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Protein

Insulin-like growth factor-binding protein 3 receptor

Gene

TMEM219

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.1 Publication

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
SignaLinkiQ86XT9

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 3 receptor
Short name:
IGFBP-3R
Alternative name(s):
Transmembrane protein 219
Gene namesi
Name:TMEM219
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000149932.16
HGNCiHGNC:25201 TMEM219
neXtProtiNX_Q86XT9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 204ExtracellularSequence analysisAdd BLAST166
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 240CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi124446
OpenTargetsiENSG00000149932
PharmGKBiPA162406570

Polymorphism and mutation databases

BioMutaiTMEM219

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000032904939 – 240Insulin-like growth factor-binding protein 3 receptorAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ86XT9
PaxDbiQ86XT9
PeptideAtlasiQ86XT9
PRIDEiQ86XT9
ProteomicsDBi70333

PTM databases

iPTMnetiQ86XT9
PhosphoSitePlusiQ86XT9

Expressioni

Tissue specificityi

Widely expressed in normal tissues but suppressed in prostate and breast tumor.1 Publication

Gene expression databases

BgeeiENSG00000149932 Expressed in 197 organ(s), highest expression level in body of stomach
CleanExiHS_TMEM219
ExpressionAtlasiQ86XT9 baseline and differential
GenevisibleiQ86XT9 HS

Organism-specific databases

HPAiHPA059185

Interactioni

Subunit structurei

Interacts with IGFBP3. Interacts with CASP8.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi125865, 13 interactors
IntActiQ86XT9, 5 interactors
STRINGi9606.ENSP00000279396

Structurei

3D structure databases

ProteinModelPortaliQ86XT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWEC Eukaryota
ENOG4110155 LUCA
GeneTreeiENSGT00390000013671
HOGENOMiHOG000154627
HOVERGENiHBG095163
InParanoidiQ86XT9
OMAiGSHIVGL
OrthoDBiEOG091G0LWI
PhylomeDBiQ86XT9
TreeFamiTF338507

Family and domain databases

InterProiView protein in InterPro
IPR039493 TMEM248/TMEM219
IPR039587 TMEM248/TMEM219_dom
PANTHERiPTHR16002 PTHR16002, 1 hit
PfamiView protein in Pfam
PF14940 TMEM219, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q86XT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNCQAGHNL HLCLAHHPPL VCATLILLLL GLSGLGLGSF LLTHRTGLRS
60 70 80 90 100
PDIPQDWVSF LRSFGQLTLC PRNGTVTGKW RGSHVVGLLT TLNFGDGPDR
110 120 130 140 150
NKTRTFQATV LGSQMGLKGS SAGQLVLITA RVTTERTAGT CLYFSAVPGI
160 170 180 190 200
LPSSQPPISC SEEGAGNATL SPRMGEECVS VWSHEGLVLT KLLTSEELAL
210 220 230 240
CGSRLLVLGS FLLLFCGLLC CVTAMCFHPR RESHWSRTRL
Length:240
Mass (Da):25,724
Last modified:June 1, 2003 - v1
Checksum:i8985EB036BB37EE8
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2J7I3L2J7_HUMAN
Insulin-like growth factor-binding ...
TMEM219
213Annotation score:
I3L2P0I3L2P0_HUMAN
Insulin-like growth factor-binding ...
TMEM219
231Annotation score:
R4GNJ4R4GNJ4_HUMAN
Insulin-like growth factor-binding ...
TMEM219
149Annotation score:
I3L4B3I3L4B3_HUMAN
Insulin-like growth factor-binding ...
TMEM219
169Annotation score:
H3BML8H3BML8_HUMAN
Insulin-like growth factor-binding ...
TMEM219
99Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ748884 mRNA Translation: ACQ72822.1
CH471238 Genomic DNA Translation: EAW79966.1
BC017488 mRNA Translation: AAH17488.1
BC050051 mRNA Translation: AAH50051.1
CCDSiCCDS42145.1
RefSeqiNP_001077082.1, NM_001083613.1
NP_919256.1, NM_194280.3
XP_005255180.1, XM_005255123.1
UniGeneiHs.460574

Genome annotation databases

EnsembliENST00000279396; ENSP00000279396; ENSG00000149932
ENST00000414689; ENSP00000388485; ENSG00000149932
ENST00000561899; ENSP00000456960; ENSG00000149932
ENST00000566848; ENSP00000457492; ENSG00000149932
GeneIDi124446
KEGGihsa:124446
UCSCiuc002duw.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ748884 mRNA Translation: ACQ72822.1
CH471238 Genomic DNA Translation: EAW79966.1
BC017488 mRNA Translation: AAH17488.1
BC050051 mRNA Translation: AAH50051.1
CCDSiCCDS42145.1
RefSeqiNP_001077082.1, NM_001083613.1
NP_919256.1, NM_194280.3
XP_005255180.1, XM_005255123.1
UniGeneiHs.460574

3D structure databases

ProteinModelPortaliQ86XT9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125865, 13 interactors
IntActiQ86XT9, 5 interactors
STRINGi9606.ENSP00000279396

PTM databases

iPTMnetiQ86XT9
PhosphoSitePlusiQ86XT9

Polymorphism and mutation databases

BioMutaiTMEM219

Proteomic databases

EPDiQ86XT9
PaxDbiQ86XT9
PeptideAtlasiQ86XT9
PRIDEiQ86XT9
ProteomicsDBi70333

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279396; ENSP00000279396; ENSG00000149932
ENST00000414689; ENSP00000388485; ENSG00000149932
ENST00000561899; ENSP00000456960; ENSG00000149932
ENST00000566848; ENSP00000457492; ENSG00000149932
GeneIDi124446
KEGGihsa:124446
UCSCiuc002duw.3 human

Organism-specific databases

CTDi124446
DisGeNETi124446
EuPathDBiHostDB:ENSG00000149932.16
GeneCardsiTMEM219
HGNCiHGNC:25201 TMEM219
HPAiHPA059185
neXtProtiNX_Q86XT9
OpenTargetsiENSG00000149932
PharmGKBiPA162406570
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWEC Eukaryota
ENOG4110155 LUCA
GeneTreeiENSGT00390000013671
HOGENOMiHOG000154627
HOVERGENiHBG095163
InParanoidiQ86XT9
OMAiGSHIVGL
OrthoDBiEOG091G0LWI
PhylomeDBiQ86XT9
TreeFamiTF338507

Enzyme and pathway databases

ReactomeiR-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
SignaLinkiQ86XT9

Miscellaneous databases

GenomeRNAii124446
PROiPR:Q86XT9

Gene expression databases

BgeeiENSG00000149932 Expressed in 197 organ(s), highest expression level in body of stomach
CleanExiHS_TMEM219
ExpressionAtlasiQ86XT9 baseline and differential
GenevisibleiQ86XT9 HS

Family and domain databases

InterProiView protein in InterPro
IPR039493 TMEM248/TMEM219
IPR039587 TMEM248/TMEM219_dom
PANTHERiPTHR16002 PTHR16002, 1 hit
PfamiView protein in Pfam
PF14940 TMEM219, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTM219_HUMAN
AccessioniPrimary (citable) accession number: Q86XT9
Secondary accession number(s): D5FK14, Q8WVV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: October 10, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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