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Protein

Serine/threonine-protein kinase VRK2

Gene

VRK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.
Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

RAN inhibits its autophosphorylation and its ability to phosphorylate histone H3.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei61ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei166Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi35 – 43ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: UniProtKB
  • peptidyl-serine phosphorylation Source: GO_Central
  • peptidyl-threonine phosphorylation Source: GO_Central
  • protein autophosphorylation Source: UniProtKB
  • protein phosphorylation Source: ProtInc
  • regulation of interleukin-1-mediated signaling pathway Source: UniProtKB
  • regulation of MAPK cascade Source: UniProtKB
  • viral process Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2993913 Clearance of Nuclear Envelope Membranes from Chromatin
R-HSA-2995383 Initiation of Nuclear Envelope Reformation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q86Y07

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q86Y07

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase VRK2 (EC:2.7.11.1)
Alternative name(s):
Vaccinia-related kinase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VRK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000028116.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12719 VRK2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602169 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86Y07

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei487 – 507Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7444

Open Targets

More...
OpenTargetsi
ENSG00000028116

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37331

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1649059

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VRK2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90116515

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000868061 – 508Serine/threonine-protein kinase VRK2Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei336PhosphothreonineCombined sources1
Modified residuei406PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 1 and isoform 2 are autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86Y07

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86Y07

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q86Y07

PeptideAtlas

More...
PeptideAtlasi
Q86Y07

PRoteomics IDEntifications database

More...
PRIDEi
Q86Y07

ProteomicsDB human proteome resource

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ProteomicsDBi
70345
70346 [Q86Y07-2]
70347 [Q86Y07-3]
70348 [Q86Y07-4]
70349 [Q86Y07-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86Y07

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86Y07

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000028116 Expressed in 221 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86Y07 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86Y07 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB046459
HPA047503

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 interacts with MAP3K7, MAP2K7, MAP2K1 and KSR1. Isoform 1 and isoform 2 interact with RAN and MAPK8IP1.4 Publications
(Microbial infection) Isoform 1 interacts with Epstein-Barr virus BHRF1; this interaction is involved in protecting cells from apoptosis.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113283, 31 interactors

Protein interaction database and analysis system

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IntActi
Q86Y07, 39 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000342381

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q86Y07

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1508
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q86Y07

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86Y07

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q86Y07

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 319Protein kinasePROSITE-ProRule annotationAdd BLAST291

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni397 – 508Interaction with MAP3K71 PublicationAdd BLAST112

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1164 Eukaryota
ENOG410XPGP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158042

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG007532

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86Y07

KEGG Orthology (KO)

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KOi
K08816

Identification of Orthologs from Complete Genome Data

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OMAi
MPPRRNE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G05V5

Database for complete collections of gene phylogenies

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PhylomeDBi
Q86Y07

TreeFam database of animal gene trees

More...
TreeFami
TF106473

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86Y07-1) [UniParc]FASTAAdd to basket
Also known as: VRK2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPKRNEKYK LPIPFPEGKV LDDMEGNQWV LGKKIGSGGF GLIYLAFPTN
60 70 80 90 100
KPEKDARHVV KVEYQENGPL FSELKFYQRV AKKDCIKKWI ERKQLDYLGI
110 120 130 140 150
PLFYGSGLTE FKGRSYRFMV MERLGIDLQK ISGQNGTFKK STVLQLGIRM
160 170 180 190 200
LDVLEYIHEN EYVHGDIKAA NLLLGYKNPD QVYLADYGLS YRYCPNGNHK
210 220 230 240 250
QYQENPRKGH NGTIEFTSLD AHKGVALSRR SDVEILGYCM LRWLCGKLPW
260 270 280 290 300
EQNLKDPVAV QTAKTNLLDE LPQSVLKWAP SGSSCCEIAQ FLVCAHSLAY
310 320 330 340 350
DEKPNYQALK KILNPHGIPL GPLDFSTKGQ SINVHTPNSQ KVDSQKAATK
360 370 380 390 400
QVNKAHNRLI EKKVHSERSA ESCATWKVQK EEKLIGLMNN EAAQESTRRR
410 420 430 440 450
QKYQESQEPL NEVNSFPQKI SYTQFPNSFY EPHQDFTSPD IFKKSRSPSW
460 470 480 490 500
YKYTSTVSTG ITDLESSTGL WPTISQFTLS EETNADVYYY RIIIPVLLML

