Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Extracellular matrix protein FRAS1

Gene

FRAS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Extracellular matrix protein FRAS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRAS1
Synonyms:KIAA1500
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138759.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19185 FRAS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607830 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86XX4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 3901ExtracellularSequence analysisAdd BLAST3875
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3902 – 3922HelicalSequence analysisAdd BLAST21
Topological domaini3923 – 4008CytoplasmicSequence analysisAdd BLAST86

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Fraser syndrome 1 (FRASRS1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Fraser syndrome, an autosomal recessive disorder characterized by cryptophthalmos, cutaneous syndactyly, and urogenital abnormalities including renal agenesis or hypoplasia. Additional features include abnormalities of the larynx, ear malformations, and facial abnormalities.
See also OMIM:219000

Organism-specific databases

DisGeNET

More...
DisGeNETi
80144

MalaCards human disease database

More...
MalaCardsi
FRAS1
MIMi219000 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000138759

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2052 Fraser syndrome
93100 Renal agenesis, unilateral

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134980133

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FRAS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
476007832

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001012027 – 4008Extracellular matrix protein FRAS1Add BLAST3982

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei344PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi728N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1093N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1504N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1777N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1948N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1978N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2664N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2682N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2908N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2985N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3070N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3218N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3676N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3875N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86XX4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86XX4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86XX4

PeptideAtlas

More...
PeptideAtlasi
Q86XX4

PRoteomics IDEntifications database

More...
PRIDEi
Q86XX4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70338
70339 [Q86XX4-2]
70340 [Q86XX4-4]
70341 [Q86XX4-5]
70342 [Q86XX4-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86XX4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86XX4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many adult tissues, with highest levels in kidney, pancreas and thalamus. Relatively high expression was also detected in fetal kidney and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138759 Expressed in 150 organ(s), highest expression level in metanephros

CleanEx database of gene expression profiles

More...
CleanExi
HS_FRAS1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86XX4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86XX4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011281
HPA051601

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123137, 38 interactors

Protein interaction database and analysis system

More...
IntActi
Q86XX4, 3 interactors

Molecular INTeraction database

More...
MINTi
Q86XX4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264895

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86XX4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 88VWFC 1PROSITE-ProRule annotationAdd BLAST62
Domaini93 – 153VWFC 2PROSITE-ProRule annotationAdd BLAST61
Domaini157 – 217VWFC 3PROSITE-ProRule annotationAdd BLAST61
Domaini219 – 279VWFC 4PROSITE-ProRule annotationAdd BLAST61
Domaini283 – 343VWFC 5PROSITE-ProRule annotationAdd BLAST61
Domaini347 – 417VWFC 6PROSITE-ProRule annotationAdd BLAST71
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati409 – 460FU 1Add BLAST52
Repeati462 – 505FU 2Add BLAST44
Repeati507 – 553FU 3Add BLAST47
Repeati555 – 599FU 4Add BLAST45
Repeati602 – 647FU 5Add BLAST46
Repeati649 – 705FU 6Add BLAST57
Repeati708 – 753FU 7Add BLAST46
Repeati755 – 800FU 8Add BLAST46
Repeati803 – 852FU 9Add BLAST50
Repeati854 – 900FU 10Add BLAST47
Repeati903 – 948FU 11Add BLAST46
Repeati952 – 997FU 12Add BLAST46
Repeati999 – 1042FU 13Add BLAST44
Repeati1046 – 1089FU 14Add BLAST44
Repeati1102 – 1197CSPG 1PROSITE-ProRule annotationAdd BLAST96
Repeati1217 – 1308CSPG 2PROSITE-ProRule annotationAdd BLAST92
Repeati1329 – 1438CSPG 3PROSITE-ProRule annotationAdd BLAST110
Repeati1463 – 1559CSPG 4PROSITE-ProRule annotationAdd BLAST97
Repeati1595 – 1689CSPG 5PROSITE-ProRule annotationAdd BLAST95
Repeati1710 – 1810CSPG 6PROSITE-ProRule annotationAdd BLAST101
Repeati1833 – 1936CSPG 7PROSITE-ProRule annotationAdd BLAST104
Repeati1957 – 2057CSPG 8PROSITE-ProRule annotationAdd BLAST101
Repeati2078 – 2177CSPG 9PROSITE-ProRule annotationAdd BLAST100
Repeati2199 – 2291CSPG 10PROSITE-ProRule annotationAdd BLAST93
Repeati2311 – 2404CSPG 11PROSITE-ProRule annotationAdd BLAST94
Repeati2439 – 2536CSPG 12PROSITE-ProRule annotationAdd BLAST98
Domaini2543 – 2646Calx-beta 1Add BLAST104
Domaini2659 – 2770Calx-beta 2Add BLAST112
Domaini2784 – 2890Calx-beta 3Add BLAST107
Domaini2905 – 3007Calx-beta 4Add BLAST103
Domaini3025 – 3129Calx-beta 5Add BLAST105

