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Protein

Protein phosphatase 1 regulatory subunit 3B

Gene

PPP1R3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCarbohydrate metabolism, Glycogen metabolism

Protein family/group databases

CAZyiCBM21 Carbohydrate-Binding Module Family 21

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3B
Alternative name(s):
Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
Protein phosphatase 1 regulatory subunit 4
Short name:
PP1 subunit R4
Protein phosphatase 1 subunit GL
Short name:
PTG
Gene namesi
Name:PPP1R3B
Synonyms:PPP1R4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000173281.4
HGNCiHGNC:14942 PPP1R3B
MIMi610541 gene
neXtProtiNX_Q86XI6

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi79660
OpenTargetsiENSG00000173281
PharmGKBiPA33652

Polymorphism and mutation databases

BioMutaiPPP1R3B
DMDMi74727837

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245431 – 285Protein phosphatase 1 regulatory subunit 3BAdd BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei261PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86XI6
MaxQBiQ86XI6
PaxDbiQ86XI6
PeptideAtlasiQ86XI6
PRIDEiQ86XI6
ProteomicsDBi70281

PTM databases

iPTMnetiQ86XI6
PhosphoSitePlusiQ86XI6

Expressioni

Tissue specificityi

Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expression in placenta and lung.2 Publications

Gene expression databases

BgeeiENSG00000173281 Expressed in 188 organ(s), highest expression level in liver
CleanExiHS_PPP1R3B
GenevisibleiQ86XI6 HS

Organism-specific databases

HPAiHPA028731

Interactioni

Subunit structurei

Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621363EBI-3918864,EBI-357253

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122786, 9 interactors
IntActiQ86XI6, 6 interactors
MINTiQ86XI6
STRINGi9606.ENSP00000308318

Structurei

Secondary structure

1285
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ86XI6
SMRiQ86XI6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86XI6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 233CBM21PROSITE-ProRule annotationAdd BLAST109

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi62 – 65PP1-binding motif4

Domaini

The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to PYGL.By similarity

Phylogenomic databases

eggNOGiKOG3986 Eukaryota
ENOG4111FT1 LUCA
GeneTreeiENSGT00530000062978
HOGENOMiHOG000026799
HOVERGENiHBG052744
InParanoidiQ86XI6
KOiK07189
OMAiEFAVCYE
OrthoDBiEOG091G0GB5
PhylomeDBiQ86XI6
TreeFamiTF105537

Family and domain databases

Gene3Di2.60.40.2440, 1 hit
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
IPR017434 Pase-1_reg-su_3B/C/D_met
IPR030682 PP1_3B
PANTHERiPTHR12307:SF13 PTHR12307:SF13, 1 hit
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PIRSFiPIRSF038207 PP1_GT_animal, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit

Sequencei

Sequence statusi: Complete.

Q86XI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAVDIEYRY NCMAPSLRQE RFAFKISPKP SKPLRPCIQL SSKNEASGMV
60 70 80 90 100
APAVQEKKVK KRVSFADNQG LALTMVKVFS EFDDPLDMPF NITELLDNIV
110 120 130 140 150
SLTTAESESF VLDFSQPSAD YLDFRNRLQA DHVCLENCVL KDKAIAGTVK
160 170 180 190 200
VQNLAFEKTV KIRMTFDTWK SYTDFPCQYV KDTYAGSDRD TFSFDISLPE
210 220 230 240 250
KIQSYERMEF AVYYECNGQT YWDSNRGKNY RIIRAELKST QGMTKPHSGP
260 270 280
DLGISFDQFG SPRCSYGLFP EWPSYLGYEK LGPYY
Length:285
Mass (Da):32,695
Last modified:June 1, 2003 - v1
Checksum:i77178FE100947989
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149V → A in BAB14811 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03981448G → E. Corresponds to variant dbSNP:rs3748140Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024067 mRNA Translation: BAB14811.1
AK096119 mRNA Translation: BAG53215.1
CH471157 Genomic DNA Translation: EAW65572.1
BC043388 mRNA Translation: AAH43388.1
CCDSiCCDS5973.1
RefSeqiNP_001188258.1, NM_001201329.1
NP_078883.2, NM_024607.3
XP_006716316.1, XM_006716253.3
XP_016869324.1, XM_017013835.1
UniGeneiHs.458513

