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Entry version 143 (25 May 2022)
Sequence version 2 (24 Nov 2009)
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Protein

Cytosolic phospholipase A2 delta

Gene

PLA2G4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560).

Has a preference for linoleic acid at the sn-2 position (PubMed:14709560).

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stimulated by cytosolic Ca2+.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. Vmax=9.23 pmol/min/mg enzyme with 1-palmitoyl-2-arachidonyl-phosphatidylcholine as substrate1 Publication
  2. Vmax=58.56 pmol/min/mg enzyme with 1-palmitoyl-2-linoleoyl-phosphatidylcholine as substrate1 Publication
  3. Vmax=11 pmol/min/mg enzyme with 1-palmitoyl-2-oleoyl-phosphatidylcholine as substrate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi38Calcium 1PROSITE-ProRule annotation1
Metal bindingi38Calcium 2PROSITE-ProRule annotation1
Metal bindingi44Calcium 1PROSITE-ProRule annotation1
Metal bindingi94Calcium 1PROSITE-ProRule annotation1
Metal bindingi94Calcium 2PROSITE-ProRule annotation1
Metal bindingi96Calcium 1PROSITE-ProRule annotation1
Metal bindingi96Calcium 2PROSITE-ProRule annotation1
Metal bindingi102Calcium 2PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei361NucleophileCombined sources1 Publication1
Active sitei647Proton acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.1.4, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86XP0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1482788, Acyl chain remodelling of PC
R-HSA-1482801, Acyl chain remodelling of PS
R-HSA-1482839, Acyl chain remodelling of PE
R-HSA-1482922, Acyl chain remodelling of PI
R-HSA-1482925, Acyl chain remodelling of PG
R-HSA-1483115, Hydrolysis of LPC
R-HSA-1483166, Synthesis of PA

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q86XP0

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00199

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001080

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosolic phospholipase A2 deltaCurated (EC:3.1.1.41 Publication)
Short name:
cPLA2-delta1 Publication
Alternative name(s):
Phospholipase A2 group IVD
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLA2G4DImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30038, PLA2G4D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612864, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86XP0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000159337

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
283748

Open Targets

More...
OpenTargetsi
ENSG00000159337

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134974074

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86XP0, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2287

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLA2G4D

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849641

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002470231 – 818Cytosolic phospholipase A2 deltaAdd BLAST818

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86XP0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86XP0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86XP0

PeptideAtlas

More...
PeptideAtlasi
Q86XP0

PRoteomics IDEntifications database

More...
PRIDEi
Q86XP0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70307 [Q86XP0-1]
70308 [Q86XP0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86XP0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86XP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues (PubMed:14709560). Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin (PubMed:14709560).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159337, Expressed in ectocervix and 52 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000159337, Group enriched (prostate, skin, vagina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
129664, 36 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000290472

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86XP0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1818
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q86XP0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86XP0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 124C2PROSITE-ProRule annotationAdd BLAST120
Domaini273 – 818PLA2cPROSITE-ProRule annotationAdd BLAST546

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni330 – 331Substrate bindingCombined sources1 Publication2

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal C2 domain mediates the association with lipid membranes upon calcium binding (Probable). An additional second C2 domain may stand in between the C2 domain and the PLA2c domain (Probable).1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1028, Eukaryota
KOG1325, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234606

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011663_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86XP0

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSSHPVW

Database of Orthologous Groups

More...
OrthoDBi
302848at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86XP0