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FRAS1 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216 Eukaryota
KOG1306 Eukaryota
KOG3525 Eukaryota
KOG3597 Eukaryota
ENOG410XQ7P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162130

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000202959

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051659

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86XX4

Identification of Orthologs from Complete Genome Data

More...
OMAi
DDTQYPV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02YT

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00064 FU, 12 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2030, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR039005 CSPG_rpt
IPR000742 EGF-like_dom
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR001007 VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03160 Calx-beta, 5 hits
PF00093 VWC, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00237 Calx_beta, 5 hits
SM00181 EGF, 9 hits
SM00261 FU, 14 hits
SM00214 VWC, 6 hits
SM00215 VWC_out, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141072 SSF141072, 5 hits
SSF57184 SSF57184, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51854 CSPG, 12 hits
PS01208 VWFC_1, 6 hits
PS50184 VWFC_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86XX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVLKVWLGL ALALAEFAVL PHHSEGACVY QDSLLADATI WKPDSCQSCR
60 70 80 90 100
CHGDIVICKP AVCRNPQCAF EKGEVLQIAA NQCCPECVLR TPGSCHHEKK
110 120 130 140 150
IHEHGTEWAS SPCSVCSCNH GEVRCTPQPC PPLSCGHQEL AFIPEGSCCP
160 170 180 190 200
VCVGLGKPCS YEGHVFQDGE DWRLSRCAKC LCRNGVAQCF TAQCQPLFCN
210 220 230 240 250
QDETVVRVPG KCCPQCSARS CSAAGQVYEH GEQWSENACT TCICDRGEVR
260 270 280 290 300
CHKQACLPLR CGKGQSRARR HGQCCEECVS PAGSCSYDGV VRYQDEMWKG
310 320 330 340 350
SACEFCMCDH GQVTCQTGEC AKVECARDEE LIHLDGKCCP ECISRNGYCV
360 370 380 390 400
YEETGEFMSS NASEVKRIPE GEKWEDGPCK VCECRGAQVT CYEPSCPPCP
410 420 430 440 450
VGTLALEVKG QCCPDCTSVH CHPDCLTCSQ SPDHCDLCQD PTKLLQNGWC
460 470 480 490 500
VHSCGLGFYQ AGSLCLACQP QCSTCTSGLE CSSCQPPLLM RHGQCVPTCG
510 520 530 540 550
DGFYQDRHSC AVCHESCAGC WGPTEKHCLA CRDPLHVLRD GGCESSCGKG
560 570 580 590 600
FYNRQGTCSA CDQSCDSCGP SSPRCLTCTE KTVLHDGKCM SECPGGYYAD
610 620 630 640 650
ATGRCKVCHN SCASCSGPTP SHCTACSPPK ALRQGHCLPR CGEGFYSDHG
660 670 680 690 700
VCKACHSSCL ACMGPAPSHC TGCKKPEEGL QVEQLSDVGI PSGECLAQCR
710 720 730 740 750
AHFYLESTGI CEACHQSCFR CAGKSPHNCT DCGPSHVLLD GQCLSQCPDG
760 770 780 790 800
YFHQEGSCTE CHPTCRQCHG PLESDCISCY PHISLTNGNC RTSCREEQFL
