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Entry version 165 (13 Feb 2019)
Sequence version 3 (23 Jan 2007)
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Protein

F-box only protein 11

Gene

FBXO11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.6 Publications

Caution

Isoform 2: Has been initially named PRMT9 and reported to act as an arginine methyltransferase that can catalyze the formation of omega-N monomethylarginine (MMA) as well as symmetrical and asymmetrical dimethylarginine (sDMA and aDMA), however no further works support these observations (PubMed:16487488). It should not be confused with official PRMT9 (AC Q6P2P2).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri833 – 904UBR-typePROSITE-ProRule annotationAdd BLAST72

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q86XK2

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box only protein 11
Alternative name(s):
Protein arginine N-methyltransferase 9
Vitiligo-associated protein 1
Short name:
VIT-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXO11
Synonyms:FBX11, PRMT9, VIT1
ORF Names:UG063H01
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138081.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13590 FBXO11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607871 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86XK2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in FBXO11 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL6, an oncoprotein that has a critical role in lymphomas.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi575Q → L: Greatly reduced ability to bind PRDM1 and reduced proteolysis of PRDM1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
80204

Open Targets

More...
OpenTargetsi
ENSG00000138081

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28031

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FBXO11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124012093

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002735741 – 927F-box only protein 11Add BLAST927

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86XK2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86XK2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86XK2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q86XK2

PeptideAtlas

More...
PeptideAtlasi
Q86XK2

PRoteomics IDEntifications database

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PRIDEi
Q86XK2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70286
70287 [Q86XK2-2]
70288 [Q86XK2-3]
70289 [Q86XK2-4]
70290 [Q86XK2-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86XK2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86XK2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Protein levels increase during G1 and S phases to decline as cells progress through G2 to enter in G1 phase of the next cell cycle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138081 Expressed in 232 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86XK2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86XK2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002690

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated). Interacts with PRMD1.6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123173, 67 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q86XK2

Database of interacting proteins

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DIPi
DIP-35680N

Protein interaction database and analysis system

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IntActi
Q86XK2, 16 interactors

Molecular INTeraction database

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MINTi
Q86XK2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384823

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1927
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VMDX-ray2.20A/B/C/D833-904[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q86XK2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86XK2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini153 – 199F-boxPROSITE-ProRule annotationAdd BLAST47
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati395 – 417PbH1 1Add BLAST23
Repeati418 – 440PbH1 2Add BLAST23
Repeati441 – 463PbH1 3Add BLAST23
Repeati464 – 486PbH1 4Add BLAST23
Repeati487 – 509PbH1 5Add BLAST23
Repeati510 – 532PbH1 6Add BLAST23
Repeati533 – 555PbH1 7Add BLAST23
Repeati556 – 578PbH1 8Add BLAST23
Repeati579 – 601PbH1 9Add BLAST23
Repeati602 – 624PbH1 10Add BLAST23
Repeati625 – 647PbH1 11Add BLAST23
Repeati648 – 670PbH1 12Add BLAST23
Repeati671 – 693PbH1 13Add BLAST23
Repeati694 – 716PbH1 14Add BLAST23
Repeati717 – 739PbH1 15Add BLAST23
Repeati740 – 762PbH1 16Add BLAST23
Repeati763 – 785PbH1 17Add BLAST23
Repeati786 – 808PbH1 18Add BLAST23
Repeati809 – 830PbH1 19Add BLAST22

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri833 – 904UBR-typePROSITE-ProRule annotationAdd BLAST72

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1777 Eukaryota
ENOG410YP8C LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063425

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000020584

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051565

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86XK2

KEGG Orthology (KO)

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KOi
K10297

Identification of Orthologs from Complete Genome Data

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OMAi
LMEQDLC

Database of Orthologous Groups

More...
OrthoDBi
355502at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86XK2

TreeFam database of animal gene trees

More...
TreeFami
TF313602

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.160.20.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039448 Beta_helix
IPR006633 Carb-bd_sugar_hydrolysis-dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR029799 FBX11/DRE-1
IPR007742 NosD_dom
IPR022441 Para_beta_helix_rpt-2
IPR006626 PbH1
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR003126 Znf_UBR

