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UniProtKB - Q86XF0 (DYR2_HUMAN)

Entry version 142 (25 May 2022)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
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Protein

Dihydrofolate reductase 2, mitochondrial

Gene

DHFR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.

2 Publications

Miscellaneous

Humans have acquired two dihydrofolate reductase enzymes during their evolution, DHFR and DHFR2. In contrast to human, mice and brown rats have just one.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=209 µM for dihydrofolate1 Publication
  2. KM=20 µM for NADPH1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate. This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei10NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei71SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi16 – 22NADPBy similarity7
Nucleotide bindingi55 – 57NADPBy similarity3
Nucleotide bindingi77 – 79NADPBy similarity3
Nucleotide bindingi117 – 124NADPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processOne-carbon metabolism
LigandNADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.5.1.3, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86XF0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-196757, Metabolism of folate and pterines

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q86XF0

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00077;UER00158

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dihydrofolate reductase 2, mitochondrial
Alternative name(s):
Dihydrofolate reductase, mitochondrial (EC:1.5.1.3)
Dihydrofolate reductase-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DHFR2Imported
Synonyms:DHFRL1, DHFRP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:27309, DHFR2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616588, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86XF0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000178700

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		200895

Open Targets

More...OpenTargetsi		ENSG00000178700

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134889916

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86XF0, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB02402, 5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine
DB02001, 5-(4-Morpholin-4-Yl-Phenylsulfanyl)-2,4-Quinazolinediamine
DB04306, 5-[(4-Methylphenyl)Sulfanyl]-2,4-Quinazolinediamine
DB01958, 5-[4-Tert-Butylphenylsulfanyl]-2,4-Quinazolinediamine
DB01929, 5-Chloryl-2,4,6-quinazolinetriamine
DB04163, 5-Phenylsulfanyl-2,4-Quinazolinediamine
DB07862, 7-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE
DB08203, 7-[2-METHOXY-1-(METHOXYMETHYL)ETHYL]-7H-PYRROLO[3,2-F] QUINAZOLINE-1,3-DIAMINE
DB12116, Epigallocatechin gallate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DHFR2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74727819

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001863681 – 187Dihydrofolate reductase 2, mitochondrialAdd BLAST187

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86XF0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86XF0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86XF0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86XF0

PeptideAtlas

More...PeptideAtlasi		Q86XF0

PRoteomics IDEntifications database

More...PRIDEi		Q86XF0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70273

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q86XF0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86XF0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86XF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in numerous cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000178700, Expressed in buccal mucosa cell and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86XF0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86XF0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000178700, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128354, 291 interactors

Protein interaction database and analysis system

More...IntActi		Q86XF0, 25 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377768

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86XF0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q86XF0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86XF0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 185DHFRPROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni31 – 36Substrate bindingBy similarity6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dihydrofolate reductase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1324, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010283

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86XF0

Identification of Orthologs from Complete Genome Data

More...OMAi		AMSQNMG

Database of Orthologous Groups

More...OrthoDBi		1489621at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86XF0

TreeFam database of animal gene trees

More...TreeFami		TF317636

Family and domain databases

Conserved Domains Database

More...CDDi		cd00209, DHFR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.430.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012259, DHFR
IPR024072, DHFR-like_dom_sf
IPR001796, DHFR_dom

The PANTHER Classification System

More...PANTHERi		PTHR48069, PTHR48069, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00186, DHFR_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53597, SSF53597, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51330, DHFR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86XF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLLLNCIVA VSQNMGIGKN GDLPRPPLRN EFRYFQRMTT TSSVEGKQNL 
        60         70         80         90        100
VIMGRKTWFS IPEKNRPLKD RINLVLSREL KEPPQGAHFL ARSLDDALKL 
       110        120        130        140        150
TERPELANKV DMIWIVGGSS VYKEAMNHLG HLKLFVTRIM QDFESDTFFS 
       160        170        180 
EIDLEKYKLL PEYPGVLSDV QEGKHIKYKF EVCEKDD
Length:187
Mass (Da):21,620
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA6548FB0F576FF7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JJ68C9JJ68_HUMAN
Dihydrofolate reductase
DHFR2
114Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061135166V → I1 PublicationCorresponds to variant dbSNP:rs17855824Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL832912 mRNA Translation: CAH10617.1
AC130896 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79895.1
CH471052 Genomic DNA Translation: EAW79896.1
BC045541 mRNA Translation: AAH45541.1
BC063379 mRNA Translation: AAH63379.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2926.1

NCBI Reference Sequences

More...RefSeqi		NP_001182572.1, NM_001195643.1
NP_789785.1, NM_176815.4
XP_011510839.1, XM_011512537.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000314636.3; ENSP00000319170.2; ENSG00000178700.9
ENST00000394221.3; ENSP00000377768.2; ENSG00000178700.9
ENST00000461173.5; ENSP00000418415.1; ENSG00000178700.9
ENST00000619045.1; ENSP00000480823.1; ENSG00000178700.9