810 820 830 840 850
NLVGYCADCH HLCQHCAADL HNTGSICLRC QNAHYLLLGD HCVPDCPSGY
860 870 880 890 900
YAERGACKKC HSSCRTCQGR GPFSCSSCDT NLVLSHTGTC STTCFPGHYL
910 920 930 940 950
DDNHVCQPCN THCGSCDSQA SCTSCRDPNK VLLFGECQYE SCAPQYYLDF
960 970 980 990 1000
STNTCKECDW SCSACSGPLK TDCLQCMDGY VLQDGACVEQ CLSSFYQDSG
1010 1020 1030 1040 1050
LCKNCDSYCL QCQGPHECTR CKGPFLLLEA QCVQECGKGY FADHAKHKCT
1060 1070 1080 1090 1100
ACPQGCLQCS HRDRCHLCDH GFFLKSGLCV YNCVPGFSVH TSNETCSGKI
1110 1120 1130 1140 1150
HTPSLHVNGS LILPIGSIKP LDFSLLNVQD QEGRVEDLLF HVVSTPTNGQ
1160 1170 1180 1190 1200
LVLSRNGKEV QLDKAGRFSW KDVNEKKVRF VHSKEKLRKG YLFLKISDQQ
1210 1220 1230 1240 1250
FFSEPQLINI QAFSTQAPYV LRNEVLHISR GERATITTQM LDIRDDDNPQ
1260 1270 1280 1290 1300
DVVIEIIDPP LHGQLLQTLQ SPATPIYQFQ LDELSRGLLH YAHDGSDSTS
1310 1320 1330 1340 1350
DVAVLQANDG HSFHNILFQV KTVPQNDRGL QLVANSMVWV PEGGMLQITN
1360 1370 1380 1390 1400
RILQAEAPGA SAEEIIYKIT QDYPQFGEVV LLVNMPADSP ADEGQHLPDG
1410 1420 1430 1440 1450
RTATPTSTFT QQDINEGIVW YRHSGAPAQS DSFRFEVSSA SNAQTRLESH
1460 1470 1480 1490 1500
MFNIAILPQT PEAPKVSLEA SLHMTAREDG LTVIQPHSLS FINSEKPSGK
1510 1520 1530 1540 1550
IVYNITLPLH PNQGIIEHRD HPHSPIRYFT QEDINQGKVM YRPPPAAPHL
1560 1570 1580 1590 1600
QELMAFSFAG LPESVKFHFT VSDGEHTSPE MVLTIHLLPS DQQLPVFQVT
1610 1620 1630 1640 1650
APRLAVSPGG STSVGLQVVV RDAETAPKEL FFELRRPPQH GVLLKHTAEF
1660 1670 1680 1690 1700
RRPMATGDTF TYEDVEKNAL QYIHDGSSTR EDSMEISVTD GLTVTMLEVR
1710 1720 1730 1740 1750
VEVSLSEDRG PRLAAGSSLS ITVASKSTAI ITRSHLAYVD DSSPDPEIWI
1760 1770 1780 1790 1800
QLNYLPSYGT LLRISGSEVE ELSEVSNFTM EDINNKKIRY SAVFETDGHL
1810 1820 1830 1840 1850
VTDSFYFSVS DMDHNHLDNQ IFTIMITPAE NPPPVIAFAD LITVDEGGRA
1860 1870 1880 1890 1900
PLSFHHFFAT DDDDNLQRDA IIKLSALPKY GCIENTGTGD RFGPETASDL
1910 1920 1930 1940 1950
EASFPIQDVL ENYIYYFQSV HESIEPTHDI FSFYVSDGTS RSEIHSINIT
1960 1970 1980 1990 2000
IERKNDEPPR MTLQPLRVQL SSGVVISNSS LSLQDLDTPD NELIFVLTKK
2010 2020 2030 2040 2050
PDHGHVLWRQ TASEPLENGR VLVQGSTFTY QDILAGLVGY VPSVPGMVVD
2060 2070 2080 2090 2100
EFQFSLTDGL HVDTGRMKIY TELPASDTPH LAINQGLQLS AGSVARITEQ
2110 2120 2130 2140 2150
HLKVTDIDSD DHQVMYIMKE DPGAGRLQMM KHGNLEQISI KGPIRSFTQA
2160 2170 2180 2190 2200
DISQGQPEYS HGTGEPGGSF AFKFDVVDGE GNRLIDKSFS ISISEDKSPP
2210 2220 2230 2240 2250
VITTNKGLVL DENSVKKITT LQLSATDQDS GPTELIYRIT RQPQLGHLEH
2260 2270 2280 2290 2300
AASPGIQISS FTQADLTSRN VQYVHSSEAE KHSDAFSFTL SDGVSEVTQT
2310 2320 2330 2340 2350
FHITLHPVDD SLPVVQNLGM RVQEGMRKTI TEFELKAVDA DTEAESVTFT
2360 2370 2380 2390 2400
IVQPPRHGTI ERTSNGQHFH LTSTFTMKDI YQNRVSYSHD GSNSLKDRFT
