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Protein

Collagen alpha-1(XXIII) chain

Gene

COL23A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-216083 Integrin cell surface interactions
R-HSA-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXIII) chain
Gene namesi
Name:COL23A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000050767.15
HGNCiHGNC:22990 COL23A1
MIMi610043 gene
neXtProtiNX_Q86Y22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST22
Topological domaini57 – 540ExtracellularSequence analysisAdd BLAST484

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi91522
OpenTargetsiENSG00000050767
PharmGKBiPA134899251

Polymorphism and mutation databases

BioMutaiCOL23A1
DMDMi74723551

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452261 – 540Collagen alpha-1(XXIII) chainAdd BLAST540

Post-translational modificationi

Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin.By similarity

Proteomic databases

EPDiQ86Y22
PaxDbiQ86Y22
PeptideAtlasiQ86Y22
PRIDEiQ86Y22
ProteomicsDBi70352
70353 [Q86Y22-2]

PTM databases

iPTMnetiQ86Y22
PhosphoSitePlusiQ86Y22

Expressioni

Gene expression databases

BgeeiENSG00000050767 Expressed in 97 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_COL23A1
ExpressionAtlasiQ86Y22 baseline and differential
GenevisibleiQ86Y22 HS

Organism-specific databases

HPAiHPA067824

Interactioni

Subunit structurei

Homotrimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EXOSC8Q96B263EBI-373279,EBI-371922

Protein-protein interaction databases

BioGridi124839, 3 interactors
ComplexPortaliCPX-1764 Collagen type XXIII trimer
IntActiQ86Y22, 2 interactors
STRINGi9606.ENSP00000375069

Structurei

3D structure databases

ProteinModelPortaliQ86Y22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 243Collagen-like 1Add BLAST120
Domaini251 – 305Collagen-like 2Add BLAST55
Domaini321 – 380Collagen-like 3Add BLAST60
Domaini412 – 460Collagen-like 4Add BLAST49
Domaini463 – 522Collagen-like 5Add BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 536Gly-richAdd BLAST535

Keywords - Domaini

Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140850
HOGENOMiHOG000085653
HOVERGENiHBG004933
InParanoidiQ86Y22
OMAiVPGRKGM
OrthoDBiEOG091G0G3Y
PhylomeDBiQ86Y22
TreeFamiTF338175

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
PfamiView protein in Pfam
PF01391 Collagen, 7 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86Y22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPGERAGGG GDAGKGNAAG GGGGGRSATT AGSRAVSALC LLLSVGSAAA
60 70 80 90 100
CLLLGVQAAA LQGRVAALEE ERELLRRAGP PGALDAWAEP HLERLLREKL
110 120 130 140 150
DGLAKIRTAR EAPSECVCPP GPPGRRGKPG RRGDPGPPGQ SGRDGYPGPL
160 170 180 190 200
GLDGKPGLPG PKGEKGAPGD FGPRGDQGQD GAAGPPGPPG PPGARGPPGD
210 220 230 240 250
TGKDGPRGAQ GPAGPKGEPG QDGEMGPKGP PGPKGEPGVP GKKGDDGTPS
260 270 280 290 300
QPGPPGPKGE PGSMGPRGEN GVDGAPGPKG EPGHRGTDGA AGPRGAPGLK
310 320 330 340 350
GEQGDTVVID YDGRILDALK GPPGPQGPPG PPGIPGAKGE LGLPGAPGID
360 370 380 390 400
GEKGPKGQKG DPGEPGPAGL KGEAGEMGLS GLPGADGLKG EKGESASDSL
410 420 430 440 450
QESLAQLIVE PGPPGPPGPP GPMGLQGIQG PKGLDGAKGE KGASGERGPS
460 470 480 490 500
GLPGPVGPPG LIGLPGTKGE KGRPGEPGLD GFPGPRGEKG DRSERGEKGE
510 520 530 540
RGVPGRKGVK GQKGEPGPPG LDQPCPVGPD GLPVPGCWHK
Length:540
Mass (Da):51,944
Last modified:June 1, 2003 - v1
Checksum:iD64D3CA50F729297
GO
Isoform 2 (identifier: Q86Y22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.
     28-98: ATTAGSRAVS...EPHLERLLRE → MESRSGIQAG...GTNSRHTLTV
     140-148: Missing.
     296-345: APGLKGEQGD...GAKGELGLPG → DVRDPGLGSV...RAGRHSGDRL
     346-540: Missing.

