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UniProtKB - Q86XP1 (DGKH_HUMAN)

Entry version 157 (25 May 2022)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
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Protein

Diacylglycerol kinase eta

Gene

DGKH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095).

Plays a key role in promoting cell growth (PubMed:19710016).

Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016).

Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016).

Curated3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycerolipid metabolism

This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri175 – 225Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri247 – 298Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processLipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.107, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86XP1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114508, Effects of PIP2 hydrolysis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q86XP1

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00230

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000928 [Q86XP1-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diacylglycerol kinase etaCurated (EC:2.7.1.1072 Publications)
Short name:
DAG kinase eta
Alternative name(s):
Diglyceride kinase eta
Short name:
DGK-eta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DGKHImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2854, DGKH

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604071, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86XP1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000102780

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1151W → G: Loss of homoligomerization and heterooligomerization but not diacylglycerol kinase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		160851

Open Targets

More...OpenTargetsi		ENSG00000102780

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27315

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86XP1, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105940

Drug and drug target database

More...DrugBanki		DB14001, alpha-Tocopherol succinate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DGKH

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762463

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002393671 – 1220Diacylglycerol kinase etaAdd BLAST1220

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation does not inhibit catalytic activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86XP1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86XP1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86XP1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86XP1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86XP1

PeptideAtlas

More...PeptideAtlasi		Q86XP1

PRoteomics IDEntifications database

More...PRIDEi		Q86XP1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5568
70309 [Q86XP1-1]
70310 [Q86XP1-2]
70311 [Q86XP1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86XP1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86XP1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed only in testis, kidney and colon.1 Publication
Ubiquitously expressed.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by glucocorticoid.1 Publication
Up-regulated by glucocorticoid.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000102780, Expressed in dorsal root ganglion and 207 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86XP1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86XP1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000102780, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAF1 and BRAF.

1 Publication

Homooligomers (PubMed:12810723). Heterooligomers (PubMed:12810723). Oligomerization through the SAM domain inhibits the diacylglycerol kinase activity (PubMed:12810723). Heterooligomerizes with SAM domain-containing isoforms of DGKD (PubMed:12810723).

1 Publication

Does not form homooligomers.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127768, 34 interactors

Protein interaction database and analysis system

More...IntActi		Q86XP1, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000337572

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86XP1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q86XP1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86XP1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 158PHPROSITE-ProRule annotationAdd BLAST94
Domaini328 – 463DAGKcPROSITE-ProRule annotationAdd BLAST136
Domaini1151 – 1214SAMPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 60DisorderedSequence analysisAdd BLAST60
Regioni581 – 617DisorderedSequence analysisAdd BLAST37
Regioni636 – 705DisorderedSequence analysisAdd BLAST70

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1218 – 1220PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi589 – 603Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi658 – 677Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SAM domain mediates homooligomerization.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri175 – 225Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri247 – 298Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1170, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158106

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001799_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86XP1

Identification of Orthologs from Complete Genome Data

More...OMAi		FERAHTR

Database of Orthologous Groups

More...OrthoDBi		43384at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86XP1

TreeFam database of animal gene trees

More...TreeFami		TF313104

Family and domain databases

Conserved Domains Database

More...CDDi		cd00029, C1, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit
2.30.29.30, 1 hit
3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR046349, C1-like_sf
IPR037607, DGK
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001660, SAM
IPR013761, SAM/pointed_sf

The PANTHER Classification System

More...PANTHERi		PTHR11255, PTHR11255, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00130, C1_1, 2 hits
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
PF00169, PH, 1 hit
PF07647, SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SM00233, PH, 1 hit
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111331, SSF111331, 1 hit
SSF47769, SSF47769, 1 hit
SSF57889, SSF57889, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50146, DAGK, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50105, SAM_DOMAIN, 1 hit
PS00479, ZF_DAG_PE_1, 2 hits
PS50081, ZF_DAG_PE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86XP1-1) [UniParc]FASTAAdd to basket
Also known as: DAG kinase eta-2, DGKH-2