2410 2420 2430 2440 2450
FTVSDGTNPF FIIEEGGKEI MTAAPQPFRV DILPVDDGTP RIVTNLGLQW
2460 2470 2480 2490 2500
LEYMDGKATN LITKKELLTM DPDTEDAQLV YEITTGPKHG FVENKLQPGR
2510 2520 2530 2540 2550
AAATFTQEDV NLGLIRYVLH KEKIREMMDS FQFLVKDSKP NVVSDNVFHI
2560 2570 2580 2590 2600
QWSLISFKYT SYNVSEKAGS VSVTVQRTGN LNQYAIVLCR TEQGTASSSS
2610 2620 2630 2640 2650
QPGQQDYVEY AGQVQFDERE DTKSCTIVIN DDDVFENVES FTVELSMPAY
2660 2670 2680 2690 2700
ALLGEFTQAK VIINDTEDEP TLEFDKKIYW VNESAGFLFA PIERKGDASS
2710 2720 2730 2740 2750
IVSAICYTVP KSAMGSLFYA LESGSDFKSR GMSAASRVIF GPGVTMSTCD
2760 2770 2780 2790 2800
VMLIDDSEYE EEEEFEIALA DASDNARIGR VATAKVLISG PNDASTVSLG
2810 2820 2830 2840 2850
NTAFTVSEDA GTVKIPVIRH GTDLSTFASV WCATRPSDPA SATPGVDYVP
2860 2870 2880 2890 2900
SSRKVEFGPG VIEQYCTLTI LDDTQYPVIE GLETFVVFLS SAQGAELTKP
2910 2920 2930 2940 2950
FQAVIAINDT FQDVPSMQFA KDLLLVKEKE GVLHVPITRS GDLSYESSVR
2960 2970 2980 2990 3000
CYTQSHSAQV MEDFEERQNA DSSRITFLKG DKVKNCTVYI HDDSMFEPEE
3010 3020 3030 3040 3050
QFRVYLGLPL GNHWSGARIG KNNMATITIS NDEDAPTIEF EEAAYQVREP
3060 3070 3080 3090 3100
AGPDAIAILN IKVIRRGDQN RTSKVRCSTR DGSAQSGVDY YPKSRVLKFS
3110 3120 3130 3140 3150
PGVDHIFFKV EILSNEDREW HESFSLVLGP DDPVEAVLGD VTTATVTILD
3160 3170 3180 3190 3200
QEAAGSLILP APPIVVTLAD YDHVEEVTKE GVKKSPSPGY PLVCVTPCDP
3210 3220 3230 3240 3250
HFPRYAVMKE RCSEAGINQT SVQFSWEVAA PTDGNGARSP FETITDNTPF
3260 3270 3280 3290 3300
TSVNHMVLDS IYFSRRFHVR CVAKAVDKVG HVGTPLRSNI VTIGTDSAIC
3310 3320 3330 3340 3350
HTPVVAGTSR GFQAQSFIAT LKYLDVKHKE HPNRIHISVQ IPHQDGMLPL
3360 3370 3380 3390 3400
ISTMPLHNLH FLLSESIYRH QHVCSNLVTT YDLRGLAEAG FLDDVVYDST
3410 3420 3430 3440 3450
ALGPGYDRPF QFDPSVREPK TIQLYKHLNL KSCVWTFDAY YDMTELIDVC
3460 3470 3480 3490 3500
GGSVTADFQV RDSAQSFLTV HVPLYVSYIY VTAPRGWASL EHHTEMEFSF
3510 3520 3530 3540 3550
FYDTVLWRTG IQTDSVLSAR LQIIRIYIRE DGRLVIEFKT HAKFRGQFVM
3560 3570 3580 3590 3600
EHHTLPEVKS FVLTPDHLGG IEFDLQLLWS AQTFDSPHQL WRATSSYNRK
3610 3620 3630 3640 3650
DYSGEYTIYL IPCTVQPTQP WVDPGEKPLA CTAHAPERFL IPIAFQQTNR
3660 3670 3680 3690 3700
PVPVVYSLNT EFQLCNNEKV FLMDPNTSDM SLAEMDYKGA FSKGQILYGR
3710 3720 3730 3740 3750
VLWNPEQNLN SAYKLQLEKV YLCTGKDGYV PFFDPTGTIY NEGPQYGCIQ
3760 3770 3780 3790 3800
PNKHLKHRFL LLDRNQPEVT DKYFHDVPFE AHFASELPDF HVVSNMPGVD
3810 3820 3830 3840 3850
GFTLKVDALY KVEAGHQWYL QVIYIIGPDT ISGPRVQRSL TAPLRRNRRD
3860 3870 3880 3890 3900
LVEPDGQLIL DDSLIYDNEG DQVKNGTNMK SLNLEMQELA VAASLSQTGA
3910 3920 3930 3940 3950
SIGSALAAIM LLLLVFLVAC FINRKCQKQR KKKPAEDILE EYPLNTKVEV
3960 3970 3980 3990 4000
PKRHPDRVEK NVNRHYCTVR NVNILSEPEA AYTFKGAKVK RLNLEVRVHN

