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Protein

Cell division cycle protein 20 homolog B

Gene

CDC20B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ86Y33

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle protein 20 homolog B
Gene namesi
Name:CDC20B
ORF Names:G6VTS76519
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164287.12
HGNCiHGNC:24222 CDC20B
neXtProtiNX_Q86Y33

Pathology & Biotechi

Organism-specific databases

DisGeNETi166979
OpenTargetsiENSG00000164287
PharmGKBiPA145149217

Polymorphism and mutation databases

BioMutaiCDC20B
DMDMi302393826

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003391101 – 519Cell division cycle protein 20 homolog BAdd BLAST519

Proteomic databases

PaxDbiQ86Y33
PeptideAtlasiQ86Y33
PRIDEiQ86Y33
ProteomicsDBi70361
70362 [Q86Y33-2]
70363 [Q86Y33-3]
70364 [Q86Y33-4]
70365 [Q86Y33-5]

PTM databases

iPTMnetiQ86Y33
PhosphoSitePlusiQ86Y33

Expressioni

Gene expression databases

BgeeiENSG00000164287 Expressed in 28 organ(s), highest expression level in secondary oocyte
CleanExiHS_CDC20B
GenevisibleiQ86Y33 HS

Organism-specific databases

HPAiHPA053900

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi127940, 19 interactors
IntActiQ86Y33, 20 interactors
STRINGi9606.ENSP00000370781

Structurei

3D structure databases

ProteinModelPortaliQ86Y33
SMRiQ86Y33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati229 – 266WD 1Add BLAST38
Repeati271 – 310WD 2Add BLAST40
Repeati311 – 341WD 3Add BLAST31
Repeati353 – 392WD 4Add BLAST40
Repeati399 – 441WD 5Add BLAST43
Repeati443 – 484WD 6Add BLAST42
Repeati487 – 519WD 7Add BLAST33

Sequence similaritiesi

Belongs to the WD repeat CDC20/Fizzy family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0305 Eukaryota
ENOG410XQ8I LUCA
GeneTreeiENSGT00870000136444
HOVERGENiHBG107630
InParanoidiQ86Y33
OMAiWCPWQSG
OrthoDBiEOG091G08T6
PhylomeDBiQ86Y33
TreeFamiTF337979

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR033010 Cdc20/Fizzy
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19918 PTHR19918, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86Y33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT
60 70 80 90 100
YSDFKSNFAK RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP
110 120 130 140 150
EASGSVLKTP PEKETLTLGS RKEQLKTPSK GISETSNSAL HFCKAPHAMD
160 170 180 190 200
RDWKESVASK GQKCLKQLFV TQNVVQQANG KMQLCEQSEC VWKGCKDGVR
210 220 230 240 250
DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS FQNLVAIALG
260 270 280 290 300
SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW
310 320 330 340 350
DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG
360 370 380 390 400
TLRHKQAVCA LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ
410 420 430 440 450
STAVKAMDWC PWQSGVLAIG GGMKDGRLHI LDINAGKSIQ TPSTNSQICS
460 470 480 490 500
LIWLPKTKEI ATGQGTPKND VTVWTCPTVS RSGGFFGHRG RVLHLSLSPD
510
QTRVFSAAAD GTASVWNCY
Length:519
Mass (Da):57,335
Last modified:August 10, 2010 - v3
Checksum:i2D40A57A4363A349
GO
Isoform 2 (identifier: Q86Y33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     483-486: Missing.

Show »
Length:515
Mass (Da):56,927
Checksum:iC9DC5381A7EA8C6D
GO
Isoform 3 (identifier: Q86Y33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-447: Missing.

Note: No experimental confirmation available.
Show »
Length:477
Mass (Da):52,898
Checksum:i156E243FF6FF2BBE
GO
Isoform 4 (identifier: Q86Y33-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-372: SGSRLGRVYH...WSPDGRLLSS → RLEFSGVISA...WGVFIITMFG
     373-519: Missing.

Note: No experimental confirmation available.
Show »
Length:372
Mass (Da):41,849
Checksum:i6C26758297E77056
GO
Isoform 5 (identifier: Q86Y33-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-42: Missing.
     194-213: GCKDGVRDESFHLKSSGDIN → DHFSGSMKKRFEQEDVGGKD
     214-519: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):21,697
Checksum:i0AF24C360751729F
GO

