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Entry version 137 (02 Dec 2020)
Sequence version 2 (24 Nov 2009)
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Protein

Cytosolic phospholipase A2 delta

Gene

PLA2G4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). Has a preference for linoleic acid at the sn-2 position (PubMed:14709560).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stimulated by cytosolic Ca2+.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=9.23 pmol/min/mg enzyme with 1-palmitoyl-2-arachidonyl-phosphatidylcholine as substrate1 Publication
    2. Vmax=58.56 pmol/min/mg enzyme with 1-palmitoyl-2-linoleoyl-phosphatidylcholine as substrate1 Publication
    3. Vmax=11 pmol/min/mg enzyme with 1-palmitoyl-2-oleoyl-phosphatidylcholine as substrate1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid metabolism

    This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi38Calcium 1PROSITE-ProRule annotation1
    Metal bindingi38Calcium 2PROSITE-ProRule annotation1
    Metal bindingi44Calcium 1PROSITE-ProRule annotation1
    Metal bindingi94Calcium 1PROSITE-ProRule annotation1
    Metal bindingi94Calcium 2PROSITE-ProRule annotation1
    Metal bindingi96Calcium 1PROSITE-ProRule annotation1
    Metal bindingi96Calcium 2PROSITE-ProRule annotation1
    Metal bindingi102Calcium 2PROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei361NucleophileCombined sources1 Publication1
    Active sitei647Proton acceptorBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processLipid degradation, Lipid metabolism
    LigandCalcium, Metal-binding

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q86XP0

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1482788, Acyl chain remodelling of PC
    R-HSA-1482801, Acyl chain remodelling of PS
    R-HSA-1482839, Acyl chain remodelling of PE
    R-HSA-1482922, Acyl chain remodelling of PI
    R-HSA-1482925, Acyl chain remodelling of PG
    R-HSA-1483115, Hydrolysis of LPC
    R-HSA-1483166, Synthesis of PA

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00199

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001080

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cytosolic phospholipase A2 deltaCurated (EC:3.1.1.41 Publication)
    Short name:
    cPLA2-delta1 Publication
    Alternative name(s):
    Phospholipase A2 group IVD
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PLA2G4DImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

    Organism-specific databases

    Eukaryotic Pathogen and Host Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000159337.6

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:30038, PLA2G4D

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    612864, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q86XP0

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    283748

    Open Targets

    More...
    OpenTargetsi
    ENSG00000159337

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134974074

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q86XP0, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PLA2G4D

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    269849641

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002470231 – 818Cytosolic phospholipase A2 deltaAdd BLAST818

    Proteomic databases

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q86XP0

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q86XP0

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q86XP0

    PeptideAtlas

    More...
    PeptideAtlasi
    Q86XP0

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q86XP0

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    70307 [Q86XP0-1]
    70308 [Q86XP0-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q86XP0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q86XP0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues (PubMed:14709560). Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin (PubMed:14709560).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000159337, Expressed in ectocervix and 52 other tissues

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000159337, Group enriched (cervix, uterine, prostate, skin, tongue, vagina)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    129664, 3 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000290472

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q86XP0, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1818
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q86XP0

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 124C2PROSITE-ProRule annotationAdd BLAST120
    Domaini273 – 818PLA2cPROSITE-ProRule annotationAdd BLAST546

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni330 – 331Substrate bindingCombined sources1 Publication2

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The N-terminal C2 domain mediates the association with lipid membranes upon calcium binding (Probable). An additional second C2 domain may stand in between the C2 domain and the PLA2c domain (Probable).1 Publication

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1028, Eukaryota
    KOG1325, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT01000000214525

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_011663_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q86XP0

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NSSHPVW

    Database of Orthologous Groups

    More...
    OrthoDBi
    302848at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q86XP0