The PANTHER Classification System

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PANTHERi
PTHR22990:SF20 PTHR22990:SF20, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF13229 Beta_helix, 2 hits
PF12937 F-box-like, 1 hit
PF05048 NosD, 1 hit
PF02207 zf-UBR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00722 CASH, 3 hits
SM00256 FBOX, 1 hit
SM00710 PbH1, 19 hits
SM00396 ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51126 SSF51126, 3 hits
SSF81383 SSF81383, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03804 para_beta_helix, 4 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50181 FBOX, 1 hit
PS51157 ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86XK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSVRAANRR PRRVSRPRPV QQQQQQPPQQ PPPQPPQQQP PQQQPPPPPQ
60 70 80 90 100
QQQQQQPPPP PPPPPPLPQE RNNVGERDDD VPADMVAEES GPGAQNSPYQ
110 120 130 140 150
LRRKTLLPKR TACPTKNSME GASTSTTENF GHRAKRARVS GKSQDLSAAP
160 170 180 190 200
AEQYLQEKLP DEVVLKIFSY LLEQDLCRAA CVCKRFSELA NDPILWKRLY
210 220 230 240 250
MEVFEYTRPM MHPEPGKFYQ INPEEYEHPN PWKESFQQLY KGAHVKPGFA
260 270 280 290 300
EHFYSNPARY KGRENMLYYD TIEDALGGVQ EAHFDGLIFV HSGIYTDEWI
310 320 330 340 350
YIESPITMIG AAPGKVADKV IIENTRDSTF VFMEGSEDAY VGYMTIRFNP
360 370 380 390 400
DDKSAQHHNA HHCLEITVNC SPIIDHCIIR STCTVGSAVC VSGQGACPTI
410 420 430 440 450
KHCNISDCEN VGLYITDHAQ GIYEDNEISN NALAGIWVKN HGNPIIRRNH
460 470 480 490 500
IHHGRDVGVF TFDHGMGYFE SCNIHRNRIA GFEVKAYANP TVVRCEIHHG
510 520 530 540 550
QTGGIYVHEK GRGQFIENKI YANNFAGVWI TSNSDPTIRG NSIFNGNQGG
560 570 580 590 600
VYIFGDGRGL IEGNDIYGNA LAGIQIRTNS CPIVRHNKIH DGQHGGIYVH
610 620 630 640 650
EKGQGVIEEN EVYSNTLAGV WVTTGSTPVL RRNRIHSGKQ VGVYFYDNGH
660 670 680 690 700
GVLEDNDIYN HMYSGVQIRT GSNPKIRRNK IWGGQNGGIL VYNSGLGCIE
710 720 730 740 750
DNEIFDNAMA GVWIKTDSNP TLRRNKIHDG RDGGICIFNG GRGLLEENDI
760 770 780 790 800
FRNAQAGVLI STNSHPILRK NRIFDGFAAG IEITNHATAT LEGNQIFNNR
810 820 830 840 850
FGGLFLASGV NVTMKDNKIM NNQDAIEKAV SRGQCLYKIS SYTSYPMHDF
860 870 880 890 900
YRCHTCNTTD RNAICVNCIK KCHQGHDVEF IRHDRFFCDC GAGTLSNPCT
910 920
LAGEPTHDTD TLYDSAPPIE SNTLQHN
Length:927
Mass (Da):103,585
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCADBD23A6B892A78
GO
Isoform 2 (identifier: Q86XK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.
     744-770: LLEENDIFRNAQAGVLISTNSHPILRK → IVVNFALVKNPVFHYSSISLMINDIAN
     771-927: Missing.

Show »
Length:561
Mass (Da):62,418
Checksum:i53E2FF0C642059C6
GO
Isoform 6 (identifier: Q86XK2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:843
Mass (Da):94,056
Checksum:i242712732406F8FA
GO
Isoform 3 (identifier: Q86XK2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     670-927: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):65,559
Checksum:i319A266C66D541B6
GO
Isoform 4 (identifier: Q86XK2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-211: KRLYMEVFEYTRPMM → LGEVAHAYNPSTLGG
     212-927: Missing.

Show »
Length:211
Mass (Da):23,441
Checksum:iEA62852C6C1C91E3
GO
Isoform 5 (identifier: Q86XK2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     885-885: R → RYVAHLLDILPNYFPPHFSNIWVSFCFR

