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Protein

RNA-binding protein MEX3D

Gene

MEX3D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri600 – 640RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

  • AU-rich element binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA destabilization Source: BHF-UCL
  • mRNA localization resulting in posttranscriptional regulation of gene expression Source: BHF-UCL

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein MEX3D
Alternative name(s):
RING finger and KH domain-containing protein 1
RING finger protein 193
TINO
Gene namesi
Name:MEX3D
Synonyms:KIAA2031, RKHD1, RNF193
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000181588.16
HGNCiHGNC:16734 MEX3D
MIMi611009 gene
neXtProtiNX_Q86XN8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi399664
OpenTargetsiENSG00000181588
PharmGKBiPA162395829

Polymorphism and mutation databases

BioMutaiMEX3D
DMDMi134047829

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501231 – 651RNA-binding protein MEX3DAdd BLAST651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei510PhosphothreonineCombined sources1
Modified residuei514PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86XN8
MaxQBiQ86XN8
PaxDbiQ86XN8
PeptideAtlasiQ86XN8
PRIDEiQ86XN8
ProteomicsDBi70305
70306 [Q86XN8-2]

PTM databases

iPTMnetiQ86XN8
PhosphoSitePlusiQ86XN8

Expressioni

Tissue specificityi

Ubiquitously expressed in all the cell lines and tissues tested.1 Publication

Gene expression databases

BgeeiENSG00000181588
CleanExiHS_MEX3D
ExpressionAtlasiQ86XN8 baseline and differential
GenevisibleiQ86XN8 HS

Organism-specific databases

HPAiHPA065385

Interactioni

Protein-protein interaction databases

BioGridi134376, 10 interactors
IntActiQ86XN8, 2 interactors
STRINGi9606.ENSP00000373476

Structurei

Secondary structure

1651
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi273 – 279Combined sources7
Helixi282 – 289Combined sources8
Turni290 – 293Combined sources4
Helixi296 – 302Combined sources7
Beta strandi306 – 308Combined sources3
Beta strandi312 – 314Combined sources3
Beta strandi317 – 322Combined sources6
Turni324 – 326Combined sources3
Helixi327 – 339Combined sources13

3D structure databases

ProteinModelPortaliQ86XN8
SMRiQ86XN8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86XN8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 240KH 1PROSITE-ProRule annotationAdd BLAST62
Domaini273 – 334KH 2PROSITE-ProRule annotationAdd BLAST62

Domaini

Binds RNA through its KH domains.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri600 – 640RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2113 Eukaryota
ENOG410YCYR LUCA
GeneTreeiENSGT00390000018714
HOGENOMiHOG000236282
HOVERGENiHBG071698
InParanoidiQ86XN8
KOiK15686
OMAiLWAKAPN
OrthoDBiEOG091G06LE
PhylomeDBiQ86XN8
TreeFamiTF315107

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00013 KH_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 2 hits
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 2 hits
PS50089 ZF_RING_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86XN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSSLGQPDG GGGGGGGGGG VGAAGEDPGP GPAPPPEGAQ EAAPAPRPPP
60 70 80 90 100
EPDDAAAALR LALDQLSALG LGGAGDTDEE GAAGDGAAAA GGADGGAAPE
110 120 130 140 150
PVPPDGPEAG APPTLAPAVA PGSLPLLDPN ASPPPPPPPR PSPPDVFAGF
160 170 180 190 200
APHPAALGPP TLLADQMSVI GSRKKSVNMT ECVPVPSSEH VAEIVGRQGC
210 220 230 240 250
KIKALRAKTN TYIKTPVRGE EPVFIVTGRK EDVEMAKREI LSAAEHFSII
260 270 280 290 300
RATRSKAGGL PGAAQGPPNL PGQTTIQVRV PYRVVGLVVG PKGATIKRIQ
310 320 330 340 350
QRTHTYIVTP GRDKEPVFAV TGMPENVDRA REEIEAHITL RTGAFTDAGP
360 370 380 390 400
DSDFHANGTD VCLDLLGAAA SLWAKTPNQG RRPPTATAGL RGDTALGAPS
410 420 430 440 450
APEAFYAGSR GGPSVPDPGP ASPYSGSGNG GFAFGAEGPG APVGTAAPDD
460 470 480 490 500
CDFGFDFDFL ALDLTVPAAA TIWAPFERAA PLPAFSGCST VNGAPGPPAA
510 520 530 540 550
GARRSSGAGT PRHSPTLPEP GGLRLELPLS RRGAPDPVGA LSWRPPQGPV
560 570 580 590 600
SFPGGAAFST ATSLPSSPAA AACAPLDSGA SENSRKPPSA SSAPALAREC
610 620 630 640 650
VVCAEGEVMA ALVPCGHNLF CMDCAVRICG KSEPECPACR TPATQAIHIF

S
Length:651
Mass (Da):64,883
Last modified:March 20, 2007 - v3
Checksum:i5E056EE2D08BC4CD
GO
Isoform 2 (identifier: Q86XN8-2) [UniParc]FASTAAdd to basket
Also known as: TINO

The sequence of this isoform differs from the canonical sequence as follows:
     648-651: HIFS → RVETPQPGGASALQRQY

Show »
Length:664
Mass (Da):66,238
Checksum:iCA8D41D3EEFD3A48
GO
Isoform 3 (identifier: Q86XN8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     648-651: HIFS → RVETETPQPGGASALQRQY

Note: No experimental confirmation available.
Show »
Length:666
Mass (Da):66,469
Checksum:i498479459CECBD6C
GO

Sequence cautioni

The sequence AAQ04763 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024019648 – 651HIFS → RVETPQPGGASALQRQY in isoform 2. 2 Publications4
Alternative sequenceiVSP_047662648 – 651HIFS → RVETETPQPGGASALQRQY in isoform 3. Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY950680 mRNA Translation: AAY34148.1
AC005943 Genomic DNA No translation available.
AC027307 Genomic DNA No translation available.
AB107353 mRNA Translation: BAC67658.1
AF458084 mRNA Translation: AAQ04763.1 Different initiation.
BC113384 mRNA Translation: AAI13385.1
BC113741 mRNA Translation: AAI13742.2
CCDSiCCDS32865.2 [Q86XN8-1]
RefSeqiNP_001167589.1, NM_001174118.1 [Q86XN8-3]
NP_976049.3, NM_203304.3 [Q86XN8-1]
UniGeneiHs.436495

Genome annotation databases

EnsembliENST00000402693; ENSP00000384398; ENSG00000181588 [Q86XN8-1]
GeneIDi399664
KEGGihsa:399664
UCSCiuc060rdi.1 human [Q86XN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMEX3D_HUMAN
AccessioniPrimary (citable) accession number: Q86XN8
Secondary accession number(s): A0PJL8
, A1L023, E9PAL6, Q71M49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 20, 2007
Last modified: June 20, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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