TreeFam database of animal gene trees

More...
TreeFami
TF325228

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04036, C2_cPLA2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016035, Acyl_Trfase/lysoPLipase
IPR041847, C2_cPLA2
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR040723, cPLA2_C2
IPR002642, LysoPLipase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF18695, cPLA2_C2, 1 hit
PF01735, PLA2_B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00022, PLAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49562, SSF49562, 1 hit
SSF52151, SSF52151, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS51210, PLA2C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86XP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESLSPGGPP GHPYQGEAST CWQLTVRVLE ARNLRWADLL SEADPYVILQ
60 70 80 90 100
LSTAPGMKFK TKTLTDTSHP VWNEAFRFLI QSQVKNVLEL SIYDEDSVTE
110 120 130 140 150
DDICFKVLYD ISEVLPGKLL RKTFSQSPQG EEELDVEFLM EETSDRPENL
160 170 180 190 200
ITNKVIVARE LSCLDVHLDS TGSTAVVADQ DKLELELVLK GSYEDTQTSF
210 220 230 240 250
LGTASAFRFH YMAALETELS GRLRSSRSNG WNGDNSAGYL TVPLRPLTIG
260 270 280 290 300
KEVTMDVPAP NAPGVRLQLK AEGCPEELAV HLGFNLCAEE QAFLSRRKQV
310 320 330 340 350
VAKALKQALQ LDRDLQEDEV PVVGIMATGG GARAMTSLYG HLLALQKLGL
360 370 380 390 400
LDCVTYFSGI SGSTWTMAHL YGDPEWSQRD LEGPIRYARE HLAKSKLEVF
410 420 430 440 450
SPERLASYRR ELELRAEQGH PTTFVDLWAL VLESMLHGQV MDQKLSGQRA
460 470 480 490 500
ALERGQNPLP LYLSLNVKEN NLETLDFKEW VEFSPYEVGF LKYGAFVPPE
510 520 530 540 550
LFGSEFFMGR LMRRIPEPRI CFLEAIWSNI FSLNLLDAWY DLTSSGESWK
560 570 580 590 600
QHIKDKTRSL EKEPLTTSGT SSRLEASWLQ PGTALAQAFK GFLTGRPLHQ
610 620 630 640 650
RSPNFLQGLQ LHQDYCSHKD FSTWADYQLD SMPSQLTPKE PRLCLVDAAY
660 670 680 690 700
FINTSSPSMF RPGRRLDLIL SFDYSLSAPF EALQQTELYC RARGLPFPRV
710 720 730 740 750
EPSPQDQHQP RECHLFSDPA CPEAPILLHF PLVNASFKDH SAPGVQRSPA
760 770 780 790 800
ELQGGQVDLT GATCPYTLSN MTYKEEDFER LLRLSDYNVQ TSQGAILQAL
810
RTALKHRTLE ARPPRAQT
Length:818
Mass (Da):91,952
Last modified:November 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06187324748A4C21
GO
Isoform 2 (identifier: Q86XP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     682-723: ALQQTELYCR...HLFSDPACPE → VPWSPQGNPS...VPKGRRGVRP
     724-818: Missing.

Note: May be due to an intron retention.Curated
Show »
Length:723
Mass (Da):80,930
Checksum:i0C385309D4BAB085
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34571 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10P → T in BAC67158 (PubMed:14709560).Curated1
Isoform 2 (identifier: Q86XP0-2)
Sequence conflicti713G → R in AAH34571 (PubMed:16572171).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057676275P → R. Corresponds to variant dbSNP:rs11635685Ensembl.1
Natural variantiVAR_057677434S → T. Corresponds to variant dbSNP:rs4924618Ensembl.1
Natural variantiVAR_027049573R → W. Corresponds to variant dbSNP:rs17747505Ensembl.1
Natural variantiVAR_027050649A → G. Corresponds to variant dbSNP:rs17690899Ensembl.1
Natural variantiVAR_027051747R → G1 PublicationCorresponds to variant dbSNP:rs2459692Ensembl.1
Natural variantiVAR_057678783R → Q. Corresponds to variant dbSNP:rs750052Ensembl.1
Natural variantiVAR_057679807R → Q. Corresponds to variant dbSNP:rs750051Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019881682 – 723ALQQT…PACPE → VPWSPQGNPSAQPGQAPEAS SRATEPLPHTAGVPKGRRGV RP in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_019882724 – 818Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB090876 mRNA Translation: BAC67158.1
AC084693 Genomic DNA No translation available.
BC034571 mRNA Translation: AAH34571.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32203.1 [Q86XP0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_828848.3, NM_178034.3 [Q86XP0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000290472.4; ENSP00000290472.3; ENSG00000159337.7

