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Protein

Serine/threonine-protein kinase VRK2

Gene

VRK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.
Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

RAN inhibits its autophosphorylation and its ability to phosphorylate histone H3.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61ATPPROSITE-ProRule annotation1
Active sitei166Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 43ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2993913 Clearance of Nuclear Envelope Membranes from Chromatin
R-HSA-2995383 Initiation of Nuclear Envelope Reformation
SignaLinkiQ86Y07
SIGNORiQ86Y07

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase VRK2 (EC:2.7.11.1)
Alternative name(s):
Vaccinia-related kinase 2
Gene namesi
Name:VRK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000028116.16
HGNCiHGNC:12719 VRK2
MIMi602169 gene
neXtProtiNX_Q86Y07

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei487 – 507Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7444
OpenTargetsiENSG00000028116
PharmGKBiPA37331

Chemistry databases

ChEMBLiCHEMBL1649059

Polymorphism and mutation databases

BioMutaiVRK2
DMDMi90116515

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868061 – 508Serine/threonine-protein kinase VRK2Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphothreonineCombined sources1
Modified residuei406PhosphoserineCombined sources1

Post-translational modificationi

Isoform 1 and isoform 2 are autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86Y07
MaxQBiQ86Y07
PaxDbiQ86Y07
PeptideAtlasiQ86Y07
PRIDEiQ86Y07
ProteomicsDBi70345
70346 [Q86Y07-2]
70347 [Q86Y07-3]
70348 [Q86Y07-4]
70349 [Q86Y07-5]

PTM databases

iPTMnetiQ86Y07
PhosphoSitePlusiQ86Y07

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis.3 Publications

Gene expression databases

BgeeiENSG00000028116 Expressed in 221 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ86Y07 baseline and differential
GenevisibleiQ86Y07 HS

Organism-specific databases

HPAiCAB046459
HPA047503

Interactioni

Subunit structurei

Isoform 1 interacts with MAP3K7, MAP2K7, MAP2K1 and KSR1. Isoform 1 and isoform 2 interact with RAN and MAPK8IP1.4 Publications
(Microbial infection) Isoform 1 interacts with Epstein-Barr virus BHRF1; this interaction is involved in protecting cells from apoptosis.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113283, 31 interactors
IntActiQ86Y07, 38 interactors
STRINGi9606.ENSP00000342381

Chemistry databases

BindingDBiQ86Y07

Structurei

Secondary structure

1508
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ86Y07
SMRiQ86Y07
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86Y07

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 319Protein kinasePROSITE-ProRule annotationAdd BLAST291

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni397 – 508Interaction with MAP3K71 PublicationAdd BLAST112

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1164 Eukaryota
ENOG410XPGP LUCA
GeneTreeiENSGT00920000148988
HOVERGENiHBG007532
InParanoidiQ86Y07
KOiK08816
OMAiSSCCEIA
OrthoDBiEOG091G05V5
PhylomeDBiQ86Y07
TreeFamiTF106473

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86Y07-1) [UniParc]FASTAAdd to basket
Also known as: VRK2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPKRNEKYK LPIPFPEGKV LDDMEGNQWV LGKKIGSGGF GLIYLAFPTN
60 70 80 90 100
KPEKDARHVV KVEYQENGPL FSELKFYQRV AKKDCIKKWI ERKQLDYLGI
110 120 130 140 150
PLFYGSGLTE FKGRSYRFMV MERLGIDLQK ISGQNGTFKK STVLQLGIRM
160 170 180 190 200
LDVLEYIHEN EYVHGDIKAA NLLLGYKNPD QVYLADYGLS YRYCPNGNHK
210 220 230 240 250
QYQENPRKGH NGTIEFTSLD AHKGVALSRR SDVEILGYCM LRWLCGKLPW
260 270 280 290 300
EQNLKDPVAV QTAKTNLLDE LPQSVLKWAP SGSSCCEIAQ FLVCAHSLAY
310 320 330 340 350
DEKPNYQALK KILNPHGIPL GPLDFSTKGQ SINVHTPNSQ KVDSQKAATK
360 370 380 390 400
QVNKAHNRLI EKKVHSERSA ESCATWKVQK EEKLIGLMNN EAAQESTRRR
410 420 430 440 450
QKYQESQEPL NEVNSFPQKI SYTQFPNSFY EPHQDFTSPD IFKKSRSPSW
460 470 480 490 500
YKYTSTVSTG ITDLESSTGL WPTISQFTLS EETNADVYYY RIIIPVLLML

