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Entry version 163 (16 Oct 2019)
Sequence version 1 (01 Jun 2003)
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Protein

TIR domain-containing adapter molecule 2

Gene

TICAM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606).6 Publications
Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-2562578 TRIF-mediated programmed cell death
R-HSA-6798695 Neutrophil degranulation
R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-HSA-937041 IKK complex recruitment mediated by RIP1
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q86XR7

SIGNOR Signaling Network Open Resource

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SIGNORi
Q86XR7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TIR domain-containing adapter molecule 2
Short name:
TICAM-2
Alternative name(s):
Putative NF-kappa-B-activating protein 502
TRIF-related adapter molecule
Toll-like receptor adaptor protein 3
Toll/interleukin-1 receptor domain-containing protein
Short name:
MyD88-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TICAM2
Synonyms:TIRAP3, TIRP, TRAM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:21354 TICAM2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608321 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86XR7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2G → A: Results in relocalization from membrane to cytosol; Loss of ability to transduce TLR4-signal. Loss of TLR2-mediated activation of IRF7. 2 Publications1
Mutagenesisi6S → A: Loss of phosphorylation. Significant reduction in the ability to activate IRF3 or NF-kappa-B. 1 Publication1
Mutagenesisi10S → A: No effect on phosphorylation and on the ability to activate IRF3 or NF-kappa-B. 1 Publication1
Mutagenesisi14S → A: No effect on phosphorylation and on the ability to activate IRF3 or NF-kappa-B. 1 Publication1
Mutagenesisi16S → A: Loss of phosphorylation. Abolishes ability to activate IRF3 or NF-kappa-B and to transduce TLR4 signal. 1 Publication1
Mutagenesisi16S → E: Significant decrease of localization in the membrane. 1 Publication1
Mutagenesisi116P → H: Loss of ability to dimerize. Significant loss of RANTES-inducing activity. Loss of ability to induce NF-kappa-B activation. 2 Publications1
Mutagenesisi117C → H: Loss of ability to dimerize. Loss of RANTES-inducing activity and ability to induce NF-kappa-B activation. Inhibition of TLR4-dependent activation of IRF3 and IRF7. Loss of interaction with TLR4. 2 Publications1
Mutagenesisi154Y → F: No effect on phosphorylation. 1 Publication1
Mutagenesisi167Y → F: Complete loss of phosphorylation in response to LPS. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
100302736
353376
51014

Open Targets

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OpenTargetsi
ENSG00000243414
ENSG00000251201

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134881157
PA165660570

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86XR7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TICAM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74727858

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003176892 – 235TIR domain-containing adapter molecule 2Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16Phosphoserine; by PKC/PRKCE1 Publication1
Modified residuei167Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation. Tyrosine phosphorylation is inhibited by phosphatase PTPN4.2 Publications
Isoform 1 is myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q86XR7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86XR7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q86XR7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q86XR7

PeptideAtlas

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PeptideAtlasi
Q86XR7

PRoteomics IDEntifications database

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PRIDEi
Q86XR7

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
66519
70323 [Q86XR7-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q86XR7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q86XR7

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q86XR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000243414 Expressed in 90 organ(s), highest expression level in leukocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86XR7 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA008960

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS.

Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6.

Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4.

Isoform 1 interacts with isoform 2; the interaction occurs in late endosomes and disrupts the interaction between isoform 1 and TICAM1.

Interacts with MYD88; the interaction decreases after IL-18 stimulation in a time-dependent manner.

Interacts with IL18R1 and IL18RAP.

Interacts with TLR2 (PubMed:25385819).

Interacts with RAB11FIP2 (PubMed:30883606).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
131694, 10 interactors
970651, 2 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q86XR7

Database of interacting proteins

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DIPi
DIP-33488N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q86XR7

Protein interaction database and analysis system

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IntActi
Q86XR7, 15 interactors

Molecular INTeraction database

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MINTi
Q86XR7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000415139

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86XR7

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 232TIRPROSITE-ProRule annotationAdd BLAST160

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TIR domain mediates the interaction with TRAF6 and MYD88.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1693 Eukaryota
ENOG4111JPD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158463
ENSGT00940000163706

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000068974

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86XR7

KEGG Orthology (KO)

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KOi
K05409

Identification of Orthologs from Complete Genome Data

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OMAi
TRVAYWH

Database of Orthologous Groups

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OrthoDBi
1328081at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q86XR7

TreeFam database of animal gene trees

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TreeFami
TF313000

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000157 TIR_dom
IPR015720 TMP21-related
IPR035897 Toll_tir_struct_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR22811 PTHR22811, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF13676 TIR_2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86XR7-1) [UniParc]FASTAAdd to basket
Also known as: TRAM

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGIGKSKINS CPLSLSWGKR HSVDTSPGYH ESDSKKSEDL SLCNVAEHSN
60 70 80 90 100
TTEGPTGKQE GAQSVEEMFE EEAEEEVFLK FVILHAEDDT DEALRVQNLL
110 120 130 140 150
QDDFGIKPGI IFAEMPCGRQ HLQNLDDAVN GSAWTILLLT ENFLRDTWCN
160 170 180 190 200
FQFYTSLMNS VNRQHKYNSV IPMRPLNNPL PRERTPFALQ TINALEEESR
210 220 230
GFPTQVERIF QESVYKTQQT IWKETRNMVQ RQFIA
Length:235
Mass (Da):26,916
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D1171F9B04D9C4C
GO
Isoform 2 (identifier: Q86XR7-2) [UniParc]FASTAAdd to basket
Also known as: TAG, TRAM adaptor with GOLD domain

