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Protein

Centrosomal protein of 57 kDa

Gene

CEP57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • fibroblast growth factor binding Source: UniProtKB
  • gamma-tubulin binding Source: InterPro
  • microtubule binding Source: GO_Central
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 57 kDa
Short name:
Cep57
Alternative name(s):
FGF2-interacting protein
Testis-specific protein 57
Translokin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP57
Synonyms:KIAA0092, TSP57
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000166037.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30794 CEP57

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607951 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86XR8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mosaic variegated aneuploidy syndrome 2 (MVA2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA severe developmental disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in several cases.
See also OMIM:614114

Organism-specific databases

DisGeNET

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DisGeNETi
9702

MalaCards human disease database

More...
MalaCardsi
CEP57
MIMi614114 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000166037

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1052 Mosaic variegated aneuploidy syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142672123

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CEP57

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56748768

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001895321 – 500Centrosomal protein of 57 kDaAdd BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei53PhosphoserineCombined sources1
Modified residuei55PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q86XR8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q86XR8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86XR8

PeptideAtlas

More...
PeptideAtlasi
Q86XR8

PRoteomics IDEntifications database

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PRIDEi
Q86XR8

ProteomicsDB human proteome resource

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ProteomicsDBi
70324
70325 [Q86XR8-2]
70326 [Q86XR8-3]
70327 [Q86XR8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86XR8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q86XR8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000166037 Expressed in 229 organ(s), highest expression level in intestine

CleanEx database of gene expression profiles

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CleanExi
HS_CEP57

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86XR8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86XR8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018315

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and homooligomer. Interacts with microtubules. Interacts with FGF2 and RAP80. Does not interact with FGF1 or FGF2 isoform 24 kDa.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115054, 121 interactors

Protein interaction database and analysis system

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IntActi
Q86XR8, 45 interactors

Molecular INTeraction database

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MINTi
Q86XR8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000317902

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1500
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q86XR8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86XR8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 239centrosome localization domain (CLD)By similarityAdd BLAST182
Regioni277 – 491Mediates interaction with microtubulesBy similarityAdd BLAST215

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili63 – 242Sequence analysisAdd BLAST180
Coiled coili392 – 492Sequence analysisAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi260 – 265Poly-Lys6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal region mediates the interaction with microtubules and is able to nucleate and bundles microtubules in vitro.By similarity
The centrosome localization domain (CLD) region mediates the localization to centrosomes and homooligomerization.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the translokin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IESE Eukaryota
ENOG410XPJC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063695

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050917

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86XR8

KEGG Orthology (KO)

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KOi
K16762

Identification of Orthologs from Complete Genome Data

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OMAi
QKDDISW

Database of Orthologous Groups

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OrthoDBi
EOG091G07B7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86XR8

TreeFam database of animal gene trees

More...
TreeFami
TF329178

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR010597 Centrosomal_protein_57kDa
IPR025913 Cep57_CLD
IPR024957 Cep57_MT-bd_dom

The PANTHER Classification System

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PANTHERi
PTHR19336:SF11 PTHR19336:SF11, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF14073 Cep57_CLD, 1 hit
PF06657 Cep57_MT_bd, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86XR8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAASVSAAS GSHLSNSFAE PSRSNGSMVR HSSSPYVVYP SDKPFLNSDL
60 70 80 90 100
RRSPSKPTLA YPESNSRAIF SALKNLQDKI RRLELERIQA EESVKTLSRE
110 120 130 140 150
TIEYKKVLDE QIQERENSKN EESKHNQELT SQLLAAENKC NLLEKQLEYM
160 170 180 190 200
RNMIKHAEME RTSVLEKQVS LERERQHDQT HVQSQLEKLD LLEQEYNKLT
210 220 230 240 250
TMQALAEKKM QELEAKLHEE EQERKRMQAK AAELQTGLET NRLIFEDKAT
260 270 280 290 300
PCVPNARRIK KKKSKPPEKK SSRNYFGAQP HYRLCLGDMP FVAGKSTSPS
310 320 330 340 350
HAVVANVQLV LHLMKQHSKA LCNDRVINSI PLAKQVSSRG GKSKKLSVTP
360 370 380 390 400
PSSNGINEEL SEVLQTLQDE FGQMSFDHQQ LAKLIQESPT VELKDKLECE
410 420 430 440 450
LEALVGRMEA KANQITKVRK YQAQLEKQKL EKQKKELKAT KKTLDEERNS
460 470 480 490 500
SSRSGITGTT NKKDFMKLRP GEKRRKNLQL LKDMQSIQNS LQSSSLCWDY
Length:500
Mass (Da):57,089
Last modified:December 21, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88FC47E7B33CE328
GO
Isoform 2 (identifier: Q86XR8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-295: Missing.