NLQDGTEV
Length:4,008
Mass (Da):443,214
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79972020FA59C3CD
GO
Isoform 2 (identifier: Q86XX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2156-2157: QP → HV
     2194-2194: S → L
     2598-2598: S → SSSRV
     2717-2718: LF → SL
     3386-3387: LA → IS

Note: No experimental confirmation available.
Show »
Length:4,012
Mass (Da):443,636
Checksum:i923B92CF3C8C65AE
GO
Isoform 4 (identifier: Q86XX4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     713-737: ACHQSCFRCAGKSPHNCTDCGPSHV → GQNLDFCQNLEVISAVCLGISSTEN
     738-4008: Missing.

Note: No experimental confirmation available.
Show »
Length:737
Mass (Da):79,240
Checksum:i059D9F0FD8FABD69
GO
Isoform 5 (identifier: Q86XX4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1953-1976: RKNDEPPRMTLQPLRVQLSSGVVI → VKTLEVGKVEPLTTIFHTIRELSL
     1977-4008: Missing.

Note: No experimental confirmation available.
Show »
Length:1,976
Mass (Da):216,629
Checksum:i6EBF480EBA73D9FA
GO
Isoform 6 (identifier: Q86XX4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     808-809: DC → GE
     810-4008: Missing.

Show »
Length:809
Mass (Da):87,173
Checksum:iAC5F091A6416D711
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCP6D6RCP6_HUMAN
Extracellular matrix protein FRAS1
FRAS1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8V2H0Y8V2_HUMAN
Extracellular matrix protein FRAS1
FRAS1
426Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9A6H0Y9A6_HUMAN
Extracellular matrix protein FRAS1
FRAS1
666Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9C9H0Y9C9_HUMAN
Extracellular matrix protein FRAS1
FRAS1
652Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15216 differs from that shown. Reason: Frameshift at positions 1858 and 1951.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06915032D → G. Corresponds to variant dbSNP:rs4859905EnsemblClinVar.1
Natural variantiVAR_05580754D → H. Corresponds to variant dbSNP:rs17003071EnsemblClinVar.1
Natural variantiVAR_055808209P → S. Corresponds to variant dbSNP:rs7699637EnsemblClinVar.1
Natural variantiVAR_055809228Y → H. Corresponds to variant dbSNP:rs7682296EnsemblClinVar.1
Natural variantiVAR_055810243I → V. Corresponds to variant dbSNP:rs6848030EnsemblClinVar.1
Natural variantiVAR_055811429S → Y. Corresponds to variant dbSNP:rs6838959EnsemblClinVar.1
Natural variantiVAR_055812466L → I. Corresponds to variant dbSNP:rs12504081EnsemblClinVar.1
Natural variantiVAR_055813590M → T. Corresponds to variant dbSNP:rs35030041EnsemblClinVar.1
Natural variantiVAR_069151687D → G. Corresponds to variant dbSNP:rs345513EnsemblClinVar.1