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MGIGKSKINSCPLSLSWGKR → MPRPGSAQRW...EDLNTRVAYW

Show »
Length:404
Mass (Da):46,173
Checksum:iC539E6D9B8185764
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0474371 – 20MGIGK…SWGKR → MPRPGSAQRWAAVAGRWGCR LLALLLLVPGPGGASEITFE LPDNAKQCFYEDIAQGTKCT LEFQVITGGHYDVDCRLEDP DGKVLYKEMKKQYDSFTFTA SKNGTYKFCFSNEFSTFTHK TVYFDFQVGEDPPLFPSENR VSALTQMESACVSIHEALKS VIDYQTHFRLREAQGRSRAE DLNTRVAYW in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY275836 mRNA Translation: AAP81748.1
AB109098 mRNA Translation: BAC98399.1
AB091054 mRNA Translation: BAC98397.1
AY232653 mRNA Translation: AAO74498.1
AY304581 mRNA Translation: AAQ97430.1
AY304582 mRNA Translation: AAQ97431.1
AY304583 mRNA Translation: AAQ97432.1
AY304584 mRNA Translation: AAQ97433.1
AB446491 mRNA Translation: BAG55268.1
AB097022 mRNA Translation: BAC77375.1
AC010226 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48960.1
CH471086 Genomic DNA Translation: EAW48961.1
BC109265 mRNA Translation: AAI09266.1
BC109266 mRNA Translation: AAI09267.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4119.1 [Q86XR7-1]

NCBI Reference Sequences

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RefSeqi
NP_001157940.1, NM_001164468.3 [Q86XR7-2]
NP_001157941.1, NM_001164469.3
NP_067681.1, NM_021649.7 [Q86XR7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000427199; ENSP00000415139; ENSG00000243414 [Q86XR7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
100302736
353376

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:100302736
hsa:353376

UCSC genome browser

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UCSCi
uc003krc.4 human [Q86XR7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275836 mRNA Translation: AAP81748.1
AB109098 mRNA Translation: BAC98399.1
AB091054 mRNA Translation: BAC98397.1
AY232653 mRNA Translation: AAO74498.1
AY304581 mRNA Translation: AAQ97430.1
AY304582 mRNA Translation: AAQ97431.1
AY304583 mRNA Translation: AAQ97432.1
AY304584 mRNA Translation: AAQ97433.1
AB446491 mRNA Translation: BAG55268.1
AB097022 mRNA Translation: BAC77375.1
AC010226 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48960.1
CH471086 Genomic DNA Translation: EAW48961.1
BC109265 mRNA Translation: AAI09266.1
BC109266 mRNA Translation: AAI09267.1
CCDSiCCDS4119.1 [Q86XR7-1]
RefSeqiNP_001157940.1, NM_001164468.3 [Q86XR7-2]
NP_001157941.1, NM_001164469.3
NP_067681.1, NM_021649.7 [Q86XR7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M1WNMR-A75-235[»]
SMRiQ86XR7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi131694, 10 interactors
970651, 2 interactors
CORUMiQ86XR7
DIPiDIP-33488N
ELMiQ86XR7
IntActiQ86XR7, 15 interactors
MINTiQ86XR7
STRINGi9606.ENSP00000415139

PTM databases

iPTMnetiQ86XR7
PhosphoSitePlusiQ86XR7
SwissPalmiQ86XR7

Polymorphism and mutation databases

BioMutaiTICAM2
DMDMi74727858

Proteomic databases

jPOSTiQ86XR7
MassIVEiQ86XR7
MaxQBiQ86XR7
PaxDbiQ86XR7
PeptideAtlasiQ86XR7
PRIDEiQ86XR7
ProteomicsDBi66519
70323 [Q86XR7-1]

Genome annotation databases

EnsembliENST00000427199; ENSP00000415139; ENSG00000243414 [Q86XR7-1]
GeneIDi100302736
353376
KEGGihsa:100302736
hsa:353376
UCSCiuc003krc.4 human [Q86XR7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
100302736
353376
DisGeNETi100302736
353376
51014

GeneCards: human genes, protein and diseases

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GeneCardsi
TICAM2
HGNCiHGNC:21354 TICAM2
HPAiHPA008960
MIMi608321 gene
neXtProtiNX_Q86XR7
OpenTargetsiENSG00000243414
ENSG00000251201
PharmGKBiPA134881157
PA165660570

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1693 Eukaryota
ENOG4111JPD LUCA
GeneTreeiENSGT00940000158463
ENSGT00940000163706
HOGENOMiHOG000068974
InParanoidiQ86XR7
KOiK05409
OMAiTRVAYWH
OrthoDBi1328081at2759
PhylomeDBiQ86XR7
TreeFamiTF313000

Enzyme and pathway databases

ReactomeiR-HSA-140534 Caspase activation via Death Receptors in the presence of ligand
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-2562578 TRIF-mediated programmed cell death
R-HSA-6798695 Neutrophil degranulation
R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-HSA-937041 IKK complex recruitment mediated by RIP1
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SignaLinkiQ86XR7
SIGNORiQ86XR7

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TICAM2
PharosiQ86XR7

Protein Ontology

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PROi
PR:Q86XR7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000243414 Expressed in 90 organ(s), highest expression level in leukocyte
GenevisibleiQ86XR7 HS

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR000157 TIR_dom
IPR015720 TMP21-related
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR22811 PTHR22811, 1 hit
PfamiView protein in Pfam
PF13676 TIR_2, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCAM2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86XR7
Secondary accession number(s): B3Y698, Q6JUT2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: October 16, 2019
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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