The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q86XJ0 (CAHM3_HUMAN)
Protein
Calcium homeostasis modulator protein 3
Gene
CALHM3
Organism
Homo sapiens (Human)
Status
Functioni
Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3-mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances.
By similarityGO - Molecular functioni
- cation channel activity Source: GO_Central
- voltage-gated ion channel activity Source: UniProtKB
GO - Biological processi
- ATP transport Source: UniProtKB
- protein heterooligomerization Source: UniProtKB
- response to stimulus Source: UniProtKB-KW
- sensory perception of taste Source: UniProtKB
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Sensory transduction, Taste, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q86XJ0 |
Reactomei | R-HSA-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9730628, Sensory perception of salty taste |
SignaLinki | Q86XJ0 |
Protein family/group databases
TCDBi | 1.A.84.1.3, the calcium homeostasis modulator ca(2+) channel (calhm-c) family |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium homeostasis modulator protein 3Alternative name(s): Protein A |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23458, CALHM3 |
MIMi | 618263, gene |
neXtProti | NX_Q86XJ0 |
VEuPathDBi | HostDB:ENSG00000183128 |
Subcellular locationi
Plasma membrane
- Basolateral cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 50 – 70 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 108 – 128 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 178 – 198 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 119395 |
OpenTargetsi | ENSG00000183128 |
PharmGKBi | PA162380976 |
Miscellaneous databases
Pharosi | Q86XJ0, Tdark |
Genetic variation databases
BioMutai | CALHM3 |
DMDMi | 68565591 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186719 | 1 – 344 | Calcium homeostasis modulator protein 3Add BLAST | 344 |
Proteomic databases
PaxDbi | Q86XJ0 |
PeptideAtlasi | Q86XJ0 |
PRIDEi | Q86XJ0 |
PTM databases
iPTMneti | Q86XJ0 |
PhosphoSitePlusi | Q86XJ0 |
Expressioni
Tissue specificityi
Specifically expressed in circumvallate taste bud cells.1 Publication
Gene expression databases
Bgeei | ENSG00000183128, Expressed in pancreas and 17 other tissues |
Genevisiblei | Q86XJ0, HS |
Organism-specific databases
HPAi | ENSG00000183128, Not detected |
Interactioni
Subunit structurei
Associates with CALHM1 as a pore-forming subunit in an hetero-hexameric channel complex.
By similarityBinary interactionsi
Q86XJ0
With | #Exp. | IntAct |
---|---|---|
DLG1 [Q12959] | 2 | EBI-20731541,EBI-357481 |
Protein-protein interaction databases
BioGRIDi | 125640, 1 interactor |
IntActi | Q86XJ0, 1 interactor |
STRINGi | 9606.ENSP00000358798 |
Miscellaneous databases
RNActi | Q86XJ0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the CALHM family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRUK, Eukaryota |
GeneTreei | ENSGT01030000234610 |
HOGENOMi | CLU_069286_0_0_1 |
InParanoidi | Q86XJ0 |
OMAi | RCWSQAL |
OrthoDBi | 960393at2759 |
PhylomeDBi | Q86XJ0 |
TreeFami | TF329085 |
Family and domain databases
InterProi | View protein in InterPro IPR029569, CALHM IPR029571, CALHM3 |
PANTHERi | PTHR32261, PTHR32261, 1 hit PTHR32261:SF7, PTHR32261:SF7, 1 hit |
Pfami | View protein in Pfam PF14798, Ca_hom_mod, 1 hit |
i Sequence
Sequence statusi: Complete.
