UniProtKB - Q86Y33 (CD20B_HUMAN)
Protein
Cell division cycle protein 20 homolog B
Gene
CDC20B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- anaphase-promoting complex binding Source: GO_Central
- ubiquitin ligase activator activity Source: GO_Central
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: GO_Central
- positive regulation of anaphase-promoting complex-dependent catabolic process Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q86Y33 |
SignaLinki | Q86Y33 |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division cycle protein 20 homolog B |
Gene namesi | Name:CDC20B ORF Names:G6VTS76519 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24222, CDC20B |
neXtProti | NX_Q86Y33 |
VEuPathDBi | HostDB:ENSG00000164287.12 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 166979 |
OpenTargetsi | ENSG00000164287 |
PharmGKBi | PA145149217 |
Miscellaneous databases
Pharosi | Q86Y33, Tdark |
Genetic variation databases
BioMutai | CDC20B |
DMDMi | 302393826 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000339110 | 1 – 519 | Cell division cycle protein 20 homolog BAdd BLAST | 519 |
Proteomic databases
jPOSTi | Q86Y33 |
PaxDbi | Q86Y33 |
PeptideAtlasi | Q86Y33 |
PRIDEi | Q86Y33 |
ProteomicsDBi | 70361 [Q86Y33-1] 70362 [Q86Y33-2] 70363 [Q86Y33-3] 70364 [Q86Y33-4] 70365 [Q86Y33-5] |
PTM databases
iPTMneti | Q86Y33 |
PhosphoSitePlusi | Q86Y33 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164287, Expressed in secondary oocyte and 38 other tissues |
Genevisiblei | Q86Y33, HS |
Organism-specific databases
HPAi | ENSG00000164287, Group enriched (endometrium, fallopian tube, kidney, lung, testis) |
Interactioni
Binary interactionsi
Hide detailsQ86Y33
Isoform 5 [Q86Y33-5]
Protein-protein interaction databases
BioGRIDi | 127940, 28 interactors |
IntActi | Q86Y33, 29 interactors |
STRINGi | 9606.ENSP00000370781 |
Miscellaneous databases
RNActi | Q86Y33, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 229 – 266 | WD 1Add BLAST | 38 | |
Repeati | 271 – 310 | WD 2Add BLAST | 40 | |
Repeati | 311 – 341 | WD 3Add BLAST | 31 | |
Repeati | 353 – 392 | WD 4Add BLAST | 40 | |
Repeati | 399 – 441 | WD 5Add BLAST | 43 | |
Repeati | 443 – 484 | WD 6Add BLAST | 42 | |
Repeati | 487 – 519 | WD 7Add BLAST | 33 |
Sequence similaritiesi
Belongs to the WD repeat CDC20/Fizzy family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0305, Eukaryota |
GeneTreei | ENSGT00950000183104 |
HOGENOMi | CLU_014831_6_2_1 |
InParanoidi | Q86Y33 |
OMAi | TACVWNC |
OrthoDBi | 1220675at2759 |
PhylomeDBi | Q86Y33 |
TreeFami | TF337979 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR033010, Cdc20/Fizzy IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR19918, PTHR19918, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (5)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q86Y33-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT
60 70 80 90 100
YSDFKSNFAK RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP
110 120 130 140 150
EASGSVLKTP PEKETLTLGS RKEQLKTPSK GISETSNSAL HFCKAPHAMD
160 170 180 190 200
RDWKESVASK GQKCLKQLFV TQNVVQQANG KMQLCEQSEC VWKGCKDGVR
210 220 230 240 250
DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS FQNLVAIALG
260 270 280 290 300
SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW
310 320 330 340 350
DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG
360 370 380 390 400
TLRHKQAVCA LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ
410 420 430 440 450
STAVKAMDWC PWQSGVLAIG GGMKDGRLHI LDINAGKSIQ TPSTNSQICS
460 470 480 490 500
LIWLPKTKEI ATGQGTPKND VTVWTCPTVS RSGGFFGHRG RVLHLSLSPD
510
QTRVFSAAAD GTASVWNCY
Sequence cautioni
The sequence BAB97393 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043860 | 8 | T → P. Corresponds to variant dbSNP:rs173042Ensembl. | 1 | |
Natural variantiVAR_043861 | 17 | E → K. Corresponds to variant dbSNP:rs423074Ensembl. | 1 | |
Natural variantiVAR_043862 | 97 | T → S. Corresponds to variant dbSNP:rs34132993Ensembl. | 1 | |
Natural variantiVAR_043863 | 121 | R → C4 PublicationsCorresponds to variant dbSNP:rs1021580Ensembl. | 1 | |
Natural variantiVAR_043864 | 496 | S → A4 PublicationsCorresponds to variant dbSNP:rs3104230Ensembl. | 1 | |
Natural variantiVAR_043865 | 503 | R → W2 PublicationsCorresponds to variant dbSNP:rs444527Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034089 | 22 – 42 | Missing in isoform 5. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_034090 | 194 – 213 | GCKDG…SGDIN → DHFSGSMKKRFEQEDVGGKD in isoform 5. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_034091 | 214 – 519 | Missing in isoform 5. 1 PublicationAdd BLAST | 306 | |