Show »
Length:474
Mass (Da):54,164
Checksum:iFC5DCDF19948F496
GO
Isoform 3 (identifier: Q86XR8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-270: K → V
     271-500: Missing.

Show »
Length:270
Mass (Da):31,147
Checksum:iDA552E20AB2A6648
GO
Isoform 4 (identifier: Q86XR8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MAAASVSAASGSHLS → MLTRID
     498-500: Missing.

Note: No experimental confirmation available.
Show »
Length:488
Mass (Da):56,026
Checksum:iFF8621FE703DB0F6
GO
Isoform 5 (identifier: Q86XR8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MAAASVSAASGSHLS → MLTRID

Note: No experimental confirmation available.
Show »
Length:491
Mass (Da):56,490
Checksum:i5C5F2F4F8621FE70
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GYW0F5GYW0_HUMAN
Centrosomal protein of 57 kDa
CEP57
473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFT8H0YFT8_HUMAN
Centrosomal protein of 57 kDa
CEP57
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0C6F5H0C6_HUMAN
Centrosomal protein of 57 kDa
CEP57
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1B0F5H1B0_HUMAN
Centrosomal protein of 57 kDa
CEP57
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGT4H0YGT4_HUMAN
Centrosomal protein of 57 kDa
CEP57
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H6R3F5H6R3_HUMAN
Centrosomal protein of 57 kDa
CEP57
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXS6F5GXS6_HUMAN
Centrosomal protein of 57 kDa
CEP57
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZ93F5GZ93_HUMAN
Centrosomal protein of 57 kDa
CEP57
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7J4F5H7J4_HUMAN
Centrosomal protein of 57 kDa
CEP57
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH29385 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA07654 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45F → S in BAF83934 (PubMed:14702039).Curated1
Sequence conflicti182V → A in BAG56806 (PubMed:14702039).Curated1
Sequence conflicti188K → E in BAF83934 (PubMed:14702039).Curated1
Sequence conflicti468L → Q in BAA07654 (PubMed:7788527).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059839448R → G2 PublicationsCorresponds to variant dbSNP:rs644799Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0378391 – 15MAAAS…GSHLS → MLTRID in isoform 4 and isoform 5. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_012262270 – 295Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_012263270K → V in isoform 3. 1 Publication1
Alternative sequenceiVSP_012264271 – 500Missing in isoform 3. 1 PublicationAdd BLAST230
Alternative sequenceiVSP_037840498 – 500Missing in isoform 4. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY225092 mRNA Translation: AAO73938.1
AY239292 mRNA Translation: AAP72184.1
D42054 mRNA Translation: BAA07654.2 Different initiation.
AK291245 mRNA Translation: BAF83934.1
AK293277 mRNA Translation: BAG56806.1
AP001877 Genomic DNA No translation available.
BC001233 mRNA Translation: AAH01233.1
BC029385 mRNA Translation: AAH29385.1 Sequence problems.
BC039711 mRNA Translation: AAH39711.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58166.1 [Q86XR8-2]
CCDS58167.1 [Q86XR8-5]
CCDS8304.1 [Q86XR8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001230705.1, NM_001243776.1 [Q86XR8-5]
NP_001230706.1, NM_001243777.1 [Q86XR8-2]
NP_055494.2, NM_014679.4 [Q86XR8-1]
XP_016874081.1, XM_017018592.1 [Q86XR8-5]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.101014