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF325228

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd04036, C2_cPLA2, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.40.150, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016035, Acyl_Trfase/lysoPLipase
    IPR041847, C2_cPLA2
    IPR000008, C2_dom
    IPR035892, C2_domain_sf
    IPR040723, cPLA2_C2
    IPR002642, LysoPLipase_cat_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00168, C2, 1 hit
    PF18695, cPLA2_C2, 1 hit
    PF01735, PLA2_B, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00239, C2, 1 hit
    SM00022, PLAc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52151, SSF52151, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50004, C2, 1 hit
    PS51210, PLA2C, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 1 (identifier: Q86XP0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MESLSPGGPP GHPYQGEAST CWQLTVRVLE ARNLRWADLL SEADPYVILQ
    60 70 80 90 100
    LSTAPGMKFK TKTLTDTSHP VWNEAFRFLI QSQVKNVLEL SIYDEDSVTE
    110 120 130 140 150
    DDICFKVLYD ISEVLPGKLL RKTFSQSPQG EEELDVEFLM EETSDRPENL
    160 170 180 190 200
    ITNKVIVARE LSCLDVHLDS TGSTAVVADQ DKLELELVLK GSYEDTQTSF
    210 220 230 240 250
    LGTASAFRFH YMAALETELS GRLRSSRSNG WNGDNSAGYL TVPLRPLTIG
    260 270 280 290 300
    KEVTMDVPAP NAPGVRLQLK AEGCPEELAV HLGFNLCAEE QAFLSRRKQV
    310 320 330 340 350
    VAKALKQALQ LDRDLQEDEV PVVGIMATGG GARAMTSLYG HLLALQKLGL
    360 370 380 390 400
    LDCVTYFSGI SGSTWTMAHL YGDPEWSQRD LEGPIRYARE HLAKSKLEVF
    410 420 430 440 450
    SPERLASYRR ELELRAEQGH PTTFVDLWAL VLESMLHGQV MDQKLSGQRA
    460 470 480 490 500
    ALERGQNPLP LYLSLNVKEN NLETLDFKEW VEFSPYEVGF LKYGAFVPPE
    510 520 530 540 550
    LFGSEFFMGR LMRRIPEPRI CFLEAIWSNI FSLNLLDAWY DLTSSGESWK
    560 570 580 590 600
    QHIKDKTRSL EKEPLTTSGT SSRLEASWLQ PGTALAQAFK GFLTGRPLHQ
    610 620 630 640 650
    RSPNFLQGLQ LHQDYCSHKD FSTWADYQLD SMPSQLTPKE PRLCLVDAAY
    660 670 680 690 700
    FINTSSPSMF RPGRRLDLIL SFDYSLSAPF EALQQTELYC RARGLPFPRV
    710 720 730 740 750
    EPSPQDQHQP RECHLFSDPA CPEAPILLHF PLVNASFKDH SAPGVQRSPA
    760 770 780 790 800
    ELQGGQVDLT GATCPYTLSN MTYKEEDFER LLRLSDYNVQ TSQGAILQAL
    810
    RTALKHRTLE ARPPRAQT
    Length:818
    Mass (Da):91,952
    Last modified:November 24, 2009 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06187324748A4C21
    GO
    Isoform 2 (identifier: Q86XP0-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         682-723: ALQQTELYCR...HLFSDPACPE → VPWSPQGNPS...VPKGRRGVRP
         724-818: Missing.

    Note: May be due to an intron retention.Curated
    Show »
    Length:723
    Mass (Da):80,930
    Checksum:i0C385309D4BAB085
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH34571 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10P → T in BAC67158 (PubMed:14709560).Curated1
    Isoform 2 (identifier: Q86XP0-2)
    Sequence conflicti713G → R in AAH34571 (PubMed:16572171).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057676275P → R. Corresponds to variant dbSNP:rs11635685Ensembl.1
    Natural variantiVAR_057677434S → T. Corresponds to variant dbSNP:rs4924618Ensembl.1
    Natural variantiVAR_027049573R → W. Corresponds to variant dbSNP:rs17747505Ensembl.1
    Natural variantiVAR_027050649A → G. Corresponds to variant dbSNP:rs17690899Ensembl.1
    Natural variantiVAR_027051747R → G1 PublicationCorresponds to variant dbSNP:rs2459692Ensembl.1
    Natural variantiVAR_057678783R → Q. Corresponds to variant dbSNP:rs750052Ensembl.1
    Natural variantiVAR_057679807R → Q. Corresponds to variant dbSNP:rs750051Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019881682 – 723ALQQT…PACPE → VPWSPQGNPSAQPGQAPEAS SRATEPLPHTAGVPKGRRGV RP in isoform 2. 1 PublicationAdd BLAST42
    Alternative sequenceiVSP_019882724 – 818Missing in isoform 2. 1 PublicationAdd BLAST95

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

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    EMBLi

    GenBank nucleotide sequence database

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    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

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    DDBJi
    Links Updated
    AB090876 mRNA Translation: BAC67158.1
    AC084693 Genomic DNA No translation available.
    BC034571 mRNA Translation: AAH34571.1 Different initiation.