Q86XJ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKFRMLFQH FQSSSESVMN GICLLLAAVT VKLYSSFDFN CPCLVHYNAL
60 70 80 90 100
YGLGLLLTPP LALFLCGLLA NRQSVVMVEE WRRPAGHRRK DPGIIRYMCS
110 120 130 140 150
SVLQRALAAP LVWILLALLD GKCFVCAFSS SVDPEKFLDF ANMTPSQVQL
160 170 180 190 200
FLAKVPCKED ELVRDSPARK AVSRYLRCLS QAIGWSVTLL LIIAAFLARC
210 220 230 240 250
LRPCFDQTVF LQRRYWSNYV DLEQKLFDET CCEHARDFAH RCVLHFFASM
260 270 280 290 300
RSELQARGLR RGNAGRRLEL PAVPEPPEGL DSGSGKAHLR AISSREQVDR
310 320 330 340
LLSTWYSSKP PLDLAASPGL CGGGLSHRAP TLALGTRLSQ HTDV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081109 | 277 | P → PAVPEPP1 PublicationCorresponds to variant dbSNP:rs143800079Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL139339 Genomic DNA No translation available. BC039499 mRNA Translation: AAH39499.1 BC043367 mRNA Translation: AAH43367.1 |
CCDSi | CCDS44476.1 |
RefSeqi | NP_001123214.1, NM_001129742.1 |
Genome annotation databases
Ensembli | ENST00000369783.4; ENSP00000358798.4; ENSG00000183128.7 |
GeneIDi | 119395 |
KEGGi | hsa:119395 |
MANE-Selecti | ENST00000369783.4; ENSP00000358798.4; NM_001129742.2; NP_001123214.1 |
UCSCi | uc001kxg.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL139339 Genomic DNA No translation available. BC039499 mRNA Translation: AAH39499.1 BC043367 mRNA Translation: AAH43367.1 |
CCDSi | CCDS44476.1 |
RefSeqi | NP_001123214.1, NM_001129742.1 |
3D structure databases
AlphaFoldDBi | Q86XJ0 |
SMRi | Q86XJ0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125640, 1 interactor |
IntActi | Q86XJ0, 1 interactor |
STRINGi | 9606.ENSP00000358798 |
Protein family/group databases
TCDBi | 1.A.84.1.3, the calcium homeostasis modulator ca(2+) channel (calhm-c) family |
PTM databases
iPTMneti | Q86XJ0 |
PhosphoSitePlusi | Q86XJ0 |
Genetic variation databases
BioMutai | CALHM3 |
DMDMi | 68565591 |
Proteomic databases
PaxDbi | Q86XJ0 |
PeptideAtlasi | Q86XJ0 |
PRIDEi | Q86XJ0 |
Protocols and materials databases
Antibodypediai | 3118, 114 antibodies from 21 providers |
DNASUi | 119395 |
Genome annotation databases
Ensembli | ENST00000369783.4; ENSP00000358798.4; ENSG00000183128.7 |
GeneIDi | 119395 |
KEGGi | hsa:119395 |
MANE-Selecti | ENST00000369783.4; ENSP00000358798.4; NM_001129742.2; NP_001123214.1 |
UCSCi | uc001kxg.4, human |
Organism-specific databases
CTDi | 119395 |
DisGeNETi | 119395 |
GeneCardsi | CALHM3 |
HGNCi | HGNC:23458, CALHM3 |
HPAi | ENSG00000183128, Not detected |
MIMi | 618263, gene |
neXtProti | NX_Q86XJ0 |
OpenTargetsi | ENSG00000183128 |
PharmGKBi | PA162380976 |
VEuPathDBi | HostDB:ENSG00000183128 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRUK, Eukaryota |
GeneTreei | ENSGT01030000234610 |
HOGENOMi | CLU_069286_0_0_1 |
InParanoidi | Q86XJ0 |
OMAi | RCWSQAL |
OrthoDBi | 960393at2759 |
PhylomeDBi | Q86XJ0 |
TreeFami | TF329085 |
Enzyme and pathway databases
PathwayCommonsi | Q86XJ0 |
Reactomei | R-HSA-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9730628, Sensory perception of salty taste |
SignaLinki | Q86XJ0 |
Miscellaneous databases
BioGRID-ORCSi | 119395, 7 hits in 1067 CRISPR screens |
GenomeRNAii | 119395 |
Pharosi | Q86XJ0, Tdark |
PROi | PR:Q86XJ0 |
RNActi | Q86XJ0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183128, Expressed in pancreas and 17 other tissues |
Genevisiblei | Q86XJ0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029569, CALHM IPR029571, CALHM3 |
PANTHERi | PTHR32261, PTHR32261, 1 hit PTHR32261:SF7, PTHR32261:SF7, 1 hit |
Pfami | View protein in Pfam PF14798, Ca_hom_mod, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CAHM3_HUMAN | |
Accessioni | Q86XJ0Primary (citable) accession number: Q86XJ0 Secondary accession number(s): Q5W090, Q8IXR2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | December 5, 2018 | |
Last modified: | May 25, 2022 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families