Natural variantiVAR_069152710I → L. Corresponds to variant dbSNP:rs345512EnsemblClinVar.1
Natural variantiVAR_055814817A → V. Corresponds to variant dbSNP:rs6835769EnsemblClinVar.1
Natural variantiVAR_055815954T → M. Corresponds to variant dbSNP:rs17003166Ensembl.1
Natural variantiVAR_0558161023G → E. Corresponds to variant dbSNP:rs17459809EnsemblClinVar.1
Natural variantiVAR_0558171136E → K. Corresponds to variant dbSNP:rs12512164EnsemblClinVar.1
Natural variantiVAR_0558181626A → V. Corresponds to variant dbSNP:rs17003213Ensembl.1
Natural variantiVAR_0691532545D → N. Corresponds to variant dbSNP:rs4388111EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011287713 – 737ACHQS…GPSHV → GQNLDFCQNLEVISAVCLGI SSTEN in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_011288738 – 4008Missing in isoform 4. 1 PublicationAdd BLAST3271
Alternative sequenceiVSP_011289808 – 809DC → GE in isoform 6. 1 Publication2
Alternative sequenceiVSP_011290810 – 4008Missing in isoform 6. 1 PublicationAdd BLAST3199
Alternative sequenceiVSP_0112911953 – 1976RKNDE…SGVVI → VKTLEVGKVEPLTTIFHTIR ELSL in isoform 5. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_0112921977 – 4008Missing in isoform 5. 2 PublicationsAdd BLAST2032
Alternative sequenceiVSP_0112932156 – 2157QP → HV in isoform 2. 1 Publication2
Alternative sequenceiVSP_0112942194S → L in isoform 2. 1 Publication1
Alternative sequenceiVSP_0112952598S → SSSRV in isoform 2. 1 Publication1
Alternative sequenceiVSP_0462322717 – 2718LF → SL in isoform 2. 1 Publication2
Alternative sequenceiVSP_0112993386 – 3387LA → IS in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ512501 Genomic DNA Translation: CAD54734.1
AC093652 Genomic DNA No translation available.
AC093886 Genomic DNA No translation available.
AC093897 Genomic DNA No translation available.
AC104808 Genomic DNA No translation available.
AC131945 Genomic DNA No translation available.
BC052281 mRNA Translation: AAH52281.1
BC064487 mRNA Translation: AAH64487.1
BC131820 mRNA Translation: AAI31821.1
AK025684 mRNA Translation: BAB15216.1 Frameshift.
AK027833 mRNA Translation: BAB55399.1
AB040933 mRNA Translation: BAA96024.2
AL831853 mRNA Translation: CAD38554.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54771.1 [Q86XX4-2]
CCDS54772.1 [Q86XX4-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001159605.1, NM_001166133.1 [Q86XX4-5]
NP_079350.5, NM_025074.6 [Q86XX4-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.369448

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000325942; ENSP00000326330; ENSG00000138759 [Q86XX4-5]
ENST00000512123; ENSP00000422834; ENSG00000138759 [Q86XX4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80144