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000325486; ENSP00000317487; ENSG00000166037 [Q86XR8-2]
ENST00000325542; ENSP00000317902; ENSG00000166037 [Q86XR8-1]
ENST00000538658; ENSP00000445706; ENSG00000166037 [Q86XR8-3]
ENST00000541150; ENSP00000443436; ENSG00000166037 [Q86XR8-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9702

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9702

UCSC genome browser

More...
UCSCi
uc001pfo.3 human [Q86XR8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY225092 mRNA Translation: AAO73938.1
AY239292 mRNA Translation: AAP72184.1
D42054 mRNA Translation: BAA07654.2 Different initiation.
AK291245 mRNA Translation: BAF83934.1
AK293277 mRNA Translation: BAG56806.1
AP001877 Genomic DNA No translation available.
BC001233 mRNA Translation: AAH01233.1
BC029385 mRNA Translation: AAH29385.1 Sequence problems.
BC039711 mRNA Translation: AAH39711.1
CCDSiCCDS58166.1 [Q86XR8-2]
CCDS58167.1 [Q86XR8-5]
CCDS8304.1 [Q86XR8-1]
RefSeqiNP_001230705.1, NM_001243776.1 [Q86XR8-5]
NP_001230706.1, NM_001243777.1 [Q86XR8-2]
NP_055494.2, NM_014679.4 [Q86XR8-1]
XP_016874081.1, XM_017018592.1 [Q86XR8-5]
UniGeneiHs.101014

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L0RX-ray2.49A/B334-433[»]
ProteinModelPortaliQ86XR8
SMRiQ86XR8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115054, 121 interactors
IntActiQ86XR8, 45 interactors
MINTiQ86XR8
STRINGi9606.ENSP00000317902

PTM databases

iPTMnetiQ86XR8
PhosphoSitePlusiQ86XR8

Polymorphism and mutation databases

BioMutaiCEP57
DMDMi56748768

Proteomic databases

EPDiQ86XR8
MaxQBiQ86XR8
PaxDbiQ86XR8
PeptideAtlasiQ86XR8
PRIDEiQ86XR8
ProteomicsDBi70324
70325 [Q86XR8-2]
70326 [Q86XR8-3]
70327 [Q86XR8-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325486; ENSP00000317487; ENSG00000166037 [Q86XR8-2]
ENST00000325542; ENSP00000317902; ENSG00000166037 [Q86XR8-1]
ENST00000538658; ENSP00000445706; ENSG00000166037 [Q86XR8-3]
ENST00000541150; ENSP00000443436; ENSG00000166037 [Q86XR8-5]
GeneIDi9702
KEGGihsa:9702
UCSCiuc001pfo.3 human [Q86XR8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9702
DisGeNETi9702
EuPathDBiHostDB:ENSG00000166037.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CEP57
HGNCiHGNC:30794 CEP57
HPAiHPA018315
MalaCardsiCEP57
MIMi607951 gene
614114 phenotype
neXtProtiNX_Q86XR8
OpenTargetsiENSG00000166037
Orphaneti1052 Mosaic variegated aneuploidy syndrome
PharmGKBiPA142672123

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IESE Eukaryota
ENOG410XPJC LUCA
GeneTreeiENSGT00530000063695
HOVERGENiHBG050917
InParanoidiQ86XR8
KOiK16762
OMAiQKDDISW
OrthoDBiEOG091G07B7
PhylomeDBiQ86XR8
TreeFamiTF329178

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CEP57 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CEP57

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9702

Protein Ontology

More...
PROi
PR:Q86XR8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166037 Expressed in 229 organ(s), highest expression level in intestine
CleanExiHS_CEP57
ExpressionAtlasiQ86XR8 baseline and differential
GenevisibleiQ86XR8 HS

Family and domain databases

InterProiView protein in InterPro
IPR010597 Centrosomal_protein_57kDa
IPR025913 Cep57_CLD
IPR024957 Cep57_MT-bd_dom
PANTHERiPTHR19336:SF11 PTHR19336:SF11, 1 hit
PfamiView protein in Pfam
PF14073 Cep57_CLD, 1 hit
PF06657 Cep57_MT_bd, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEP57_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86XR8
Secondary accession number(s): A0PJH1
, A8K5D0, B4DDP5, F5H5F7, Q14704, Q5JB46, Q8IXP0, Q9BVF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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