Sequence cautioni

The sequence BAB97393 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0438608T → P. Corresponds to variant dbSNP:rs173042Ensembl.1
Natural variantiVAR_04386117E → K. Corresponds to variant dbSNP:rs423074Ensembl.1
Natural variantiVAR_04386297T → S. Corresponds to variant dbSNP:rs34132993Ensembl.1
Natural variantiVAR_043863121R → C4 PublicationsCorresponds to variant dbSNP:rs1021580Ensembl.1
Natural variantiVAR_043864496S → A4 PublicationsCorresponds to variant dbSNP:rs3104230Ensembl.1
Natural variantiVAR_043865503R → W2 PublicationsCorresponds to variant dbSNP:rs444527Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03408922 – 42Missing in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_034090194 – 213GCKDG…SGDIN → DHFSGSMKKRFEQEDVGGKD in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_034091214 – 519Missing in isoform 5. 1 PublicationAdd BLAST306
Alternative sequenceiVSP_034092330 – 372SGSRL…RLLSS → RLEFSGVISAHCNLHLPSSW DYRRPPPCLVGQDWGVFIIT MFG in isoform 4. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_034093373 – 519Missing in isoform 4. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_034094406 – 447Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_034095483 – 486Missing in isoform 2. 2 Publications4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077043 mRNA Translation: BAC67701.1
AB077044 mRNA Translation: BAB97393.1 Different initiation.
AB081750 mRNA Translation: BAC67702.1
AB086378 mRNA Translation: BAC67705.1
AK095246 mRNA Translation: BAC04508.1
AC091977 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54901.1
BC037547 mRNA Translation: AAH37547.1
BC136572 mRNA Translation: AAI36573.1
CCDSiCCDS3966.1 [Q86Y33-2]
CCDS47207.1 [Q86Y33-3]
CCDS54852.1 [Q86Y33-1]
RefSeqiNP_001139206.2, NM_001145734.2 [Q86Y33-3]
NP_001163873.1, NM_001170402.1 [Q86Y33-1]
NP_689836.2, NM_152623.2 [Q86Y33-2]
UniGeneiHs.669184

Genome annotation databases

EnsembliENST00000296733; ENSP00000296733; ENSG00000164287 [Q86Y33-2]
ENST00000322374; ENSP00000315720; ENSG00000164287 [Q86Y33-3]
ENST00000381375; ENSP00000370781; ENSG00000164287 [Q86Y33-1]
ENST00000507931; ENSP00000423919; ENSG00000164287 [Q86Y33-5]
ENST00000513180; ENSP00000426776; ENSG00000164287 [Q86Y33-4]
GeneIDi166979
KEGGihsa:166979
UCSCiuc003jpn.3 human [Q86Y33-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077043 mRNA Translation: BAC67701.1
AB077044 mRNA Translation: BAB97393.1 Different initiation.
AB081750 mRNA Translation: BAC67702.1
AB086378 mRNA Translation: BAC67705.1
AK095246 mRNA Translation: BAC04508.1
AC091977 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54901.1
BC037547 mRNA Translation: AAH37547.1
BC136572 mRNA Translation: AAI36573.1
CCDSiCCDS3966.1 [Q86Y33-2]
CCDS47207.1 [Q86Y33-3]
CCDS54852.1 [Q86Y33-1]
RefSeqiNP_001139206.2, NM_001145734.2 [Q86Y33-3]
NP_001163873.1, NM_001170402.1 [Q86Y33-1]
NP_689836.2, NM_152623.2 [Q86Y33-2]
UniGeneiHs.669184

3D structure databases

ProteinModelPortaliQ86Y33
SMRiQ86Y33
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127940, 19 interactors
IntActiQ86Y33, 20 interactors
STRINGi9606.ENSP00000370781

PTM databases

iPTMnetiQ86Y33
PhosphoSitePlusiQ86Y33

Polymorphism and mutation databases

BioMutaiCDC20B
DMDMi302393826

Proteomic databases

PaxDbiQ86Y33
PeptideAtlasiQ86Y33
PRIDEiQ86Y33
ProteomicsDBi70361
70362 [Q86Y33-2]
70363 [Q86Y33-3]
70364 [Q86Y33-4]
70365 [Q86Y33-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296733; ENSP00000296733; ENSG00000164287 [Q86Y33-2]
ENST00000322374; ENSP00000315720; ENSG00000164287 [Q86Y33-3]
ENST00000381375; ENSP00000370781; ENSG00000164287 [Q86Y33-1]
ENST00000507931; ENSP00000423919; ENSG00000164287 [Q86Y33-5]
ENST00000513180; ENSP00000426776; ENSG00000164287 [Q86Y33-4]
GeneIDi166979
KEGGihsa:166979
UCSCiuc003jpn.3 human [Q86Y33-1]

Organism-specific databases

CTDi166979
DisGeNETi166979
EuPathDBiHostDB:ENSG00000164287.12
GeneCardsiCDC20B
HGNCiHGNC:24222 CDC20B
HPAiHPA053900
neXtProtiNX_Q86Y33
OpenTargetsiENSG00000164287
PharmGKBiPA145149217
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0305 Eukaryota
ENOG410XQ8I LUCA
GeneTreeiENSGT00870000136444
HOVERGENiHBG107630
InParanoidiQ86Y33
OMAiWCPWQSG
OrthoDBiEOG091G08T6
PhylomeDBiQ86Y33
TreeFamiTF337979

Enzyme and pathway databases

SignaLinkiQ86Y33

Miscellaneous databases

ChiTaRSiCDC20B human
GenomeRNAii166979
PROiPR:Q86Y33

Gene expression databases

BgeeiENSG00000164287 Expressed in 28 organ(s), highest expression level in secondary oocyte
CleanExiHS_CDC20B
GenevisibleiQ86Y33 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR033010 Cdc20/Fizzy
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19918 PTHR19918, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD20B_HUMAN
AccessioniPrimary (citable) accession number: Q86Y33
Secondary accession number(s): B7WNV8
, B9EGL8, C9J6X8, C9JHE9, C9JKL5, Q86Y31, Q86Y32, Q8IUZ8, Q8N1S1, Q8NG56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 10, 2010
Last modified: November 7, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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