VFLALFFL
Length:508
Mass (Da):58,141
Last modified:March 7, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F3F6FCC9280568F
GO
Isoform 2 (identifier: Q86Y07-2) [UniParc]FASTAAdd to basket
Also known as: VRK2B

The sequence of this isoform differs from the canonical sequence as follows:
     395-397: EST → VEA
     398-508: Missing.

Show »
Length:397
Mass (Da):45,030
Checksum:i0308378DD02D85EC
GO
Isoform 3 (identifier: Q86Y07-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):55,446
Checksum:i425363D6092A57FC
GO
Isoform 4 (identifier: Q86Y07-4) [UniParc]FASTAAdd to basket
Also known as: 5

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Show »
Length:390
Mass (Da):44,411
Checksum:i9F320B446A872E5D
GO
Isoform 5 (identifier: Q86Y07-5) [UniParc]FASTAAdd to basket
Also known as: 6

The sequence of this isoform differs from the canonical sequence as follows:
     395-396: ES → FR
     397-508: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):45,034
Checksum:i773C8DD02D85EC43
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERS5E7ERS5_HUMAN
Serine/threonine-protein kinase VRK...
VRK2
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PBU1E9PBU1_HUMAN
Serine/threonine-protein kinase VRK...
VRK2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD54446 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti419K → E in AAO73048 (Ref. 3) Curated1
Sequence conflicti419K → E in AAO73049 (Ref. 3) Curated1
Sequence conflicti419K → E in AAO73051 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04129350N → D1 PublicationCorresponds to variant dbSNP:rs34130684Ensembl.1
Natural variantiVAR_041294157I → M1 PublicationCorresponds to variant dbSNP:rs35966666Ensembl.1
Natural variantiVAR_017095167I → V4 PublicationsCorresponds to variant dbSNP:rs1051061Ensembl.1
Natural variantiVAR_051681211N → S. Corresponds to variant dbSNP:rs36081172Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0085341 – 118Missing in isoform 4. 2 PublicationsAdd BLAST118
Alternative sequenceiVSP_0085331 – 23Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_008537395 – 397EST → VEA in isoform 2. 1 Publication3
Alternative sequenceiVSP_008535395 – 396ES → FR in isoform 5. 1 Publication2
Alternative sequenceiVSP_008536397 – 508Missing in isoform 5. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_008538398 – 508Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB000450 mRNA Translation: BAA19109.1
AJ512204 mRNA Translation: CAD54446.2 Sequence problems.
AY228367 mRNA Translation: AAO73047.1
AY228368 mRNA Translation: AAO73048.1
AY228369 mRNA Translation: AAO73049.1
AY228370 mRNA Translation: AAO73050.1
AY228371 mRNA Translation: AAO73051.1
AY228372 mRNA Translation: AAO73052.1
AK296611 mRNA Translation: BAG59222.1
AK223540 mRNA Translation: BAD97260.1
AC007250 Genomic DNA Translation: AAY15019.1
AC068193 Genomic DNA Translation: AAX93262.1
AC073215 Genomic DNA Translation: AAY14648.1
CH471053 Genomic DNA Translation: EAX00062.1
CH471053 Genomic DNA Translation: EAX00064.1
CH471053 Genomic DNA Translation: EAX00066.1
CH471053 Genomic DNA Translation: EAX00067.1
CH471053 Genomic DNA Translation: EAX00068.1
BC027854 mRNA Translation: AAH27854.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1859.1 [Q86Y07-1]
CCDS46291.1 [Q86Y07-5]
CCDS46292.1 [Q86Y07-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001123952.1, NM_001130480.2 [Q86Y07-1]
NP_001123953.1, NM_001130481.2 [Q86Y07-1]
NP_001123954.1, NM_001130482.2 [Q86Y07-3]
NP_001123955.1, NM_001130483.2 [Q86Y07-5]
NP_001275765.1, NM_001288836.1 [Q86Y07-4]
NP_001275766.1, NM_001288837.1 [Q86Y07-1]
NP_001275767.1, NM_001288838.1 [Q86Y07-5]
NP_001275768.1, NM_001288839.1 [Q86Y07-4]
NP_006287.2, NM_006296.6 [Q86Y07-1]
XP_005264597.1, XM_005264540.4 [Q86Y07-1]
XP_006712153.1, XM_006712090.3 [Q86Y07-2]
XP_006712154.1, XM_006712091.3 [Q86Y07-5]
XP_006712155.1, XM_006712092.3 [Q86Y07-4]
XP_006712156.1, XM_006712093.3 [Q86Y07-4]
XP_011531394.1, XM_011533092.2 [Q86Y07-1]
XP_016860347.1, XM_017004858.1 [Q86Y07-2]
XP_016860348.1, XM_017004859.1 [Q86Y07-4]
XP_016860349.1, XM_017004860.1 [Q86Y07-4]
XP_016860350.1, XM_017004861.1 [Q86Y07-4]
XP_016860351.1, XM_017004862.1 [Q86Y07-4]
XP_016860352.1, XM_017004863.1 [Q86Y07-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.715298
Hs.744058