Alternative sequenceiVSP_034092 | 330 – 372 | SGSRL…RLLSS → RLEFSGVISAHCNLHLPSSW DYRRPPPCLVGQDWGVFIIT MFG in isoform 4. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_034093 | 373 – 519 | Missing in isoform 4. 1 PublicationAdd BLAST | 147 | |
Alternative sequenceiVSP_034094 | 406 – 447 | Missing in isoform 3. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_034095 | 483 – 486 | Missing in isoform 2. 2 Publications | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB077043 mRNA Translation: BAC67701.1 AB077044 mRNA Translation: BAB97393.1 Different initiation. AB081750 mRNA Translation: BAC67702.1 AB086378 mRNA Translation: BAC67705.1 AK095246 mRNA Translation: BAC04508.1 AC091977 Genomic DNA No translation available. CH471123 Genomic DNA Translation: EAW54901.1 BC037547 mRNA Translation: AAH37547.1 BC136572 mRNA Translation: AAI36573.1 |
CCDSi | CCDS3966.1 [Q86Y33-2] CCDS47207.1 [Q86Y33-3] CCDS54852.1 [Q86Y33-1] |
RefSeqi | NP_001139206.2, NM_001145734.2 [Q86Y33-3] NP_001163873.1, NM_001170402.1 [Q86Y33-1] NP_689836.2, NM_152623.2 [Q86Y33-2] |
Genome annotation databases
Ensembli | ENST00000296733; ENSP00000296733; ENSG00000164287 [Q86Y33-2] ENST00000322374; ENSP00000315720; ENSG00000164287 [Q86Y33-3] ENST00000381375; ENSP00000370781; ENSG00000164287 [Q86Y33-1] ENST00000507931; ENSP00000423919; ENSG00000164287 [Q86Y33-5] ENST00000513180; ENSP00000426776; ENSG00000164287 [Q86Y33-4] |
GeneIDi | 166979 |
KEGGi | hsa:166979 |
UCSCi | uc003jpn.3, human [Q86Y33-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB077043 mRNA Translation: BAC67701.1 AB077044 mRNA Translation: BAB97393.1 Different initiation. AB081750 mRNA Translation: BAC67702.1 AB086378 mRNA Translation: BAC67705.1 AK095246 mRNA Translation: BAC04508.1 AC091977 Genomic DNA No translation available. CH471123 Genomic DNA Translation: EAW54901.1 BC037547 mRNA Translation: AAH37547.1 BC136572 mRNA Translation: AAI36573.1 |
CCDSi | CCDS3966.1 [Q86Y33-2] CCDS47207.1 [Q86Y33-3] CCDS54852.1 [Q86Y33-1] |
RefSeqi | NP_001139206.2, NM_001145734.2 [Q86Y33-3] NP_001163873.1, NM_001170402.1 [Q86Y33-1] NP_689836.2, NM_152623.2 [Q86Y33-2] |
3D structure databases
SMRi | Q86Y33 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127940, 28 interactors |
IntActi | Q86Y33, 29 interactors |
STRINGi | 9606.ENSP00000370781 |
PTM databases
iPTMneti | Q86Y33 |
PhosphoSitePlusi | Q86Y33 |
Genetic variation databases
BioMutai | CDC20B |
DMDMi | 302393826 |
Proteomic databases
jPOSTi | Q86Y33 |
PaxDbi | Q86Y33 |
PeptideAtlasi | Q86Y33 |
PRIDEi | Q86Y33 |
ProteomicsDBi | 70361 [Q86Y33-1] 70362 [Q86Y33-2] 70363 [Q86Y33-3] 70364 [Q86Y33-4] 70365 [Q86Y33-5] |
Protocols and materials databases
Antibodypediai | 23375, 137 antibodies |
Genome annotation databases
Ensembli | ENST00000296733; ENSP00000296733; ENSG00000164287 [Q86Y33-2] ENST00000322374; ENSP00000315720; ENSG00000164287 [Q86Y33-3] ENST00000381375; ENSP00000370781; ENSG00000164287 [Q86Y33-1] ENST00000507931; ENSP00000423919; ENSG00000164287 [Q86Y33-5] ENST00000513180; ENSP00000426776; ENSG00000164287 [Q86Y33-4] |
GeneIDi | 166979 |
KEGGi | hsa:166979 |
UCSCi | uc003jpn.3, human [Q86Y33-1] |
Organism-specific databases
CTDi | 166979 |
DisGeNETi | 166979 |
GeneCardsi | CDC20B |
HGNCi | HGNC:24222, CDC20B |
HPAi | ENSG00000164287, Group enriched (endometrium, fallopian tube, kidney, lung, testis) |
neXtProti | NX_Q86Y33 |
OpenTargetsi | ENSG00000164287 |
PharmGKBi | PA145149217 |
VEuPathDBi | HostDB:ENSG00000164287.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0305, Eukaryota |
GeneTreei | ENSGT00950000183104 |
HOGENOMi | CLU_014831_6_2_1 |
InParanoidi | Q86Y33 |
OMAi | TACVWNC |
OrthoDBi | 1220675at2759 |
PhylomeDBi | Q86Y33 |
TreeFami | TF337979 |
Enzyme and pathway databases
PathwayCommonsi | Q86Y33 |
SignaLinki | Q86Y33 |
Miscellaneous databases
BioGRID-ORCSi | 166979, 6 hits in 979 CRISPR screens |
ChiTaRSi | CDC20B, human |
GenomeRNAii | 166979 |
Pharosi | Q86Y33, Tdark |
PROi | PR:Q86Y33 |
RNActi | Q86Y33, protein |
Gene expression databases
Bgeei | ENSG00000164287, Expressed in secondary oocyte and 38 other tissues |
Genevisiblei | Q86Y33, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR033010, Cdc20/Fizzy IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR19918, PTHR19918, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD20B_HUMAN | |
Accessioni | Q86Y33Primary (citable) accession number: Q86Y33 Secondary accession number(s): B7WNV8 Q8NG56 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | August 10, 2010 | |
Last modified: | April 7, 2021 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families