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Protein

Angiopoietin-related protein 5

Gene

ANGPTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 5
Alternative name(s):
Angiopoietin-like protein 5
Gene namesi
Name:ANGPTL5
ORF Names:UNQ5795/PRO19600
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000187151.7
HGNCiHGNC:19705 ANGPTL5
MIMi607666 gene
neXtProtiNX_Q86XS5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187151
PharmGKBiPA134944139

Polymorphism and mutation databases

BioMutaiANGPTL5
DMDMi296439430

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000912726 – 388Angiopoietin-related protein 5Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi310 ↔ 314PROSITE-ProRule annotation
Disulfide bondi324 ↔ 338PROSITE-ProRule annotation
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86XS5
PRIDEiQ86XS5
ProteomicsDBi70328

PTM databases

iPTMnetiQ86XS5
PhosphoSitePlusiQ86XS5

Expressioni

Tissue specificityi

Mainly expressed in adult heart.1 Publication

Gene expression databases

BgeeiENSG00000187151 Expressed in 67 organ(s), highest expression level in right ovary
CleanExiHS_ANGPTL5
ExpressionAtlasiQ86XS5 baseline and differential

Organism-specific databases

HPAiHPA038516

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LILRB2Q8N4235EBI-15485927,EBI-2816428

Protein-protein interaction databases

DIPiDIP-59887N
IntActiQ86XS5, 2 interactors
STRINGi9606.ENSP00000335255

Structurei

3D structure databases

ProteinModelPortaliQ86XS5
SMRiQ86XS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 383Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST243

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili98 – 123Sequence analysisAdd BLAST26

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00920000148942
HOGENOMiHOG000168535
HOVERGENiHBG050502
InParanoidiQ86XS5
OMAiSHGLDCT
OrthoDBiEOG091G03M1
PhylomeDBiQ86XS5
TreeFamiTF351983

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q86XS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSPSQASLL FLNVCIFICG EAVQGNCVHH STDSSVVNIV EDGSNAKDES
60 70 80 90 100
KSNDTVCKED CEESCDVKTK ITREEKHFMC RNLQNSIVSY TRSTKKLLRN
110 120 130 140 150
MMDEQQASLD YLSNQVNELM NRVLLLTTEV FRKQLDPFPH RPVQSHGLDC
160 170 180 190 200
TDIKDTIGSV TKTPSGLYII HPEGSSYPFE VMCDMDYRGG GRTVIQKRID
210 220 230 240 250
GIIDFQRLWC DYLDGFGDLL GEFWLGLKKI FYIVNQKNTS FMLYVALESE
260 270 280 290 300
DDTLAYASYD NFWLEDETRF FKMHLGRYSG NAGDAFRGLK KEDNQNAMPF
310 320 330 340 350
STSDVDNDGC RPACLVNGQS VKSCSHLHNK TGWWFNECGL ANLNGIHHFS
360 370 380
GKLLATGIQW GTWTKNNSPV KIKSVSMKIR RMYNPYFK
Length:388
Mass (Da):44,144
Last modified:May 18, 2010 - v3
Checksum:i4060C998885151BF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKF7E9PKF7_HUMAN
Angiopoietin-related protein 5
ANGPTL5
192Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192R → W in AAO38749 (PubMed:12624729).Curated1
Sequence conflicti192R → W in AAQ89186 (PubMed:12975309).Curated1
Sequence conflicti192R → W in BAF84212 (PubMed:14702039).Curated1
Sequence conflicti192R → W in AAH49170 (PubMed:15489334).Curated1
Sequence conflicti281N → S in AAO38749 (PubMed:12624729).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055803175S → P. Corresponds to variant dbSNP:rs7946238Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169281 mRNA Translation: AAO38749.1
AY358827 mRNA Translation: AAQ89186.1
AK291523 mRNA Translation: BAF84212.1
AP003383 Genomic DNA No translation available.
BC049170 mRNA Translation: AAH49170.1
CCDSiCCDS8312.1
RefSeqiNP_835228.2, NM_178127.4
UniGeneiHs.318370

Genome annotation databases

EnsembliENST00000334289; ENSP00000335255; ENSG00000187151
GeneIDi253935
KEGGihsa:253935
UCSCiuc001pgl.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169281 mRNA Translation: AAO38749.1
AY358827 mRNA Translation: AAQ89186.1
AK291523 mRNA Translation: BAF84212.1
AP003383 Genomic DNA No translation available.
BC049170 mRNA Translation: AAH49170.1
CCDSiCCDS8312.1
RefSeqiNP_835228.2, NM_178127.4
UniGeneiHs.318370

3D structure databases

ProteinModelPortaliQ86XS5
SMRiQ86XS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59887N
IntActiQ86XS5, 2 interactors
STRINGi9606.ENSP00000335255

PTM databases

iPTMnetiQ86XS5
PhosphoSitePlusiQ86XS5

Polymorphism and mutation databases

BioMutaiANGPTL5
DMDMi296439430

Proteomic databases

PaxDbiQ86XS5
PRIDEiQ86XS5
ProteomicsDBi70328

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334289; ENSP00000335255; ENSG00000187151
GeneIDi253935
KEGGihsa:253935
UCSCiuc001pgl.3 human

Organism-specific databases

CTDi253935
EuPathDBiHostDB:ENSG00000187151.7
GeneCardsiANGPTL5
H-InvDBiHIX0026172
HGNCiHGNC:19705 ANGPTL5
HPAiHPA038516
MIMi607666 gene
neXtProtiNX_Q86XS5
OpenTargetsiENSG00000187151
PharmGKBiPA134944139
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00920000148942
HOGENOMiHOG000168535
HOVERGENiHBG050502
InParanoidiQ86XS5
OMAiSHGLDCT
OrthoDBiEOG091G03M1
PhylomeDBiQ86XS5
TreeFamiTF351983

Miscellaneous databases

ChiTaRSiANGPTL5 human
GenomeRNAii253935
PROiPR:Q86XS5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187151 Expressed in 67 organ(s), highest expression level in right ovary
CleanExiHS_ANGPTL5
ExpressionAtlasiQ86XS5 baseline and differential

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiANGL5_HUMAN
AccessioniPrimary (citable) accession number: Q86XS5
Secondary accession number(s): A8K658, Q86VR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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