    The Consensus CDS (CCDS) project

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    CCDSi
    CCDS32203.1 [Q86XP0-1]

    NCBI Reference Sequences

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    RefSeqi
    NP_828848.3, NM_178034.3 [Q86XP0-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

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    Ensembli
    ENST00000290472; ENSP00000290472; ENSG00000159337 [Q86XP0-1]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    283748

    KEGG: Kyoto Encyclopedia of Genes and Genomes

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    KEGGi
    hsa:283748

    UCSC genome browser

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    UCSCi
    uc001zox.3, human [Q86XP0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB090876 mRNA Translation: BAC67158.1
    AC084693 Genomic DNA No translation available.
    BC034571 mRNA Translation: AAH34571.1 Different initiation.
    CCDSiCCDS32203.1 [Q86XP0-1]
    RefSeqiNP_828848.3, NM_178034.3 [Q86XP0-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

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    RCSB PDBi

    Protein Data Bank Japan

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    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    5IXCX-ray2.65A/B2-810[»]
    5IZ5X-ray2.20A/B2-810[»]
    5IZRX-ray3.25A/B/C/D2-810[»]
    SMRiQ86XP0
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi129664, 3 interactors
    STRINGi9606.ENSP00000290472

    Chemistry databases

    SwissLipidsiSLP:000001080

    PTM databases

    iPTMnetiQ86XP0
    PhosphoSitePlusiQ86XP0

    Polymorphism and mutation databases

    BioMutaiPLA2G4D
    DMDMi269849641

    Proteomic databases

    MassIVEiQ86XP0
    MaxQBiQ86XP0
    PaxDbiQ86XP0
    PeptideAtlasiQ86XP0
    PRIDEiQ86XP0
    ProteomicsDBi70307 [Q86XP0-1]
    70308 [Q86XP0-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

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    Antibodypediai
    23488, 69 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    283748

    Genome annotation databases

    EnsembliENST00000290472; ENSP00000290472; ENSG00000159337 [Q86XP0-1]
    GeneIDi283748
    KEGGihsa:283748
    UCSCiuc001zox.3, human [Q86XP0-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    283748
    DisGeNETi283748
    EuPathDBiHostDB:ENSG00000159337.6

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PLA2G4D
    HGNCiHGNC:30038, PLA2G4D
    HPAiENSG00000159337, Group enriched (cervix, uterine, prostate, skin, tongue, vagina)
    MIMi612864, gene
    neXtProtiNX_Q86XP0
    OpenTargetsiENSG00000159337
    PharmGKBiPA134974074

    GenAtlas: human gene database

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    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1028, Eukaryota
    KOG1325, Eukaryota
    GeneTreeiENSGT01000000214525
    HOGENOMiCLU_011663_0_0_1
    InParanoidiQ86XP0
    OMAiNSSHPVW
    OrthoDBi302848at2759
    PhylomeDBiQ86XP0
    TreeFamiTF325228

    Enzyme and pathway databases

    UniPathwayiUPA00199
    PathwayCommonsiQ86XP0
    ReactomeiR-HSA-1482788, Acyl chain remodelling of PC
    R-HSA-1482801, Acyl chain remodelling of PS
    R-HSA-1482839, Acyl chain remodelling of PE
    R-HSA-1482922, Acyl chain remodelling of PI
    R-HSA-1482925, Acyl chain remodelling of PG
    R-HSA-1483115, Hydrolysis of LPC
    R-HSA-1483166, Synthesis of PA

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

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    BioGRID-ORCSi
    283748, 7 hits in 841 CRISPR screens

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    283748
    PharosiQ86XP0, Tbio

    Protein Ontology

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    PROi
    PR:Q86XP0
    RNActiQ86XP0, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000159337, Expressed in ectocervix and 52 other tissues

    Family and domain databases

    CDDicd04036, C2_cPLA2, 1 hit
    Gene3Di2.60.40.150, 1 hit
    InterProiView protein in InterPro
    IPR016035, Acyl_Trfase/lysoPLipase
    IPR041847, C2_cPLA2
    IPR000008, C2_dom
    IPR035892, C2_domain_sf
    IPR040723, cPLA2_C2
    IPR002642, LysoPLipase_cat_dom
    PfamiView protein in Pfam
    PF00168, C2, 1 hit
    PF18695, cPLA2_C2, 1 hit
    PF01735, PLA2_B, 1 hit
    SMARTiView protein in SMART
    SM00239, C2, 1 hit
    SM00022, PLAc, 1 hit
    SUPFAMiSSF52151, SSF52151, 1 hit
    PROSITEiView protein in PROSITE
    PS50004, C2, 1 hit
    PS51210, PLA2C, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPA24D_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86XP0
    Secondary accession number(s): Q8N176
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: November 24, 2009
    Last modified: December 2, 2020
    This is version 137 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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