Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 677

Gene

ZNF677

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 285C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 677
Gene namesi
Name:ZNF677
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197928.10
HGNCiHGNC:28730 ZNF677
neXtProtiNX_Q86XU0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi342926
OpenTargetsiENSG00000197928
PharmGKBiPA142670478

Polymorphism and mutation databases

BioMutaiZNF677
DMDMi74759507

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339971 – 584Zinc finger protein 677Add BLAST584

Proteomic databases

EPDiQ86XU0
MaxQBiQ86XU0
PaxDbiQ86XU0
PeptideAtlasiQ86XU0
PRIDEiQ86XU0
ProteomicsDBi70334

PTM databases

iPTMnetiQ86XU0
PhosphoSitePlusiQ86XU0

Expressioni

Gene expression databases

BgeeiENSG00000197928
CleanExiHS_ZNF677
ExpressionAtlasiQ86XU0 baseline and differential
GenevisibleiQ86XU0 HS

Organism-specific databases

HPAiHPA023106
HPA024796

Interactioni

Protein-protein interaction databases

BioGridi131210, 2 interactors
IntActiQ86XU0, 2 interactors
STRINGi9606.ENSP00000334394

Structurei

3D structure databases

ProteinModelPortaliQ86XU0
SMRiQ86XU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 90KRABPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 285C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149028
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ86XU0
KOiK09228
OMAiWGHQRTH
OrthoDBiEOG091G02KC
PhylomeDBiQ86XU0
TreeFamiTF341892

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

Q86XU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSQGLFTF KDVAIEFSQE EWECLDPAQR ALYRDVMLEN YRNLLSLDED
60 70 80 90 100
NIPPEDDISV GFTSKGLSPK ENNKEELYHL VILERKESHG INNFDLKEVW
110 120 130 140 150
ENMPKFDSLW DYDVKNYKGM PLTCNKNLTH RKDQQHNKSS IHFSLKQSVS
160 170 180 190 200
IRDSAHQYFI HDKPFIRNLL KLKNNIRYAG NKYVKCFENK IGLSLQAQLA
210 220 230 240 250
ELQRFQTGEK MYECNPVEKS INSSSVSPLP PCVKNICNKY RKILKYPLLH
260 270 280 290 300
TQYGRTHIRE KSYKCNDCGK AFSKSSNLTN HQRIHSGQRP YKCNECGKAF
310 320 330 340 350
NQCSNLTRHQ RVHTGEKPYQ CNICGKVCSQ NSNLASHQRM HTGEKPYKCN
360 370 380 390 400
ECGKAFIQRS HLWGHERIHT GEKPYKCNEC DKAFAERSSL TQHKRIHTGE
410 420 430 440 450
KPYICNECGK AFKQCSHLTR HQNIHPGEKP HKCNVCGRAF IQSSSLVEHQ
460 470 480 490 500
RIHTGEKPYK CNKCDKAFIK RSHLWGHQRT HTGEKPYKCT ECGKAFTERS
510 520 530 540 550
NLTQHKKIHT GEKPYKCTEC GKAFTQFANL TRHQKIHIEK KHCKHNIHGN
560 570 580
ALFQSSNLGD HQKSYNREKH IKYNETKIKY SSCT
Length:584
Mass (Da):67,996
Last modified:June 1, 2003 - v1
Checksum:iF111E49F528CB29F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05288956D → N. Corresponds to variant dbSNP:rs11881131Ensembl.1
Natural variantiVAR_052890254G → E. Corresponds to variant dbSNP:rs10425706Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC050038 mRNA Translation: AAH50038.1
CCDSiCCDS12861.1
RefSeqiNP_001304927.1, NM_001317998.1
NP_872415.1, NM_182609.3
XP_011525214.1, XM_011526912.2
UniGeneiHs.20506

Genome annotation databases

EnsembliENST00000333952; ENSP00000334394; ENSG00000197928
ENST00000598513; ENSP00000469391; ENSG00000197928
GeneIDi342926
KEGGihsa:342926
UCSCiuc002qbg.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN677_HUMAN
AccessioniPrimary (citable) accession number: Q86XU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2003
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health