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340157; ENSP00000342381; ENSG00000028116 [Q86Y07-1]
ENST00000412104; ENSP00000404156; ENSG00000028116 [Q86Y07-4]
ENST00000417641; ENSP00000402375; ENSG00000028116 [Q86Y07-5]
ENST00000435505; ENSP00000408002; ENSG00000028116 [Q86Y07-1]
ENST00000440705; ENSP00000398323; ENSG00000028116 [Q86Y07-3]
ENST00000648897; ENSP00000497378; ENSG00000028116 [Q86Y07-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7444

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7444

UCSC genome browser

More...
UCSCi
uc002rzo.3 human [Q86Y07-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000450 mRNA Translation: BAA19109.1
AJ512204 mRNA Translation: CAD54446.2 Sequence problems.
AY228367 mRNA Translation: AAO73047.1
AY228368 mRNA Translation: AAO73048.1
AY228369 mRNA Translation: AAO73049.1
AY228370 mRNA Translation: AAO73050.1
AY228371 mRNA Translation: AAO73051.1
AY228372 mRNA Translation: AAO73052.1
AK296611 mRNA Translation: BAG59222.1
AK223540 mRNA Translation: BAD97260.1
AC007250 Genomic DNA Translation: AAY15019.1
AC068193 Genomic DNA Translation: AAX93262.1
AC073215 Genomic DNA Translation: AAY14648.1
CH471053 Genomic DNA Translation: EAX00062.1
CH471053 Genomic DNA Translation: EAX00064.1
CH471053 Genomic DNA Translation: EAX00066.1
CH471053 Genomic DNA Translation: EAX00067.1
CH471053 Genomic DNA Translation: EAX00068.1
BC027854 mRNA Translation: AAH27854.1
CCDSiCCDS1859.1 [Q86Y07-1]
CCDS46291.1 [Q86Y07-5]
CCDS46292.1 [Q86Y07-3]
RefSeqiNP_001123952.1, NM_001130480.2 [Q86Y07-1]
NP_001123953.1, NM_001130481.2 [Q86Y07-1]
NP_001123954.1, NM_001130482.2 [Q86Y07-3]
NP_001123955.1, NM_001130483.2 [Q86Y07-5]
NP_001275765.1, NM_001288836.1 [Q86Y07-4]
NP_001275766.1, NM_001288837.1 [Q86Y07-1]
NP_001275767.1, NM_001288838.1 [Q86Y07-5]
NP_001275768.1, NM_001288839.1 [Q86Y07-4]
NP_006287.2, NM_006296.6 [Q86Y07-1]
XP_005264597.1, XM_005264540.4 [Q86Y07-1]
XP_006712153.1, XM_006712090.3 [Q86Y07-2]
XP_006712154.1, XM_006712091.3 [Q86Y07-5]
XP_006712155.1, XM_006712092.3 [Q86Y07-4]
XP_006712156.1, XM_006712093.3 [Q86Y07-4]
XP_011531394.1, XM_011533092.2 [Q86Y07-1]
XP_016860347.1, XM_017004858.1 [Q86Y07-2]
XP_016860348.1, XM_017004859.1 [Q86Y07-4]
XP_016860349.1, XM_017004860.1 [Q86Y07-4]
XP_016860350.1, XM_017004861.1 [Q86Y07-4]
XP_016860351.1, XM_017004862.1 [Q86Y07-4]
XP_016860352.1, XM_017004863.1 [Q86Y07-4]
UniGeneiHs.715298
Hs.744058

