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Protein

Vacuolar protein sorting-associated protein 37D

Gene

VPS37D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-162588 Budding and maturation of HIV virion
R-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 37D
Alternative name(s):
ESCRT-I complex subunit VPS37D
Williams-Beuren syndrome chromosomal region 24 protein
Gene namesi
Name:VPS37DImported
Synonyms:WBSCR24Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000176428.5
HGNCiHGNC:18287 VPS37D
MIMi610039 gene
neXtProtiNX_Q86XT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

VPS37D is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Keywords - Diseasei

Williams-Beuren syndrome

Organism-specific databases

OpenTargetsiENSG00000176428
PharmGKBiPA38308

Polymorphism and mutation databases

BioMutaiVPS37D
DMDMi182702221

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003289271 – 251Vacuolar protein sorting-associated protein 37DAdd BLAST251

Proteomic databases

PaxDbiQ86XT2
PeptideAtlasiQ86XT2
PRIDEiQ86XT2
ProteomicsDBi70330

PTM databases

iPTMnetiQ86XT2
PhosphoSitePlusiQ86XT2

Expressioni

Gene expression databases

BgeeiENSG00000176428 Expressed in 156 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_VPS37D
ExpressionAtlasiQ86XT2 baseline and differential
GenevisibleiQ86XT2 HS

Organism-specific databases

HPAiHPA040978

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101 and MVB12A. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry.2 Publications

Protein-protein interaction databases

BioGridi127583, 9 interactors
IntActiQ86XT2, 2 interactors
MINTiQ86XT2
STRINGi9606.ENSP00000320416

Structurei

3D structure databases

ProteinModelPortaliQ86XT2
SMRiQ86XT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 182VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST90

Sequence similaritiesi

Belongs to the VPS37 family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IX4Z Eukaryota
ENOG4111T7T LUCA
GeneTreeiENSGT00530000063123
HOGENOMiHOG000057287
HOVERGENiHBG095499
InParanoidiQ86XT2
KOiK12185
OMAiQPEPPYR
OrthoDBiEOG091G0J9K
PhylomeDBiQ86XT2
TreeFamiTF321840

Family and domain databases

InterProiView protein in InterPro
IPR009851 Mod_r
IPR037859 Vps37
PANTHERiPTHR13678 PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200 Mod_r, 1 hit
PROSITEiView protein in PROSITE
PS51314 VPS37_C, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86XT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYRARAARAG PEPGSPGRFG ILSTGQLRDL LQDEPKLDRI VRLSRKFQGL
60 70 80 90 100
QLEREACLAS NYALAKENLA LRPRLEMGRA ALAIKYQELR EVAENCADKL
110 120 130 140 150
QRLEESMHRW SPHCALGWLQ AELEEAEQEA EEQMEQLLLG EQSLEAFLPA
160 170 180 190 200
FQRGRALAHL RRTQAEKLQE LLRRRERSAQ PAPTSAADPP KSFPAAAVLP
210 220 230 240 250
TGAARGPPAV PRSLPPLDSR PVPPLKGSPG CPLGPAPLLS PRPSQPEPPH

R
Length:251
Mass (Da):27,730
Last modified:April 8, 2008 - v2
Checksum:iA07E752409455026
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYT9C9JYT9_HUMAN
Vacuolar protein sorting-associated...
VPS37D
166Annotation score:

Sequence cautioni

The sequence AAL91075 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081952 mRNA Translation: AAL91075.1 Different initiation.
AC073846 Genomic DNA No translation available.
BC064621 mRNA Translation: AAH64621.2
CCDSiCCDS43596.1
RefSeqiNP_001071089.1, NM_001077621.1
UniGeneiHs.647037

Genome annotation databases

EnsembliENST00000324941; ENSP00000320416; ENSG00000176428
GeneIDi155382
KEGGihsa:155382
UCSCiuc003tyr.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081952 mRNA Translation: AAL91075.1 Different initiation.
AC073846 Genomic DNA No translation available.
BC064621 mRNA Translation: AAH64621.2
CCDSiCCDS43596.1
RefSeqiNP_001071089.1, NM_001077621.1
UniGeneiHs.647037

3D structure databases

ProteinModelPortaliQ86XT2
SMRiQ86XT2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127583, 9 interactors
IntActiQ86XT2, 2 interactors
MINTiQ86XT2
STRINGi9606.ENSP00000320416

PTM databases

iPTMnetiQ86XT2
PhosphoSitePlusiQ86XT2

Polymorphism and mutation databases

BioMutaiVPS37D
DMDMi182702221

Proteomic databases

PaxDbiQ86XT2
PeptideAtlasiQ86XT2
PRIDEiQ86XT2
ProteomicsDBi70330

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324941; ENSP00000320416; ENSG00000176428
GeneIDi155382
KEGGihsa:155382
UCSCiuc003tyr.4 human

Organism-specific databases

CTDi155382
EuPathDBiHostDB:ENSG00000176428.5
GeneCardsiVPS37D
HGNCiHGNC:18287 VPS37D
HPAiHPA040978
MIMi610039 gene
neXtProtiNX_Q86XT2
OpenTargetsiENSG00000176428
PharmGKBiPA38308
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX4Z Eukaryota
ENOG4111T7T LUCA
GeneTreeiENSGT00530000063123
HOGENOMiHOG000057287
HOVERGENiHBG095499
InParanoidiQ86XT2
KOiK12185
OMAiQPEPPYR
OrthoDBiEOG091G0J9K
PhylomeDBiQ86XT2
TreeFamiTF321840

Enzyme and pathway databases

ReactomeiR-HSA-162588 Budding and maturation of HIV virion
R-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Miscellaneous databases

GenomeRNAii155382
PROiPR:Q86XT2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176428 Expressed in 156 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_VPS37D
ExpressionAtlasiQ86XT2 baseline and differential
GenevisibleiQ86XT2 HS

Family and domain databases

InterProiView protein in InterPro
IPR009851 Mod_r
IPR037859 Vps37
PANTHERiPTHR13678 PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200 Mod_r, 1 hit
PROSITEiView protein in PROSITE
PS51314 VPS37_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVP37D_HUMAN
AccessioniPrimary (citable) accession number: Q86XT2
Secondary accession number(s): Q6P2C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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