱVSP_013937	304 – 369	Missing in isoform 2. 1 PublicationAdd BLAST	66

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ544771 mRNA Translation: CAD67614.1 AY743663 mRNA Translation: AAU89709.1 Frameshift. AK097728 mRNA Translation: BAC05153.1 AL139407 Genomic DNA No translation available. BC038294 mRNA Translation: AAH38294.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41570.1 [Q86Y37-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_722517.3, NM_153810.4 [Q86Y37-1]
UniGeneⁱ	Hs.420024 Hs.669999

Genome annotation databases

Ensemblⁱ	ENST00000369151; ENSP00000358147; ENSG00000151893 [Q86Y37-1] ENST00000493518; ENSP00000431329; ENSG00000151893 [Q86Y37-2]
GeneIDⁱ	143384
KEGGⁱ	hsa:143384
UCSC genome browser More...UCSCⁱ	uc001lds.2 human [Q86Y37-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q86Y37	Uncharacterized protein C10orf46 (Fragment)		MACMU		264	UniRef100_Q86Y37
Isoform 4 of CDK2-associated and cullin domain-containing protein 1		HUMAN		246

Protein	Similar proteins		Species	Score	Length	Source
Q86Y37	Uncharacterized protein C10orf46 (Fragment)		MACMU		264	UniRef90_Q86Y37
Isoform 4 of CDK2-associated and cullin domain-containing protein 1		HUMAN		246
CDK2-associated and cullin domain-containing protein 1 isoform X1		Enhydra lutris kenyoni		437
Uncharacterized protein (Fragment)		MUSPF		193
CDK2-associated and cullin domain-containing protein 1		LEPWE		246
+73
Q86Y37-2	CDK2-associated and cullin domain-containing protein 1		DIPOR		370	UniRef90_Q86Y37-2
CDK2 associated cullin domain 1		AILME		335
CACUL1 isoform 1		PANTR		303
CACUL1 isoform 1		PONAB		303

Protein	Similar proteins		Species	Score	Length	Source
Q86Y37	Uncharacterized protein C10orf46 (Fragment)		MACMU		264	UniRef50_Q86Y37
Isoform 4 of CDK2-associated and cullin domain-containing protein 1		HUMAN		246
CDK2-associated and cullin domain-containing protein 1 isoform X1		Enhydra lutris kenyoni		437
Uncharacterized protein (Fragment)		MUSPF		193
CDK2-associated and cullin domain-containing protein 1		LEPWE		246
+122
Q86Y37-2	CDK2-associated and cullin domain-containing protein 1		DIPOR		370	UniRef50_Q86Y37-2
CDK2 associated cullin domain 1		AILME		335
CACUL1 isoform 1		PONAB		303
CACUL1 isoform 1		PANTR		303
Uncharacterized protein		LATCH		334
+69

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ544771 mRNA Translation: CAD67614.1 AY743663 mRNA Translation: AAU89709.1 Frameshift. AK097728 mRNA Translation: BAC05153.1 AL139407 Genomic DNA No translation available. BC038294 mRNA Translation: AAH38294.1
CCDSⁱ	CCDS41570.1 [Q86Y37-1]
RefSeqⁱ	NP_722517.3, NM_153810.4 [Q86Y37-1]
UniGeneⁱ	Hs.420024 Hs.669999

3D structure databases

ProteinModelPortalⁱ	Q86Y37
SMRⁱ	Q86Y37
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126801, 4 interactors
IntActⁱ	Q86Y37, 2 interactors
MINTⁱ	Q86Y37
STRINGⁱ	9606.ENSP00000358147

PTM databases

iPTMnetⁱ	Q86Y37
PhosphoSitePlusⁱ	Q86Y37

Polymorphism and mutation databases

BioMutaⁱ	CACUL1
DMDMⁱ	67460542

Proteomic databases

EPDⁱ	Q86Y37
MaxQBⁱ	Q86Y37
PaxDbⁱ	Q86Y37
PeptideAtlasⁱ	Q86Y37
PRIDEⁱ	Q86Y37
ProteomicsDBⁱ	70367 70368 [Q86Y37-2] 70369 [Q86Y37-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000369151; ENSP00000358147; ENSG00000151893 [Q86Y37-1] ENST00000493518; ENSP00000431329; ENSG00000151893 [Q86Y37-2]
GeneIDⁱ	143384
KEGGⁱ	hsa:143384
UCSCⁱ	uc001lds.2 human [Q86Y37-1]

Organism-specific databases

CTDⁱ	143384
DisGeNETⁱ	143384
EuPathDBⁱ	HostDB:ENSG00000151893.14
GeneCardsⁱ	CACUL1
HGNCⁱ	HGNC:23727 CACUL1
HPAⁱ	HPA050611
neXtProtⁱ	NX_Q86Y37
OpenTargetsⁱ	ENSG00000151893
PharmGKBⁱ	PA134869023
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2166 Eukaryota COG5647 LUCA
GeneTreeⁱ	ENSGT00390000000403
HOGENOMⁱ	HOG000111684
HOVERGENⁱ	HBG059519
InParanoidⁱ	Q86Y37
OMAⁱ	WVQMAPA
OrthoDBⁱ	EOG091G0EJ6
PhylomeDBⁱ	Q86Y37
TreeFamⁱ	TF329263

Miscellaneous databases

ChiTaRSⁱ	CACUL1 human
GenomeRNAiⁱ	143384
Protein Ontology More...PROⁱ	PR:Q86Y37

Gene expression databases

Bgeeⁱ	ENSG00000151893 Expressed in 206 organ(s), highest expression level in epithelium of mammary gland
CleanExⁱ	HS_C10orf46
Genevisibleⁱ	Q86Y37 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001373 Cullin_N IPR016159 Cullin_repeat-like_dom_sf
Pfamⁱ	View protein in Pfam PF00888 Cullin, 1 hit
SUPFAMⁱ	SSF74788 SSF74788, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CACL1_HUMAN
Accessionⁱ	Q86Y37Primary (citable) accession number: Q86Y37 Secondary accession number(s): Q5XPL7, Q8IY11, Q8N7S4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
	Last sequence update:	June 1, 2003
	Last modified:	November 7, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q86Y37 (CACL1_HUMAN)

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CDK2-associated and cullin domain-containing protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