Genome annotation databases

EnsembliENST00000310455; ENSP00000308318; ENSG00000173281
ENST00000519699; ENSP00000428642; ENSG00000173281
ENST00000644687; ENSP00000493491; ENSG00000285343
ENST00000645121; ENSP00000494659; ENSG00000285343
GeneIDi79660
KEGGihsa:79660
UCSCiuc003wsn.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024067 mRNA Translation: BAB14811.1
AK096119 mRNA Translation: BAG53215.1
CH471157 Genomic DNA Translation: EAW65572.1
BC043388 mRNA Translation: AAH43388.1
CCDSiCCDS5973.1
RefSeqiNP_001188258.1, NM_001201329.1
NP_078883.2, NM_024607.3
XP_006716316.1, XM_006716253.3
XP_016869324.1, XM_017013835.1
UniGeneiHs.458513

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EEFNMR-A105-253[»]
ProteinModelPortaliQ86XI6
SMRiQ86XI6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122786, 9 interactors
IntActiQ86XI6, 6 interactors
MINTiQ86XI6
STRINGi9606.ENSP00000308318

Protein family/group databases

CAZyiCBM21 Carbohydrate-Binding Module Family 21

PTM databases

iPTMnetiQ86XI6
PhosphoSitePlusiQ86XI6

Polymorphism and mutation databases

BioMutaiPPP1R3B
DMDMi74727837

Proteomic databases

EPDiQ86XI6
MaxQBiQ86XI6
PaxDbiQ86XI6
PeptideAtlasiQ86XI6
PRIDEiQ86XI6
ProteomicsDBi70281

Protocols and materials databases

DNASUi79660
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310455; ENSP00000308318; ENSG00000173281
ENST00000519699; ENSP00000428642; ENSG00000173281
ENST00000644687; ENSP00000493491; ENSG00000285343
ENST00000645121; ENSP00000494659; ENSG00000285343
GeneIDi79660
KEGGihsa:79660
UCSCiuc003wsn.5 human

Organism-specific databases

CTDi79660
DisGeNETi79660
EuPathDBiHostDB:ENSG00000173281.4
GeneCardsiPPP1R3B
H-InvDBiHIX0007298
HGNCiHGNC:14942 PPP1R3B
HPAiHPA028731
MIMi610541 gene
neXtProtiNX_Q86XI6
OpenTargetsiENSG00000173281
PharmGKBiPA33652
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3986 Eukaryota
ENOG4111FT1 LUCA
GeneTreeiENSGT00530000062978
HOGENOMiHOG000026799
HOVERGENiHBG052744
InParanoidiQ86XI6
KOiK07189
OMAiEFAVCYE
OrthoDBiEOG091G0GB5
PhylomeDBiQ86XI6
TreeFamiTF105537

Miscellaneous databases

ChiTaRSiPPP1R3B human
EvolutionaryTraceiQ86XI6
GenomeRNAii79660
PROiPR:Q86XI6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173281 Expressed in 188 organ(s), highest expression level in liver
CleanExiHS_PPP1R3B
GenevisibleiQ86XI6 HS

Family and domain databases

Gene3Di2.60.40.2440, 1 hit
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
IPR017434 Pase-1_reg-su_3B/C/D_met
IPR030682 PP1_3B
PANTHERiPTHR12307:SF13 PTHR12307:SF13, 1 hit
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PIRSFiPIRSF038207 PP1_GT_animal, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPR3B_HUMAN
AccessioniPrimary (citable) accession number: Q86XI6
Secondary accession number(s): B3KTV3, Q9H812
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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