VFLALFFL
Length:508
Mass (Da):58,141
Last modified:March 7, 2006 - v3
Checksum:i9F3F6FCC9280568F
GO
Isoform 2 (identifier: Q86Y07-2) [UniParc]FASTAAdd to basket
Also known as: VRK2B

The sequence of this isoform differs from the canonical sequence as follows:
     395-397: EST → VEA
     398-508: Missing.

Show »
Length:397
Mass (Da):45,030
Checksum:i0308378DD02D85EC
GO
Isoform 3 (identifier: Q86Y07-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):55,446
Checksum:i425363D6092A57FC
GO
Isoform 4 (identifier: Q86Y07-4) [UniParc]FASTAAdd to basket
Also known as: 5

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Show »
Length:390
Mass (Da):44,411
Checksum:i9F320B446A872E5D
GO
Isoform 5 (identifier: Q86Y07-5) [UniParc]FASTAAdd to basket
Also known as: 6

The sequence of this isoform differs from the canonical sequence as follows:
     395-396: ES → FR
     397-508: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):45,034
Checksum:i773C8DD02D85EC43
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERS5E7ERS5_HUMAN
Serine/threonine-protein kinase VRK...
VRK2
82Annotation score:
E9PBU1E9PBU1_HUMAN
Serine/threonine-protein kinase VRK...
VRK2
59Annotation score:

Sequence cautioni

The sequence CAD54446 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti419K → E in AAO73048 (Ref. 3) Curated1
Sequence conflicti419K → E in AAO73049 (Ref. 3) Curated1
Sequence conflicti419K → E in AAO73051 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04129350N → D1 PublicationCorresponds to variant dbSNP:rs34130684Ensembl.1
Natural variantiVAR_041294157I → M1 PublicationCorresponds to variant dbSNP:rs35966666Ensembl.1
Natural variantiVAR_017095167I → V4 PublicationsCorresponds to variant dbSNP:rs1051061Ensembl.1
Natural variantiVAR_051681211N → S. Corresponds to variant dbSNP:rs36081172Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0085341 – 118Missing in isoform 4. 2 PublicationsAdd BLAST118
Alternative sequenceiVSP_0085331 – 23Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_008537395 – 397EST → VEA in isoform 2. 1 Publication3
Alternative sequenceiVSP_008535395 – 396ES → FR in isoform 5. 1 Publication2
Alternative sequenceiVSP_008536397 – 508Missing in isoform 5. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_008538398 – 508Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000450 mRNA Translation: BAA19109.1
AJ512204 mRNA Translation: CAD54446.2 Sequence problems.
AY228367 mRNA Translation: AAO73047.1
AY228368 mRNA Translation: AAO73048.1
AY228369 mRNA Translation: AAO73049.1
AY228370 mRNA Translation: AAO73050.1
AY228371 mRNA Translation: AAO73051.1
AY228372 mRNA Translation: AAO73052.1
AK296611 mRNA Translation: BAG59222.1
AK223540 mRNA Translation: BAD97260.1
AC007250 Genomic DNA Translation: AAY15019.1
AC068193 Genomic DNA Translation: AAX93262.1
AC073215 Genomic DNA Translation: AAY14648.1
CH471053 Genomic DNA Translation: EAX00062.1
CH471053 Genomic DNA Translation: EAX00064.1
CH471053 Genomic DNA Translation: EAX00066.1
CH471053 Genomic DNA Translation: EAX00067.1
CH471053 Genomic DNA Translation: EAX00068.1
BC027854 mRNA Translation: AAH27854.1
CCDSiCCDS1859.1 [Q86Y07-1]
CCDS46291.1 [Q86Y07-5]
CCDS46292.1 [Q86Y07-3]
RefSeqiNP_001123952.1, NM_001130480.2 [Q86Y07-1]
NP_001123953.1, NM_001130481.2 [Q86Y07-1]
NP_001123954.1, NM_001130482.2 [Q86Y07-3]
NP_001123955.1, NM_001130483.2 [Q86Y07-5]
NP_001275765.1, NM_001288836.1 [Q86Y07-4]
NP_001275766.1, NM_001288837.1 [Q86Y07-1]
NP_001275767.1, NM_001288838.1 [Q86Y07-5]
NP_001275768.1, NM_001288839.1 [Q86Y07-4]
NP_006287.2, NM_006296.6 [Q86Y07-1]
XP_005264597.1, XM_005264540.4 [Q86Y07-1]
XP_006712153.1, XM_006712090.3 [Q86Y07-2]
XP_006712154.1, XM_006712091.3 [Q86Y07-5]
XP_006712155.1, XM_006712092.3 [Q86Y07-4]
XP_006712156.1, XM_006712093.3 [Q86Y07-4]
XP_011531394.1, XM_011533092.2 [Q86Y07-1]
XP_016860347.1, XM_017004858.1 [Q86Y07-2]
XP_016860348.1, XM_017004859.1 [Q86Y07-4]
XP_016860349.1, XM_017004860.1 [Q86Y07-4]
XP_016860350.1, XM_017004861.1 [Q86Y07-4]
XP_016860351.1, XM_017004862.1 [Q86Y07-4]
XP_016860352.1, XM_017004863.1 [Q86Y07-4]
UniGeneiHs.715298
Hs.744058

