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Protein

Insulin-like growth factor-binding protein 3 receptor

Gene

TMEM219

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q86XT9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 3 receptor
Short name:
IGFBP-3R
Alternative name(s):
Transmembrane protein 219
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM219
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000149932.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25201 TMEM219

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86XT9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini39 – 204ExtracellularSequence analysisAdd BLAST166
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 240CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
124446

Open Targets

More...
OpenTargetsi
ENSG00000149932

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162406570

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM219

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 38Sequence analysisAdd BLAST38
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032904939 – 240Insulin-like growth factor-binding protein 3 receptorAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86XT9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86XT9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86XT9

PeptideAtlas

More...
PeptideAtlasi
Q86XT9

PRoteomics IDEntifications database

More...
PRIDEi
Q86XT9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70333

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86XT9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86XT9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in normal tissues but suppressed in prostate and breast tumor.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149932 Expressed in 197 organ(s), highest expression level in body of stomach

CleanEx database of gene expression profiles

More...
CleanExi
HS_TMEM219

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86XT9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86XT9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059185

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IGFBP3. Interacts with CASP8.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125865, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q86XT9, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000279396

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86XT9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWEC Eukaryota
ENOG4110155 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153883

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154627

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG095163

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86XT9

Identification of Orthologs from Complete Genome Data

More...
OMAi
GSHIVGL

Database of Orthologous Groups

More...
OrthoDBi
1408433at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86XT9

TreeFam database of animal gene trees

More...
TreeFami
TF338507

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039493 TMEM248/TMEM219
IPR039587 TMEM248/TMEM219_dom

The PANTHER Classification System

More...
PANTHERi
PTHR16002 PTHR16002, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14940 TMEM219, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q86XT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNCQAGHNL HLCLAHHPPL VCATLILLLL GLSGLGLGSF LLTHRTGLRS
60 70 80 90 100
PDIPQDWVSF LRSFGQLTLC PRNGTVTGKW RGSHVVGLLT TLNFGDGPDR
110 120 130 140 150
NKTRTFQATV LGSQMGLKGS SAGQLVLITA RVTTERTAGT CLYFSAVPGI
160 170 180 190 200
LPSSQPPISC SEEGAGNATL SPRMGEECVS VWSHEGLVLT KLLTSEELAL
210 220 230 240
CGSRLLVLGS FLLLFCGLLC CVTAMCFHPR RESHWSRTRL
Length:240
Mass (Da):25,724
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8985EB036BB37EE8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2J7I3L2J7_HUMAN
Insulin-like growth factor-binding ...
TMEM219
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2P0I3L2P0_HUMAN
Insulin-like growth factor-binding ...
TMEM219
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GNJ4R4GNJ4_HUMAN
Insulin-like growth factor-binding ...
TMEM219
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4B3I3L4B3_HUMAN
Insulin-like growth factor-binding ...
TMEM219
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BML8H3BML8_HUMAN
Insulin-like growth factor-binding ...
TMEM219
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ748884 mRNA Translation: ACQ72822.1
CH471238 Genomic DNA Translation: EAW79966.1
BC017488 mRNA Translation: AAH17488.1
BC050051 mRNA Translation: AAH50051.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42145.1

NCBI Reference Sequences

More...
RefSeqi
NP_001077082.1, NM_001083613.1
NP_919256.1, NM_194280.3
XP_005255180.1, XM_005255123.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.460574

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000279396; ENSP00000279396; ENSG00000149932
ENST00000414689; ENSP00000388485; ENSG00000149932
ENST00000561899; ENSP00000456960; ENSG00000149932
ENST00000566848; ENSP00000457492; ENSG00000149932

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
124446

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:124446

UCSC genome browser

More...
UCSCi
uc002duw.3 human

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ748884 mRNA Translation: ACQ72822.1
CH471238 Genomic DNA Translation: EAW79966.1
BC017488 mRNA Translation: AAH17488.1
BC050051 mRNA Translation: AAH50051.1
CCDSiCCDS42145.1
RefSeqiNP_001077082.1, NM_001083613.1
NP_919256.1, NM_194280.3
XP_005255180.1, XM_005255123.1
UniGeneiHs.460574

3D structure databases

ProteinModelPortaliQ86XT9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125865, 13 interactors
IntActiQ86XT9, 6 interactors
STRINGi9606.ENSP00000279396

PTM databases

iPTMnetiQ86XT9
PhosphoSitePlusiQ86XT9

Polymorphism and mutation databases

BioMutaiTMEM219

Proteomic databases

EPDiQ86XT9
jPOSTiQ86XT9
PaxDbiQ86XT9
PeptideAtlasiQ86XT9
PRIDEiQ86XT9
ProteomicsDBi70333

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279396; ENSP00000279396; ENSG00000149932
ENST00000414689; ENSP00000388485; ENSG00000149932
ENST00000561899; ENSP00000456960; ENSG00000149932
ENST00000566848; ENSP00000457492; ENSG00000149932
GeneIDi124446
KEGGihsa:124446
UCSCiuc002duw.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
124446
DisGeNETi124446
EuPathDBiHostDB:ENSG00000149932.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM219
HGNCiHGNC:25201 TMEM219
HPAiHPA059185
neXtProtiNX_Q86XT9
OpenTargetsiENSG00000149932
PharmGKBiPA162406570

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWEC Eukaryota
ENOG4110155 LUCA
GeneTreeiENSGT00940000153883
HOGENOMiHOG000154627
HOVERGENiHBG095163
InParanoidiQ86XT9
OMAiGSHIVGL
OrthoDBi1408433at2759
PhylomeDBiQ86XT9
TreeFamiTF338507

Enzyme and pathway databases

ReactomeiR-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
SignaLinkiQ86XT9

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
124446

Protein Ontology

More...
PROi
PR:Q86XT9

Gene expression databases

BgeeiENSG00000149932 Expressed in 197 organ(s), highest expression level in body of stomach
CleanExiHS_TMEM219
ExpressionAtlasiQ86XT9 baseline and differential
GenevisibleiQ86XT9 HS

Family and domain databases

InterProiView protein in InterPro
IPR039493 TMEM248/TMEM219
IPR039587 TMEM248/TMEM219_dom
PANTHERiPTHR16002 PTHR16002, 1 hit
PfamiView protein in Pfam
PF14940 TMEM219, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM219_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86XT9
Secondary accession number(s): D5FK14, Q8WVV8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: January 16, 2019
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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