Note: No experimental confirmation available.
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Length:954
Mass (Da):106,864
Checksum:i1F8E7073B253AC2D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MCV6B5MCV6_HUMAN
F-box only protein 11
FBXO11
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EP88E7EP88_HUMAN
F-box only protein 11
FBXO11
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYF0C9IYF0_HUMAN
F-box only protein 11
FBXO11
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAV3H0YAV3_HUMAN
F-box only protein 11
FBXO11
562Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF76888 differs from that shown. Intron retention.Curated
The sequence AAN76518 differs from that shown. Reason: Frameshift at position 141.Curated
The sequence AAY24083 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB15143 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti239L → S in BAB14214 (PubMed:14702039).Curated1
Sequence conflicti577R → G in AAN76518 (Ref. 2) Curated1
Sequence conflicti632R → G in BAD97312 (Ref. 3) Curated1
Sequence conflicti903G → S in AAV87312 (PubMed:17098746).Curated1
Sequence conflicti903G → S in AAH43258 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024441126T → S. Corresponds to variant dbSNP:rs17036993Ensembl.1
Natural variantiVAR_070073206Y → C Found in a patient with lymphoma. 1 Publication1
Natural variantiVAR_070074644Y → C Found in a lymphoma cell line; diminishes ubiquitin-mediated degradation of BCL6. 1 Publication1
Natural variantiVAR_070075684G → E Found in a patient with lymphoma; strongly diminishes ubiquitin-mediated degradation of BCL6. 1 Publication1
Natural variantiVAR_070076715K → N Found in a patient with lymphoma; strongly diminishes ubiquitin-mediated degradation of BCL6. 1 Publication1
Natural variantiVAR_070077715K → Q Found in a patient with lymphoma; almost abolishes ubiquitin-mediated degradation of BCL6. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0225741 – 209Missing in isoform 2. 1 PublicationAdd BLAST209
Alternative sequenceiVSP_0225731 – 84Missing in isoform 3 and isoform 6. 4 PublicationsAdd BLAST84
Alternative sequenceiVSP_008860197 – 211KRLYM…TRPMM → LGEVAHAYNPSTLGG in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_008861212 – 927Missing in isoform 4. 1 PublicationAdd BLAST716
Alternative sequenceiVSP_008862670 – 927Missing in isoform 3. 1 PublicationAdd BLAST258
Alternative sequenceiVSP_008863744 – 770LLEEN…PILRK → IVVNFALVKNPVFHYSSISL MINDIAN in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_008864771 – 927Missing in isoform 2. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_008865885R → RYVAHLLDILPNYFPPHFSN IWVSFCFR in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY827075 mRNA Translation: AAV87312.1
AF351618 mRNA Translation: AAN76518.1 Sequence problems.
AK223592 mRNA Translation: BAD97312.1
AK022735 mRNA Translation: BAB14214.1
AK025477 mRNA Translation: BAB15143.1 Different initiation.
AK292877 mRNA Translation: BAF85566.1
AC006509 Genomic DNA No translation available.
AC079807 Genomic DNA Translation: AAY24083.1 Sequence problems.
CH471053 Genomic DNA Translation: EAX00205.1
BC012728 mRNA Translation: AAH12728.2
BC043258 mRNA Translation: AAH43258.2
BC130445 mRNA Translation: AAI30446.1
BC136480 mRNA Translation: AAI36481.1
AF174599 mRNA Translation: AAF04520.1
AF176706 mRNA Translation: AAF17611.1
AL117620 mRNA Translation: CAB56019.1
AF264714 mRNA Translation: AAF76888.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS1837.1 [Q86XK2-6]
CCDS54357.1 [Q86XK2-1]

Protein sequence database of the Protein Information Resource

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PIRi
T17329

NCBI Reference Sequences

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RefSeqi
NP_001177203.1, NM_001190274.1 [Q86XK2-1]
NP_079409.3, NM_025133.4 [Q86XK2-6]
XP_005264629.1, XM_005264572.4 [Q86XK2-5]
XP_016860506.1, XM_017005017.1 [Q86XK2-6]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.352677

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000402508; ENSP00000385398; ENSG00000138081 [Q86XK2-6]
ENST00000403359; ENSP00000384823; ENSG00000138081 [Q86XK2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80204