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGAGGQHHP PGAAGGAAAG AGAAVTSAAA SAGPGEDSSD SEAEQEGPQK 
        60         70         80         90        100
LIRKVSTSGQ IRTKTSIKEG QLLKQTSSFQ RWKKRYFKLR GRTLYYAKDS 
       110        120        130        140        150
KSLIFDEVDL SDASVAEAST KNANNSFTII TPFRRLMLCA ENRKEMEDWI 
       160        170        180        190        200
SSLKSVQTRE PYEVAQFNVE HFSGMHNWYA CSHARPTFCN VCRESLSGVT 
       210        220        230        240        250
SHGLSCEVCK FKAHKRCAVR ATNNCKWTTL ASIGKDIIED EDGVAMPHQW 
       260        270        280        290        300
LEGNLPVSAK CAVCDKTCGS VLRLQDWKCL WCKTMVHTAC KDLYHPICPL 
       310        320        330        340        350
GQCKVSIIPP IALNSTDSDG FCRATFSFCV SPLLVFVNSK SGDNQGVKFL 
       360        370        380        390        400
RRFKQLLNPA QVFDLMNGGP HLGLRLFQKF DNFRILVCGG DGSVGWVLSE 
       410        420        430        440        450
IDKLNLNKQC QLGVLPLGTG NDLARVLGWG GSYDDDTQLP QILEKLERAS 
       460        470        480        490        500
TKMLDRWSIM TYELKLPPKA SLLPGPPEAS EEFYMTIYED SVATHLTKIL 
       510        520        530        540        550
NSDEHAVVIS SAKTLCETVK DFVAKVEKTY DKTLENAVVA DAVASKCSVL 
       560        570        580        590        600
NEKLEQLLQA LHTDSQAAPV LPGLSPLIVE EDAVESSSEE SLGESKEQLG 
       610        620        630        640        650
DDVTKPSSQK AVKPREIMLR ANSLKKAVRQ VIEEAGKVMD DPTVHPCEPA 
       660        670        680        690        700
NQSSDYDSTE TDESKEEAKD DGAKESITVK TAPRSPDARA SYGHSQTDSV 
       710        720        730        740        750
PGPAVAASKE NLPVLNTRII CPGLRAGLAA SIAGSSIINK MLLANIDPFG 
       760        770        780        790        800
ATPFIDPDLD SVDGYSEKCV MNNYFGIGLD AKISLEFNNK REEHPEKCRS 
       810        820        830        840        850
RTKNLMWYGV LGTRELLQRS YKNLEQRVQL ECDGQYIPLP SLQGIAVLNI 
       860        870        880        890        900
PSYAGGTNFW GGTKEDDIFA APSFDDKILE VVAIFDSMQM AVSRVIKLQH 
       910        920        930        940        950
HRIAQCRTVK ITIFGDEGVP VQVDGEAWVQ PPGIIKIVHK NRAQMLTRDR 
       960        970        980        990       1000
AFESTLKSWE DKQKCDSGKP VLRTHLYIHH AIDLATEEVS QMQLCSQAAE 
      1010       1020       1030       1040       1050
ELITRICDAA TIHCLLEQEL AHAVNACSHA LNKANPRCPE SLTRDTATEI 
      1060       1070       1080       1090       1100
AINVKALYNE TESLLVGRVP LQLESPHEER VSNALHSVEV ELQKLTEIPW 
      1110       1120       1130       1140       1150
LYYILHPNED EEPPMDCTKR NNRSTVFRIV PKFKKEKVQK QKTSSQPVQK 
      1160       1170       1180       1190       1200
WGTEEVAAWL DLLNLGEYKD IFIRHDIRGA ELLHLERRDL KDLGIPKVGH 
      1210       1220
VKRILQGIKE LGRSTPQSEV
Length:1,220
Mass (Da):134,866
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1BBF5B7FA582C97
GO
Isoform 2 (identifier: Q86XP1-2) [UniParc]FASTAAdd to basket
Also known as: DAG kinase eta-1, DGKH-1

The sequence of this isoform differs from the canonical sequence as follows:
     1148-1220: VQKWGTEEVA...LGRSTPQSEV → GSGDTESGSCEANSPGN