Database of genes from NCBI RefSeq genomes

More...GeneIDi		200895

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:200895

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000314636.3; ENSP00000319170.2; NM_176815.5; NP_789785.1

UCSC genome browser

More...UCSCi		uc003dri.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832912 mRNA Translation: CAH10617.1
AC130896 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79895.1
CH471052 Genomic DNA Translation: EAW79896.1
BC045541 mRNA Translation: AAH45541.1
BC063379 mRNA Translation: AAH63379.1
CCDSiCCDS2926.1
RefSeqiNP_001182572.1, NM_001195643.1
NP_789785.1, NM_176815.4
XP_011510839.1, XM_011512537.2

3D structure databases

AlphaFoldDBiQ86XF0
SMRiQ86XF0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128354, 291 interactors
IntActiQ86XF0, 25 interactors
STRINGi9606.ENSP00000377768

Chemistry databases

DrugBankiDB02402, 5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine
DB02001, 5-(4-Morpholin-4-Yl-Phenylsulfanyl)-2,4-Quinazolinediamine
DB04306, 5-[(4-Methylphenyl)Sulfanyl]-2,4-Quinazolinediamine
DB01958, 5-[4-Tert-Butylphenylsulfanyl]-2,4-Quinazolinediamine
DB01929, 5-Chloryl-2,4,6-quinazolinetriamine
DB04163, 5-Phenylsulfanyl-2,4-Quinazolinediamine
DB07862, 7-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE
DB08203, 7-[2-METHOXY-1-(METHOXYMETHYL)ETHYL]-7H-PYRROLO[3,2-F] QUINAZOLINE-1,3-DIAMINE
DB12116, Epigallocatechin gallate

PTM databases

iPTMnetiQ86XF0
PhosphoSitePlusiQ86XF0

Genetic variation databases

BioMutaiDHFR2
DMDMi74727819

Proteomic databases

jPOSTiQ86XF0
MassIVEiQ86XF0
MaxQBiQ86XF0
PaxDbiQ86XF0
PeptideAtlasiQ86XF0
PRIDEiQ86XF0
ProteomicsDBi70273
TopDownProteomicsiQ86XF0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32082, 120 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		200895

Genome annotation databases

EnsembliENST00000314636.3; ENSP00000319170.2; ENSG00000178700.9
ENST00000394221.3; ENSP00000377768.2; ENSG00000178700.9
ENST00000461173.5; ENSP00000418415.1; ENSG00000178700.9
ENST00000619045.1; ENSP00000480823.1; ENSG00000178700.9
GeneIDi200895
KEGGihsa:200895
MANE-SelectiENST00000314636.3; ENSP00000319170.2; NM_176815.5; NP_789785.1
UCSCiuc003dri.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		200895
DisGeNETi200895

GeneCards: human genes, protein and diseases

More...GeneCardsi		DHFR2
HGNCiHGNC:27309, DHFR2
HPAiENSG00000178700, Low tissue specificity
MIMi616588, gene
neXtProtiNX_Q86XF0
OpenTargetsiENSG00000178700
PharmGKBiPA134889916
VEuPathDBiHostDB:ENSG00000178700

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1324, Eukaryota
GeneTreeiENSGT00390000010283
InParanoidiQ86XF0
OMAiAMSQNMG
OrthoDBi1489621at2759
PhylomeDBiQ86XF0
TreeFamiTF317636

Enzyme and pathway databases

UniPathwayiUPA00077;UER00158
BRENDAi1.5.1.3, 2681
PathwayCommonsiQ86XF0
ReactomeiR-HSA-196757, Metabolism of folate and pterines
SignaLinkiQ86XF0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		200895, 379 hits in 1004 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DHFR2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		200895
PharosiQ86XF0, Tbio

Protein Ontology

More...PROi		PR:Q86XF0
RNActiQ86XF0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000178700, Expressed in buccal mucosa cell and 223 other tissues
ExpressionAtlasiQ86XF0, baseline and differential
GenevisibleiQ86XF0, HS

Family and domain databases

CDDicd00209, DHFR, 1 hit
Gene3Di3.40.430.10, 1 hit
InterProiView protein in InterPro
IPR012259, DHFR
IPR024072, DHFR-like_dom_sf
IPR001796, DHFR_dom
PANTHERiPTHR48069, PTHR48069, 1 hit
PfamiView protein in Pfam
PF00186, DHFR_1, 1 hit
SUPFAMiSSF53597, SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS51330, DHFR_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86XF0
Secondary accession number(s): D3DN30, Q6P4I9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2003
Last modified: May 25, 2022
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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