Database of genes from NCBI RefSeq genomes

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GeneIDi
283748

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:283748

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

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MANE-Selecti
ENST00000290472.4; ENSP00000290472.3; NM_178034.4; NP_828848.3

UCSC genome browser

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UCSCi
uc001zox.3, human [Q86XP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB090876 mRNA Translation: BAC67158.1
AC084693 Genomic DNA No translation available.
BC034571 mRNA Translation: AAH34571.1 Different initiation.
CCDSiCCDS32203.1 [Q86XP0-1]
RefSeqiNP_828848.3, NM_178034.3 [Q86XP0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IXCX-ray2.65A/B2-810[»]
5IZ5X-ray2.20A/B2-810[»]
5IZRX-ray3.25A/B/C/D2-810[»]
AlphaFoldDBiQ86XP0
SMRiQ86XP0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi129664, 36 interactors
STRINGi9606.ENSP00000290472

Chemistry databases

ChEMBLiCHEMBL2287
SwissLipidsiSLP:000001080

PTM databases

iPTMnetiQ86XP0
PhosphoSitePlusiQ86XP0

Genetic variation databases

BioMutaiPLA2G4D
DMDMi269849641

Proteomic databases

MassIVEiQ86XP0
MaxQBiQ86XP0
PaxDbiQ86XP0
PeptideAtlasiQ86XP0
PRIDEiQ86XP0
ProteomicsDBi70307 [Q86XP0-1]
70308 [Q86XP0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23488, 75 antibodies from 22 providers

The DNASU plasmid repository

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DNASUi
283748

Genome annotation databases

EnsembliENST00000290472.4; ENSP00000290472.3; ENSG00000159337.7
GeneIDi283748
KEGGihsa:283748
MANE-SelectiENST00000290472.4; ENSP00000290472.3; NM_178034.4; NP_828848.3
UCSCiuc001zox.3, human [Q86XP0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
283748
DisGeNETi283748

GeneCards: human genes, protein and diseases

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GeneCardsi
PLA2G4D
HGNCiHGNC:30038, PLA2G4D
HPAiENSG00000159337, Group enriched (prostate, skin, vagina)
MIMi612864, gene
neXtProtiNX_Q86XP0
OpenTargetsiENSG00000159337
PharmGKBiPA134974074
VEuPathDBiHostDB:ENSG00000159337

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1028, Eukaryota
KOG1325, Eukaryota
GeneTreeiENSGT01030000234606
HOGENOMiCLU_011663_0_0_1
InParanoidiQ86XP0
OMAiNSSHPVW
OrthoDBi302848at2759
PhylomeDBiQ86XP0
TreeFamiTF325228

Enzyme and pathway databases

UniPathwayiUPA00199
BRENDAi3.1.1.4, 2681
PathwayCommonsiQ86XP0
ReactomeiR-HSA-1482788, Acyl chain remodelling of PC
R-HSA-1482801, Acyl chain remodelling of PS
R-HSA-1482839, Acyl chain remodelling of PE
R-HSA-1482922, Acyl chain remodelling of PI
R-HSA-1482925, Acyl chain remodelling of PG
R-HSA-1483115, Hydrolysis of LPC
R-HSA-1483166, Synthesis of PA
SignaLinkiQ86XP0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
283748, 15 hits in 1068 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
283748
PharosiQ86XP0, Tbio

Protein Ontology

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PROi
PR:Q86XP0
RNActiQ86XP0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000159337, Expressed in ectocervix and 52 other tissues

Family and domain databases

CDDicd04036, C2_cPLA2, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016035, Acyl_Trfase/lysoPLipase
IPR041847, C2_cPLA2
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR040723, cPLA2_C2
IPR002642, LysoPLipase_cat_dom
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF18695, cPLA2_C2, 1 hit
PF01735, PLA2_B, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00022, PLAc, 1 hit
SUPFAMiSSF49562, SSF49562, 1 hit
SSF52151, SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS51210, PLA2C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPA24D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86XP0
Secondary accession number(s): Q8N176
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 24, 2009
Last modified: May 25, 2022
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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