Show »
Length:1,164
Mass (Da):128,035
Checksum:iDF39B04BECC0B629
GO
Isoform 3 (identifier: Q86XP1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.
     1191-1191: K → KNTVGEKRDTKENGKHM

Show »
Length:1,100
Mass (Da):122,392
Checksum:i0D36C1FA1E7C1A43
GO
Isoform 4 (identifier: Q86XP1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Show »
Length:1,084
Mass (Da):120,566
Checksum:i8994FBC10F6DB99D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SFR6A0A0D9SFR6_HUMAN
Diacylglycerol kinase
DGKH
1,028Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SF65A0A0D9SF65_HUMAN
Diacylglycerol kinase eta
DGKH
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ02A0A087WZ02_HUMAN
Diacylglycerol kinase eta
DGKH
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05280 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti677I → M in BAC05280 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0338671201V → A. Corresponds to variant dbSNP:rs17646069Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0191831 – 136Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST136
Alternative sequenceiVSP_0191851148 – 1220VQKWG…PQSEV → GSGDTESGSCEANSPGN in isoform 2. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0191861191K → KNTVGEKRDTKENGKHM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB078967 mRNA Translation: BAC66960.1
AB078968 mRNA Translation: BAC66961.1
AK302727 mRNA Translation: BAG63946.1
AL136527 Genomic DNA No translation available.
AL139328 Genomic DNA No translation available.
AL157932 Genomic DNA No translation available.
BC043292 mRNA Translation: AAH43292.1
AL833883 mRNA Translation: CAD38739.1
AK098302 mRNA Translation: BAC05280.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55898.1 [Q86XP1-3]
CCDS55899.1 [Q86XP1-5]
CCDS9381.1 [Q86XP1-1]
CCDS9382.1 [Q86XP1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001191433.1, NM_001204504.2 [Q86XP1-2]
NP_001191434.1, NM_001204505.2 [Q86XP1-3]
NP_001191435.1, NM_001204506.2 [Q86XP1-5]
NP_001284358.1, NM_001297429.1
NP_690874.2, NM_152910.5 [Q86XP1-2]
NP_821077.1, NM_178009.4 [Q86XP1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261491.9; ENSP00000261491.4; ENSG00000102780.17 [Q86XP1-2]
ENST00000337343.9; ENSP00000337572.4; ENSG00000102780.17
ENST00000379274.6; ENSP00000368576.3; ENSG00000102780.17 [Q86XP1-2]
ENST00000536612.3; ENSP00000445114.2; ENSG00000102780.17 [Q86XP1-3]
ENST00000628433.2; ENSP00000485809.1; ENSG00000102780.17 [Q86XP1-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		160851

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:160851

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000337343.9; ENSP00000337572.4; NM_178009.5; NP_821077.1

UCSC genome browser

More...UCSCi		uc001uyl.3, human [Q86XP1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078967 mRNA Translation: BAC66960.1
AB078968 mRNA Translation: BAC66961.1
AK302727 mRNA Translation: BAG63946.1
AL136527 Genomic DNA No translation available.
AL139328 Genomic DNA No translation available.
AL157932 Genomic DNA No translation available.
BC043292 mRNA Translation: AAH43292.1
AL833883 mRNA Translation: CAD38739.1
AK098302 mRNA Translation: BAC05280.1 Different initiation.
CCDSiCCDS55898.1 [Q86XP1-3]
CCDS55899.1 [Q86XP1-5]
CCDS9381.1 [Q86XP1-1]
CCDS9382.1 [Q86XP1-2]
RefSeqiNP_001191433.1, NM_001204504.2 [Q86XP1-2]
NP_001191434.1, NM_001204505.2 [Q86XP1-3]
NP_001191435.1, NM_001204506.2 [Q86XP1-5]
NP_001284358.1, NM_001297429.1
NP_690874.2, NM_152910.5 [Q86XP1-2]
NP_821077.1, NM_178009.4 [Q86XP1-1]