Genome annotation databases

EnsembliENST00000340157; ENSP00000342381; ENSG00000028116 [Q86Y07-1]
ENST00000412104; ENSP00000404156; ENSG00000028116 [Q86Y07-4]
ENST00000417641; ENSP00000402375; ENSG00000028116 [Q86Y07-5]
ENST00000435505; ENSP00000408002; ENSG00000028116 [Q86Y07-1]
ENST00000440705; ENSP00000398323; ENSG00000028116 [Q86Y07-3]
GeneIDi7444
KEGGihsa:7444
UCSCiuc002rzo.3 human [Q86Y07-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000450 mRNA Translation: BAA19109.1
AJ512204 mRNA Translation: CAD54446.2 Sequence problems.
AY228367 mRNA Translation: AAO73047.1
AY228368 mRNA Translation: AAO73048.1
AY228369 mRNA Translation: AAO73049.1
AY228370 mRNA Translation: AAO73050.1
AY228371 mRNA Translation: AAO73051.1
AY228372 mRNA Translation: AAO73052.1
AK296611 mRNA Translation: BAG59222.1
AK223540 mRNA Translation: BAD97260.1
AC007250 Genomic DNA Translation: AAY15019.1
AC068193 Genomic DNA Translation: AAX93262.1
AC073215 Genomic DNA Translation: AAY14648.1
CH471053 Genomic DNA Translation: EAX00062.1
CH471053 Genomic DNA Translation: EAX00064.1
CH471053 Genomic DNA Translation: EAX00066.1
CH471053 Genomic DNA Translation: EAX00067.1
CH471053 Genomic DNA Translation: EAX00068.1
BC027854 mRNA Translation: AAH27854.1
CCDSiCCDS1859.1 [Q86Y07-1]
CCDS46291.1 [Q86Y07-5]
CCDS46292.1 [Q86Y07-3]
RefSeqiNP_001123952.1, NM_001130480.2 [Q86Y07-1]
NP_001123953.1, NM_001130481.2 [Q86Y07-1]
NP_001123954.1, NM_001130482.2 [Q86Y07-3]
NP_001123955.1, NM_001130483.2 [Q86Y07-5]
NP_001275765.1, NM_001288836.1 [Q86Y07-4]
NP_001275766.1, NM_001288837.1 [Q86Y07-1]
NP_001275767.1, NM_001288838.1 [Q86Y07-5]
NP_001275768.1, NM_001288839.1 [Q86Y07-4]
NP_006287.2, NM_006296.6 [Q86Y07-1]
XP_005264597.1, XM_005264540.4 [Q86Y07-1]
XP_006712153.1, XM_006712090.3 [Q86Y07-2]
XP_006712154.1, XM_006712091.3 [Q86Y07-5]
XP_006712155.1, XM_006712092.3 [Q86Y07-4]
XP_006712156.1, XM_006712093.3 [Q86Y07-4]
XP_011531394.1, XM_011533092.2 [Q86Y07-1]
XP_016860347.1, XM_017004858.1 [Q86Y07-2]
XP_016860348.1, XM_017004859.1 [Q86Y07-4]
XP_016860349.1, XM_017004860.1 [Q86Y07-4]
XP_016860350.1, XM_017004861.1 [Q86Y07-4]
XP_016860351.1, XM_017004862.1 [Q86Y07-4]
XP_016860352.1, XM_017004863.1 [Q86Y07-4]
UniGeneiHs.715298
Hs.744058