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80204

UCSC genome browser

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UCSCi
uc002rwe.3 human [Q86XK2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY827075 mRNA Translation: AAV87312.1
AF351618 mRNA Translation: AAN76518.1 Sequence problems.
AK223592 mRNA Translation: BAD97312.1
AK022735 mRNA Translation: BAB14214.1
AK025477 mRNA Translation: BAB15143.1 Different initiation.
AK292877 mRNA Translation: BAF85566.1
AC006509 Genomic DNA No translation available.
AC079807 Genomic DNA Translation: AAY24083.1 Sequence problems.
CH471053 Genomic DNA Translation: EAX00205.1
BC012728 mRNA Translation: AAH12728.2
BC043258 mRNA Translation: AAH43258.2
BC130445 mRNA Translation: AAI30446.1
BC136480 mRNA Translation: AAI36481.1
AF174599 mRNA Translation: AAF04520.1
AF176706 mRNA Translation: AAF17611.1
AL117620 mRNA Translation: CAB56019.1
AF264714 mRNA Translation: AAF76888.1 Sequence problems.
CCDSiCCDS1837.1 [Q86XK2-6]
CCDS54357.1 [Q86XK2-1]
PIRiT17329
RefSeqiNP_001177203.1, NM_001190274.1 [Q86XK2-1]
NP_079409.3, NM_025133.4 [Q86XK2-6]
XP_005264629.1, XM_005264572.4 [Q86XK2-5]
XP_016860506.1, XM_017005017.1 [Q86XK2-6]
UniGeneiHs.352677

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VMDX-ray2.20A/B/C/D833-904[»]
ProteinModelPortaliQ86XK2
SMRiQ86XK2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123173, 67 interactors
CORUMiQ86XK2
DIPiDIP-35680N
IntActiQ86XK2, 16 interactors
MINTiQ86XK2
STRINGi9606.ENSP00000384823

PTM databases

iPTMnetiQ86XK2
PhosphoSitePlusiQ86XK2

Polymorphism and mutation databases

BioMutaiFBXO11
DMDMi124012093

Proteomic databases

EPDiQ86XK2
jPOSTiQ86XK2
MaxQBiQ86XK2
PaxDbiQ86XK2
PeptideAtlasiQ86XK2
PRIDEiQ86XK2
ProteomicsDBi70286
70287 [Q86XK2-2]
70288 [Q86XK2-3]
70289 [Q86XK2-4]
70290 [Q86XK2-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80204
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402508; ENSP00000385398; ENSG00000138081 [Q86XK2-6]
ENST00000403359; ENSP00000384823; ENSG00000138081 [Q86XK2-1]
GeneIDi80204
KEGGihsa:80204
UCSCiuc002rwe.3 human [Q86XK2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80204
DisGeNETi80204
EuPathDBiHostDB:ENSG00000138081.19

GeneCards: human genes, protein and diseases

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GeneCardsi
FBXO11

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0002044
HGNCiHGNC:13590 FBXO11
HPAiHPA002690
MIMi607871 gene
neXtProtiNX_Q86XK2
OpenTargetsiENSG00000138081
PharmGKBiPA28031

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1777 Eukaryota
ENOG410YP8C LUCA
GeneTreeiENSGT00530000063425
HOGENOMiHOG000020584
HOVERGENiHBG051565
InParanoidiQ86XK2
KOiK10297
OMAiLMEQDLC
OrthoDBi355502at2759
PhylomeDBiQ86XK2
TreeFamiTF313602

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ86XK2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FBXO11 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FBXO11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80204

Protein Ontology

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PROi
PR:Q86XK2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138081 Expressed in 232 organ(s), highest expression level in forebrain
ExpressionAtlasiQ86XK2 baseline and differential
GenevisibleiQ86XK2 HS

Family and domain databases

Gene3Di2.160.20.10, 3 hits
InterProiView protein in InterPro
IPR039448 Beta_helix
IPR006633 Carb-bd_sugar_hydrolysis-dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR029799 FBX11/DRE-1
IPR007742 NosD_dom
IPR022441 Para_beta_helix_rpt-2
IPR006626 PbH1
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR003126 Znf_UBR
PANTHERiPTHR22990:SF20 PTHR22990:SF20, 1 hit
PfamiView protein in Pfam
PF13229 Beta_helix, 2 hits
PF12937 F-box-like, 1 hit
PF05048 NosD, 1 hit
PF02207 zf-UBR, 1 hit
SMARTiView protein in SMART
SM00722 CASH, 3 hits
SM00256 FBOX, 1 hit
SM00710 PbH1, 19 hits
SM00396 ZnF_UBR1, 1 hit
SUPFAMiSSF51126 SSF51126, 3 hits
SSF81383 SSF81383, 1 hit
TIGRFAMsiTIGR03804 para_beta_helix, 4 hits
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS51157 ZF_UBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBX11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86XK2
Secondary accession number(s): A1L491
, Q52ZP1, Q53EP7, Q53RT5, Q8IXG3, Q96E90, Q9H6V8, Q9H9L1, Q9NR14, Q9UFK1, Q9UHI1, Q9UKC2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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