3D structure databases

AlphaFoldDBiQ86XP1
SMRiQ86XP1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127768, 34 interactors
IntActiQ86XP1, 7 interactors
STRINGi9606.ENSP00000337572

Chemistry databases

ChEMBLiCHEMBL4105940
DrugBankiDB14001, alpha-Tocopherol succinate
SwissLipidsiSLP:000000928 [Q86XP1-2]

PTM databases

iPTMnetiQ86XP1
PhosphoSitePlusiQ86XP1

Genetic variation databases

BioMutaiDGKH
DMDMi74762463

Proteomic databases

EPDiQ86XP1
jPOSTiQ86XP1
MassIVEiQ86XP1
MaxQBiQ86XP1
PaxDbiQ86XP1
PeptideAtlasiQ86XP1
PRIDEiQ86XP1
ProteomicsDBi5568
70309 [Q86XP1-1]
70310 [Q86XP1-2]
70311 [Q86XP1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23454, 128 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		160851

Genome annotation databases

EnsembliENST00000261491.9; ENSP00000261491.4; ENSG00000102780.17 [Q86XP1-2]
ENST00000337343.9; ENSP00000337572.4; ENSG00000102780.17
ENST00000379274.6; ENSP00000368576.3; ENSG00000102780.17 [Q86XP1-2]
ENST00000536612.3; ENSP00000445114.2; ENSG00000102780.17 [Q86XP1-3]
ENST00000628433.2; ENSP00000485809.1; ENSG00000102780.17 [Q86XP1-5]
GeneIDi160851
KEGGihsa:160851
MANE-SelectiENST00000337343.9; ENSP00000337572.4; NM_178009.5; NP_821077.1
UCSCiuc001uyl.3, human [Q86XP1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		160851
DisGeNETi160851

GeneCards: human genes, protein and diseases

More...GeneCardsi		DGKH
HGNCiHGNC:2854, DGKH
HPAiENSG00000102780, Tissue enhanced (brain)
MIMi604071, gene
neXtProtiNX_Q86XP1
OpenTargetsiENSG00000102780
PharmGKBiPA27315
VEuPathDBiHostDB:ENSG00000102780

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1170, Eukaryota
GeneTreeiENSGT00940000158106
HOGENOMiCLU_001799_3_0_1
InParanoidiQ86XP1
OMAiFERAHTR
OrthoDBi43384at2759
PhylomeDBiQ86XP1
TreeFamiTF313104

Enzyme and pathway databases

UniPathwayiUPA00230
BRENDAi2.7.1.107, 2681
PathwayCommonsiQ86XP1
ReactomeiR-HSA-114508, Effects of PIP2 hydrolysis
SignaLinkiQ86XP1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		160851, 15 hits in 1081 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DGKH, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		160851
PharosiQ86XP1, Tbio

Protein Ontology

More...PROi		PR:Q86XP1
RNActiQ86XP1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000102780, Expressed in dorsal root ganglion and 207 other tissues
ExpressionAtlasiQ86XP1, baseline and differential
GenevisibleiQ86XP1, HS

Family and domain databases

CDDicd00029, C1, 2 hits
Gene3Di1.10.150.50, 1 hit
2.30.29.30, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR046349, C1-like_sf
IPR037607, DGK
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001660, SAM
IPR013761, SAM/pointed_sf
PANTHERiPTHR11255, PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130, C1_1, 2 hits
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
PF00169, PH, 1 hit
PF07647, SAM_2, 1 hit
SMARTiView protein in SMART
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SM00233, PH, 1 hit
SM00454, SAM, 1 hit
SUPFAMiSSF111331, SSF111331, 1 hit
SSF47769, SSF47769, 1 hit
SSF57889, SSF57889, 2 hits
PROSITEiView protein in PROSITE
PS50146, DAGK, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50105, SAM_DOMAIN, 1 hit
PS00479, ZF_DAG_PE_1, 2 hits
PS50081, ZF_DAG_PE_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGKH_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86XP1
Secondary accession number(s): A2A2W7
, A6NFX7, B4DZ34, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 1, 2003
Last modified: May 25, 2022
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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