Note: No experimental confirmation available.
Show »
Length:309
Mass (Da):30,672
Checksum:iC5FE20DAFA84FBE9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSD3A0A0A0MSD3_HUMAN
Collagen alpha-1(XXIII) chain
COL23A1
393Annotation score:
A0A2R8Y887A0A2R8Y887_HUMAN
Collagen alpha-1(XXIII) chain
COL23A1
63Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026964287T → A. Corresponds to variant dbSNP:rs890802Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0196271 – 27Missing in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_01962828 – 98ATTAG…RLLRE → MESRSGIQAGVRCRDLGSLQ PPPLALKQFSSLSLPSSWDY RRLPPRCGFLFEVSETTNPP AGTNSRHTLTV in isoform 2. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_019629140 – 148Missing in isoform 2. 1 Publication9
Alternative sequenceiVSP_019630296 – 345APGLK…LGLPG → DVRDPGLGSVSSCSQRLASS SKKNGSEPPPGCAGCPRPQG RAGRHSGDRL in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_019631346 – 540Missing in isoform 2. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158895 mRNA Translation: AAO18361.1
AY898961 mRNA Translation: AAX84028.1
BC042428 mRNA Translation: AAH42428.1
AL137461 mRNA Translation: CAB70749.1
CCDSiCCDS4436.1 [Q86Y22-1]
PIRiT46404
RefSeqiNP_775736.2, NM_173465.3 [Q86Y22-1]
UniGeneiHs.660026

Genome annotation databases

EnsembliENST00000390654; ENSP00000375069; ENSG00000050767 [Q86Y22-1]
GeneIDi91522
KEGGihsa:91522
UCSCiuc063kkp.1 human [Q86Y22-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158895 mRNA Translation: AAO18361.1
AY898961 mRNA Translation: AAX84028.1
BC042428 mRNA Translation: AAH42428.1
AL137461 mRNA Translation: CAB70749.1
CCDSiCCDS4436.1 [Q86Y22-1]
PIRiT46404
RefSeqiNP_775736.2, NM_173465.3 [Q86Y22-1]
UniGeneiHs.660026

3D structure databases

ProteinModelPortaliQ86Y22
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124839, 3 interactors
ComplexPortaliCPX-1764 Collagen type XXIII trimer
IntActiQ86Y22, 2 interactors
STRINGi9606.ENSP00000375069

PTM databases

iPTMnetiQ86Y22
PhosphoSitePlusiQ86Y22

Polymorphism and mutation databases

BioMutaiCOL23A1
DMDMi74723551

Proteomic databases

EPDiQ86Y22
PaxDbiQ86Y22
PeptideAtlasiQ86Y22
PRIDEiQ86Y22
ProteomicsDBi70352
70353 [Q86Y22-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390654; ENSP00000375069; ENSG00000050767 [Q86Y22-1]
GeneIDi91522
KEGGihsa:91522
UCSCiuc063kkp.1 human [Q86Y22-1]

Organism-specific databases

CTDi91522
DisGeNETi91522
EuPathDBiHostDB:ENSG00000050767.15
GeneCardsiCOL23A1
HGNCiHGNC:22990 COL23A1
HPAiHPA067824
MIMi610043 gene
neXtProtiNX_Q86Y22
OpenTargetsiENSG00000050767
PharmGKBiPA134899251
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140850
HOGENOMiHOG000085653
HOVERGENiHBG004933
InParanoidiQ86Y22
OMAiVPGRKGM
OrthoDBiEOG091G0G3Y
PhylomeDBiQ86Y22
TreeFamiTF338175

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-216083 Integrin cell surface interactions
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRSiCOL23A1 human
GenomeRNAii91522
PROiPR:Q86Y22
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000050767 Expressed in 97 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_COL23A1
ExpressionAtlasiQ86Y22 baseline and differential
GenevisibleiQ86Y22 HS

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
PfamiView protein in Pfam
PF01391 Collagen, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCONA1_HUMAN
AccessioniPrimary (citable) accession number: Q86Y22
Secondary accession number(s): Q8IVR4, Q9NT93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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