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80144

UCSC genome browser

More...
UCSCi
uc003hkw.4 human [Q86XX4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ512501 Genomic DNA Translation: CAD54734.1
AC093652 Genomic DNA No translation available.
AC093886 Genomic DNA No translation available.
AC093897 Genomic DNA No translation available.
AC104808 Genomic DNA No translation available.
AC131945 Genomic DNA No translation available.
BC052281 mRNA Translation: AAH52281.1
BC064487 mRNA Translation: AAH64487.1
BC131820 mRNA Translation: AAI31821.1
AK025684 mRNA Translation: BAB15216.1 Frameshift.
AK027833 mRNA Translation: BAB55399.1
AB040933 mRNA Translation: BAA96024.2
AL831853 mRNA Translation: CAD38554.1
CCDSiCCDS54771.1 [Q86XX4-2]
CCDS54772.1 [Q86XX4-5]
RefSeqiNP_001159605.1, NM_001166133.1 [Q86XX4-5]
NP_079350.5, NM_025074.6 [Q86XX4-2]
UniGeneiHs.369448

3D structure databases

ProteinModelPortaliQ86XX4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123137, 38 interactors
IntActiQ86XX4, 3 interactors
MINTiQ86XX4
STRINGi9606.ENSP00000264895

PTM databases

iPTMnetiQ86XX4
PhosphoSitePlusiQ86XX4

Polymorphism and mutation databases

BioMutaiFRAS1
DMDMi476007832

Proteomic databases

EPDiQ86XX4
MaxQBiQ86XX4
PaxDbiQ86XX4
PeptideAtlasiQ86XX4
PRIDEiQ86XX4
ProteomicsDBi70338
70339 [Q86XX4-2]
70340 [Q86XX4-4]
70341 [Q86XX4-5]
70342 [Q86XX4-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325942; ENSP00000326330; ENSG00000138759 [Q86XX4-5]
ENST00000512123; ENSP00000422834; ENSG00000138759 [Q86XX4-2]
GeneIDi80144
KEGGihsa:80144
UCSCiuc003hkw.4 human [Q86XX4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80144
DisGeNETi80144
EuPathDBiHostDB:ENSG00000138759.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FRAS1
HGNCiHGNC:19185 FRAS1
HPAiHPA011281
HPA051601
MalaCardsiFRAS1
MIMi219000 phenotype
607830 gene
neXtProtiNX_Q86XX4
OpenTargetsiENSG00000138759
Orphaneti2052 Fraser syndrome
93100 Renal agenesis, unilateral
PharmGKBiPA134980133

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
KOG1306 Eukaryota
KOG3525 Eukaryota
KOG3597 Eukaryota
ENOG410XQ7P LUCA
GeneTreeiENSGT00940000162130
HOGENOMiHOG000202959
HOVERGENiHBG051659
InParanoidiQ86XX4
OMAiDDTQYPV
OrthoDBiEOG091G02YT

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FRAS1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FRAS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80144

Protein Ontology

More...
PROi
PR:Q86XX4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138759 Expressed in 150 organ(s), highest expression level in metanephros
CleanExiHS_FRAS1
ExpressionAtlasiQ86XX4 baseline and differential
GenevisibleiQ86XX4 HS

Family and domain databases

CDDicd00064 FU, 12 hits
Gene3Di2.60.40.2030, 5 hits
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR039005 CSPG_rpt
IPR000742 EGF-like_dom
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF03160 Calx-beta, 5 hits
PF00093 VWC, 4 hits
SMARTiView protein in SMART
SM00237 Calx_beta, 5 hits
SM00181 EGF, 9 hits
SM00261 FU, 14 hits
SM00214 VWC, 6 hits
SM00215 VWC_out, 3 hits
SUPFAMiSSF141072 SSF141072, 5 hits
SSF57184 SSF57184, 6 hits
PROSITEiView protein in PROSITE
PS51854 CSPG, 12 hits
PS01208 VWFC_1, 6 hits
PS50184 VWFC_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRAS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86XX4
Secondary accession number(s): A2RRR8
, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: April 3, 2013
Last modified: December 5, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again