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V62X-ray1.70A/B14-335[»]
5UU1X-ray2.00A14-335[»]
ProteinModelPortaliQ86Y07
SMRiQ86Y07
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113283, 31 interactors
IntActiQ86Y07, 39 interactors
STRINGi9606.ENSP00000342381

Chemistry databases

BindingDBiQ86Y07
ChEMBLiCHEMBL1649059

PTM databases

iPTMnetiQ86Y07
PhosphoSitePlusiQ86Y07

Polymorphism and mutation databases

BioMutaiVRK2
DMDMi90116515

Proteomic databases

EPDiQ86Y07
MaxQBiQ86Y07
PaxDbiQ86Y07
PeptideAtlasiQ86Y07
PRIDEiQ86Y07
ProteomicsDBi70345
70346 [Q86Y07-2]
70347 [Q86Y07-3]
70348 [Q86Y07-4]
70349 [Q86Y07-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7444
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340157; ENSP00000342381; ENSG00000028116 [Q86Y07-1]
ENST00000412104; ENSP00000404156; ENSG00000028116 [Q86Y07-4]
ENST00000417641; ENSP00000402375; ENSG00000028116 [Q86Y07-5]
ENST00000435505; ENSP00000408002; ENSG00000028116 [Q86Y07-1]
ENST00000440705; ENSP00000398323; ENSG00000028116 [Q86Y07-3]
ENST00000648897; ENSP00000497378; ENSG00000028116 [Q86Y07-2]
GeneIDi7444
KEGGihsa:7444
UCSCiuc002rzo.3 human [Q86Y07-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7444
DisGeNETi7444
EuPathDBiHostDB:ENSG00000028116.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
VRK2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0002070
HGNCiHGNC:12719 VRK2
HPAiCAB046459
HPA047503
MIMi602169 gene
neXtProtiNX_Q86Y07
OpenTargetsiENSG00000028116
PharmGKBiPA37331

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1164 Eukaryota
ENOG410XPGP LUCA
GeneTreeiENSGT00940000158042
HOVERGENiHBG007532
InParanoidiQ86Y07
KOiK08816
OMAiMPPRRNE
OrthoDBiEOG091G05V5
PhylomeDBiQ86Y07
TreeFamiTF106473

Enzyme and pathway databases

ReactomeiR-HSA-2993913 Clearance of Nuclear Envelope Membranes from Chromatin
R-HSA-2995383 Initiation of Nuclear Envelope Reformation
SignaLinkiQ86Y07
SIGNORiQ86Y07

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
VRK2 human
EvolutionaryTraceiQ86Y07

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
VRK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7444

Protein Ontology

More...
PROi
PR:Q86Y07

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000028116 Expressed in 221 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ86Y07 baseline and differential
GenevisibleiQ86Y07 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVRK2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86Y07
Secondary accession number(s): B4DKL0
, D6W5D4, D6W5D6, Q49AK9, Q53EU9, Q53S39, Q53S77, Q53TU1, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 7, 2006
Last modified: December 5, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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