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V62X-ray1.70A/B14-335[»]
5UU1X-ray2.00A14-335[»]
ProteinModelPortaliQ86Y07
SMRiQ86Y07
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113283, 31 interactors
IntActiQ86Y07, 38 interactors
STRINGi9606.ENSP00000342381

Chemistry databases

BindingDBiQ86Y07
ChEMBLiCHEMBL1649059

PTM databases

iPTMnetiQ86Y07
PhosphoSitePlusiQ86Y07

Polymorphism and mutation databases

BioMutaiVRK2
DMDMi90116515

Proteomic databases

EPDiQ86Y07
MaxQBiQ86Y07
PaxDbiQ86Y07
PeptideAtlasiQ86Y07
PRIDEiQ86Y07
ProteomicsDBi70345
70346 [Q86Y07-2]
70347 [Q86Y07-3]
70348 [Q86Y07-4]
70349 [Q86Y07-5]

Protocols and materials databases

DNASUi7444
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340157; ENSP00000342381; ENSG00000028116 [Q86Y07-1]
ENST00000412104; ENSP00000404156; ENSG00000028116 [Q86Y07-4]
ENST00000417641; ENSP00000402375; ENSG00000028116 [Q86Y07-5]
ENST00000435505; ENSP00000408002; ENSG00000028116 [Q86Y07-1]
ENST00000440705; ENSP00000398323; ENSG00000028116 [Q86Y07-3]
GeneIDi7444
KEGGihsa:7444
UCSCiuc002rzo.3 human [Q86Y07-1]

Organism-specific databases

CTDi7444
DisGeNETi7444
EuPathDBiHostDB:ENSG00000028116.16
GeneCardsiVRK2
H-InvDBiHIX0002070
HGNCiHGNC:12719 VRK2
HPAiCAB046459
HPA047503
MIMi602169 gene
neXtProtiNX_Q86Y07
OpenTargetsiENSG00000028116
PharmGKBiPA37331
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1164 Eukaryota
ENOG410XPGP LUCA
GeneTreeiENSGT00920000148988
HOVERGENiHBG007532
InParanoidiQ86Y07
KOiK08816
OMAiSSCCEIA
OrthoDBiEOG091G05V5
PhylomeDBiQ86Y07
TreeFamiTF106473

Enzyme and pathway databases

ReactomeiR-HSA-2993913 Clearance of Nuclear Envelope Membranes from Chromatin
R-HSA-2995383 Initiation of Nuclear Envelope Reformation
SignaLinkiQ86Y07
SIGNORiQ86Y07

Miscellaneous databases

ChiTaRSiVRK2 human
EvolutionaryTraceiQ86Y07
GeneWikiiVRK2
GenomeRNAii7444
PROiPR:Q86Y07
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000028116 Expressed in 221 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ86Y07 baseline and differential
GenevisibleiQ86Y07 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVRK2_HUMAN
AccessioniPrimary (citable) accession number: Q86Y07
Secondary accession number(s): B4DKL0
, D6W5D4, D6W5D6, Q49AK9, Q53EU9, Q53S39, Q53S77, Q53TU1, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 7, 2006
Last modified: October 10, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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