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Protein

B melanoma antigen 3

Gene

BAGE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Unknown. Candidate gene encoding tumor antigens.

Miscellaneous

The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.

Names & Taxonomyi

Protein namesi
Recommended name:
B melanoma antigen 3
Alternative name(s):
Cancer/testis antigen 2.3
Short name:
CT2.3
Gene namesi
Name:BAGE3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15728 BAGE3
MIMi617777 gene
neXtProtiNX_Q86Y29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002077618 – 109B melanoma antigen 3Add BLAST92

Proteomic databases

PRIDEiQ86Y29
ProteomicsDBi70359

Expressioni

Tissue specificityi

Not expressed in normal tissues except in testis. Expressed in melanoma, bladder and lung carcinomas.

Structurei

3D structure databases

SMRiQ86Y29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAGE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG050657
InParanoidiQ86Y29

Family and domain databases

InterProiView protein in InterPro
IPR039115 BAGE
IPR012530 BAGE-like
PANTHERiPTHR39655 PTHR39655, 1 hit
PfamiView protein in Pfam
PF08180 BAGE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86Y29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGVVFLAL SAQLLQARLM KEESPVVSWR LEPEDGTALD VHFVSTLEPL
60 70 80 90 100
SNAVKRNVPR CIIILVLQEP TPFRISVTSS CFVQNTLTKL LKDRRKMQTV

QCATAQETS
Length:109
Mass (Da):12,112
Last modified:June 1, 2003 - v1
Checksum:iA477B7A8FC3A2F4E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72P → A in AAI01135 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05958795R → T. Corresponds to variant dbSNP:rs2740327Ensembl.1
Natural variantiVAR_059588106Q → R1 PublicationCorresponds to variant dbSNP:rs9808647Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339514 mRNA Translation: AAO32634.1
BC101134 mRNA Translation: AAI01135.1
RefSeqiNP_872287.1, NM_182481.1
UniGeneiHs.545789

Genome annotation databases

GeneIDi85318
KEGGihsa:85318

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBAGE3_HUMAN
AccessioniPrimary (citable) accession number: Q86Y29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: July 18, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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