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UniProtKB - Q86XJ0 (CAHM3_HUMAN)

Entry version 127 (07 Apr 2021)
Sequence version 2 (05 Dec 2018)
Previous versions | rss
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Protein

Calcium homeostasis modulator protein 3

Gene

CALHM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3-mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Sensory transduction, Taste, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86XJ0

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.84.1.3, the calcium homeostasis modulator ca(2+) channel (calhm-c) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium homeostasis modulator protein 3
Alternative name(s):
Protein A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CALHM3Imported
Synonyms:FAM26A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23458, CALHM3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618263, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86XJ0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000183128.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		119395

Open Targets

More...OpenTargetsi		ENSG00000183128

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162380976

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86XJ0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CALHM3

Domain mapping of disease mutations (DMDM)

More...DMDMi		68565591

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001867191 – 344Calcium homeostasis modulator protein 3Add BLAST344

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86XJ0

PeptideAtlas

More...PeptideAtlasi		Q86XJ0

PRoteomics IDEntifications database

More...PRIDEi		Q86XJ0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86XJ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86XJ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in circumvallate taste bud cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183128, Expressed in pancreas and 17 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86XJ0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000183128, Tissue enhanced (blood, pancreas, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with CALHM1 as a pore-forming subunit in an hetero-hexameric channel complex.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125640, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q86XJ0, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358798

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86XJ0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86XJ0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CALHM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRUK, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_069286_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86XJ0

Identification of Orthologs from Complete Genome Data

More...OMAi		HLLSTWY

Database of Orthologous Groups

More...OrthoDBi		960393at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86XJ0

TreeFam database of animal gene trees

More...TreeFami		TF329085

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029569, CALHM
IPR029571, CALHM3

The PANTHER Classification System

More...PANTHERi		PTHR32261, PTHR32261, 1 hit
PTHR32261:SF7, PTHR32261:SF7, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14798, Ca_hom_mod, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86XJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKFRMLFQH FQSSSESVMN GICLLLAAVT VKLYSSFDFN CPCLVHYNAL 
        60         70         80         90        100
YGLGLLLTPP LALFLCGLLA NRQSVVMVEE WRRPAGHRRK DPGIIRYMCS 
       110        120        130        140        150
SVLQRALAAP LVWILLALLD GKCFVCAFSS SVDPEKFLDF ANMTPSQVQL 
       160        170        180        190        200
FLAKVPCKED ELVRDSPARK AVSRYLRCLS QAIGWSVTLL LIIAAFLARC 
       210        220        230        240        250
LRPCFDQTVF LQRRYWSNYV DLEQKLFDET CCEHARDFAH RCVLHFFASM 
       260        270        280        290        300
RSELQARGLR RGNAGRRLEL PAVPEPPEGL DSGSGKAHLR AISSREQVDR 
       310        320        330        340 
LLSTWYSSKP PLDLAASPGL CGGGLSHRAP TLALGTRLSQ HTDV
Length:344
Mass (Da):38,496
Last modified:December 5, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC35B67BBDE58EA61
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081109277P → PAVPEPP1 PublicationCorresponds to variant dbSNP:rs143800079Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL139339 Genomic DNA No translation available.
BC039499 mRNA Translation: AAH39499.1
BC043367 mRNA Translation: AAH43367.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44476.1

NCBI Reference Sequences

More...RefSeqi		NP_001123214.1, NM_001129742.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369783; ENSP00000358798; ENSG00000183128

Database of genes from NCBI RefSeq genomes

More...GeneIDi		119395

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:119395

UCSC genome browser

More...UCSCi		uc001kxg.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139339 Genomic DNA No translation available.
BC039499 mRNA Translation: AAH39499.1
BC043367 mRNA Translation: AAH43367.1
CCDSiCCDS44476.1
RefSeqiNP_001123214.1, NM_001129742.1

3D structure databases

SMRiQ86XJ0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125640, 1 interactor
IntActiQ86XJ0, 1 interactor
STRINGi9606.ENSP00000358798

Protein family/group databases

TCDBi1.A.84.1.3, the calcium homeostasis modulator ca(2+) channel (calhm-c) family

PTM databases

iPTMnetiQ86XJ0
PhosphoSitePlusiQ86XJ0

Genetic variation databases

BioMutaiCALHM3
DMDMi68565591

Proteomic databases

PaxDbiQ86XJ0
PeptideAtlasiQ86XJ0
PRIDEiQ86XJ0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3118, 111 antibodies

The DNASU plasmid repository

More...DNASUi		119395

Genome annotation databases

EnsembliENST00000369783; ENSP00000358798; ENSG00000183128
GeneIDi119395
KEGGihsa:119395
UCSCiuc001kxg.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		119395
DisGeNETi119395

GeneCards: human genes, protein and diseases

More...GeneCardsi		CALHM3
HGNCiHGNC:23458, CALHM3
HPAiENSG00000183128, Tissue enhanced (blood, pancreas, testis)
MIMi618263, gene
neXtProtiNX_Q86XJ0
OpenTargetsiENSG00000183128
PharmGKBiPA162380976
VEuPathDBiHostDB:ENSG00000183128.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRUK, Eukaryota
GeneTreeiENSGT01000000214602
HOGENOMiCLU_069286_0_0_1
InParanoidiQ86XJ0
OMAiHLLSTWY
OrthoDBi960393at2759
PhylomeDBiQ86XJ0
TreeFamiTF329085

Enzyme and pathway databases

PathwayCommonsiQ86XJ0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		119395, 3 hits in 987 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		119395
PharosiQ86XJ0, Tdark

Protein Ontology

More...PROi		PR:Q86XJ0
RNActiQ86XJ0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000183128, Expressed in pancreas and 17 other tissues
GenevisibleiQ86XJ0, HS

Family and domain databases

InterProiView protein in InterPro
IPR029569, CALHM
IPR029571, CALHM3
PANTHERiPTHR32261, PTHR32261, 1 hit
PTHR32261:SF7, PTHR32261:SF7, 1 hit
PfamiView protein in Pfam
PF14798, Ca_hom_mod, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAHM3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86XJ0
Secondary accession number(s): Q5W090, Q8IXR2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 5, 2018
Last modified: April 7, 2021
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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